A preparation method of di(4-biphenyl)amine
By synthesizing the intermediate di(4-biphenyl)acetamide and removing its acetyl group under basic conditions, the problems of expensive raw materials and catalysts in the prior art preparation method and inefficient and environmentally friendly reactions are solved, and economical, environmentally friendly and efficient preparation of di(4-biphenyl)amine is achieved.
CN114213256BActive Publication Date: 2025-03-25WEISIPU NEW MATERIAL (SUZHOU) CO LTD
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Patent Information
- Application Number
- CN202111612943.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2021-12-27
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2041-12-27
AI Technical Summary
Technical Problem
The prior art methods for preparing bis(4-biphenyl)amines have problems such as expensive raw materials and catalysts, and the reaction process is not efficient and environmentally friendly enough.
Method used
The preparation of bis(4-biphenyl)amine is achieved by synthesizing the intermediate di(4-biphenyl)acetamide and removing its acetyl group under basic conditions. This method uses copper series compounds as catalysts, the reaction temperature is low, and the raw materials are relatively economical.
Benefits of technology
It reduces the production cost of bis(4-biphenyl)amine, improves the economic and environmental protection of the process, simplifies the process flow, and is suitable for industrial scale production.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides a preparation method of di(4-biphenyl)amine, including synthesizing intermediate di(4-biphenyl)acetamide, and then removing the acetyl group of the intermediate to obtain the target product; 1) 4-bromobiphenyl, acetamide, catalyst, nitrogen-containing ligand L, alkali 1 and solvent 1 are mixed, and heated to react; 2) after reacting, the reaction system is cooled to room temperature, the liquid separation is washed, and the organic phase is concentrated to obtain a crude di(4-biphenyl)acetamide product; 3) the crude di(4-biphenyl)acetamide product is loaded with column chromatography silica, and purified by column chromatography separation and purification to obtain di(4-biphenyl)acetamide; 4) di(4-biphenyl)acetamide, alkali 2 and solvent 2 are mixed, and heated to react; 5) after reacting, the reaction system is cooled to room temperature, and suction filtration, washing and drying obtain di(4-biphenyl)amine. The present invention belongs to the field of fine chemicals, and the preparation method of the present invention is economical and safe, environmentally friendly and efficient, and is suitable for industrialized production.
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