A modified bacterium and its preparation method and application

By modifying cationic polymers on the bacterial surface, modifying bacteria to activate dendritic cells in the tumor immunosuppressive environment, solving the problem of insufficient effectiveness of existing anti-tumor immunotherapy in the tumor immunosuppressive microenvironment, and significantly improving the effectiveness of anti-tumor immunotherapy.

CN114317377BActive Publication Date: 2025-03-25NANJING UNIV
3 Cites 0 Cited by

Patent Information

Application Number
CN202210061247.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-01-19
Publication Date
2025-03-25
Estimated Expiration
2042-01-19

AI Technical Summary

Technical Problem

Existing anti-tumor immunotherapy is not effective in the tumor immunosuppressive microenvironment, and it is difficult to effectively activate dendritic cells in the tumor, resulting in insufficient immune response.

Method used

Using modified bacteria, dendritic cells in tumor marginal tissues are activated by modifying cationic polymers on the bacteria's surface to enhance their antigen transport capabilities in tumor immunosuppressive environments.

Benefits of technology

It significantly improves the delivery distance of tumor antigens and the antigen presentation ability of dendritic cells, enhances the body's adaptive immune response, and improves the effect of anti-tumor immunotherapy.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The present invention discloses a modified bacterium, which includes a bacterium and a cationic polymer modified on its surface. The modified bacterium has the ability to capture antigens, significantly improves the presentation of model antigens and the percentage of antigen-specific dendritic cells in vitro, and can capture more tumor neoantigens and damage-related molecular pattern proteins released by radiotherapy-induced CT26 tumor tissue. Most importantly, the modified bacteria combined with radiotherapy and immune checkpoint inhibitors can significantly enhance the effect of anti-tumor immunotherapy.
Need to check novelty before this filing date? Find Prior Art