sample analyser

Abstract

The application discloses a sample analyzer, which comprises a sampling assembly, a routine blood measurement assembly, a specific protein measurement assembly, a sample unit for conveying a sample and a latex assembly for storing a latex reagent; a sampling path of the sampling assembly is a straight path; a sampling position of the sample unit, a latex position of the latex assembly, a routine blood pool position of the routine blood measurement assembly and a specific protein pool position of the specific protein measurement assembly are all located on the sampling path; wherein the sampling position is a position for extracting a sample on the sample unit; the latex position is a position for extracting a latex on the latex assembly; the routine blood pool position is a position for injecting a sample on the routine blood measurement assembly; and the specific protein pool position is a position for injecting a sample and a latex reagent on the specific protein measurement assembly. The sample analyzer provided by the application simplifies the structure of the sample analyzer, effectively improves the arrangement compactness between components and optimizes the internal layout.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a sample analyzer. Background Technology

[0002] With the widespread application of sample analyzers, their diverse functional requirements have also increased. Taking hematology analyzers as an example, there is no analyzer that combines specific protein measurement functions with five-part differential fluorescence measurement methods. Integrating both specific protein measurement components and routine blood count measurement components into the analyzer results in a complex structure, easily leading to space constraints and layout difficulties.

[0003] Therefore, how to simplify the structure and optimize the layout is a technical problem that needs to be solved by those skilled in the art. Summary of the Invention

[0004] The purpose of this invention is to provide a sample analyzer with simplified structure and optimized layout.

[0005] The present invention provides a sample analyzer, including a sampling component, a blood routine measurement component, a specific protein measurement component, a sample unit for transporting samples, and a latex component for storing latex reagents;

[0006] The sampling path of the sampling component is a straight path;

[0007] The sampling position of the sample unit, the latex position of the latex component, the blood routine measurement position of the blood routine measurement component, and the specific protein position of the specific protein measurement component are all located on the sampling path;

[0008] Wherein, the sampling position is the location on the sample unit where the sample is extracted; the latex position is the location on the latex assembly where latex is extracted; the blood routine pool position is the location on the blood routine measurement assembly where the sample is injected; and the specific protein pool position is the location on the specific protein measurement assembly where the sample and latex reagent are injected.

[0009] The sample analyzer provided by this invention sets the sampling path of the sampling component to a straight path, so that the sampling position, latex position, blood routine measurement pool position, and specific protein pool position are all located on the sampling path. This allows for the measurement of blood routine and specific proteins through the reciprocating motion of the same sampling component, avoiding the need for multiple sampling components to separately operate the blood routine measurement component and the specific protein measurement component, thus simplifying the structure of the sample analyzer. Furthermore, since the sampling position, latex position, blood routine measurement pool position, and specific protein pool position are all located on the sampling path, the sample unit, latex component, blood routine measurement component, and specific protein measurement component can be arranged in a straight line, effectively improving the compactness of the arrangement between components and thus optimizing the internal layout. Attached Figure Description

[0010] Figure 1 This is a schematic diagram of the sampling path layout of the sample analyzer provided by the present invention;

[0011] Figure 2 This is a three-dimensional structural schematic diagram of the sample analyzer provided by the present invention;

[0012] Figure 3 This is a schematic diagram of the right side structure of the sample analyzer provided by the present invention;

[0013] Figure 4 This is a schematic diagram of the left-side structure of the sample analyzer provided by the present invention;

[0014] Figure 5 This is a schematic diagram of the front view structure of the sample analyzer provided by the present invention;

[0015] Figure 6 This is a rear view schematic diagram of the sample analyzer provided by the present invention;

[0016] Figure 7 A schematic diagram of the sample analyzer provided by the present invention with its front cover opened;

[0017] Figure 8 A schematic diagram of the sample analyzer provided by the present invention with the top cover and right side plate removed;

[0018] Figure 9 This is a partial enlarged view of the interior of the sample analyzer provided by the present invention;

[0019] Figure 10 This is a schematic diagram of the right-side structure of the sample analyzer provided by the present invention after removing the right-side panel;

[0020] Figure 11 This is a schematic diagram of the left-side structure of the sample analyzer provided by the present invention after removing the left-side plate;

[0021] Figure 12 This is a schematic diagram of the structure of the left side panel of the frame of the sample analyzer provided by the present invention;

[0022] Figure 13 This is a schematic diagram of the sample analyzer provided by the present invention with the front shell removed.

[0023] Figure 14 This is a top view of the sample analyzer provided by the present invention with the top cover removed.

[0024] Figure 15 This is a schematic diagram of the air duct structure of the sample analyzer provided by the present invention;

[0025] Figure 16This is a schematic diagram of the air duct installation of the sample analyzer provided by the present invention;

[0026] Figure 17 This is a first schematic diagram of the frame of the sample analyzer provided by the present invention;

[0027] Figure 18 This is a second schematic diagram of the frame of the sample analyzer provided by the present invention;

[0028] Figure 19 This is a schematic diagram of the structure of the gas tank assembly and the gas pump assembly provided by the present invention.

[0029] in,

[0030] Micro-blood position -1, Normal blood position -2, Puncture position -3, First latex position -4, Second latex position -5, First CRP pool position -6, Second CRP pool position -7, HGB pool position -8, WNB pool position -9, DIFF pool position -10, RET pool position -11, Shut-off valve assembly -12, Compression-off valve assembly -13, Sheath flow assembly -14, LVM valve -15, Peripheral blood mixer -16, Latex assembly -17, Mixing assembly -18, Specific protein Measurement Component-19, Pressure Cutoff Valve Component-21, Right Valve Component-22, Power Supply Component-23, Preheating Tank Component-24, Hinge Component-25, Optical Component-26, Gas Tank Component-27, Negative Pressure Gas Tank-271, First Positive Pressure Gas Tank-272, Second Positive Pressure Gas Tank-273, Third Positive Pressure Gas Tank-274, Circuit Board-28, Sampling Component-29, RET Reaction Cell Component-30, WBC Reaction Cell Component-31, Dustproof Net- 32. Cooling Fan - 33. Heatsink Fins - 34. Front Housing - 35. Model Insert - 36. Lower Left Housing - 37. Automatic Sample Feeding Assembly - 38. Test Tube Rack - 39. Test Tubes - 40. Lower Right Housing - 41. Buttons - 42. Short Reservoir - 43. Upper Left Valve Assembly - 44. Reagent Detection Assembly - 45. Middle Left Valve Assembly - 46. Long Waste Liquid Pool - 47. Lower Left Valve Assembly - 48. Pump and Pressure Cutoff Valve Assembly - 49. Metering Pump - 50. Syringe - 51. Hydraulic Detection Assembly Component-52, LVM valve assembly-53, sampling manifold assembly-54, sheath fluid filter assembly-55, buffer tank assembly-56, air pump assembly-57, front valve assembly-58, fluorescent reagent assembly-59, dye bag fixing position-60, clamping and scanning assembly-61, cooling temperature control assembly-62, air pressure detection assembly-63, uprighting assembly-64, support rod-65, closed sample inlet assembly-66, sample compartment door-67, right side reservoir-70;

[0031] Left side panel -100, left side small door -101;

[0032] Front panel of the rack - 201, bottom panel of the rack - 202, power supply partition of the rack - 203, rear panel of the rack - 204, middle partition of the rack - 205, optical base plate of the rack - 206, board base plate of the rack - 207, left side panel of the rack - 208; clearance part - 2081, liquid-proof plate - 2082;

[0033] Back panel - 300, network interface - 301, power input socket - 302, first power switch - 303, waste liquid connector - 304, BNC socket - 305, DS diluent interface - 306, DR diluent interface - 307, LN hemolysin interface - 308, LD hemolysin interface - 309, LH hemolysin interface - 310, LC hemolysin interface - 311, fan assembly - 312;

[0034] Crossbeam support - 400;

[0035] Right side panel - 500, USB component - 501, USB protective cover - 502, latex replacement door - 503, second power switch - 504;

[0036] Top cover-600, power conversion board PCBA-601, valve drive board PCBA-602, SSD-603, main control board PCBA-604, analog board PCBA-605, burn-in power board PCBA-606, isolated power board PCBA-607, conventional drive board-608. Detailed Implementation

[0037] The core of this invention is to provide a sample analyzer with simplified structure and optimized layout.

[0038] To enable those skilled in the art to better understand the present invention, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0039] like Figures 1-19 As shown, this embodiment of the invention provides a sample analyzer, including a sampling component 29, a blood routine measurement component, a specific protein measurement component, a sample unit for transporting samples, and a latex component 17 for storing latex reagents; the sampling path of the sampling component 29 is a straight path; the sampling position of the sample unit, the latex position of the latex component 17, the blood routine measurement pool position of the blood routine measurement component, and the specific protein measurement component's specific protein pool position are all located on the sampling path; wherein, the sampling position is the position where the sample is extracted on the sample unit; the latex position is the position where latex is extracted on the latex component 17; the blood routine measurement pool position is the position where the sample is injected on the blood routine measurement component; and the specific protein pool position is the position where the sample and latex reagent are injected on the specific protein measurement component.

[0040] The sample analyzer provided in this embodiment of the invention sets the sampling path of the sampling component 29 to a straight path, so that the sampling position, latex position, blood routine pool position, and specific protein pool position are all located on the sampling path. This allows for the measurement of blood routine and specific proteins through the reciprocating motion of the same sampling component, avoiding the need to set up multiple sampling components to perform separate sampling operations on the blood routine measurement component and the specific protein measurement component, thus simplifying the structure of the sample analyzer. Furthermore, since the sampling position, latex position, blood routine pool position, and specific protein pool position are all located on the sampling path, the sample unit, latex component 17, blood routine measurement component, and specific protein measurement component can be arranged in a straight line, effectively improving the compactness of the arrangement between components and thus optimizing the internal layout.

[0041] in, Figure 1 The bottom of the image shows the front of the sample analyzer. Figure 1 The upper part of the image shows the rear of the sample analyzer. Figure 1 The left side of the image is the left side of the sample analyzer. Figure 1 The right side of the image represents the right side of the sample analyzer. Further, the sample unit, latex assembly 17, specific protein measurement assembly, and blood routine measurement assembly are arranged sequentially along the front-to-back direction of the sample analyzer; the front-to-back direction of the sample analyzer is the direction from the front to the rear of the analyzer. This arrangement ensures that the sample unit, latex assembly 17, specific protein measurement assembly, and blood routine measurement assembly are arranged along the front to the rear of the sample analyzer, placing the sample unit and latex assembly 17 close to the front of the analyzer. This facilitates placing samples (such as test tubes) into the sample unit from the front of the analyzer and allows operators to easily replace the latex reagents in the latex assembly 17 while standing at the front of the analyzer.

[0042] Furthermore, the latex assembly 17 is positioned near the front housing 35 of the sample analyzer; the front portion of the right side panel 500 of the sample analyzer has a latex replacement door 503 for replacing latex reagents, and the front portion of the right side panel 500 is the part of the right side panel 500 near the front housing 35 of the sample analyzer. During operation, the latex reagents inside the latex assembly 17 are replaced by opening the latex replacement door 503; and, instead of placing the latex replacement door 503 on the front housing 35 of the sample analyzer, the latex replacement door 503 is positioned on the right side panel 500 near the front housing 35 of the sample analyzer, so that the operator can stand in front of the sample analyzer to replace the latex reagents inside the latex assembly 17, and without occupying the structure of the front housing 35.

[0043] In this embodiment, a heat dissipation duct for cooling the latex chamber is located below the latex assembly 17. For example... Figure 15 and Figure 16As shown, the heat dissipation duct includes heat dissipation fins 34 located below the latex compartment of the latex assembly 17. The air inlet of the heat dissipation duct is equipped with a dust filter 32 and a cooling fan 33. The air inlet is located on the left side of the sample analyzer, and the latex replacement door 503 is located on the right side of the sample analyzer (e.g., ...). Figure 15 and Figure 16 direction shown).

[0044] The complete blood count (CBC) measurement assembly includes a RET reaction chamber assembly 30, a WBC reaction chamber assembly 31, and an HGB reaction chamber assembly. The CBC chamber position on the RET reaction chamber assembly 30 is RET chamber position 11; the CBC chamber positions on the WBC reaction chamber assembly 31 include WNB chamber position 9 and DIFF chamber position 10; and the CBC chamber position on the reaction chamber assembly is HGB chamber position 8.

[0045] In this embodiment, the specific protein measurement component is a CRP measurement component. Therefore, the specific protein pool is the CRP pool, and the specific protein pool position is the CRP pool position (first CRP pool position 6 and second CRP pool position 7). Other types of protein measurement components can also be used, which will not be described in detail here and are all within the scope of protection.

[0046] The blood separation process of the sample analyzer provided in this embodiment of the invention is as follows: blood is collected by the sampling needle—the outer wall of the sampling needle is cleaned—blood is separated into RET pool 11—blood is separated into HGB pool 8—blood is separated into WNB pool 9—blood is separated into DIFF pool 10—blood is separated into CRP pool (the first CRP pool 6 and the second CRP pool 7 are used alternately)—the sampling needle is cleaned—latex reagent is extracted by the sampling needle—latex is injected into the CRP pool.

[0047] Before the blood collection operation, blood mixing and other operations can also be performed.

[0048] The sample analyzer provided in this embodiment of the invention further includes a sheath flow assembly 14, which is positioned close to the HGB reaction cell assembly. The sheath flow assembly 14 can be an RBC sheath flow impedance device. Located to the right of the HGB reaction cell assembly, the sheath flow assembly 14 facilitates sample transfer from the HGB reaction cell to the sheath flow assembly 14. Because the sheath flow assembly 14 is positioned close to the HGB reaction cell assembly, the path length of the liquid (sample and reagent) from the HGB reaction cell assembly to the sheath flow assembly 14 is shortened, thereby improving detection accuracy.

[0049] Furthermore, the optical flow chamber is located above the sample analyzer, and the LVM valve 15, which controls the sheath fluid, is installed next to the optical flow chamber, facilitating connection and making full use of space.

[0050] In this embodiment, the sample analyzer has a total of 10 reagents, including 3 optical dye reagents, 4 types of hemolysing agents, 2 types of diluents and 1 type of CRP latex reagent.

[0051] Because the dye reagent is consumed in small quantities each time, a storage tank is not required. A dye bag fixing position 60 is provided on the front panel 201 of the frame to secure the dye reagent bag. The dye reagent bag is built into the front housing 35, i.e., installed on the front panel 201 of the frame. The user can easily replace the dye reagent bag by opening the front housing 35. Furthermore, the relevant dispensing pump and valve are installed above the dye reagent bag.

[0052] CRP latex reagent is used to directly aspirate and add liquid using a sampling needle.

[0053] like Figure 6 As shown, other reagents are first stored in the internal storage tank via tubing connected to the connector on the back panel 300 from an external reagent container. The back panel 300 is equipped with a network interface 301, a power input socket 302, a first power switch 303, a waste liquid connector 304, a BNC socket 305, a DS diluent interface 306, a DR diluent interface 307, an LN hemolysin interface 308, an LD hemolysin interface 309, an LH hemolysin interface 310, an LC hemolysin interface 311, and a fan assembly 312. The LN hemolysin interface 308, LD hemolysin interface 309, LH hemolysin interface 310, and LC hemolysin interface 311 are interfaces for four types of hemolysins, while the DS diluent interface 306 and DR diluent interface 307 are interfaces for two types of diluents.

[0054] The reagents stored in the storage tank flow to each reaction tank according to demand.

[0055] The DIL diluent has three reservoirs: one for optical sheath fluid measurement (FCM), one for other measurements or cleaning, and the last one is an SCI reservoir for RBC sheath current impedance. These three reservoirs are mounted on the right side panel of the machine; that is, the aforementioned reservoir is the right-side reservoir 70.

[0056] Four reservoirs for hemolytic agents and DR diluent for optical RET channel measurements are mounted on the upper part of the left side panel of the instrument. These reservoirs are short reservoirs 43.

[0057] The CRP latex reagent is located at the lower right of the sample analyzer, allowing customers to easily pull it out from the right side via the latex replacement door 503 to change the latex reagent.

[0058] Furthermore, it also includes an optical component 26 connected to the RET pool position 11, the WNB pool position 9 and the DIFF pool position 10; the sample analyzer also includes a preheating pool component 24 for heating the right-side reservoir 70 of the sample analyzer; the preheating pool component 24 is located close to the optical component 26.

[0059] like Figure 8and Figure 10 As shown, the layout on the right side of the sample analyzer mainly includes: a latex assembly 17, a mixing assembly 18, a specific protein measurement assembly 19, a sheath flow assembly 14, a pressure-cutoff valve assembly 21, a right valve assembly 22, a shut-off valve assembly (Baldell valve assembly) 12, a preheating tank assembly 24, a hinge assembly 25, an optical assembly 26, a gas tank assembly 27, a circuit board 28, a sampling assembly 29, a RET reaction tank assembly 30, and a WBC reaction tank assembly 31. The preheating tank assembly 24 is fixed to the back of the hinge assembly 25, which can rotate within an angle range of approximately 0-150°. The preheating tank assembly 24 is located close to the inside of the main unit and near the optical assembly 26, shortening the length of the connection channel between them and ensuring effective temperature maintenance of the preheated liquid. The preheating tank assembly 24 preheats the right-side storage tank 70 (right-side tank assembly), and the specific protein measurement assembly 19 is used to measure the concentration of specific proteins.

[0060] like Figure 9 As shown, a test tube 40 (peripheral blood test tube) is provided inside the peripheral blood mixer 16, and the mixing component 18 performs a mixing operation on the sample in the test tube 40.

[0061] like Figure 3 As shown, the right side panel 500 of the sample analyzer can also be equipped with a USB component 501, a USB protective cover (silk screen printing) 502, a latex replacement door 503, and a second power switch 504.

[0062] like Figure 2 and Figure 5 As shown, the front shell 35 is provided with a model insert 36, a lower left shell 37, an automatic sample injection assembly 38, a lower right shell 41, a button 42, and a closed sample injection chamber assembly 66.

[0063] The front cover 35 is designed as a neutral face cover, and the buttons 42 and model inserts 36 are set on the front cover 35. The buttons 42 and model inserts 36 can be replaced according to different instrument models.

[0064] The test tube rack 39 (such as a capillary blood test tube rack) on the automatic sample injection assembly 38 is equipped with test tubes 40. The closed sample injection chamber assembly 66 is equipped with a sample chamber door 67 that can be opened and closed. After opening the sample chamber door 67, the test tubes 40 can be placed inside the closed sample injection chamber assembly 66.

[0065] In this embodiment, a hinge assembly 25 is provided on the frame of the sample analyzer. The hinge assembly 25 includes a right side plate of the frame and a hinge part. The hinge part connects the right side plate of the frame and the rear plate 204 of the frame. An optical assembly 26 is provided on the frame, and a preheating pool assembly 24 is provided on the side of the right side plate of the frame facing the optical assembly 26.

[0066] Furthermore, the right-side liquid storage tank 70 of the sample analyzer is located on the opposite side of the right-side plate of the frame, away from the preheating tank assembly 24.

[0067] The sample unit includes a closed sample inlet assembly 66 and an automated sample inlet assembly. The sampling positions include a constant blood position 2 and a micro-blood position 1 located on the closed sample inlet assembly; the sampling positions also include an automated sample inlet sampling position located on the automated sample inlet assembly. That is, there are at least three sampling positions: the automated sample inlet sampling position, constant blood position 2, and micro-blood position 1 are all located on the sampling path. Specifically, constant blood position 2 is used to place venous blood tubes, and micro-blood position 1 is used to place capillary blood tubes.

[0068] To improve detection efficiency, the latex assembly 17 has at least two latex positions, both of which are connected to the latex reagent bottle of the latex assembly 17.

[0069] In this embodiment, the specific protein measurement component includes a specific protein measurement component 19, which has at least two independent specific protein pools, each with a corresponding specific protein pool position. This arrangement allows for the alternating use of the two specific protein pools, effectively improving detection efficiency. The specific protein measurement component 19 is used to measure the concentration of a specific protein.

[0070] The sample analyzer provided in this embodiment of the invention also includes a power supply component 23; the power supply component 23 is located below the sample analyzer. The power supply component 23 is arranged at the right rear of the main unit of the sample analyzer, below the preheating tank component 24, making maximum use of the layout space. The frame of the sample analyzer includes: a front frame plate 201; a rear frame plate 204; and a frame partition 205 disposed between the front frame plate 201 and the rear frame plate 204, the frame partition 205 dividing the inner cavity of the sample analyzer housing into a left cavity and a right cavity.

[0071] In this embodiment, the measurement reaction pool (the reaction pool of the blood routine measurement component and the reaction pool of the specific protein measurement component) and the latex chamber of the latex component are located at the position of the partition 205 and are arranged in a row. By moving the sampling needle along the partition 205, blood sample collection, blood sample addition to each reaction pool, latex aspiration and latex addition to the CRP pool can all be completed by the same drive, reducing costs and making the layout compact.

[0072] like Figure 7 , Figure 13 and Figure 17As shown, after the front shell 35 is opened relative to the frame, the front panel 201 of the frame is exposed. The front panel 201 of the frame is provided with a front valve assembly 58, a fluorescent reagent assembly 59, a dye bag fixing position 60, a pressing and scanning assembly 61, a cooling temperature control assembly 62, a gas pressure detection assembly 63, and a straightening assembly 64. Furthermore, a support rod 65 can be provided between the front shell 35 and the front panel 201 of the frame to ensure the opening stability of the front shell 35 relative to the frame.

[0073] Furthermore, the rack of the sample analyzer also includes: a rack base plate 202 disposed at the bottom of the rack front plate 201 and the rack rear plate 204; and a rack power supply partition 203 disposed on the right side of the rack middle partition 205, wherein the rack power supply partition 203 and the rack base plate 202 form a space for placing the power supply assembly 23 of the sample analyzer.

[0074] The sample analyzer's frame also includes a frame optical base plate 206 located on the right side of the frame partition 205, and the sample analyzer's optical components 26 are mounted on the frame optical base plate 206.

[0075] Preferably, the frame of the sample analyzer also includes a frame board base plate 207 disposed on the upper part of the front plate 201 and the rear plate 204 of the frame, and the board 28 of the sample analyzer is mounted on the frame board base plate 207.

[0076] Most of the circuit boards of the sample analyzer are located at the top of the analyzer, separate from the lower pool components (such as the right-side reservoir 70 and short reservoir 43), enabling liquid-electric separation. For example... Figure 14 As shown, after the top cover 600 is opened, board 28 can be seen mounted on the rack board base plate 207. Board 28 includes, but is not limited to, power conversion board PCBA601, valve drive board PCBA602, SSD 603, main control board PCBA604, analog board PCBA605, burn-in power board PCBA606, isolated power board PCBA607, and conventional driver board 608.

[0077] The sample analyzer's frame also includes a left side plate 208 located to the left of the central partition 205; the sample analyzer's short reservoir 43 and reagent detection assembly 45 are mounted on the left side plate 208. Figure 11As shown, the left-side layout of the sample analyzer mainly includes: a short reservoir 43, an upper left valve assembly 44, a reagent detection component 45, a middle left valve assembly 46, a long waste liquid reservoir 47, a lower left valve assembly 48, a pump and pressure-cutoff valve assembly 49, a metering pump 50, a syringe 51, a hydraulic inspection assembly 52, an LVM valve assembly 53, a sampling manifold assembly 54, a sheath fluid filter assembly 55, a buffer tank assembly 56, and an air pump assembly 57. Two-way and / or three-way assemblies (upper left valve assembly 44, middle left valve assembly 46, and lower left valve assembly 48) are located in the left-side layout of the sample analyzer; and a fan is located at the lower part of the left-side layout of the sample analyzer. This fan can be a cooling fan 33 in the heat dissipation channel, or other fans used for cooling and drying the interior of the sample analyzer.

[0078] In this embodiment, all the metering pumps 50 are distributed on the lower left side of the sample analyzer. The corresponding gas valves and liquid valves (such as the left valve group 44, the middle left valve group 46, and the lower left valve group 48) are located above the metering pumps 50, which facilitates the metering pumps 50 to expel air bubbles. The CRP and sampling syringes 51 are located below the left partition of the sample analyzer, while the sample syringe for the optical channel and the perfusion syringe for the FCM reservoir can be located on the lower right side of the middle partition.

[0079] like Figure 12 As shown, in a conventional design, the short storage tank 43 has a side connection port and a bottom connection port to facilitate the selection of different connection ports and pipelines according to layout requirements. In this embodiment, the side connection port is plugged with a plug, and the bottom connection port is connected to the pipeline of the sample analyzer. To avoid interference between the plug of the side connection port and the left side plate 208 of the frame and to improve the structural compactness, a clearance part 2081 for avoiding the plug is provided on the left side plate 208 of the frame.

[0080] To improve waterproofing, the short reservoir 43 is positioned above the reagent detection assembly 45; a waterproof plate 2082 is installed on the left side panel 208 of the frame, located between the short reservoir 43 and the reagent detection assembly 45. Figure 12 As shown, by setting up the liquid-proof plate 2082, the short liquid storage tank 43 and the reagent detection component 45 are isolated, which effectively prevents the liquid leaking from the short liquid storage tank 43 from flowing into the reagent detection component 45 and ensures the normal operation of the reagent detection component 45.

[0081] In this embodiment, the left side plate 208 of the frame has a fixing frame for fixing the reagent detection assembly 45, and the top plate of the fixing frame is a liquid-proof plate 2082.

[0082] Optionally, the sampling path is arranged along the length direction of the rack partition 205; the length direction of the rack partition 205 is the extension direction of the side of the rack partition 205 from the front plate 201 of the rack to the rear plate 204 of the rack.

[0083] The gas tank assembly 27 of the sample analyzer is located on the upper right side of the partition 205 in the frame.

[0084] In this embodiment, the sample analyzer also includes a pressure detection component 63 for detecting the gas tank assembly 27; the pressure detection component 63 is disposed on the front plate 201 of the frame near the gas tank assembly 27.

[0085] The pressure detection component 63 is used to monitor the pressure of the gas storage tank of the gas tank assembly 27. Therefore, the shorter the pipe between the pressure detection component 63 and the gas tank assembly 27, the better, so that it can reflect the pressure changes of the gas storage tank in real time. Therefore, it is located in front of the gas tank assembly 27.

[0086] Furthermore, the air pump assembly 57 of the sample analyzer is located on the upper left side of the rack partition 205; the rack partition 205 has a through hole through which the pipe connecting the gas tank assembly 27 and the air pump assembly 57 passes. The air pump assembly 57 is a device for pressurizing the gas tank of the gas tank assembly 27. The shorter the pipe connecting the air pump assembly 57 and the gas tank assembly 27, the smaller the flow resistance. Therefore, the air pump assembly 57 is located on the upper left side of the rack partition 205, which is also above the left side plate 100. The compressed air in the air pump assembly 57 may contain condensate. If liquid enters the air pump assembly 57, it will cause the air pump to fail. Therefore, the pipe runs downwards at the outlet of the air pump assembly 57, so that even if there is condensate, the condensate will not flow back into the air pump assembly 57 when it is not working.

[0087] A front valve assembly 58, which controls the pressurization of the air pump assembly 57 and the air tank assembly 27, is located above the front plate 201 of the frame. The front valve assembly 58 controls the pressurization of the air tanks of the air pump assembly 57 and the air tank assembly 27. By positioning the front valve assembly 58 above the front plate 201 of the frame, the distance from the front valve assembly 58 to the air pump assembly 57 and the air tank assembly 27 is shorter, the pipe length is shorter, the flow resistance is smaller, and the flow loss is smaller.

[0088] The gas tank assembly 27 is equipped with a liquid detection component for detecting the liquid level inside its gas storage tank. Some of the gas storage tanks in the gas tank assembly 27 (such as the negative pressure gas storage tank 271 with a pressure of -40 kPa and the second positive pressure gas storage tank 273 with a pressure of 90 kPa) may allow liquid to enter if a malfunction occurs in their liquid circuit design. Therefore, the addition of the liquid detection component enables an alarm operation when liquid enters the gas storage tank. In this embodiment, the liquid detection component is a float. Adding a float to the gas storage tank causes it to float and trigger an alarm if liquid enters the tank.

[0089] like Figure 19As shown, the gas tank assembly 27 in this embodiment includes four gas storage tanks: a negative pressure gas storage tank 271, a first positive pressure gas storage tank 272, a second positive pressure gas storage tank 273, and a third positive pressure gas storage tank 274. The negative pressure gas storage tank 271 and the first positive pressure gas storage tank 272 are connected to the air pump assembly 57. The first positive pressure gas storage tank 272 is connected to the second positive pressure gas storage tank 273, and the second positive pressure gas storage tank 273 is connected to the third positive pressure gas storage tank 274. Through adjustment, the pressures in the first positive pressure gas storage tank 272, the second positive pressure gas storage tank 273, and the third positive pressure gas storage tank 274 are different. In this embodiment, the pressure of the first positive pressure gas storage tank 272 is 120 kPa, the pressure of the second positive pressure gas storage tank 273 is 90 kPa, the pressure of the third positive pressure gas storage tank 274 is 50 kPa, and the pressure of the negative pressure gas storage tank 271 is -40 kPa. Since the four gas tanks in the gas tank assembly 27 are theoretically components without liquid, from the perspective of electrohydraulic isolation, they are suitable to be placed at the highest point of the sample analyzer. Therefore, in this embodiment, the gas tank assembly 27 is located at the upper right of the sample analyzer.

[0090] Each of the four gas storage tanks has a float.

[0091] The right-side cavity contains a sample unit, a latex assembly 17, a blood routine measurement assembly, and a specific protein measurement assembly.

[0092] The front housing 35 of the sample analyzer is located on the outer side of the front panel 201 of the rack, and the front housing 35 can be opened and closed relative to the front panel 201 of the rack; a dye bag fixing position 60 for installing dye reagent bags is provided on the outer side of the front panel 201 of the rack; and / or, a fluorescent reagent assembly 59 is provided on the outer side of the front panel 201 of the rack.

[0093] The sample analyzer provided by this invention has been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this invention. The descriptions of the embodiments above are merely for the purpose of helping to understand the method and core ideas of this invention. It should be noted that those skilled in the art can make various improvements and modifications to this invention without departing from its principles, and these improvements and modifications also fall within the protection scope of the claims of this invention.

Claims

1. A sample analyzer, characterized in that, It includes a frame, a sampling assembly (29), a blood routine measurement assembly, a specific protein measurement assembly, a sample unit for transporting samples, a latex assembly (17) for storing latex reagents, an optical assembly (26), and a preheating pool assembly (24) for heating the right-side reservoir (70) of the sample analyzer. The sampling path of the sampling component (29) is a straight path; The sampling position of the sample unit, the latex position of the latex component (17), the blood routine measurement position of the blood routine measurement component, and the specific protein measurement position of the specific protein measurement component are all located on the sampling path; Wherein, the sampling position is the position where the sample is extracted on the sample unit; the latex position is the position where the latex reagent is extracted on the latex assembly (17); the blood routine pool position is the position where the sample is injected on the blood routine measurement assembly; the specific protein pool position is the position where the sample and latex reagent are injected on the specific protein measurement assembly; the frame is also provided with a hinge assembly (25), the hinge assembly (25) includes a right side plate of the frame, the preheating pool assembly (24) is disposed on one side of the right side plate of the frame, the right side reservoir (70) is disposed on the other side of the right side plate of the frame away from the preheating pool assembly (24), the optical assembly (26) and the hinge assembly (25) are both disposed close to the rear plate (204) of the frame of the frame, the right side reservoir (70) includes at least a reservoir for storing the sheath fluid to be used by the optical assembly, and the preheating pool assembly (24) is disposed close to the optical assembly (26).

2. The sample analyzer according to claim 1, characterized in that, The sample unit, latex assembly (17), specific protein measurement assembly and blood routine measurement assembly are arranged sequentially along the front and back direction of the sample analyzer; The front-to-back direction of the sample analyzer is the direction from the front of the sample analyzer to its rear.

3. The sample analyzer according to claim 1, characterized in that, The latex assembly (17) is positioned near the front housing (35) of the sample analyzer; The front part of the right side panel (500) of the sample analyzer has a latex replacement door (503) for replacing latex reagents. The front part of the right side panel (500) is the part of the right side panel (500) close to the front shell (35) of the sample analyzer.

4. The sample analyzer according to claim 1, characterized in that, The blood routine measurement component includes: RET reaction pool assembly (30), wherein the blood routine pool position on the RET reaction pool assembly (30) is the RET pool position (11). WBC reaction pool assembly (31), wherein the blood routine pool positions on the WBC reaction pool assembly (31) include WNB pool position (9) and DIFF pool position (10). HGB reaction pool assembly, wherein the blood routine pool position on the reaction pool assembly is the HGB pool position (8).

5. The sample analyzer according to claim 4, characterized in that, It also includes a sheath flow assembly (14) located near the HGB reaction cell assembly.

6. The sample analyzer according to claim 4, characterized in that, The optical component (26) is connected to the RET pool position (11), the WNB pool position (9) and the DIFF pool position (10).

7. The sample analyzer according to claim 6, characterized in that, The hinge assembly (25) further includes a hinge portion that connects the right side plate of the frame and the rear plate of the frame (204); or, the hinge assembly (25) can be rotated relative to the frame within an angle range of 0-150°.

8. The sample analyzer according to claim 1, characterized in that, The preheating pool assembly (24) is disposed on the side of the right side plate of the frame facing the optical assembly (26); or, the preheating pool assembly (24) is disposed close to the inside of the sample analyzer; or, the preheating pool assembly (24) is disposed above the optical assembly (26).

9. The sample analyzer according to claim 1, characterized in that, A connection channel is provided between the preheating pool assembly (24) and the optical assembly (26). The sheath fluid stored in the storage pool for storing the sheath fluid to be used by the optical assembly (26) is heated by the preheating pool assembly (24) and flows into the optical assembly (26) through the connection channel.

10. The sample analyzer according to claim 1, characterized in that, The right-side liquid reservoir (70) includes three liquid reservoirs, which are installed on the right side plate of the frame. One of the liquid reservoirs is for storing the sheath fluid required for the optical components, one is for measuring or cleaning, and one is for sheath flow impedance.

11. The sample analyzer according to claim 1, characterized in that, The sample unit includes: The closed sample inlet assembly (66) includes a constant blood position (2) for placing venous blood tubes and a micro blood position (1) for placing capillary blood tubes located on the closed sample inlet assembly. The automatic sampling component (38) includes an automatic sampling position located on the automatic sampling component, wherein the automatic sampling position, the constant blood position (2) and the micro blood position (1) are all located on the sampling path.

12. The sample analyzer according to claim 11, characterized in that, The automatic sample feeding component (38) is used to automatically feed samples into the test tubes set on the test tube rack.

13. The sample analyzer according to claim 12, wherein the automatic sample introduction component (38) is further used to automatically introduce samples into the test tubes set on the peripheral blood test tube rack.

14. The sample analyzer according to claim 11, characterized in that, The sampling needle of the sampling component is used to extract samples from venous blood tubes or capillary blood tubes at the automatic sampling position, the constant blood position (2) or the micro blood position (1), and inject the extracted samples into the routine blood pool and / or the specific protein pool.

15. The sample analyzer according to claim 11, wherein the sampling needle of the sampling component is used to extract latex reagent at the latex site of the latex component and inject the extracted latex reagent into the specific protein pool site.

16. The sample analyzer according to claim 11, wherein the blood routine pools include RET pool, WNB pool (9), DIFF pool (10) and HGB (8) pools, and the sampling needle of the sampling component is used to inject the extracted sample into the RET pool (11), WNB pool (9), DIFF pool (10), HGB pool (8) and the specific protein pool.

17. The sample analyzer according to claim 1, characterized in that, The latex assembly (17) has at least two latex positions, and at least two latex positions are in communication with the latex reagent bottle of the latex assembly (17).

18. The sample analyzer according to claim 1, characterized in that, The specific protein measurement component includes a specific protein measurement component (19) for measuring the concentration of a specific protein. The specific protein measurement component (19) has at least two independent specific protein pools, and the two specific protein pools have specific protein pool positions set one-to-one with them.

19. The sample analyzer according to claim 1, characterized in that, It also includes the power supply component (23) of the sample analyzer; The power supply component (23) is located below the sample analyzer.

20. The sample analyzer according to claim 1, characterized in that, The rack of the sample analyzer includes: Front panel of rack (201); Rear panel of the rack (204); A frame partition (205) is disposed between the front plate (201) and the rear plate (204) of the frame, which divides the inner cavity of the sample analyzer housing into a left cavity and a right cavity.

21. The sample analyzer according to claim 20, characterized in that, The rack of the sample analyzer also includes: A rack base plate (202) is disposed at the bottom of the front plate (201) and the rear plate (204) of the rack. A rack power supply partition (203) is disposed on the right side of the rack partition (205), and a space for placing the power supply assembly (23) of the sample analyzer is formed between the rack power supply partition (203) and the rack base plate (202).

22. The sample analyzer according to claim 21, characterized in that, The frame of the sample analyzer also includes a frame optical base plate (206) disposed on the right side of the frame partition (205), and the optical components (26) of the sample analyzer are mounted on the frame optical base plate (206).

23. The sample analyzer according to claim 22, characterized in that, The gas tank assembly (27) of the sample analyzer is located on the right side of the partition plate (205) and above the optical base plate (206) of the frame. The gas tank assembly is suspended above the optical base plate (206).

24. The sample analyzer according to claim 20, characterized in that, The frame of the sample analyzer also includes a frame board base plate (207) disposed on the upper part of the front plate (201) and the rear plate (204) of the frame, and the board of the sample analyzer is installed on the frame board base plate (207).

25. The sample analyzer according to claim 20, characterized in that, The rack of the sample analyzer also includes a rack left side plate (208) located on the left side of the rack partition (205). The short reservoir (43) and reagent detection assembly (45) of the sample analyzer are mounted on the left side plate (208) of the frame.

26. The sample analyzer according to claim 25, characterized in that, The short storage tank (43) has a side connection port and a bottom connection port. The side connection port is blocked by a plug, and the bottom connection port is connected to the pipeline of the sample analyzer. The left side plate (208) of the frame is provided with a clearance part (2081) to avoid the plug.

27. The sample analyzer according to claim 25, characterized in that, The short reservoir (43) is located above the reagent detection assembly (45); A liquid-proof plate (2082) is provided on the left side plate (208) of the frame, located between the short liquid storage tank (43) and the reagent detection component (45).

28. The sample analyzer according to claim 27, characterized in that, The left side panel (208) of the frame has a fixing frame for fixing the reagent detection assembly (45), and the top plate of the fixing frame is the liquid-proof plate (2082).

29. The sample analyzer according to claim 20, characterized in that, The sampling path is arranged along the length of the partition plate (205) in the frame; The length direction of the rack partition (205) is the extension direction of the side of the rack partition (205) from the front plate (201) of the rack to the rear plate (204) of the rack.

30. The sample analyzer according to claim 20, characterized in that, The gas tank assembly (27) of the sample analyzer is located on the upper right side of the partition (205) in the frame.

31. The sample analyzer according to claim 30, characterized in that, The sample analyzer also includes a pressure detection component (63) for detecting the gas tank assembly (27). The air pressure detection component (63) is located on the front panel (201) of the frame near the air tank assembly (27).

32. The sample analyzer according to claim 30, characterized in that, The air pump assembly (57) of the sample analyzer is located on the upper left side of the partition (205) in the frame; The frame partition (205) has through holes through which pipes for connecting the gas tank assembly (27) and the gas pump assembly (57) pass.

33. The sample analyzer according to claim 32, characterized in that, A front valve assembly (58) controlling the pressure build-up of the air pump assembly (57) and the air tank assembly (27) is located above the front plate (201) of the frame.

34. The sample analyzer according to claim 30, characterized in that, The gas tank assembly (27) is equipped with a liquid detection component for detecting the liquid level inside the gas storage tank.

35. The sample analyzer according to claim 20, characterized in that, The sample unit, latex assembly (17), blood routine measurement assembly and specific protein measurement assembly are disposed in the right cavity.

36. The sample analyzer according to claim 20, characterized in that, The front housing (35) of the sample analyzer is located on the outer side of the front panel (201) of the rack, and the front housing (35) can be opened and closed relative to the front panel (201); The outer side of the front panel (201) of the rack is provided with a dye bag fixing position (60) for installing dye reagent bags; and / or, a fluorescent reagent assembly (59) is provided on the outer side of the front panel (201) of the rack.

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