A method for separating and purifying 2-nitroethanol
By reacting paraformaldehyde and nitromethane under alkali catalysis, combining solvent extraction and reduced pressure recovery, the safety, yield and environmental pollution problems in the existing 2-nitroethanol preparation methods were successfully solved, and efficient, safe and economical 2-nitroethanol purification was achieved.
CN116410093BActive Publication Date: 2025-03-25FUDAN UNIVERSITY
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Patent Information
- Application Number
- CN202310278933.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-03-21
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2043-03-21
AI Technical Summary
Technical Problem
The existing preparation methods of 2-nitroethanol have problems such as explosion risk, low yield, expensive reagent prices and environmental pollution, which are difficult to meet the needs of industrial production.
Method used
By reacting paraformaldehyde with nitromethane under alkali catalysis, a mixture of 2-nitroethanol, 2-nitro-1,3-propylene glycol and trimethylolnitromethane was obtained. The high-purity 2-nitroethanol was purified by solvent extraction, separation and recovery under reduced pressure.
Benefits of technology
The method is safe to operate, has low cost, and has a yield of up to 80-85%. It has high purity of products. It is suitable for industrial applications and avoids explosion risks and environmental pollution.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention belongs to the technical field of organic chemistry, and is specifically a method for separating and purifying 2-nitroethanol. The present invention reacts paraformaldehyde with nitromethane under base catalysis to obtain a mixture of 2-nitroethanol, 2-nitro-1,3-propylene glycol, and trimethylolnitromethane. According to the different solubilities of the three products in a specific solvent, pure 2-nitroethanol is obtained by extraction and separation. The purification conditions of the inventive method are mild, easy to operate, safe, and the product yield and purity are high, which is convenient for industrial production. It overcomes the outstanding problems of high distillation temperature, easy decomposition and explosiveness of products when obtaining high-purity 2-nitroethanol by vacuum distillation in current industrial production, which brings potential safety hazards to industrial production.
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