An anticancer drug intermediate and its preparation method
Through the 14-step reaction starting from L-arabinose, using inert gas protection and a variety of organic solvents, the synthesis of Elibrin intermediate fragment VI was successfully simplified, solving the problems of high cost and complex operation in the prior art, achieving high yield and low cost synthesis, and is suitable for industrial production.
CN116063257BActive Publication Date: 2025-03-25CHINA PHARM UNIV
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Patent Information
- Application Number
- CN202111290263.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2021-11-02
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2041-11-02
AI Technical Summary
Technical Problem
In the existing Alibring synthesis, the synthesis of key intermediate fragment VI has problems such as high cost, complex operation and low selectivity, making it difficult to achieve large-scale industrial production.
Method used
A new synthesis method of intermediate fragment VI is provided. Starting from L-arabinose through 14-step reaction, the combination of inert gas protection, a combination of multiple organic solvents and specific protective groups is achieved, and synthesis with ease of operation and high yield is achieved.
Benefits of technology
This method simplifies the synthesis steps, improves the reaction yield, reduces the synthesis cost, is suitable for industrial large-scale production, and provides a synthesis route for the new Elibrin intermediate ERB.
✦ Generated by Eureka AI based on patent content.
Abstract
This invention discloses an anticancer drug intermediate and its preparation method. The method starts with arabinose and yields the target compound through a 14-step reaction. The method is simple to operate, has a high yield, low cost, and is suitable for industrial production.
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