An improved method for kidney preservation solution

By adding Ganoderma lucidum extract and epimedium extract to HC-A solution, the mitochondrial structure is protected, the activity of calczyme is improved, and the apoptosis and oxidative stress response is inhibited, the problem of ischemic damage in the kidney preservation liquid during the preservation process is solved, and the kidney preservation time is extended and the transplant survival rate is improved.

CN112369404BActive Publication Date: 2025-08-22HANGZHOU FIRST PEOPLES HOSPITAL +1
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Patent Information

Application Number
CN202011090872.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2020-10-13
Publication Date
2025-08-22
Estimated Expiration
2040-10-13

AI Technical Summary

Technical Problem

During the preservation process, existing renal preservation fluids are difficult to effectively protect the mitochondrial structure, prevent calcium overload, inhibit cell apoptosis and oxidative stress response, resulting in serious ischemia damage to the ex vivo kidneys during low temperature storage.

Method used

Add Ganoderma lucidum extract and epimedium extract to HC-A solution. Ganoderma lucidum extract contains Ganoderma lucidum polysaccharide and total triterpenes of Ganoderma lucidum. The epimedium extract contains icariin and pyrhodin. By protecting the mitochondrial structure, it improves calczyme activity, inhibits cell apoptosis and oxidative stress response.

Benefits of technology

It extends the storage time of the kidney, improves the survival rate of kidney transplantation, reduces ischemia damage to the isolated kidney during the low-temperature shelf life, and improves the storage effect of the kidney.

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Abstract

The present invention discloses an improved method for kidney preservation solution, belonging to the technical field of organ preservation solutions. The method comprises adding a ganoderma lucidum extract and an epimedium extract to HC-A solution. The ganoderma lucidum extract contains ganoderma lucidum polysaccharides and total ganoderma lucidum triterpenes, while the epimedium extract contains icariin and epimedin. The improved method of the present invention, which adds the ganoderma lucidum extract and the epimedium extract to the HC-A solution, can reduce ischemic damage during cryopreservation of isolated kidneys by protecting mitochondrial structure, increasing calpain activity, and inhibiting cell apoptosis, oxidative stress, and inflammatory reactions. This method improves the preservation effect of HC-A solution for isolated kidneys, prolongs their preservation time, and thus increases the survival rate of kidney transplantation. This method provides a clinical approach to finding a safe and effective method for preserving donor kidneys.
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