Beam delivery methods, devices, electronic equipment and media

Abstract

This disclosure provides a beam delivery method, apparatus, electronic device, and medium. The method includes: dividing the cross-sectional shape of a target area into several equally spaced scanning points; delivering the same dose of particles to each scanning point based on a point-by-point active position delivery method, forming a uniform beam field distributed in a plane perpendicular to the beam direction. The shape of the uniformly distributed beam field is consistent with the shape of the target area and covers the entire target area. The depth, Bragg peak broadening, and penumbra of the uniformly distributed beam field are adjusted using a beam modulation module, and the adjusted uniformly distributed beam is delivered to the target area. This method reduces beam waste, increases beam utilization, shortens treatment time, reduces secondary radiation and induced radioactivity, and effectively reduces positional and dose deviations caused by organ movement.

Description

Technical Field

[0001] This disclosure relates to the fields of particle therapy and proton and heavy ion radiotherapy, and in particular to a beam delivery method, apparatus, electronic device and medium. Background Technology

[0002] The depth-dose distribution of ion beams when penetrating biological tissue is ideally suited for tumor treatment. As an ion beam passes through matter, its kinetic energy is primarily lost at the end of its range, exhibiting a sharply enhanced Bragg peak. This means that energy loss during ion-matter interaction occurs primarily within a millimeter-scale range at the end of the beam's range, and the position of the Bragg peak is highly controllable. Utilizing these characteristics, energy can be deposited to the tumor target area to the greatest extent possible, resulting in enhanced local tumor control and reduced risk of complications in normal tissues. Therefore, proton / heavy ion therapy is more advantageous than traditional photon radiotherapy for tumors adjacent to organs at risk. Ion beam radiotherapy possesses unique depth-dose distribution and a high relative biological effect, advantages that are difficult to match with conventional radiotherapy methods, thus earning it the title of "the most ideal medical radiotherapy beam of the 21st century."

[0003] Currently, there are two types of beam delivery methods used in ion therapy: active delivery and passive delivery. In realizing this invention, the applicant discovered that existing beam delivery methods have at least the following drawbacks: Passive beam delivery systems use scanning magnets to scan the beam spot into a fixed-size, uniform square field. During treatment, the beam delivery system selects a square field larger than the target area's cross-section. However, the target area's cross-sectional shape is mostly not square; in fact, the actual target area's cross-sectional area is much smaller than the selected fixed square field. The dose within the excess area is blocked by the MLC (Medium Linear Cavity), resulting in wasted beam outside the target area's cross-sectional area. This wasted beam increases treatment time and generates more secondary radiation and induced radioactivity. Active beam delivery systems deliver a specific dose point-by-point and layer-by-layer, frequently changing points and energy, increasing treatment time. In proton therapy, this significantly reduces proton flux, thereby reducing treatment efficiency. In addition, active beam delivery is a one-time dose delivery at each point. For organs with large range of motion, there is a high probability that the delivery position will not match the tumor target area, or cause accidental irradiation of organs at risk, increasing the treatment risk. Summary of the Invention

[0004] To address the aforementioned technical problems, this disclosure provides a beam delivery method, apparatus, electronic device, and medium, which at least partially solve the aforementioned technical problems.

[0005] Based on this, the first aspect of this disclosure provides a beam delivery method, comprising: dividing the cross-sectional shape of the target area into several equally spaced scanning points; delivering the same dose of particles to the scanning points based on a point-by-point active position delivery method to form a uniform beam field distributed in a plane perpendicular to the beam direction, wherein the shape of the uniform beam field distributed in the plane is consistent with the shape of the target area and covers the entire target area; adjusting the depth of the uniform beam field, the broadening of the Bragg peak in the depth direction, and the penumbra of the edge of the uniform beam field through a beam modulation module, and delivering the adjusted uniformly distributed beam to the target area.

[0006] According to embodiments of this disclosure, orthogonal scanning magnets are used to deliver the same dose of particles to equally spaced scanning points based on a point-by-point active position delivery method, forming a uniform beam field distributed in a plane perpendicular to the beam direction.

[0007] According to embodiments of this disclosure, the beam modulation module includes a ridge filter, a de-energizer, a multi-leaf grating, and a compensator arranged in sequence; the depth of the uniform field is adjusted by the de-energizer and the compensator; the Bragg peak broadening in the depth direction of the uniform field is adjusted by the ridge filter; and the shape and penumbra of the uniform field are adjusted by the multi-leaf grating.

[0008] According to embodiments of this disclosure, a multi-leaf grating configuration is located at the edge of a uniform field of view.

[0009] According to embodiments of this disclosure, the area of ​​a uniformly distributed planar field is slightly larger than the area of ​​the target cross-section.

[0010] According to embodiments of this disclosure, the method further includes: dividing the required dose at the scanning point into multiple repeated irradiations of the target area.

[0011] According to embodiments of this disclosure, a beam with a large beam size can be used to irradiate the target area.

[0012] A second aspect of this disclosure provides a beam delivery device, comprising: a scanning module for delivering the same dose of particles to equally spaced scanning points on a target cross-section based on a point-by-point active position delivery method, forming a uniform beam field distributed in a plane perpendicular to the beam direction, wherein the shape of the uniformly distributed beam field is consistent with the shape of the target area and covers the entire target area; and a beam modulation module for adjusting the depth of the uniform beam field, the broadening of the Bragg peak in the depth direction, and the penumbra of the edge of the uniform beam field, and delivering the adjusted uniformly distributed beam to the target area.

[0013] A third aspect of this disclosure provides an electronic device, comprising: one or more processors; and a memory for storing one or more programs, wherein when the one or more programs are executed by the one or more processors, the one or more processors cause the one or more processors to implement the method described above.

[0014] A fourth aspect of this disclosure provides a computer-readable storage medium having executable instructions stored thereon, which, when executed by a processor, cause the processor to perform the methods described above.

[0015] The beam delivery method, apparatus, electronic device, and medium provided according to the embodiments of this disclosure have at least the following beneficial effects:

[0016] Employing a combined active and passive beam delivery method, the target area is divided into several isoenergetic sections along the beam injection direction. Based on a point-by-point active delivery method, the same dose of particles is delivered to scanning points within the same isoenergetic section, forming a uniform radiation field distributed perpendicular to the beam direction. This allows for flexible adjustment of the size and shape according to the transverse cross-section of the target area, reducing beam waste, increasing beam utilization, shortening treatment time, and minimizing secondary radiation and induced radioactivity. Furthermore, the beam modulation module adjusts the depth of the uniform radiation field, the Bragg peak broadening in the depth direction, and the penumbra at the edge of the field, ensuring the beam falls entirely within the irradiation area. This achieves both tumor treatment and effective protection of normal tissue.

[0017] Furthermore, based on the point-to-point active positioning delivery method, the requirement for beam spot size is less stringent, allowing the selection of a larger beam spot. This reduces the number of scanning magnet switching points during delivery, ensuring consistent delivery dose and residence time at each point, thus increasing the stability of beam delivery. Further adjustments to the shape of the uniform field generated by active point-to-point delivery using a multi-leaf grating can improve conformity, reduce the penumbra of the uniform field, and make the field edges sharper.

[0018] Furthermore, dividing the required particle dose for the scanning point into multiple repeated irradiations of the target area can effectively reduce positional and dose deviations caused by organ movement.

[0019] Furthermore, compared to a single active beam delivery mode, the active and passive combined delivery mode has lower requirements for the response speed of the active scanning magnet power supply than modulation scanning, making it easier to implement. Attached Figure Description

[0020] The above and other objects, features and advantages of this disclosure will become clearer from the following description of embodiments with reference to the accompanying drawings, in which:

[0021] Figure 1 A schematic flowchart of the beam delivery method provided in an embodiment of this disclosure is shown.

[0022] Figure 2 The illustration schematically shows an active location delivery map provided in an embodiment of this disclosure.

[0023] Figure 3The illustration schematically shows a spatial dose distribution map conforming to the target region provided by an embodiment of the present disclosure.

[0024] Figure 4A The diagram illustrates the process of a two-dimensional conformal irradiation method provided in an embodiment of this disclosure.

[0025] Figure 4B The diagram illustrates the process of a three-dimensional layered conformal irradiation method provided in an embodiment of this disclosure.

[0026] Figure 5A The diagram schematically illustrates the field shape corresponding to different target regions in traditional beam delivery methods.

[0027] Figure 5B The schematic diagram illustrates the field shape corresponding to different target regions provided in the embodiments of this disclosure.

[0028] Figure 6A The diagram illustrates a square beam delivery method provided in an embodiment of this disclosure, showing a scanning path diagram of the beam delivery method.

[0029] Figure 6B The diagram illustrates an irregular beam field scanning path of the beam delivery method provided in an embodiment of this disclosure.

[0030] Figure 7 A schematic diagram of a beam delivery apparatus provided in an embodiment of this disclosure is shown.

[0031] Figure 8 A schematic diagram of the beam delivery device provided in an embodiment of this disclosure is shown.

[0032] Figure 9 A block diagram of an electronic device suitable for implementing the methods described above, according to embodiments of the present disclosure, is illustrated schematically. Detailed Implementation

[0033] To make the objectives, technical solutions, and advantages of this disclosure clearer, the following detailed description is provided in conjunction with specific embodiments and accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this disclosure. All other embodiments obtained by those skilled in the art based on the embodiments of this disclosure without inventive effort are within the scope of protection of this disclosure.

[0034] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit this disclosure. The terms “comprising,” “including,” etc., as used herein indicate the presence of the stated features, steps, operations, and / or components, but do not exclude the presence or addition of one or more other features, steps, operations, or components.

[0035] In this disclosure, unless otherwise expressly specified and limited, the terms "installation," "connection," "linking," "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this disclosure according to the specific circumstances.

[0036] In the description of this disclosure, it should be understood that the terms "longitudinal", "length", "circumferential", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this disclosure and simplifying the description, and do not indicate or imply that the subsystem or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this disclosure.

[0037] Throughout the accompanying drawings, identical elements are represented by the same or similar reference numerals. Conventional structures or constructions have been omitted where they may cause confusion in understanding this disclosure. Furthermore, the shapes, dimensions, and positional relationships of the components in the drawings do not reflect actual size, scale, or actual positional relationships. Additionally, any reference numerals placed between parentheses in the claims should not be construed as limiting the claims.

[0038] Similarly, to simplify this disclosure and aid in understanding one or more of the various aspects of the disclosure, in the above description of exemplary embodiments of the present disclosure, various features of the present disclosure are sometimes grouped together in a single embodiment, figure, or description thereof. The use of terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refers to a specific feature, structure, material, or characteristic described in connection with that embodiment or example, which is included in at least one embodiment or example of the present disclosure. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0039] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this disclosure, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0040] To fully leverage the advantages of ion beam therapy, the purpose of this disclosure is to optimize the beam delivery process, maximize beam utilization, reduce secondary radiation and induced radioactivity, and improve treatment efficiency. Simultaneously, it enables repeated scanning under uniform scanning beam delivery, reducing dose deviation caused by organ motion.

[0041] Figure 1 A schematic flowchart of the beam delivery method provided in an embodiment of this disclosure is shown.

[0042] like Figure 1 As shown, the beam delivery method may include, for example, operations S101 to S102.

[0043] In operation S101, the cross-sectional shape of the target area is divided into several equally spaced scanning points. Based on the point-by-point active position delivery method, the same dose of particles is delivered to the scanning points to form a uniform radiation field that is distributed in a plane perpendicular to the beam direction. The shape of the uniform radiation field distributed in the plane is consistent with the shape of the target area and covers the entire target area.

[0044] In this embodiment of the disclosure, the lateral expansion of the uniform field adopts a point-by-point active position delivery method. The distance between scanning points can be the same, and each scanning point delivers the same dose (MU) of particles to form a planar uniform field perpendicular to the beam direction. Since point-by-point active position delivery is used, the size and shape of the uniform field can be adjusted more flexibly according to the lateral cross-sectional shape of the target area.

[0045] Figure 2 The illustration schematically shows an active location delivery map provided in an embodiment of this disclosure.

[0046] like Figure 2 As shown, orthogonal scanning magnets can be used to deliver the same dose of particles to the scanning points based on a point-to-point active positioning delivery method, forming a uniform beam field distributed in a plane perpendicular to the beam direction. For example, a scanning magnet in the X direction can be used to deflect the beam in the X direction, and a scanning magnet in the Y direction can be used to deflect the beam in the Y direction. By combining the beam deflection directions in the X and Y directions, the size and shape of the uniform beam field can be flexibly adjusted.

[0047] In operation S103, the depth of the uniform field, the broadening of the Bragg peak in the depth direction, and the penumbra at the edge of the uniform field are adjusted by the beam modulation module, and the adjusted uniformly distributed beam is delivered to the target area.

[0048] In this embodiment of the disclosure, for the regular or irregular uniform radiation field obtained by the point-by-point active location delivery method, the radiation field with different depths, different Bragg expansions and different target areas required for treatment can be further adjusted by the beam modulation module to obtain a spatial dose distribution that conforms to the target area.

[0049] Figure 3 The illustration schematically shows a spatial dose distribution map conforming to the target region provided by an embodiment of the present disclosure.

[0050] In this embodiment, the beam modulation module includes a ridge filter, a de-energizer, a multi-leaf grating, and a compensator arranged sequentially. The de-energizer and compensator jointly adjust the depth of the uniform beam field; the ridge filter adjusts the Bragg broadening in the depth direction of the uniform beam field, slightly broadening the monoenergetic Bragg peak into a spread-out Bragg peak (SOBP); and the multi-leaf grating adjusts the shape of the uniform beam field, thereby obtaining the desired beam pattern. Figure 3 The spatial dose distribution shown is conformal to the target area.

[0051] In the embodiments disclosed herein, two types of irradiation methods can be used: two-dimensional conformal irradiation and three-dimensional layered conformal irradiation.

[0052] Figure 4A The diagram illustrates the process of a two-dimensional conformal irradiation method provided in an embodiment of this disclosure.

[0053] like Figure 4A As shown, the two-dimensional conformal irradiation method uses a thick ridge filter to broaden the Bragg peak of the monoenergetic heavy ion beam to SOBP consistent with the thickness of the target in one step, and then uses a collimator or multi-leaf grating to intercept the irradiation field to achieve conformal irradiation.

[0054] Figure 4B The diagram illustrates the process of a three-dimensional layered conformal irradiation method provided in an embodiment of this disclosure.

[0055] like Figure 4B As shown, the three-dimensional layered conformal irradiation method can first use a mini-ridge filter (mini-RF) to slightly broaden the Bragg peak of the monoenergetic beam into a mini-SOBP where the physical absorbed dose is approximately Gaussian distributed in the broadened peak region. During the irradiation process, the multi-leaf grating configuration changes according to the shape of the target area of ​​each energy tomography and the contour of the current irradiation tomography. The ion beam energy is adjusted by a range shifter or the accelerator is actively converted to irradiate the next layer.

[0056] Furthermore, in one embodiment of this disclosure, a multi-leaf grating can be configured at the edge of the uniform beam field to improve conformity, reduce the penumbra at the edge of the uniform beam field, and make the edge of the beam field sharper.

[0057] In one embodiment of this disclosure, the area of ​​the uniformly distributed beam field is slightly larger than the area of ​​the target region. This ensures that the uniformly distributed beam field completely covers the target region while minimizing beam waste and damage to normal tissues. It should be understood that "slightly larger than" means that the beam is appropriately expanded based on the size of the target region, and should not be expanded excessively.

[0058] In one embodiment of this disclosure, a larger beam spot can be used to irradiate the target area, thereby reducing the number of scanning magnet switching operations during delivery. In modulated scanning therapy, the smaller the beam spot, the smaller the penumbra of the radiation field. For example, modulated scanning in a carbon ion therapy system requires a beam spot of 4mm-15mm, but in one embodiment of this disclosure, a multi-leaf grating can be used to reduce the penumbra, so the beam spot size can be greater than 15mm, and even 30mm can achieve the requirement of a smaller penumbra.

[0059] In one embodiment of this disclosure, under the above-described beam delivery method, multiple fast scanning beam deliveries can be used for the same fractionated treatment to repeatedly scan the target area. This can effectively reduce position and dose deviations caused by organ movement, increase the success rate of clinical treatment, and reduce side effects.

[0060] For example, during dose calibration, a square point-by-point irradiation field is executed, such as a 10*10cm square dot matrix field, with each dot having the same spacing determined by the beam spot size. Each dot receives the same amount of MU (mu), ensuring uniform dose distribution across the 10*10cm field. Dose calibration is then performed to derive a calibration factor, which is used to calculate the required MU for each point (here, the required MU for each point is the same) based on the dose needed for target area treatment. In this case, the required MU for each point can be divided into multiple irradiations, thus achieving the purpose of repeated scanning.

[0061] To more intuitively illustrate the advantages of the beam delivery method provided in the embodiments of this disclosure, further explanation is provided below.

[0062] Figure 5A The diagram schematically illustrates the field shape corresponding to different target regions in traditional beam delivery methods.

[0063] like Figure 5A As shown, the shaded area represents the target area shape. For square, cross-shaped, or rectangular target areas, the beam delivery method generally forms a square radiation field. The scanning path corresponding to the square radiation field will also deliver dose to areas outside the target area, which will lead to beam waste, increase treatment time, and generate more secondary radiation and induced radioactivity.

[0064] Figure 5B The schematic diagram illustrates the field shape corresponding to different target regions provided in the embodiments of this disclosure.

[0065] like Figure 5B As shown, the shaded area represents the target area shape. For square, cross-shaped, or rectangular target areas, the beam scanning field formed by this disclosure is an irregularly shaped field, and the shape of the irregularly shaped field is consistent with the shape of the target area. The area of ​​the irregularly shaped field is slightly larger than the area of ​​the target area, which can greatly reduce beam waste.

[0066] Figure 6A The diagram illustrates a square beam delivery method provided in an embodiment of this disclosure, showing a scanning path diagram of the beam delivery method.

[0067] Figure 6B The diagram illustrates the irregular field scanning path of the beam delivery method provided in the embodiments of this disclosure.

[0068] like Figure 6A and 6B As shown, the beam delivery method provided in this embodiment can form either a square beam field or an irregular beam field. The scanning path corresponding to the square beam field is along the edge of the target, while the scanning path corresponding to the irregular beam field will not deliver dose to areas outside the target area, thereby reducing beam waste, increasing beam utilization, shortening treatment time, and reducing secondary radiation and induced radioactivity.

[0069] Based on the same inventive concept, this disclosure also provides a beam delivery device.

[0070] Figure 7 A schematic diagram of a beam delivery apparatus provided in an embodiment of this disclosure is shown.

[0071] like Figure 7 As shown, the beam delivery device 700 may include a scanning module 710 and a beam modulation module 720.

[0072] The scanning magnet 710 is used to deliver the same dose of particles to equally spaced scanning points on the cross-section of the target area based on a point-by-point active position delivery method, forming a uniform radiation field that is distributed in a plane perpendicular to the beam direction. The shape of the uniform radiation field distributed in the plane is consistent with the shape of the target area and covers the entire target area.

[0073] The beam modulation module 720 is used to adjust the depth of the uniform field, the broadening of the Bragg peak in the depth direction, and the penumbra at the edge of the uniform field, and to deliver the adjusted uniformly distributed beam to the target area.

[0074] Figure 8 A schematic diagram of the beam delivery device provided in an embodiment of this disclosure is shown.

[0075] like Figure 8As shown, the scanning magnet 710 includes an orthogonal X-direction scanning magnet and a Y-direction scanning magnet. The X-direction scanning magnet is used to deflect the beam in the X direction, and the Y-direction scanning magnet is used to deflect the beam in the Y direction. By combining the beam deflection directions in the X and Y directions, the size and shape of the uniform beam field can be flexibly adjusted.

[0076] The beam modulation module 720 includes a ridge filter, a de-energizer, a multi-leaf grating, and a compensator arranged in sequence. The depth of the uniform field is adjusted by the de-energizer and the compensator, the broadening of the uniform field is adjusted by the ridge filter, and the monoenergized Bragg peak is slightly broadened into an extended Bragg peak. The shape and edge penumbra of the uniform field are adjusted by the multi-leaf grating.

[0077] Any one or more of the modules, submodules, units, and subunits according to embodiments of the present disclosure, or at least part of the functions of any one or more of them, can be implemented in one module. Any one or more of the modules, submodules, units, and subunits according to embodiments of the present disclosure can be implemented by dividing them into multiple modules. Any one or more of the modules, submodules, units, and subunits according to embodiments of the present disclosure can be at least partially implemented as hardware circuitry, such as Field Programmable Gate Arrays (FPGAs), Programmable Logic Arrays (PLAs), Systems-on-Chip, Systems-on-Substrate, Systems-on-Package, Application-Specific Integrated Circuits (ASICs), or implemented in hardware or firmware by any other reasonable means of integrating or packaging circuitry, or implemented in software, hardware, or firmware, or in any suitable combination of any of these three implementation methods. Alternatively, one or more of the modules, submodules, units, and subunits according to embodiments of the present disclosure can be at least partially implemented as computer program modules, which, when run, can perform corresponding functions.

[0078] For example, any plurality of scanning magnets 710 and beam modulation modules 720 can be combined into one module / unit / subunit, or any one of these modules / units / subunits can be split into multiple modules / units / subunits. Alternatively, at least part of the functionality of one or more of these modules / units / subunits can be combined with at least part of the functionality of other modules / units / subunits and implemented in one module / unit / subunit. According to embodiments of this disclosure, at least one of the scanning magnets 710 and beam modulation modules 720 can be at least partially implemented as hardware circuitry, such as field-programmable gate arrays (FPGAs), programmable logic arrays (PLAs), systems-on-a-chip, systems-on-a-substrate, systems-on-package, application-specific integrated circuits (ASICs), or any other reasonable means of integrating or packaging circuitry, or implemented in software, hardware, or firmware, or in any suitable combination of any of these three implementation methods. Alternatively, at least one of the scanning magnets 710 and beam modulation modules 720 can be at least partially implemented as a computer program module, which, when run, can perform corresponding functions.

[0079] It should be noted that the beam delivery device part in the embodiments of this disclosure corresponds to the beam delivery method part in the embodiments of this disclosure, and their specific implementation details and the resulting technical effects are the same, so they will not be repeated here.

[0080] Figure 9 A block diagram of an electronic device suitable for implementing the methods described above, according to embodiments of the present disclosure, is illustrated schematically. Figure 9 The electronic device shown is merely an example and should not be construed as limiting the functionality and scope of the embodiments disclosed herein.

[0081] like Figure 9 As shown, an electronic device 900 according to an embodiment of the present disclosure includes a processor 901, which can perform various appropriate actions and processes according to a program stored in a read-only memory (ROM) 902 or a program loaded from a storage portion 908 into a random access memory (RAM) 903. The processor 901 may include, for example, a general-purpose microprocessor (e.g., a CPU), an instruction set processor and / or an associated chipset and / or a special-purpose microprocessor (e.g., an application-specific integrated circuit (ASIC)), etc. The processor 901 may also include onboard memory for caching purposes. The processor 901 may include a single processing unit or multiple processing units for performing different actions of the method flow according to an embodiment of the present disclosure.

[0082] RAM 903 stores various programs and data required for the operation of electronic device 900. Processor 901, ROM 902, and RAM 903 are interconnected via bus 904. Processor 901 performs various operations of the method flow according to embodiments of the present disclosure by executing programs in ROM 902 and / or RAM 903. It should be noted that the programs may also be stored in one or more memories other than ROM 902 and RAM 903. Processor 901 may also perform various operations of the method flow according to embodiments of the present disclosure by executing programs stored in said one or more memories.

[0083] According to embodiments of this disclosure, the electronic device 900 may further include an input / output (I / O) interface 905, which is also connected to a bus 904. The electronic device 900 may also include one or more of the following components connected to the I / O interface 905: an input section 906 including a keyboard, mouse, etc.; an output section 907 including a cathode ray tube (CRT), liquid crystal display (LCD), etc., and a speaker, etc.; a storage section 908 including a hard disk, etc.; and a communication section 909 including a network interface card such as a LAN card, modem, etc. The communication section 909 performs communication processing via a network such as the Internet. A drive 910 is also connected to the I / O interface 905 as needed. A removable medium 911, such as a disk, optical disk, magneto-optical disk, semiconductor memory, etc., is installed on the drive 910 as needed so that computer programs read from it can be installed into the storage section 908 as needed.

[0084] According to embodiments of this disclosure, the method flow according to embodiments of this disclosure can be implemented as a computer software program. For example, embodiments of this disclosure include a computer program product comprising a computer program carried on a computer-readable storage medium, the computer program containing program code for performing the methods shown in the flowchart. In such embodiments, the computer program can be downloaded and installed from a network via communication section 909, and / or installed from removable medium 911. When the computer program is executed by processor 901, it performs the functions defined in the system of embodiments of this disclosure. According to embodiments of this disclosure, the systems, devices, apparatuses, modules, units, etc., described above can be implemented by computer program modules.

[0085] This disclosure also provides a computer-readable storage medium, which may be included in the device / apparatus / system described in the above embodiments; or it may exist independently and not assembled into the device / apparatus / system. The computer-readable storage medium carries one or more programs that, when executed, implement the method according to the embodiments of this disclosure.

[0086] According to embodiments of this disclosure, the computer-readable storage medium can be a non-volatile computer-readable storage medium. Examples include, but are not limited to: portable computer disks, hard disks, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), portable compact disk read-only memory (CD-ROM), optical storage devices, magnetic storage devices, or any suitable combination thereof. In this disclosure, the computer-readable storage medium can be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, apparatus, or device.

[0087] For example, according to embodiments of this disclosure, a computer-readable storage medium may include one or more memories other than ROM 902 and / or RAM 903 described above.

[0088] The flowcharts and block diagrams in the accompanying drawings illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of the present disclosure. In this regard, each block in a flowchart or block diagram may represent a module, segment, or portion of code containing one or more executable instructions for implementing a specified logical function. It should also be noted that in some alternative implementations, the functions indicated in the blocks may occur in a different order than those indicated in the drawings. For example, two consecutively indicated blocks may actually be executed substantially in parallel, and they may sometimes be executed in reverse order, depending on the functions involved. It should also be noted that each block in a block diagram or flowchart, and combinations of blocks in a block diagram or flowchart, may be implemented using a dedicated hardware-based system that performs the specified function or operation, or using a combination of dedicated hardware and computer instructions. Those skilled in the art will understand that the features recited in the various embodiments and / or claims of this disclosure can be combined and / or combined in various ways, even if such combinations or combinations are not expressly described in this disclosure. In particular, the features described in the various embodiments and / or claims of this disclosure may be combined and / or combined in various ways without departing from the spirit and teachings of this disclosure. All such combinations and / or combinations fall within the scope of this disclosure.

Claims

1. A beam delivery method, characterized in that, include: The cross-sectional shape of the target area is divided into several equally spaced scanning points. Based on the point-by-point active position delivery method, the same dose of particles is delivered to the scanning points to form a uniform radiation field that is distributed in a plane perpendicular to the beam direction. The shape of the uniform radiation field distributed in the plane is consistent with the shape of the target area and covers the entire target area. The beam modulation module adjusts the depth of the uniform field, the broadening of the Bragg peak in the depth direction, and the penumbra at the edge of the uniform field, and then delivers the adjusted uniformly distributed beam to the target area. Using orthogonal scanning magnets, based on a point-by-point active position delivery method, the same dose of particles is delivered to equally spaced scanning points to form a uniform radiation field distributed in a plane perpendicular to the beam direction. The beam modulation module includes a ridge filter, a de-energizer, a multi-leaf grating, and a compensator arranged in sequence. The depth of the uniform radiation field is adjusted by the energy reduction plate and the compensator. The ridge filter adjusts the Bragg peak broadening in the depth direction of the uniform field. The shape and edge penumbra of the uniform field are adjusted by using a multi-leaf grating.

2. The beam delivery method according to claim 1, characterized in that, The multileaf grating configuration is located at the edge of the uniform field of view.

3. The beam delivery method according to claim 1, characterized in that, The area of ​​the uniformly distributed planar field is slightly larger than the cross-sectional area of ​​the target area.

4. The beam delivery method according to claim 1, characterized in that, The method further includes: The required dose for the scanning point is divided into multiple irradiations of the target area.

5. The beam delivery method according to claim 1, characterized in that, The target area is irradiated with a beam with a large beam size.

6. A beam delivery device, characterized in that, include: The scanning module is used to deliver the same dose of particles to equally spaced scanning points on the cross-section of the target area based on a point-by-point active position delivery method, forming a uniform radiation field that is distributed in a plane perpendicular to the beam direction. The shape of the uniform radiation field distributed in the plane is consistent with the shape of the target area and covers the entire target area. A beam modulation module is used to adjust the depth of the uniform field, the Bragg peak broadening in the depth direction, and the penumbra at the edge of the uniform field, and to deliver the adjusted uniformly distributed beam to the target area. Using orthogonal scanning magnets, based on a point-by-point active position delivery method, the same dose of particles is delivered to equally spaced scanning points to form a uniform field distributed in a plane perpendicular to the beam direction. The beam modulation module includes a ridge filter, a de-energizer, a multi-leaf grating, and a compensator arranged in sequence. The depth of the uniform field is adjusted by the de-energizer and the compensator; the Bragg peak broadening in the depth direction of the uniform field is adjusted by the ridge filter; and the shape and penumbra at the edge of the uniform field are adjusted by the multi-leaf grating.

7. An electronic device, characterized in that, include: One or more processors; Memory, used to store one or more programs. Wherein, when the one or more programs are executed by the one or more processors, the one or more processors cause the one or more processors to implement the method according to any one of claims 1 to 5.

8. A computer-readable storage medium, characterized in that, It stores executable instructions that, when executed by a processor, cause the processor to perform the method described in any one of claims 1 to 5.

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