A method for constructing a rat model of chemotherapy-induced phlebitis

A rat model of chemotherapy-induced phlebitis was established by administering vinorelbine saline solution to the dorsal vein of the rat paw. This solved the problems of difficult operation and short duration in the existing technology, and achieved a simulation consistent with clinical symptoms and an efficient experimental model.

CN115568441BActive Publication Date: 2025-12-12SHANXI PROVINCE CHINESE MEDICINE RESEARCH INSTITUTE
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Patent Information

Application Number
CN202211238811.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-10-11
Publication Date
2025-12-12
Estimated Expiration
2042-10-11

AI Technical Summary

Technical Problem

Existing animal models of chemotherapy-induced phlebitis in rabbit ear veins and mouse tail veins suffer from difficulties in operation, low success rates, high costs, and short durations, and cannot effectively simulate the symptoms of clinical chemotherapy-induced phlebitis.

Method used

A rat model of chemotherapy-induced phlebitis was established by administering vinorelbine saline solution (≤3 mg/kg, concentration 2-5 mg/ml) via the dorsal vein of the rat paw. The symptoms of chemotherapy-induced phlebitis were simulated by observing changes in venous pathology and intimal microstructure.

Benefits of technology

The prepared model is consistent with the clinical symptoms of chemotherapy-induced phlebitis. It is simple to operate, low in cost, has a high success rate, long duration, clear quality control indicators, and good reproducibility.

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Abstract

The application belongs to the technical field of medical animal model modeling, and provides a simple and easy-to-operate model construction method which can simulate the characteristics of clinical chemotherapy phlebitis to solve the problems of complicated replication method and lack of clinical typical characteristics of the current chemotherapy phlebitis animal model. The model agent is administered to the dorsal vein of the rat foot, and the best replication scheme of the chemotherapy phlebitis rat model is determined by investigating the concentration, dose and duration. The chemotherapy phlebitis rat model is replicated by using vinorelbine physiological saline solution with a concentration of 2-5 mg / ml and a total dose of ≤3 mg / kg. The local characterization of the dorsal foot and the foot swelling rate on the next day after modeling meet the diagnostic criteria of chemotherapy phlebitis. The pathological characteristics of chemotherapy phlebitis can be observed in the blood vessel pathological section under a light microscope and an intima scanning electron microscope, and the duration is 7 days. The model has the advantages of simple preparation method, clear quality control index, long maintenance time, low preparation cost and close to human diseases.
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