Pharmaceutical composition of a prodrug of vortioxetine and methods of preparation and use thereof

By modifying vortioxetine into a vortioxetine prodrug and preparing it into a micron or nanocrystal drug composition, the problems of high bioirritation and short absorption time of vortioxetine hydrobromide have been solved, achieving long-acting treatment and improving patient compliance and safety.

CN114767681BActive Publication Date: 2026-06-19CHANGZHOU HANSOH PHARM CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGZHOU HANSOH PHARM CO LTD
Filing Date
2022-01-06
Publication Date
2026-06-19

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Abstract

This invention relates to a pharmaceutical composition of a vortioxetine prodrug, its preparation method, and its application. The vortioxetine prodrug is in crystalline form, including microcrystalline or nanocrystalline forms. The pharmaceutical composition prepared by this invention can effectively prolong the duration of drug action, improve medication safety, and enhance patient compliance.
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