A composition with anti-dandruff and oil control efficacy and application thereof

Abstract

The present application aims to provide a composition with the effect of dandruff control and oil control and its application, the composition comprises magnolia officinalis extract, piroctone olamine and salvia hispanica seed extract, through the combination of the three ingredients, it has obvious effect in inhibiting the growth of scalp bacteria, controlling the secretion of oil, repairing and strengthening the skin barrier, so as to achieve more efficient oil control and dandruff removal effect, and can be used for preparing dandruff removal and care products, and has wide market prospect.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of washing and care products, and relates to a composition with anti-dandruff and oil control effects and application thereof. BACKGROUND

[0002] Dandruff is a common disease of the scalp, which is medically known as "seborrheic dermatitis", and is clinically manifested as excessive fine grayish white dry or slightly oily bran-like dandruff on the scalp or hair, which can be accompanied by itching, and the incidence rate in the population is extremely high. The occurrence of dandruff can be summarized as the following three points: first, imbalance of scalp microorganisms, mainly referring to abnormal proliferation of Malassezia, Staphylococcus aureus and other microorganisms; second, increased secretion of scalp sebum; and third, impaired barrier function of the scalp.

[0003] Malassezia mainly grows in the epidermal keratin layer of humans, and belongs to the yeast genus of lipophilic basidiomycete. Due to the lack of cytoplasmic fatty acid synthase gene, it cannot synthesize fatty acids from scratch, and contains multiple lipase, phosphatase and sphingomyelinase genes, which can decompose lipids to generate free fatty acids. Because of this property, Malassezia tends to inhabit the parts of the human skin where the secretion of lipids is vigorous, leading to imbalance of lipids in the human skin and causing dermatitis or dandruff symptoms.

[0004] Staphylococcus aureus is a gram-negative bacterium, which belongs to the Staphylococcus family of Bacillales. Staphylococcus aureus plays an important role in the infection diseases of the skin, and is one of the main pathogenic bacteria causing skin eczema and specific dermatitis, which can cause skin inflammatory response and oxidative stress of the skin, and even cause local pyogenic infection in severe cases.

[0005] When the scalp secretes too much oil, it provides a rich source of nutrients for microbial colonization, and is more likely to adsorb dust and pollutants in the air, in addition, the products of the oxidation of scalp sebum by ultraviolet light also have some impact on the scalp.

[0006] The skin barrier includes the sebum film and the stratum corneum, wherein the sebum film is a protective film formed on the surface of the skin by low-temperature emulsification of the oil secreted by the sebaceous glands, the lipid produced by the keratinocytes, the sweat secreted by the sweat glands and the exfoliated keratinocytes, and the stratum corneum is a "brick wall structure" composed of 10 to 20 layers of flat dead keratinocytes, with lipids such as ceramide, free fatty acids and cholesterol filling between the cells. The skin barrier plays an important role in resisting external stimuli and maintaining normal functions of the skin.

[0007] At present, most of the commercially available anti-dandruff cosmetics are added with various antifungal drugs as the main functional ingredients to reduce the growth of scalp microorganisms, inhibit the excessive division of scalp keratinocytes, reduce the speed of epidermal turnover, and prevent the accumulation of cells to be shed into visible clumps of scales, so as to achieve the purpose of dandruff removal. Early anti-dandruff agents include sulfur, salicylic acid, selenium disulfide, etc. Among them, sulfur and salicylic acid have less ideal dandruff removal effect and greater irritation, and selenium disulfide can make the hair become dry and cause the hair to fade after use. Later, zinc pyrithione (ZPT, 1-hydroxy pyridine-2-sulfur copper zinc, also known as zinc pyrithione), climbazole (trade name Sebozole, CLM) and piroctone olamine salt (trade name Octopirox, OCT, 1-hydroxy-4-methyl-6-(2,4,4-trimethylphenyl) pyridine ketone ethanolamine complex salt) and the like appeared in succession.

[0008] The shampoo in the prior art can usually only repair one or two causes of dandruff growth. For example, patent CN102716045B only aims at the growth of scalp microorganisms, and achieves the effect of effective sterilization and dandruff removal by adding a combination of dandruff agents piroctone olamine salt and pyrithione salt. Patent CN114129464A uses a combination of chemical dandruff agents such as piroctone olamine salt, dandruff synergists such as cinnamon bark extract, and repair synergists such as angelica extract to inhibit the growth of microorganisms in the scalp while repairing the skin barrier. However, there is currently no shampoo that can repair three causes of dandruff growth at the same time.

[0009] Therefore, it is necessary to develop a shampoo that can simultaneously address the three factors that cause dandruff, inhibit microbial growth, control oil secretion, and repair and strengthen the skin barrier to achieve a more comprehensive, efficient and long-lasting dandruff removal effect. SUMMARY

[0010] To solve the above problems, the purpose of the present application is to provide a composition with dandruff and oil control effect and its application, which comprises Magnolia officinalis extract, piroctone olamine salt and Spanish sage seed extract. Through the combination of the three ingredients, it has significant effect in inhibiting the growth of Staphylococcus aureus, controlling oil secretion, repairing and strengthening the skin barrier, thereby achieving a more efficient oil control and dandruff removal effect. It can be used for preparing dandruff removal and care products, and has a broad market prospect.

[0011] In one aspect, the present application provides an anti-dandruff and oil control composition, which comprises Magnolia officinalis extract, piroctone olamine salt and Spanish sage seed extract.

[0012] Magnolia officinalis is a plant of Magnoliaceae officinalis, growing in the forest between 300-1500 meters above sea level. The main components of Magnolia officinalis extract are lignin, alkaloids and volatile oil compounds, among which lignin compounds mainly include magnolol, honokiol, isomagnolol and magnolol new phenol. Magnolia officinalis extract also has broad-spectrum antibacterial effect, and has significant bactericidal and inhibitory effect on many bacteria including Staphylococcus aureus, Escherichia coli and Streptococcus. It can reduce the expression of inflammatory mediators and inflammatory factors by inhibiting PI3K / Akt and NFκB / MAPK signaling pathways, and show good soothing effect. In addition, magnolol in Magnolia officinalis extract has good scavenging effect on oxygen free radicals, can enhance the activity of antioxidant enzymes, and prevent scalp lipid peroxidation.

[0013] The Magnolia officinalis extract of the present application can be extracted from Magnolia officinalis by water extraction method, alcohol extraction method, alkali extraction method, supercritical CO2 extraction method, ultrasonic assisted extraction method, high-speed counter-current chromatography separation method and the like, and the supercritical CO2 extraction method is preferred.

[0014] In some ways, the total phenol content of Magnolia officinalis extract of the present application is more than 90%.

[0015] The total phenol of Magnolia officinalis refers to all phenolic substances in Magnolia officinalis extract including magnolol, honokiol and the like.

[0016] The active substance in Magnolia officinalis extract is mainly phenolic substance, and its content directly affects the activity of Magnolia officinalis extract, so it is necessary to ensure that the total phenol content of the extract is more than 90%.

[0017] Piroctone olamine is a highly effective, non-toxic and non-irritating anti-dandruff agent. Its chemical structure name is 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)-pyridinone-2-aminoethanol salt (1:1), which is a white or light yellow crystalline powder with very light characteristic odor, and can be obtained by organic synthesis method. Its anti-dandruff and itching mechanism is to fundamentally block the external channel of dandruff production through bactericidal and antioxidant effects, thereby effectively curing dandruff and stopping itching. It has good bactericidal and inhibitory effect on many bacteria and fungi including Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli.

[0018] Spanish chamomile seed extract contains a large amount of unsaturated fatty acids, which has strong inhibitory effect on Propionibacterium acnes. It can repair the skin barrier, significantly reduce the transdermal water loss, and continuously improve the water content of the skin. 0.001% of Spanish chamomile seed extract can significantly increase the expression of water channel protein AQP3 and hyaluronic acid synthase HAS2 genes in normal human epidermal keratinocytes, that is, it can enhance the moisturizing capacity of the skin barrier.

[0019] The Spanish sage seed extract of the present application can be obtained from pressed and ground Spanish sage seeds by solid-liquid extraction-dry fractionation. Preferably, the Spanish sage seed extract is concentrated after fractionation.

[0020] In some embodiments, the Spanish sage seed extract of the present application has a total content of linoleic acid and linolenic acid of more than 8%.

[0021] In some embodiments, the Spanish sage seed extract of the present application has a content of linolenic acid of more than 8%.

[0022] The content of linolenic acid in the Spanish sage seed extract directly affects the activity of the Spanish sage seed extract in enhancing the skin barrier, and therefore the content of linolenic acid in the Spanish sage seed extract is required to be more than 8% so that the composition achieves better dandruff control effect.

[0023] The above three compounds are related to the three causes of dandruff production, including inhibiting abnormal proliferation of microorganisms, reducing oil secretion, and enhancing the skin barrier. The present application has found that the dandruff-removing cosmetic formula of the three components of Magnolia bark extract, piroctone olamine, and Spanish sage seed extract has a synergistic effect, which can achieve high-efficiency oil control and dandruff removal from the three factors causing dandruff.

[0024] In another aspect, the present application provides a dandruff control product, which comprises the composition as described above.

[0025] The dandruff-removing composition of the present application: piroctone olamine, Magnolia bark extract, and Spanish sage seed extract, can be used for preparing dandruff control products such as shampoo, and the application of the dandruff-removing composition in cosmetics is provided.

[0026] In some embodiments, the dandruff-removing composition accounts for 0.01-20% of the dandruff control product. The cosmetic product includes shampoo, hair conditioner, cream, hand sanitizer, shower gel, emulsion, or other daily chemical product forms.

[0027] In some embodiments, the dandruff-removing composition accounts for 0.1-10% of the dandruff control product.

[0028] In another aspect, the present application provides a use of a composition for preparing a Staphylococcus aureus inhibitor, wherein the composition comprises Magnolia bark extract, piroctone olamine, and Spanish sage seed extract.

[0029] The research proves that the composition provided by the application has obvious synergistic effect in inhibiting Staphylococcus aureus; and although the composition does not have obvious synergistic effect in inhibiting Malassezia furfur, the composition can still effectively inhibit Malassezia furfur, thereby helping to remove dandruff.

[0030] Further, the mass percentage of the Magnolia Bark extract, the piroctone olamine and the Salvia hispanica seed extract is 1:(0.00001-10):(0.00001-1).

[0031] Further, the total phenol content of the Magnolia Bark extract is more than 90%, and the linolenic acid content of the Salvia hispanica seed extract is more than 8%.

[0032] Further, the mass percentage of the Magnolia Bark extract, the piroctone olamine and the Salvia hispanica seed extract in the composition is (10-40):(10-40):(1-10).

[0033] Further, the mass percentage of the Magnolia Bark extract, the piroctone olamine and the Salvia hispanica seed extract in the dandruff-removing composition is (20-30):(30-40):(1-5).

[0034] Further, the mass percentage of the Magnolia Bark extract, the piroctone olamine and the Salvia hispanica seed extract in the dandruff-removing composition is 20:40:1.

[0035] In still another aspect, the application provides a use of a composition comprising Magnolia Bark extract, piroctone olamine and Salvia hispanica seed extract for preparing a sebum secretion inhibitor.

[0036] Further, the mass percentage of the Magnolia Bark extract, the piroctone olamine and the Salvia hispanica seed extract in the composition is (10-40):(10-40):(1-10).

[0037] Further, the mass percentage of the Magnolia Bark extract, the piroctone olamine and the Salvia hispanica seed extract in the dandruff-removing composition is (10-30):(10-30):(1-5).

[0038] Further, the mass percentage of the Magnolia Bark extract, the piroctone olamine and the Salvia hispanica seed extract in the dandruff-removing composition is 10:10:2.5.

[0039] In still another aspect, the application provides a use of a composition comprising Magnolia Bark extract, piroctone olamine and Salvia hispanica seed extract for preparing a preparation for repairing and strengthening skin barrier.

[0040] In still another aspect, the present application provides a use of a composition for the preparation of a preparation capable of simultaneously inhibiting Staphylococcus aureus and Malassezia furfur, inhibiting sebaceous gland cell sebum secretion, repairing and strengthening the skin barrier, the composition comprising Magnolia officinalis extract, piroctone olamine and Salvia hispanica seed extract.

[0041] The composition provided by the present application can effectively control dandruff and oil by simultaneously inhibiting Staphylococcus aureus and Malassezia furfur, inhibiting sebaceous gland cell sebum secretion, repairing and strengthening the skin barrier.

[0042] The present application has the following beneficial effects relative to the prior art:

[0043] 1. A dandruff control composition comprising Magnolia officinalis extract, piroctone olamine and Salvia hispanica seed extract, simultaneously targeting three factors causing dandruff, inhibiting microbial growth, controlling sebum secretion, repairing and strengthening the skin barrier, to achieve more comprehensive, efficient and persistent dandruff control effect;

[0044] 2. The three dandruff active substances are compounded, which can strongly inhibit Staphylococcus aureus causing dandruff and have a synergistic effect;

[0045] 3. The three dandruff active substances are compounded, which have a synergistic effect in inhibiting sebaceous gland cell sebum secretion;

[0046] 5. Achieve more efficient oil control and dandruff control effect, which can be used for preparing dandruff shampoo and conditioner products, and has a broad market prospect. BRIEF DESCRIPTION OF DRAWINGS

[0047] Figure 1 Figure 2 is a microscope photograph of the blank control group, the positive control group, the Magnolia officinalis extract group, the piroctone olamine group, the Salvia hispanica seed extract group, and the combination group in Example 2. DETAILED DESCRIPTION

[0048] The preferred embodiments of the present application will be further described in conjunction with the accompanying drawings, it should be noted that the following embodiments are intended to facilitate the understanding of the present application and do not limit the present application in any way, all the features disclosed in the embodiments of the present application, or the steps in all the disclosed methods or processes, can be combined in any way, except that the features and / or steps are mutually exclusive.

[0049] The piroctone olamine used in the following examples was purchased from Yantai Dongfang Chemical Co., Ltd., the Magnolia officinalis extract was purchased from Hunan and Guangdong Biotechnology Co., Ltd., the total phenol content of Magnolia officinalis was 98%, and the content of honokiol was greater than 50% and the content of magnolol was greater than 40%; the Salvia hispanica seed extract was purchased from Signum Biosciences, Inc., and the linolenic acid content was 12%.

[0050] Example 1: Synergistic inhibition of dandruff-causing bacteria by the composition provided by the present application

[0051] According to QB2738-2012 "Evaluation method of antibacterial and bacteriostatic effect of daily chemical products", the inhibition effect of three active substances and their combinations on Staphylococcus aureus was determined by the bacteriostatic ring method. The types and concentrations of the test samples, and the corresponding bacteriostatic ring sizes are shown in Table 1.

[0052] Table 1, Inhibition of Staphylococcus aureus by active substances and compositions

[0053]

[0054]

[0055] According to WS / T639-2018 "Technical requirements for antimicrobial susceptibility testing", the inhibition effect of three active substances on Malassezia furfur was determined by agar dilution method. The types and concentrations of the test samples, and the corresponding bacterial growth are shown in Table 2. First, gradient concentrations of single raw material samples were prepared, and the minimum inhibitory concentration was determined by testing. The bacteriostatic effect of the composition was determined by reducing the concentration by an appropriate amount based on this benchmark.

[0056] Table 2, Inhibition of Malassezia furfur by active substances and compositions

[0057]

[0058] The results of Table 1 show that the bacteriostatic ring diameter corresponding to Magnolia officinalis extract at a concentration of 20 ppm is 17.0 mm, the bacteriostatic ring diameter corresponding to piroctone olamine at a concentration of 40 ppm is 19.5 mm, and the bacteriostatic ring diameter corresponding to Salvia hispanica seed extract at a concentration of 1 ppm is 12.0 mm. It can be seen that piroctone olamine and Magnolia officinalis extract have good inhibition effect on Staphylococcus aureus, and the inhibition effect of Salvia hispanica seed extract is not obvious.

[0059] By comparing a single component and a combination of two components, the bacteriostatic ring diameter of Staphylococcus aureus increases after combining Magnolia officinalis extract, piroctone olamine, and Salvia hispanica seed extract, showing a synergistic effect.

[0060] The results of Table 2 show that among the three active substances, piroctone olamine has the best antibacterial effect on Pityrosporum ovale, and no bacteria grow in the culture dish at a concentration of 25 ppm; Magnolia bark extract and Spanish chamomile seed extract have similar antibacterial effects, and no bacteria grow in the culture dish at a concentration of 50 ppm. However, when the concentrations of the three compositions are 40, 20, and 40 ppm, respectively, bacteria grow in the culture dish, that is, there is no synergistic effect on the inhibition of Pityrosporum ovale.

[0061] It can be seen that the combination of Magnolia bark extract, piroctone olamine, and Spanish chamomile seed extract has a synergistic effect on the inhibition of Staphylococcus aureus, but has no synergistic effect on the inhibition of Pityrosporum ovale.

[0062] In this embodiment, experiments are also conducted on the mass percentage of Magnolia bark extract, piroctone olamine, and Spanish chamomile seed extract in the range of 1: (0.00001-10): (0.00001-1), and it is found that the compositions in this range have a certain synergistic effect on the inhibition of Staphylococcus aureus.

[0063] Example 2: Synergistic effect of the composition provided by the present application on the inhibition of sebum cell oil secretion

[0064] In this embodiment, oil red O staining experiments are used to analyze the inhibitory effect of the active substances and compositions shown in Table 2 on sebum cell oil secretion.

[0065] The specific experimental method is as follows: 8x10 4 Sebum cells SZ95 (purchased from Guangdong Boxi Biological Technology Co., Ltd.) are inoculated into a 24-well plate at 8x10 Figure 1 .

[0066] Table 2: Inhibitory effect of active substances on sebum cell oil secretion

[0067]

[0068] According to Table 2, the amount of oil secretion of the positive control group is significantly reduced compared with the blank control group, and the inhibition rate reaches 77.29%, proving that the test is effective. Among the three components, the inhibition rate of Magnolia officinalis extract on oil secretion is the highest, reaching 82.78%, the inhibition rate of piroctone olamine on oil secretion is the lowest, being 13.74%, and the seed extract of Salvia hispanica has certain inhibitory effect on oil secretion, and the inhibition rate is 45.36%. The inhibition rate of the composition of the three substances compared with the blank control group reaches 93.55%, that is, after the combination of Magnolia officinalis extract, piroctone olamine and seed extract of Salvia hispanica, the inhibition effect on oil secretion of sebaceous gland cells can be significantly improved, and compared with the combination of one or two components, it has obvious synergistic effect.

[0069] In this embodiment, the mass percentage of Magnolia officinalis extract, piroctone olamine and seed extract of Salvia hispanica is also tested in the range of 1:(0.00001-10):(0.00001-1), and it is found that the composition has certain synergistic effect on inhibiting oil secretion of sebaceous gland cells in this range.

[0070] Example 3: Effect of anti-dandruff composition on the expression of skin barrier related genes

[0071] In this embodiment, the effect of the composition of Magnolia officinalis extract, piroctone olamine and seed extract of Salvia hispanica on the expression of skin barrier related genes is tested, and the specific steps are as follows: normal human epidermal keratinocytes (purchased from Thermo Fisher) are inoculated into a 6-well plate and incubated in an incubator overnight. After being treated with a composition of 0.001% Magnolia officinalis extract, 0.0001% piroctone olamine and 0.001% seed extract of Salvia hispanica for 24 hours, RNA is extracted, reverse transcribed and subjected to fluorescent quantitative PCR detection, and 2 -ΔΔCT Method calculation results. The expression changes of aquaporin gene AQP3 and hyaluronic acid synthase gene HAS2 are determined. The results show that the composition provided by the application can increase the expression of AQP3 gene by 1.9 times and the expression of HAS2 gene by 2.2 times, and can enhance the moisturizing ability of skin barrier.

[0072] Example 4: Preparation of shampoo containing anti-dandruff and oil control composition

[0073] The antidandruff shampoos were prepared according to the conventional methods in the technical field, wherein the antidandruff active substances were respectively: 0.2% Magnolia officinalis extract and 0.4% piroctone olamine in Group 1, and 0.2% Magnolia officinalis extract, 0.4% piroctone olamine and 0.01% Salvia hispanica seed extract in Group 2. The specific formulations are shown in Table 5.

[0074] Table 5, antidandruff shampoos

[0075]

[0076]

[0077] The antidandruff shampoo 1 was prepared using the antidandruff active ingredients in Group 1, and the antidandruff shampoo 2 was prepared using the antidandruff active ingredients in Group 1. The antidandruff and oil control effects of the antidandruff shampoo 1 and the antidandruff shampoo 2 were verified, and the specific steps were as follows:

[0078] 1. Test samples: the antidandruff shampoos 1 and 2 containing the antidandruff active substances prepared in the examples;

[0079] 2. Subjects: 66 subjects were selected in each group (a total of two groups, corresponding to the antidandruff shampoo 1 and the antidandruff shampoo 2, respectively), who met the voluntary selection criteria of the subjects: self-reported existence of dandruff problem, frequency of washing hair once every two days, no history of allergy to the test product ingredients, no mental illness, no severe liver and kidney diseases or other autoimmune diseases, not in the pregnancy period or within six months after delivery, and no oral administration of antibiotics, glucocorticoids, spironolactone and other antiandrogens, and other treatments for acne within 4 weeks before the test, and no use of physical therapy or salicylic acid and fruit acid treatment for acne. The number of subjects corresponding to the antidandruff shampoo 1 was 66, the average age was 32.26 years, the standard error was 1.38 years, the maximum age was 57 years, the minimum age was 18 years, the male subject accounted for 40.91%, the 18-30 year-old subject accounted for 57.58%, 100% of the subjects self-evaluated existence of dandruff problem, 33.33% considered oily, 24.24% considered dry and itchy scalp, and 15.15% considered sensitive scalp. The number of subjects corresponding to the antidandruff shampoo 2 was 66, the average age was 34.80 years, the standard error was 1.36 years, the maximum age was 59 years, the minimum age was 22 years, the male subject accounted for 53.03%, the 18-30 year-old subject accounted for 53.03%, 100% of the subjects self-evaluated existence of dandruff problem, 71.21% considered oily, 46.97% considered dry and itchy scalp, and 31.82% considered sensitive scalp.

[0080] 3. Test method: The subjects take the appropriate amount of test product in the palm of the hand and rub out the foam, apply it to the scalp and use the finger pulp to massage and wash thoroughly, after 2-3 minutes, rinse with clean water, instead of the original shampoo, the frequency of use is 1 time per 2 days. During the entire test period, long-term sun exposure, outdoor activities, travel, etc. cannot be performed, and during the entire test period, no cosmetics or drugs similar in function to the product can be used, and during the test period, the subjects cannot change their daily care habits.

[0081] 4. Observation results: The subjects self-evaluated the dandruff, scalp itching, hair roughness, dry hair, hair breakage, scalp oil and hair knotting on a scale of 0-10, the higher the score, the more serious the problem, the scoring results are shown in Table 6, the data in the table is the change rate of the score compared with the 0th day on the 14th and 28th days. The SPSS software was used to analyze the significant difference between the data, and a significant gap indicated that the data results had statistical significance. In addition, the satisfaction of the subjects with the test product was collected, including the improvement of skin problems such as dandruff, scalp itching, and the evaluation of the cleaning and oil control effect of the product, etc., the results are shown in Table 7.

[0082] Table 6, dandruff and oil control effect verification

[0083]

[0084] Table 7, self-evaluation results of the subjects

[0085]

[0086] According to Table 6 and Table 7, the self-evaluation scores of the subjects in the process of using dandruff shampoo 1 and dandruff shampoo 2 for 28 days, including dandruff, scalp itching, and scalp oil, were significantly decreased, i.e. the scalp problems were significantly reduced. And dandruff shampoo 2 had significant improvement (p<0.05) in dandruff and scalp oil compared with dandruff shampoo 1 on the 14th day. 100% of the subjects believed that there was no adverse reaction after using the test product, and there was no scalp erythema, scalp edema, scalp papules and scalp blisters. After using the test product for 28 days, more than 90% of the subjects were satisfied with the overall oil control, cleaning, and itching improvement ability of dandruff shampoo 1; more than 95% of the subjects were satisfied with the improvement of dandruff, scalp itching, and scalp oiliness by dandruff shampoo 2, and recognized the effect of dandruff shampoo 2 on scalp cleaning and hair smoothing; more than 90% of the subjects were satisfied with the overall dandruff and itching improvement ability of dandruff shampoo 2. The combination of dandruff active substances (Magnolia officinalis extract, piroctone olamine and Salvia hispanica seed extract) had significant dandruff and oil control effect, and had better effect compared with the combination of Magnolia officinalis extract and piroctone olamine.

[0087] The above embodiments of the present application are described in detail, it should be understood that the above description is only a specific embodiment of the present application, and is not intended to limit the present application, any modification, supplement or similar way of substitution within the principle range of the present application, should be included in the protection scope of the present application.

Claims

1. The use of a composition in the preparation of an anti-dandruff and oil-controlling shampoo, characterized in that, The composition comprises Magnolia officinalis extract, pyrrolidone ethanolamine salt, and Sage in Spanish sage seed extract, wherein the mass percentages of the Magnolia officinalis extract, pyrrolidone ethanolamine salt, and Sage in Spanish sage seed extract are 20:40:

1.

2. The use as described in claim 1, characterized in that, The total phenol content of the magnolia bark extract is 98%, and the linolenic acid content of the Spanish sage seed extract is 12%.

3. The use of a composition in the preparation of an anti-dandruff and oil-controlling shampoo, characterized in that, The composition comprises Magnolia officinalis extract, pyrrolidone ethanolamine salt, and Sage in Spanish sage seed extract, wherein the mass percentages of the Magnolia officinalis extract, pyrrolidone ethanolamine salt, and Sage in Spanish sage seed extract are 10:10:2.5.

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