Aqueous dispersion gastric soluble coating liquid and its preparation method and application

By using long-chain fatty acids or long-chain fatty acid glycerides as anti-adhesive agents in the aqueous dispersion gastric dissolving coating liquid, the adhesion problem during the coating process is solved. The coating film formed is dense, has low permeability, and is quickly dissolved in the gastric environment, achieving better drug taste and therapeutic effect.

CN115919740BActive Publication Date: 2025-03-25ZHEJIANG UNIV
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Patent Information

Application Number
CN202211720433.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-12-30
Publication Date
2025-03-25
Estimated Expiration
2042-12-30

AI Technical Summary

Technical Problem

The existing aqueous dispersion gastric dissolving coating liquid is prone to adhesion problems during the coating process, and the coating film formed is not dense enough and difficult to dissolve quickly in the gastric environment.

Method used

The prepared aqueous dispersion gastric dispersion is made of low viscosity and is not easy to adhere. The coated film formed is dense, has low permeability and has low permeability, and has certain flexibility and compressive resistance.

Benefits of technology

It realizes the reduction of adhesion during the gastric dissolution coating process, and the formed coating film is quickly dissolved in the stomach environment, effectively exerting the functions of moisture-proofing and smell-covering, and improving the taste and therapeutic effect of the drug.

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Abstract

The invention discloses a water-dispersible gastric-soluble coating liquid and a preparation method and application thereof, belonging to the field of pharmaceutical preparations. The water-dispersible gastric-soluble coating liquid is composed of the following components in weight percentage: 0.2-3% anti-adhesive agent, 0.2-3% emulsifier, 6-15% gastric-soluble coating material, 0.2-3% coating material salt-forming agent, and the balance is water; wherein the anti-adhesive agent is a long-chain fatty acid or a long-chain fatty acid glyceride with an alkyl chain length of more than 18 carbon atoms. The water-dispersible gastric-soluble coating liquid has low viscosity, and the coating film is not easy to adhere, and is suitable for substrates with high surface curvature; and the formed coating film is dense, has low permeability, and can be quickly dissolved in the gastric environment, thereby playing the functions of moisture-proof and taste-masking. The gastric-soluble coating taste-masking layer of cefpodoxime proxetil prepared by the water-dispersible gastric-soluble coating liquid can mask the bitterness of the drug, and there is no gritty feeling when taken orally, which solves the problems of strong bitterness and difficulty in swallowing of existing cefpodoxime proxetil products.
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