Amine compound for inhibiting SSAO / VAP-1 and application of amine compound
By developing amine compounds that inhibit the activity of SSAO/VAP-1, we solve the problem of difficulty in effectively inhibiting the activity of these enzymes in the existing technology, significantly reduce inflammatory reactions, improve symptoms of diabetes and vascular diseases, and provide new therapeutic targets.
Patent Information
- Application Number
- CN201811599129.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2017-12-29
- Filing Date
- 2018-12-26
- Publication Date
- 2019-07-09
- Estimated Expiration
- 2038-12-26
AI Technical Summary
Existing technologies are difficult to effectively inhibit the activities of semicarbazide-sensitive amine oxidase (SSAO) and vascular adhesion protein-1 (VAP-1), leading to treatment difficulties for inflammation, diabetes, vascular diseases and other related diseases.
A new class of amine compounds has been developed, which has good SSAO/VAP-1 inhibitory activity and is used to prepare and prevent, treat or alleviate inflammatory diseases, diabetes, psychiatric disorders, ischemic diseases, vascular diseases, and fibrosis. or drugs for tissue transplant rejection.
By inhibiting the activity of SSAO/VAP-1, it can significantly reduce the inflammatory response and improve the symptoms of diabetes and vascular diseases, providing a new therapeutic target and having good prospects for pharmaceutical development.