Metabolomic characterization of microorganisms

By adjusting metabolite concentration in growth medium and using chemical analysis and mass spectrometry, the microorganisms and their sensitivity to toxic substances are quickly identified, and the problem of excessive detection time in the prior art is solved, achieving faster identification and sensitivity detection.

CN114174527BActive Publication Date: 2025-03-28I A 路易斯 +1
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Patent Information

Application Number
CN201980098971.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2019-05-31
Filing Date
2019-09-20
Publication Date
2025-03-28
Estimated Expiration
2039-09-20

AI Technical Summary

Technical Problem

Prior art In the treatment of diseases, especially in the case of hematogenous infection, it takes 2-4 days to identify unknown organisms and their sensitivity to toxic substances by chemical detection or spectrometry.

Method used

By changing the concentration of metabolites consumed and/or produced in the growth medium, chemical analysis and mass spectrometry are used to analyze metabolites in the medium to achieve rapid identification of microorganisms and their sensitivity to toxic substances.

Benefits of technology

Identification and toxin sensitivity detection were completed approximately half of the time compared to the current method, significantly shortening the detection time.

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Abstract

Methods and systems are used to identify the cell type of an unknown microorganism. The device includes: an instrument for culturing the unknown organism, a diagnostic data collection tool, and a computer program. The method includes: incubating the sample with a growth medium (with or without a toxin) and analyzing the metabolites detected in the sample. The computer system compares the results collected from the device with a reference metabolite profile.
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