A composition for treating gallstones

Abstract

The present application discloses a composition for treating gallstones, which is prepared from the following raw materials in the following weight ratio: 30-60 parts of Herba Artemisiae Scopariae, 10-15 parts of Radix Bupleuri, 10-20 parts of Radix Anemarrhenae, 10-15 parts of Radix Gentianae Macrophyllae, 10-20 parts of Radix Clematidis, 10-15 parts of Rhizoma Sparganii, 10-20 parts of Rhizoma Curcumae, 10-20 parts of Semen Persicae, 10-20 parts of Flos Carthami, 10-15 parts of Rhizoma Chuanxiong, 10-30 parts of Semen Ziziphi Spinosae, 10-15 parts of Scorpio, 15-30 parts of Endothelium Corneum Gigeriae Galli and 10-30 parts of Fructus Crataegi. The composition can relieve the clinical symptoms such as upper abdominal pain, hypochondrium pain, shoulder and back pain caused by hepatobiliary duct stones, improve liver metabolic function disorder, repair hepatobiliary duct pathological stenosis gradually, and prevent the regeneration of hepatobiliary duct stones.

Description

Technical Field

[0001] This invention specifically relates to a composition for treating hepatobiliary stones. Background Technology

[0002] Bile secreted by the liver enters the intestines through the intrahepatic and extrahepatic bile duct system. The intrahepatic bile ducts branch into two secondary branches at the porta hepatis, each gradually branching upwards into tertiary, quaternary, and quinary branches, eventually forming numerous extremely fine capillary bile ducts that connect with the hepatocytes. The extrahepatic bile ducts are collectively called the common bile duct. The upper segment of the common bile duct, from the confluence of the left and right hepatic ducts to its junction with the gallbladder neck, is also known as the common hepatic duct. The lower end of the common bile duct merges with the pancreatic duct and enters the duodenum. The sphincter of Oddi II controls the outflow of bile at its terminal segment.

[0003] Intrahepatic and extrahepatic bile duct stones are mostly caused by liver metabolic dysfunction accompanied by congenital intrahepatic bile duct stenosis. Liver metabolic dysfunction leads to an imbalance in the composition of bile secreted by hepatocytes. The content of solid particles such as cholesterol and bile pigment calcium increases, and these particles aggregate through adhesion with viscous substances such as mucoproteins and glycoproteins in the bile, gradually increasing in size to form stones. These stones occupy space within the ducts, causing bile stasis, accompanied by bacterial infection, inducing recurrent episodes of acute cholangitis. During inflammation, the connective tissue in the duct wall proliferates and thickens, forming scars, narrowing the lumen and hindering the downward movement of stones while accelerating their growth. This creates a vicious cycle of "stenosis—stone—obstruction—infection—stenosis—stone—obstruction—infection," leading to recurrent episodes of acute cholangitis and biliary pancreatitis, and even acute obstructive suppurative cholangitis and septicemia, which can be life-threatening. It is the benign biliary tract disease with the highest mortality rate.

[0004] Currently, the main treatment for intrahepatic and extrahepatic bile duct stones is Western surgical surgery. However, due to the high rate of residual stones after surgery, the rate of repeat surgery is also high. Even if the diseased liver lobe with stones is removed, the surgery cannot correct the liver's metabolic dysfunction, resulting in a high rate of stone recurrence in other parts of the body. These "three highs" characteristics (high blood pressure, high blood sugar, and high cholesterol) make intrahepatic and extrahepatic bile duct stones difficult to cure, making it a stubborn disease that is difficult to treat worldwide.

[0005] For a long time, traditional Chinese medicine (TCM) in China has typically treated hepatobiliary stones based on holistic diagnosis, employing methods such as soothing the liver and gallbladder, clearing heat and detoxifying, softening and dispersing masses, and purging the bowels, primarily targeting the stones and infection. While these methods have some effect in alleviating clinical symptoms, TCM generally lacks understanding of the local lesions of hepatobiliary stones—"hepatobiliary duct stenosis, which is both a pathogenic factor and a result of pathological damage"—leading TCM treatment to focus on treating the symptoms while neglecting the root cause, making a complete cure difficult. Furthermore, long-term use of bitter and cold medications, excessive purging, weakens the spleen and stomach, leading to a weakened immune system and further hindering the expulsion of stones. Summary of the Invention

[0006] To address the above problems, the present invention provides a composition for treating gallstones, which is prepared from raw materials in the following weight ratios:

[0007] Artemisia capillaris 30-60 parts, Bupleurum chinense 10-15 parts, Curcuma longa 10-20 parts, Gentiana macrophylla 10-15 parts, Clematis chinensis 10-20 parts, Sparganium stoloniferum 10-15 parts, Curcuma zedoaria 10-20 parts, Prunus persica 10-20 parts, Carthamus tinctorius 10-20 parts, Ligusticum chuanxiong 10-15 parts, Gleditsia sinensis thorns 10-30 parts, Buthus martensii 10-15 parts, Gallus gallus domesticus gizzard lining 15-30 parts, Crataegus pinnatifida 10-30 parts.

[0008] Furthermore, it is prepared from raw materials containing the following weight ratio:

[0009] Artemisia capillaris 40 parts, Bupleurum chinense 12 parts, Curcuma longa 20 parts, Gentiana macrophylla 15 parts, Clematis chinensis 20 parts, Sparganium stoloniferum 15 parts, Curcuma zedoaria 20 parts, Prunus persica 15 parts, Carthamus tinctorius 15 parts, Ligusticum chuanxiong 15 parts, Gleditsia sinensis thorns 30 parts, Buthus martensii 12 parts, Gallus gallus domesticus gizzard lining 30 parts, Crataegus pinnatifida 20 parts.

[0010] Furthermore, it is a formulation prepared by adding pharmaceutically acceptable excipients to a powder of a raw material or an aqueous or organic solvent extract of the raw material as the active ingredient.

[0011] Furthermore, the formulation is an oral formulation.

[0012] Furthermore, the oral preparation is a solution, granules, pills, or capsules.

[0013] The present invention provides a method for preparing the aforementioned composition, comprising the following steps:

[0014] 1) Weigh the raw materials according to the proportions;

[0015] 2) Grind the raw materials into powder, or extract the raw materials into water or organic solvents, and add commonly used excipients or auxiliary ingredients to obtain the final product.

[0016] The present invention also provides the use of the aforementioned composition in the preparation of a medicament for treating gallstones.

[0017] Furthermore, the medication is for relieving pain caused by gallstones and / or liver metabolic disorders.

[0018] Furthermore, the drug is a drug for repairing pathological stenosis of the hepatobiliary ducts.

[0019] Furthermore, the drug is a drug for eliminating gallstones and / or preventing the recurrence of gallstones.

[0020] The composition of this invention is based on the summarization of decades of clinical experience and is made from the selection of medicinal ingredients, combining traditional Chinese medicine theory with Western medical physiology and pathology.

[0021] The formula uses Bupleurum, Curcuma, and Artemisia capillaris as the principal ingredients, which have the effects of soothing the liver and relieving depression, regulating qi and relieving pain, and promoting bile secretion and reducing jaundice. It can improve liver metabolic dysfunction, correct the ratio of bile components, prevent the proliferation of stones, and relieve clinical symptoms such as chest and rib pain. Artemisia capillaris can significantly increase bile secretion, strengthen the flushing of intrahepatic bile ducts, directly enhance the power of stone expulsion, and promote the elimination of pathogens in inflammatory bile.

[0022] The ingredients, including Curcuma zedoaria, Sparganium stoloniferum, Prunus persica, Carthamus tinctorius, Ligusticum chuanxiong, and Scorpio, have the effects of promoting qi circulation and resolving stagnation, removing blood stasis and relieving pain, and eliminating masses and dissipating nodules. While repairing the lesions of the hepatobiliary duct wall, relieving the scarring and stenosis of the hepatobiliary duct, and expanding the pathway for the downward movement of stones, it can also relieve chest and rib pain.

[0023] Gentian root and Clematis root are used as adjuvants to relax muscles and tendons, promote qi circulation and relieve pain, and can relieve pain in the ribs and shoulders caused by gallstones.

[0024] The ingredients, including soapberry thorns, chicken gizzard lining, and hawthorn, can soften and disperse hardened masses, causing the outer layer of the stones to fall off, reducing their size and facilitating their downward movement and expulsion from the bile duct.

[0025] The combination of these herbs has the effects of clearing the liver and gallbladder, promoting qi circulation and resolving stagnation, removing blood stasis and relieving pain, softening and dispersing nodules. It can improve liver metabolic dysfunction, gradually repair pathological stenosis of the bile ducts, and quickly relieve clinical symptoms such as upper abdominal, rib, shoulder and back pain caused by bile duct stones. It can dissolve and expel stones, and prevent the regeneration of intrahepatic bile duct stones.

[0026] The components of this invention are all made from natural Chinese medicinal herbs, which are refined, easy to prepare, widely available, and low in cost. This invention follows the principles of traditional Chinese medicine drug combination, with all components prepared by decoction. Extensive clinical application has verified its significant and reliable efficacy, mild medicinal properties, and the absence of any toxic side effects.

[0027] Obviously, based on the above description of the present invention, and according to common technical knowledge and conventional methods in the field, various other modifications, substitutions or alterations can be made without departing from the basic technical concept of the present invention.

[0028] The following detailed embodiments further illustrate the above-described content of the present invention. However, this should not be construed as limiting the scope of the present invention to the following examples. All technologies implemented based on the above-described content of the present invention fall within the scope of the present invention. Attached Figure Description

[0029] Figure 1 Image of expelling stones ①

[0030] Figure 2 Image ② of expelling stones Detailed Implementation

[0031] Example 1: Preparation of the drug of the present invention

[0032] Formula: 40 parts Artemisia capillaris, 12 parts Bupleurum chinense, 20 parts Curcuma longa, 15 parts Gentiana macrophylla, 20 parts Clematis chinensis, 15 parts Sparganium stoloniferum, 20 parts Curcuma zedoaria, 15 parts Prunus persica, 15 parts Carthamus tinctorius, 15 parts Ligusticum chuanxiong, 30 parts Gleditsia sinensis thorns, 12 parts Buthus martensii, 30 parts Chicken gizzard lining, 20 parts Crataegus pinnatifida.

[0033] Preparation method: Weigh the above raw materials according to the ratio, add water and decoct into a soup, each 1ml contains 0.465g of raw herbs; or grind into fine powder and fill into #0 capsules, each capsule contains 0.5g of raw herbs.

[0034] Example 2: Preparation of the drug of the present invention

[0035] Formula: 30 parts Artemisia capillaris, 10 parts Bupleurum chinense, 10 parts Curcuma longa, 10 parts Gentiana macrophylla, 10 parts Clematis chinensis, 10 parts Sparganium stoloniferum, 10 parts Curcuma zedoaria, 10 parts Prunus persica, 10 parts Carthamus tinctorius, 10 parts Ligusticum chuanxiong, 10 parts Gleditsia sinensis thorns, 10 parts Buthus martensii, 15 parts Chicken gizzard lining, 10 parts Crataegus pinnatifida

[0036] Preparation method: Weigh the above raw materials according to the ratio, add water and decoct into a soup, each 1ml contains 0.33g of raw herbs;

[0037] Example 3: Preparation of the drug of the present invention

[0038] Formula: 60 parts Artemisia capillaris, 15 parts Bupleurum chinense, 20 parts Curcuma longa, 15 parts Gentiana macrophylla, 20 parts Clematis chinensis, 15 parts Sparganium stoloniferum, 20 parts Curcuma zedoaria, 20 parts Prunus persica, 20 parts Carthamus tinctorius, 15 parts Ligusticum chuanxiong, 30 parts Gleditsia sinensis thorns, 15 parts Buthus martensii, 30 parts Chicken gizzard lining, 30 parts Crataegus pinnatifida.

[0039] Preparation method: Weigh the above raw materials according to the ratio, add water and decoct into a soup, each 1ml contains 0.54g of raw herbs;

[0040] The following experimental examples illustrate the beneficial effects of the present invention.

[0041] Experimental Example 1: Clinical efficacy of the composition of the present invention

[0042] 1. Clinical Data

[0043] Ninety patients with hepatobiliary duct stones who were treated at Chengdu Qingyang Baian Yisheng Traditional Chinese Medicine Clinic from September 2016 to September 2021 were selected. There were 22 males and 68 females, aged 19 to 81 years, with an average age of 45.5 years.

[0044] Of the 64 patients, 49 had a history of hepatobiliary surgery, with the most having undergone two or more surgeries, the highest being seven. During the surgeries, 15 patients underwent hepatectomy, 15 underwent choledochoenterostomy, 26 underwent common bile duct stone removal and drainage, 52 underwent cholecystectomy, and 15 underwent ERCP.

[0045] Of the 90 patients, 84 had intrahepatic bile duct stones (11 of which were staghorn stones, all of which were resolved into beaded stones after treatment), 46 had simple intrahepatic bile duct stones, and 38 had intrahepatic bile duct stones combined with extrahepatic common bile duct stones; 6 had simple extrahepatic common bile duct stones.

[0046] 2. Criteria for judging therapeutic efficacy

[0047] Clinical symptom efficacy criteria

[0048] Cured: Pain in the upper abdomen, below the xiphoid process, flank, and scapular region completely disappeared; chills, high fever, and acute cholangitis did not recur.

[0049] Significant effect: Pain in the upper abdomen, below the xiphoid process, flank, and scapular region is significantly reduced; chills, high fever, and acute cholangitis are basically under control, with occasional recurrences.

[0050] Ineffective: Pain in the upper abdomen, xiphoid process, flank, and scapula was not relieved, and chills, high fever, and acute cholangitis continued to recur.

[0051] Standards for the treatment of kidney stone removal

[0052] Cured: The above clinical symptoms disappeared, and ultrasound and CT scans showed that the gallstones in the hepatobiliary ducts had disappeared;

[0053] Significant effect: The above clinical symptoms are significantly relieved, and the number of hepatobiliary stones is significantly reduced by more than 1 / 2 as shown by ultrasound and CT scans;

[0054] Effective: The above clinical symptoms are alleviated, and ultrasound and CT scans show that the gallstones in the hepatobiliary ducts have become smaller or reduced to less than 1 / 2.

[0055] Ineffective: The above clinical symptoms did not improve, and ultrasound and CT scans showed no change in the hepatobiliary stones.

[0056] 3. Treatment methods

[0057] The decoction prepared in Example 1 was taken in three divided doses, 150ml each time, 30 minutes after each of the three meals; or the capsules prepared in Example 1 were taken in three divided doses, 6 capsules each time, 30 minutes after each of the three meals. One course of treatment lasted 3 months, and the therapeutic effect was evaluated after a total of 4 courses of treatment.

[0058] 4. Treatment Results

[0059] (1) Clinical symptom treatment effect

[0060] ① Of the 90 cases, 69 cases also had pain in the right upper quadrant and below the xiphoid process.

[0061] Cured: After 3 months of treatment, the pain in the right upper quadrant and below the xiphoid process completely disappeared in 49 cases, with a cure rate of 71.0%.

[0062] Significant effect: After 3 months of treatment, 16 cases showed significant relief of pain in the right upper quadrant and under the xiphoid process, with a significant effect rate of 23.1%.

[0063] Ineffective: Four patients showed no improvement in right upper quadrant and xiphoid pain after 3 months of treatment, with an ineffectiveness rate of 5.9%.

[0064] The overall effectiveness rate was 94.1%.

[0065] ② Of the 90 cases, 65 had rib and back pain.

[0066] Cured: 47 patients experienced relief from back and rib pain after 3 months of treatment, resulting in a cure rate of 72.3%.

[0067] Significant effect: After 3 months of treatment, 17 cases showed significant relief of rib and back pain, with a significant effect rate of 26.2%;

[0068] Ineffective: One case showed no significant reduction in rib and back pain after 3 months of treatment, with an ineffectiveness rate of 1.5%.

[0069] The overall effectiveness rate was 98.4%.

[0070] ③Among the 90 cases, 41 cases had recurrent acute cholangitis.

[0071] Cure: 28 patients did not experience a recurrence of symptoms of acute cholangitis with chills and high fever after 3 months of treatment, with a cure rate of 68.3%.

[0072] Significant effect: After 3 months of treatment, chills and high fever were basically eliminated. Only 9 cases occasionally recurred due to improper care, with a significant effect rate of 21.9%.

[0073] Ineffective: Four cases of patients with recurrent acute cholangitis and high fever after 3 months of treatment had an ineffectiveness rate of 9.7%.

[0074] The overall effectiveness rate was 90.3%.

[0075] (2) Stone expulsion effect after treatment in 90 patients with hepatobiliary stones:

[0076] Cure: After one year of continuous treatment, the above clinical symptoms completely disappeared, and ultrasound and CT scans showed that the gallstones in the hepatobiliary ducts were completely expelled, with a cure rate of 28.9%.

[0077] Significant efficacy: After one year of continuous treatment, the above-mentioned clinical symptoms were significantly relieved, and B-ultrasound and CT scans showed that more than half of the hepatobiliary stones were expelled, with a significant efficacy rate of 48.9%.

[0078] Effective: After one year of continuous treatment, the above clinical symptoms were alleviated, and ultrasound and CT scans showed that more than half of the hepatobiliary stones were expelled in 16 cases, with an effective rate of 17.8%.

[0079] Ineffective: After one year of continuous treatment, the above clinical symptoms did not improve, and ultrasound and CT scans showed no change in hepatobiliary stones in 4 cases, with an ineffectiveness rate of 4.4%.

[0080] The overall effectiveness rate was 95.6%.

[0081] Experimental Case 2 (Typical Case)

[0082] Ms. Peng, 57 years old, is a farmer from Puyang, Henan Province.

[0083] Brief medical history

[0084] In 2008, the patient underwent laparoscopic choledochotomy at Puyang People's Hospital due to choledocholithiasis.

[0085] In 2013, the patient experienced recurrent episodes of upper abdominal pain, chills, and high fever for three months. He underwent cholecystectomy, choledochotomy, and choledochojejunostomy at the same hospital, with a surgical incision length of 19 cm.

[0086] On January 16, 2020, the patient experienced persistent pain in the upper right abdomen radiating to the right flank, shoulder, and back, along with intermittent fever, which had recently worsened, accompanied by chills and high fever (40°C). A CT scan at Shandong Provincial Hospital diagnosed multiple intrahepatic and extrahepatic bile duct stones. The hospital informed the patient that surgery was no longer possible and recommended that they consult a specialist at Jiangsu Provincial Hospital for percutaneous transhepatic cholangiography (PTCS).

[0087] On January 20, 2020, surgical experts at Qilu Hospital in Shandong Province suggested: first remove part of the right liver, and if necessary, perform a liver transplant.

[0088] On January 22, 2020, the patient's family brought the medical records to Jiangsu Provincial Hospital for a consultation. After a detailed understanding of the patient's condition, an expert believed that PTCS surgery could be performed.

[0089] On January 22, 2020, the patient sought treatment from a local traditional Chinese medicine practitioner. After taking Chinese medicine for over a month, the symptoms eased slightly, and the fever subsided. A follow-up CT scan at the county hospital revealed the same intrahepatic and extrahepatic bile duct stones. The doctor informed the patient that traditional Chinese medicine could not possibly expel the bile duct stones.

[0090] Treatment process

[0091] Initial consultation on January 25, 2020:

[0092] The patient's family contacted the Chengdu Qingyang Bai'an Yisheng Traditional Chinese Medicine Clinic by phone. According to the clinic, after understanding the patient's condition of intrahepatic bile duct stones, they prescribed seven doses of traditional Chinese medicine, focusing on overall conditioning and clearing the liver and gallbladder.

[0093] Second consultation on March 6, 2020:

[0094] During a video call, the patient reported that the pain in their right upper abdomen, right flank, and shoulder had lessened a few days after taking the above-mentioned medication, but fever returned on the sixth day. After a more detailed understanding of the patient's condition and surgical history, and based on the clinical symptoms of acute intrahepatic cholangitis, such as recurrent chills and fever, traditional Chinese medicine treatment was prescribed, focusing on clearing heat and detoxifying, soothing the liver and gallbladder, cooling the blood and removing blood stasis.

[0095] Third consultation on March 17, 2020:

[0096] During the online video consultation, the patient reported that after taking the Chinese medicine, the chills and fever had subsided, and the patient only experienced discomfort in the right hypochondrium and tenderness in the upper abdomen. Given the numerous stones in the intrahepatic and extrahepatic bile ducts, the prescription was changed to a formula for dissolving liver and gallbladder stones that promotes blood circulation, removes blood stasis, softens and disperses hard masses.

[0097] Formula: Artemisia capillaris 40g, Bupleurum chinense 12g, Curcuma longa 20g, Gentiana macrophylla 15g, Clematis chinensis 20g, Sparganium stoloniferum 15g, Curcuma zedoaria 20g, Prunus persica 15g, Carthamus tinctorius 15g, Ligusticum chuanxiong 15g, Gleditsia sinensis thorns 30g, Buthus martensii 12g, Crataegus pinnatifida 20g, Chicken gizzard lining 30g

[0098] Four diagnostic methods performed on May 8, 2020:

[0099] After a video consultation, the patient persisted in taking the above prescription for 30 doses. Recently, the chills and fever have subsided, and the discomfort in the right hypochondrium, shoulder and back, as well as the tenderness in the upper abdomen, has been reduced. Since the prescription is effective, the patient continues to take the above medicine.

[0100] Fifth consultation on May 26, 2020:

[0101] The patient recently experienced a fever of 39°C, accompanied by chills. The fever subsided after taking Western medicine and receiving injections. The patient then continued taking a traditional Chinese medicine formula to expel gallstones. In early June, the patient experienced intermittent fever and chills again, prompting the family to decide to take the patient to Jiangsu Provincial Hospital for percutaneous transhepatic cholecystectomy (PTCS). The family traveled from out of town to consult the inventor by phone. The reply was: Surgery cannot remove all intrahepatic bile duct stones. Damage to the intrahepatic bile ducts caused by surgery can lead to bile duct scarring and stenosis, causing stones to grow faster in the future. The family wanted to bring the patient to Chengdu for treatment. Considering the patient's recent good recovery of clinical symptoms, based on experience, the patient was showing signs of stone expulsion after taking the traditional Chinese medicine. Due to economic considerations, the patient continued taking the traditional Chinese medicine formula locally.

[0102] On June 7, 2020, the patient underwent an ultrasound examination at the local county hospital: the results showed no stones in the intrahepatic bile ducts, but a large stone was visible in the common bile duct. Based on the ultrasound results provided by the patient, the inventor determined that this was indeed a sign of stone passage, and reminded the patient that severe abdominal pain, high fever, and chills might also occur, but there was no need to panic.

[0103] Around 5 p.m. that day, the patient's abdominal pain gradually worsened. After taking Chinese medicine again around 10 p.m., the severe abdominal pain suddenly disappeared around 11 p.m.

[0104] On the morning of June 8, 2020, the patient reported that there were many black, stone-like objects in his stool that night.

[0105] Sixth consultation on June 9, 2020:

[0106] During the online video consultation, the patient reported significant abdominal relief after defecation, reduced pain in the right flank and shoulder, normal body temperature, appetite, and improved mental state. Several smooth, shiny black objects were found, the largest measuring 0.9 cm and the smallest 0.3 cm. When the larger object was crushed, its interior was yellowish-brown. Figure 1 This confirmed that the patient was passing pigment stones from the intrahepatic bile ducts. A follow-up ultrasound after the online consultation showed the common bile duct stones had disappeared, but numerous stones remained in the intrahepatic bile ducts. Based on the patient's description, it was determined that these were stones from grade 2 or 3 or higher intrahepatic bile ducts. After treatment, these stones were expected to migrate and converge into grade 2 or 3 bile ducts, a positive sign indicating the peak of stone expulsion. The patient was advised to continue taking the hepatobiliary stone-expelling decoction.

[0107] From June 11 to 14, 2020, the patient found stones being expelled every day during bowel movements, the largest being 1 cm long and the smallest 0.3 cm. The patient felt much better overall, and all symptoms in the upper right abdomen, right flank, and shoulder disappeared. The patient continued taking the previous medication.

[0108] No more stones were found on June 15, 2020. The collected stones, when laid end to end, were a full 20cm long. Figure 2 The patient's mental state and appetite are basically normal, and he has begun to do some light work.

[0109] Seventh consultation on July 7, 2020:

[0110] The patient had a rosy complexion, was energetic, and worked easily without fatigue. A follow-up ultrasound at the county hospital revealed only a few small stones in the intrahepatic bile ducts, with no stones found in the common bile duct. The doctors were astonished by the images of the stones and the patient's improved condition. They instructed the patient to continue taking the liver and gallbladder stone-expelling decoction to prevent the recurrence of intrahepatic bile duct stones.

[0111] To date, the patient is in good overall condition, has returned to a normal life, participates in physical labor every day, and has not experienced a recurrence of the disease.

[0112] In summary, this invention follows the principles of traditional Chinese medicine in the combination of herbs, with each herb being precisely matched. It has the effects of clearing the liver and gallbladder, promoting qi circulation and resolving stagnation, removing blood stasis and relieving pain, and softening and dispersing nodules. It can not only improve liver metabolic dysfunction and gradually repair pathological stenosis of the hepatobiliary ducts, but also quickly relieve clinical symptoms such as upper abdominal, hypochondriac, and shoulder and back pain caused by hepatobiliary stones. It can dissolve and expel stones, and prevent the regeneration of intrahepatic bile duct stones, thus having practical application value.

Claims

1. A composition for treating gallstones, characterized in that: It is prepared from the following raw materials in the following weight ratio: Artemisia capillaris 40 parts, Bupleurum chinense 12 parts, Curcuma longa 20 parts, Gentiana macrophylla 15 parts, Clematis chinensis 20 parts, Sparganium stoloniferum 15 parts, Curcuma zedoaria 20 parts, Prunus persica 15 parts, Carthamus tinctorius 15 parts, Ligusticum chuanxiong 15 parts, Gleditsia sinensis thorns 30 parts, Buthus martensii 12 parts, Gallus gallus domesticus gizzard lining 30 parts, Crataegus pinnatifida 20 parts.

2. The composition according to claim 1, characterized in that: It is a preparation made from water extracts of raw materials as active ingredients, plus pharmaceutically acceptable excipients.

3. The composition according to claim 2, characterized in that: The preparation is an oral preparation.

4. The composition according to claim 3, characterized in that: The oral preparation is a solution, granules, pills, or capsules.

5. A method for preparing the composition according to any one of claims 1 to 4, characterized in that: It includes the following steps: 1) Weigh the raw materials according to the proportions; 2) The aqueous extract of the raw material is then mixed with commonly used pharmaceutical excipients to obtain the final product.

6. Use of the composition according to any one of claims 1 to 4 in the preparation of a medicament for treating gallstones.

7. The use according to claim 6, characterized in that: The medication in question is for relieving pain caused by gallstones.

8. The use according to claim 6, characterized in that: The drug is used to eliminate gallstones and / or prevent the recurrence of gallstones.

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