Liquid distributor for chromatography column with secondary flow channel

Abstract

The invention relates to a liquid distributor with two stages of runners for a chromatographic column. The liquid distributor is provided with a main distribution disc, wherein a plurality of radial launders distributed along the circumference are formed in the surface of one side of the main distribution disc, an annular axial through hole communicated with the launders is formed in the middle of the main distribution disc, the longitudinal fracture surfaces of one sections, from the near edge of the main distribution disc to the axial through hole, of the launders are in tilted curve shapes, and the longitudinal fracture surfaces of one sections, from the axial through hole to the main distribution disc, of the launders are in downward-inclined linear shapes; a second-stage distribution disc is arranged on the other side of the main distribution disc, an annular runner is formed between the second-stage distribution disc and the main distribution disc, a central hole and a plurality of radial runners are formed in the second-stage distribution disc, the radial runners are communicated with the annular runner and the central hole, and a liquid outlet or inlet pipe is arranged on the second-stage distribution disc. According to the liquid distributor with two stages of runners, the longest flowing distances of liquid in the launders can be shortened, and the distribution uniformity and chromatography efficiency of the liquid are improved.

Description

Technical field

[0001] The invention relates to a chromatographic column in gel chromatography technology, in particular to a liquid distributor of a chromatographic column with a secondary flow channel.

Background technique

[0002] Chromatography is a gel separation method, typically silica gel chromatography. It is separated by reacting the separation liquid with the gel in the chromatographic column through molecular sieve, ion exchange, etc. Chromatographic column is the main body in gel chromatography technology, generally using glass tube or plexiglass tube, which is filled with gel, and equipped with liquid distribution plate and sieve plate at both ends. The traditional chromatography column liquid distribution plate has a radial flow groove on one side, and a liquid inlet or outlet in the center. The liquid enters from the liquid inlet and flows out from the edge of the liquid distribution plate through the radial flow groove; or by the liquid The edge of the...

Examples

Embodiment Construction

[0015] The following examples are further explanations and illustrations of the present invention, and do not constitute any limitation to the present invention.

[0016] refer to figure 1 , The liquid distributor of the chromatographic column with the secondary flow channel of the present invention includes a main distribution plate 10 , a secondary distribution plate 20 , an annular flow channel 30 and a liquid outlet or inlet pipe 40 .

[0017] Such as Figure 2 ~ Figure 4 As shown, the main distribution plate 10 is a circular disc-shaped body, which can be arranged at both ends of a chromatography column (not shown in the figure) in actual application. In this embodiment, a plurality of flow channels 11 are arranged on the lower surface of the main distribution plate 10, and the plurality of flow channels 11 are radially spaced along the circumferential direction of the main distribution plate 10. Each flow channel 11 is composed of two sections of different groove types....

Technical field

[0001] The invention relates to a chromatographic column in gel chromatography technology, in particular to a liquid distributor of a chromatographic column with a secondary flow channel.

Background technique

[0002] Chromatography is a gel separation method, typically silica gel chromatography. It is separated by reacting the separation liquid with the gel in the chromatographic column through molecular sieve, ion exchange, etc. Chromatographic column is the main body in gel chromatography technology, generally using glass tube or plexiglass tube, which is filled with gel, and equipped with liquid distribution plate and sieve plate at both ends. The traditional chromatography column liquid distribution plate has a radial flow groove on one side, and a liquid inlet or outlet in the center. The liquid enters from the liquid inlet and flows out from the edge of the liquid distribution plate through the radial flow groove; or by the liquid The edge of the...

Examples

Embodiment Construction

[0015] The following examples are further explanations and illustrations of the present invention, and do not constitute any limitation to the present invention.

[0016] refer to figure 1 , The liquid distributor of the chromatographic column with the secondary flow channel of the present invention includes a main distribution plate 10 , a secondary distribution plate 20 , an annular flow channel 30 and a liquid outlet or inlet pipe 40 .

[0017] Such as Figure 2 ~ Figure 4 As shown, the main distribution plate 10 is a circular disc-shaped body, which can be arranged at both ends of a chromatography column (not shown in the figure) in actual application. In this embodiment, a plurality of flow channels 11 are arranged on the lower surface of the main distribution plate 10, and the plurality of flow channels 11 are radially spaced along the circumferential direction of the main distribution plate 10. Each flow channel 11 is composed of two sections of different groove types....

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