Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof
By designing and synthesizing novel pyranose-substituted benzene derivatives, the inhibitory effect on SGLT2 is enhanced, overcoming the shortcomings of existing compounds in the treatment of diabetes and providing a more effective pharmaceutical composition for the treatment of metabolic disorders.
Patent Information
- Application Number
- CN201310414119.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2005-02-09
- Filing Date
- 2005-03-11
- Publication Date
- 2013-12-18
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Existing pyranose-substituted benzene derivatives have limited effectiveness in inhibiting the sodium-dependent glucose cotransporter SGLT2 and have poor pharmacological or pharmacokinetic properties, making them difficult to use effectively for the treatment of metabolic diseases such as diabetes.
Develop novel pyranose-substituted benzene derivatives, enhance their inhibitory effect on SGLT2 through specific structural design and synthetic methods, and prepare them into pharmaceutical compositions for the treatment of related diseases.
It improves the inhibitory effect on SGLT2, enhances the pharmacological and pharmacokinetic properties of the drug, and provides an effective drug solution for the treatment of diabetes and other metabolic disorders.