A method for extracting artemisinin by ultrasonic technology

A technology of artemisinin and ultrasound, applied in the direction of organic chemistry, can solve the problem of low extraction efficiency of artemisinin, achieve the effect of improving extraction yield, strong collapse, and increasing vibration amplitude

CN105294728BInactive Publication Date: 2017-06-16JIANGYIN POLYTECHNIC COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2017-06-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for extracting artemisinin through the ultrasonic technology. The method includes the following steps that 1, artemisia annua serves as a raw material, after the artemisia annua is smashed, a petroleum ether solvent is added to be evenly mixed, extracting is carrying out under the condition of ultrasonic oscillation, and an extracting solution is obtained, wherein the ultrasonic oscillation mode is that sinusoidal-condition ultrasonic waves, cosine-condition ultrasonic waves and frequency-conversion ultrasonic waves are alternately adopted; 2, a concentrated solution obtained by distilling the extracting solution, extract obtained through repeat distilling is degreased, then ethyl alcohol is added for crystallization, and an artemisinin crude product is obtained; 3, the obtained artemisinin crude product is crystallized multiple times, and the artemisinin is obtained. As the ultrasonic oscillation mode most suitable for artemisinin extracting is adopted, more intense collapse is generated, the maximum-effect synergistic effect is achieved, and the extracting productivity of the artemisinin is increased to the maximal degree.
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Description

technical field

[0001] The invention belongs to the technical field of artemisinin extraction, and in particular relates to a process for extracting artemisinin by ultrasonic technology. Background technique

[0002] Artemisinin (artemisine) is an antimalarial drug extracted from Artemisia annua sesquiterpene lactones from traditional Chinese medicine, and its chemical name is (3R, artemisinin 5aS, 6R, 8aS, 9R, 12S, 12aR)-octahydro -3,6,9-trimethyl-3,12-oxo-12H-pyrano[4,3-j]-1,2-benzodisepin-10(3H)-one, chemical formula C15H22O5 , molecular weight 282.33. Artemisinin is a colorless needle-like crystal with a bitter taste; its melting point is 156-157°C, and its optical rotation is +69° (c=0.5, CHCl3); it is easily soluble in acetone, ethyl acetate, chloroform, benzene and glacial acetic acid , Soluble in ethanol, methanol, ether, slightly soluble in cold petroleum ether, almost insoluble in water. Artemisinin is easily reduced by ferrous sulfate and reacts with triphenylp...

Examples

Embodiment 12～14

[0028] The steps of extracting artemisinin in Examples 12-14 are the same as those in Examples 1-11, the only difference is that only sine state ultrasonic waves, cosine state ultrasonic waves and variable frequency ultrasonic waves are used for ultrasonic extraction, and the parameters of the ultrasonic steps are detailed in Table 1 below.

[0029] Table 1 List of ultrasonic parameters of each embodiment

[0030]