BINOL derivative and preparation method and application thereof

A technology of derivatives and products, applied in the field of chemistry, can solve the problems of low recognition ability and small slope ratio difference, etc., and achieve the effect of fast and accurate analysis, small sample amount, and real-time rapid analysis

CN105669389AActive Publication Date: 2016-06-15SOUTHWEST MEDICAL UNIVERISTY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2016-06-15

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Abstract

The invention relates to a BINOL derivative.The BINOL derivative has the R or S configuration of a compound represented as the general formula in the description, wherein R1 and R2 are alkyl groups or fluorine-containing phenyl groups independently.When R1 and R2 are the same and both methyl groups, ethyl groups or 3,5-bis (trifluoromethyl) phenyl, the BINOL derivative has a good chiral recognition effect.The BINOL derivative can quickly analyze and determine a chiral amino alcohol absolute configuration in real time.According to the method, the quantity of samples in use is small, analysis is quick and accurate, the sample structure is not damaged, configuration determination does not need a complex chemical reaction, the BINOL derivative has the advantage that fluorescence is enhanced along with increase of concentration of amino alcohol to be tested, and a recognition effect is good.
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