Montelukast acid berberine quaternary ammonium salt compound, double salt composition, synthesis method and use thereof
By making berberine and montelustic acid into berberine Montelustic acid, forming a new quaternary ammonium salt compound or its complex salt composition, the problem of poor water solubility of berberine is solved, the bioavailability and anti-inflammatory effect are improved, and the side effects are reduced, and it is suitable for the treatment of various diseases.
Patent Information
- Application Number
- CN202211438277.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Priority Date
- 2021-11-16
- Filing Date
- 2022-11-16
- Publication Date
- 2025-08-26
- Estimated Expiration
- 2042-11-16
AI Technical Summary
The poor water solubility of berberine leads to its low oral bioavailability, affecting systemic treatment effect, and berberine hydrochloride has a risk of hyperchloremia. There is no collaborative anti-inflammatory research on berberine and montelusteric acid.
Berberine and montelustic acid are used to make corresponding berberine montelustic acid, which improves solubility and bioavailability, reduces side effects, and forms a new quaternary ammonium salt compound or its complex salt composition.
It improves anti-inflammatory effects, reduces side effects, and especially avoids the potential risk of hyperchloremia of hydrochloride. It is suitable for drugs that prevent and treat diseases related to allergies, inflammation, vascular malformations, infections, immunity, etc.