A drug delivery device for tree shrew nasal cavity

Abstract

The present invention discloses a drug delivery device for the nasal cavity of a tree shrew, which mainly relates to the field of drug delivery for experimental animals. The device comprises a developing device, an external insert hose, an injection inner sleeve hose, and a flow blocking device; the external insert hose comprises a middle lumen and an annular cleaning cavity, a cleaning through hole is arranged on the top surface of the external insert hose head, and a drug delivery short tube is arranged on the side of the external insert hose head; the developing device is arranged at the center of the top surface of the external insert hose head; and a drug delivery port is arranged on the side of the injection inner sleeve hose head. The beneficial effects of the present invention are: it is suitable for drug delivery for tree shrew nasal disease models, can track the position of the nasal cannula in real time, determine the cannula position, and make the drug delivery position more accurate; and can clear and clean the nasal fluid in real time during the advancement process, which facilitates the insertion of the cannula; when injecting the drug, it can also prevent the injected drug solution from flowing into the digestive tract, making the injection dosage more accurate.

Description

Technical Field

[0001] The invention relates to the field of nasal drug administration for experimental animals, in particular to a drug administration device for the nasal cavity of a tree shrew. Background Art

[0002] Tree shrews are a new type of experimental animal. They are small in size, reproduce quickly, and are more closely related to primates than traditional experimental animals (rats, mice, rabbits, etc.). In the past, they were considered to be lower primates. Therefore, they have a wide range of applications in the biomedical field, especially in the role of animal models of human diseases, which has attracted more and more attention. For the study of different diseases, different routes of administration are often required. For the creation of nasal disease models, the administration site is usually limited to the local part of the nose to obtain the ideal model effect. However, the nasal structure of tree shrews is complex, the nasal concha and sinuses occupy a large space, and the nasal passages are narrow, the nasal mucosa is very thin, and there is a lot of nasal fluid, which makes it difficult to administer drugs through the nasal route. At present, there is no device for nasal administration of tree shrews, which has caused great inconvenience to the establishment of nasal disease models of tree shrews.

[0003] There is no literature or patent reporting on a method for administering drugs through the nose of tree shrews. The method currently used in the industry is to insert one end of a plastic hose into the inferior nasal passage of the tree shrew's nasal cavity and connect the other end to a syringe for administration. The inconvenience is:

[0004] 1. The hose has no scale and the insertion depth cannot be known, so it is impossible to infer the final administration site, which may lead to inaccurate administration site.

[0005] 2. The liquid medicine directly output through the hose may flow into the digestive tract through the posterior nasal cavity. The loss of liquid medicine may lead to inaccurate dosage of local drug injection.

[0006] 3. There is a lot of nasal fluid in the nasal cavity of tree shrews. The nasal fluid is relatively thick and the plastic hose is relatively soft. During the continuous insertion process, the nasal fluid will be pushed inward to accumulate and increase the resistance, thereby hindering the further insertion of the plastic hose and making the entire insertion process very difficult. Summary of the invention

[0007] The purpose of the present invention is to provide a drug delivery device for the nasal cavity of a tree shrew, which is suitable for drug delivery in a tree shrew nasal disease model, can track the position of a cannula in the nasal cavity in real time, determine the cannula position, and make the drug delivery position more accurate; and can clear the nasal fluid in real time during the advancement process, facilitating the insertion of the cannula; and can also prevent the injected drug solution from flowing into the digestive tract during drug injection, making the injection dosage more accurate.

[0008] In order to achieve the above object, the present invention is implemented through the following technical solutions:

[0009] A drug delivery device for the nasal cavity of a tree shrew, comprising a developing device, an external plug-in hose, an injection hose with an inner sleeve, and a flow blocking device;

[0010] External hose:

[0011] The external plug-in hose comprises a middle tube cavity and an annular cleaning cavity outside the middle tube cavity, the diameter of the middle tube cavity is adapted to the outer diameter of the injection inner sleeve hose, a plurality of cleaning through holes connected to the annular cleaning cavity are arranged in an annular array on the top surface of the tube head of the external plug-in hose, and a cleaning pipe joint connected to the annular cleaning cavity is arranged on the detachable tail cover of the tail of the external plug-in hose;

[0012] The side of the externally inserted hose head is provided with a conical short injection tube, the inner end of which is connected to the middle tube cavity; the short injection tube is not connected to the annular cleaning cavity;

[0013] Development device:

[0014] The developing device is arranged at the center of the top surface of the external hose head;

[0015] Injection hose:

[0016] The inner injection hose is inserted into the middle tube cavity, and a drug injection port is arranged on the side of the inner injection hose head. After the inner injection hose is pressed against the inner surface of the outer insertion hose head, the position of the drug injection port is just aligned with the drug injection short tube.

[0017] The device also includes a flow blocking device; an annular groove is provided on the side of the external hose head, and the flow blocking device includes an inflatable airbag and an inflatable inner tube; the inflatable airbag is arranged in the annular groove, one end of the inflatable inner tube is connected to the inflatable airbag, the inflatable inner tube is arranged in an annular cleaning cavity, and the other end of the inflatable inner tube passes through a detachable tail cover at the tail of the external hose.

[0018] The developing device comprises a shell and a contrast agent in the shell, and the shell is detachably arranged at the center position of the top surface of the external insertion hose head.

[0019] The externally inserted hose is provided with scale lines.

[0020] The distance between the developing device and the medicine injection short tube is 5 mm.

[0021] Compared with the prior art, the beneficial effects of the present invention are:

[0022] This device is an accurate drug delivery device based on contrast positioning. By taking advantage of the fact that X-rays cannot penetrate the developer, the image of the developer displayed under X-ray is used to track the insertion position of the external hose tube head in the nasal cavity, so that the image of the developer device in the nasal cavity can be observed in real time on the computer's image information. After the developer device reaches the drug delivery position, it is inserted 5mm away to align the short injection tube with the drug delivery position, thereby making the drug delivery position more accurate.

[0023] Moreover, during the advancement of the outer insertion hose of the inner injection hose, as the nasal fluid accumulates, the accumulated nasal fluid can be cleared by negative pressure through the cleaning pipe joint, the annular cleaning cavity, and the cleaning through hole through the external negative pressure equipment, so that the accumulated nasal fluid is cleaned in turn through the cleaning through hole, the annular cleaning cavity, and the cleaning pipe joint. This ensures that the nasal fluid can be cleared in real time during the advancement process, making it convenient to insert the cannula.

[0024] In addition, the device is also provided with a flow blocking device. After the short injection tube is aligned with the drug administration position, the inflatable airbag is first inflated through the external inflation device through the inflation inner tube, so that the inflatable airbag deflated in the annular groove is inflated, and its outer edge is in close contact with the inner wall of the nasal cavity, blocking the channel for the drug solution to flow into the oral cavity, and then the drug is injected. In this way, the injected drug solution can be prevented from flowing into the digestive tract through the oral cavity during injection, making the injection dosage more accurate. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the structure of the present invention when the inflatable airbag is not inflated.

[0026] Figure 2 It is a schematic diagram of the structure of the present invention after the inflatable airbag is inflated.

[0027] Figure 3 It is a cross-sectional view of the present invention.

[0028] Figure 4 It is a schematic diagram of the structure of the present invention after the inflatable airbag is inflated.

[0029] Figure 5 It is a schematic diagram of the structure of the externally inserted hose in the present invention.

[0030] Figure 6 It is a schematic diagram of the structure of the medicine injection inner sleeve hose in the present invention.

[0031] Figure 7 It is a schematic structural diagram of the inflatable airbag when the inflatable airbag is not inflated during the insertion of the present invention into the nasal cavity.

[0032] Figure 8 It is a schematic diagram of the structure after the present invention is inserted into the nasal cavity and the inflatable air bag is inflated.

[0033] Fig. 9 This is a diagram of the nasal passage structure of a tree shrew.

[0034] Fig.10 It is the state diagram used in the present invention.

[0035] Numbers shown in the accompanying drawings:

[0036] 1. Development device; 2. External plug-in hose; 3. Injection inner hose; 4. Middle tube cavity; 5. Annular cleaning cavity; 6. Cleaning through hole; 7. Removable tail cover; 8. Cleaning pipe joint; 9. Injection short tube; 10. Injection port; 11. Annular groove; 12. Inflatable airbag; 13. Inflatable inner tube; 14. Outer shell; 15. Contrast agent. DETAILED DESCRIPTION

[0037] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms fall within the scope limited by the application equally.

[0038] The present invention is a drug delivery device for the tree shrew nasal cavity, the main structure of which includes a developing device 1, an external plug hose 2, an injection inner hose 3, and a flow blocking device. The following is a detailed structural principle analysis of the above device in conjunction with the accompanying drawings:

[0039] External hose 2:

[0040] The external plug-in hose 2 is provided with scale lines to roughly predict the insertion position. The external plug-in hose 2 includes a middle tube cavity 4 and an annular cleaning cavity 5 outside the middle tube cavity 4. The middle tube cavity 4 and the annular cleaning cavity 5 are separated by an inner tube, and there is no connection between the two tube cavities. The cavity diameter of the middle tube cavity 4 is adapted to the outer diameter of the injection inner sleeve hose 3. A plurality of cleaning through holes 6 connected to the annular cleaning cavity 5 are arranged in an annular array on the top surface of the tube head of the external plug-in hose 2. A cleaning pipe joint 8 connected to the annular cleaning cavity 5 is arranged on the detachable tail cover 7 at the tail of the external plug-in hose 2.

[0041] The outer insert hose 2 is provided with a conical injection short tube 9 at the side of the tube head, and the diameter of the injection short tube 9 is conical with the outer end larger than the inner end, so as to expand the drug administration area. The inner end of the injection short tube 9 is connected to the middle tube cavity 4; the injection short tube 9 is not connected to the annular cleaning cavity 5.

[0042] Development device 1:

[0043] The developing device 1 is arranged at the center of the top surface of the external plug hose 2; the developing device 1 comprises a shell 14 and a contrast agent 15 in the shell 14, and the shell 14 is detachably arranged at the center of the top surface of the external plug hose 2. The distance between the developing device 1 and the injection short tube 9 is 5 mm.

[0044] Injection inner hose 3:

[0045] The inner injection hose 3 is inserted into the middle tube cavity 4, and a drug injection port 10 is provided on the side of the tube head of the inner injection hose 3. After the inner injection hose 3 and the inner surface of the tube head of the outer insertion hose 2 are pressed against each other, the position of the drug injection port 10 is just aligned with the drug injection short tube 9.

[0046] The device also includes a flow-blocking device; an annular groove 11 is provided on the side of the tube head of the externally inserted hose 2, and the flow-blocking device includes an inflatable airbag 12 and an inflatable inner tube 13; the inflatable airbag 12 is arranged in the annular groove 11, one end of the inflatable inner tube 13 is connected to the inflatable airbag 12, the inflatable inner tube 13 is arranged in the annular cleaning chamber 5, and the other end of the inflatable inner tube 13 passes through the detachable tail cover 7 at the tail of the externally inserted hose 2.

[0047] Specific principles and usage:

[0048] This device is a precise drug delivery device based on contrast positioning. By taking advantage of the fact that X-rays cannot penetrate the developer, the insertion position of the external hose 2 in the nasal cavity is tracked through the image displayed by the developer under X-rays, so that the insertion position of the image of the developer 1 in the nasal cavity can be observed in real time on the computer's image information.

[0049] Specifically, since the distance between the developing device 1 and the short injection tube 9 is 5 mm, the developing device 1 is further inserted 5 mm after reaching the dosing position, so that the short injection tube 9 is aligned with the dosing position for dosing, thereby making the dosing position more accurate.

[0050] Moreover, during the advancement of the outer insertion hose 2 of the inner injection hose 3, as the nasal fluid accumulates, the accumulated nasal fluid can be cleared by negative pressure through the cleaning pipe joint 8, the annular cleaning cavity 5, and the cleaning through hole 6 through the external negative pressure equipment, so that the accumulated nasal fluid is cleaned in turn through the cleaning through hole 6, the annular cleaning cavity 5, and the cleaning pipe joint 8. This ensures that the nasal fluid can be cleared in real time during the advancement process, making it convenient to insert the cannula.

[0051] In addition, in order to prevent the injected medicine from flowing into the digestive tract through the oral cavity during drug injection, the device is also provided with a flow blocking device. After the injection short tube 9 is aligned with the drug administration position, the inflation airbag 12 is first inflated through the external inflation device via the inflation inner tube 13, so that the inflation airbag 12 deflated in the annular groove 11 is inflated, and its outer edge is in close contact with the inner wall of the nasal cavity, blocking the channel for the medicine to flow into the oral cavity, and then the injection is performed. In this way, the injected medicine can be prevented from flowing into the digestive tract through the oral cavity during drug injection, so that the injection dosage is more accurate.

[0052] In addition, since the diameter of the nasopharynx behind the posterior nasal cavity is larger than the posterior nasal cavity, when administering medicine to the nasopharynx, in order to prevent the injected medicine from flowing into the digestive tract through the oral cavity, an inflation balloon 12 with a larger inflation capacity is required.

Claims

1. A drug delivery device for the nasal cavity of a tree shrew, characterized in that: It comprises a developing device (1), an external plug-in hose (2), a medicine injection inner hose (3), and a flow blocking device; External hose (2): The externally inserted hose (2) comprises a middle tube cavity (4) and an annular cleaning cavity (5) outside the middle tube cavity (4); the cavity diameter of the middle tube cavity (4) is adapted to the outer diameter of the injection inner sleeve hose (3); a plurality of cleaning through holes (6) communicating with the annular cleaning cavity (5) are arranged in an annular array on the top surface of the tube head of the externally inserted hose (2); and a cleaning pipe joint (8) communicating with the annular cleaning cavity (5) is arranged on a detachable tail cover (7) at the tail of the externally inserted hose (2); A conical short injection tube (9) is provided at the side of the head of the externally inserted hose (2), and the inner end of the short injection tube (9) is connected to the middle tube cavity (4); the short injection tube (9) is not connected to the annular cleaning cavity (5); Development device (1): The developing device (1) is arranged at the center of the top surface of the tube head of the external plug-in hose (2); Injection inner hose (3): The medicine injection inner sleeve hose (3) is inserted into the middle tube cavity (4), and a medicine injection port (10) is provided on the side of the tube head of the medicine injection inner sleeve hose (3). After the medicine injection inner sleeve hose (3) and the inner surface of the tube head of the external insert hose (2) are pressed against each other, the position of the medicine injection port (10) is just aligned with the medicine injection short tube (9); It also includes a flow blocking device; an annular groove (11) is provided on the side of the tube head of the externally inserted hose (2); the flow blocking device includes an inflatable airbag (12) and an inflatable inner tube (13); the inflatable airbag (12) is arranged in the annular groove (11); one end of the inflatable inner tube (13) is connected to the inflatable airbag (12); the inflatable inner tube (13) is arranged in the annular cleaning chamber (5); the other end of the inflatable inner tube (13) passes through a detachable tail cover (7) at the tail of the externally inserted hose (2); The developing device (1) comprises a shell (14) and a contrast agent (15) in the shell (14); the shell (14) is detachably arranged at the center of the top surface of the tube head of the external insertion hose (2).

2. The tree shrew nasal drug delivery device according to claim 1, characterized in that: The external insert hose (2) is provided with scale lines.

3. The tree shrew nasal drug delivery device according to claim 1, characterized in that: The distance between the developing device (1) and the medicine injection short tube (9) is a fixed distance of 5 mm.

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