A medicinal wine containing roasted jujube seeds for improving sleep, its preparation method and uses.

Abstract

This invention discloses a medicinal wine containing roasted jujube seeds for improving sleep, its preparation method, and its uses. The medicinal wine is prepared from the following ingredients in parts by weight: Poria cocos 8-15%, longan pulp 9-12%, mulberry 9-12%, roasted jujube seeds 12-16%, Ganoderma lucidum 6-10%, raw lily bulb 8-15%, and baijiu or rice wine 800-1000%. The preparation method includes the following steps: carefully selecting the prescribed amount of Chinese medicinal materials, washing them with clean water, and air-drying them naturally. The dried herbs are then pulverized and placed in a percolation device. Baijiu or rice wine is poured in from top to bottom for percolation. After percolation, the mixture is filtered, and the alcohol content is adjusted to 55%. This medicinal wine has the effects of nourishing qi and blood, calming the mind and soothing the nerves. It can be used for insomnia, excessive dreaming, palpitations, night sweats, and restlessness caused by qi and blood deficiency, thereby improving sleep.

Description

[Technical Field]

[0001] This invention relates to the field of pharmaceutical technology, and in particular to a medicinal wine containing roasted jujube seeds for improving sleep, its preparation method, and its uses. [Technical Background]

[0002] With the rapid development of society and the accelerated pace of people's work and life, the pressure of life and work is constantly increasing. Frequent overtime work, staying up late, and all-night entertainment have become the norm, leading to many people experiencing poor sleep, anxiety, depression, irritability, and other physical conditions. This has further resulted in a rapid increase in the incidence of mental illnesses such as insomnia, anxiety, and depression.

[0003] Insomnia is the inability to fall asleep or maintain a state of sleep, resulting in insufficient sleep, primarily manifested as insufficient sleep duration and depth, thus failing to eliminate fatigue and restore physical strength and energy. Mild cases involve difficulty falling asleep, restless sleep, frequent awakenings, or inability to fall back asleep after waking; severe cases involve complete sleeplessness. Insomnia is one of the most obvious and prominent manifestations of sub-health, often serving as a precursor to other sub-health conditions. Without improved sleep, fatigue cannot be eliminated and physical strength and energy restored, leading to increased mental burden, accumulated fatigue, and illness. This can cause psychological disorders, organ dysfunction, and decreased immune function. If not intervened in time, this vicious cycle exacerbates the sub-health condition, leading to a qualitative change and eventually developing into disease.

[0004] Traditional Chinese medicine (TCM) has a rich connotation in drug-based health preservation and has unique efficacy in improving sub-health conditions. TCM emphasizes "treating disease before it manifests," and its concept of "prevention of disease" encompasses the sub-health state in modern medicine. By "providing assistance to health," TCM has great potential in preventing the development and progression of diseases. [Summary of the Invention]

[0005] The purpose of this invention is to provide a medicinal wine containing roasted jujube seeds for improving sleep, its preparation method, and its uses. The formula is simple, has a good taste, low cost, significant therapeutic effect, and high safety. It has the effects of nourishing the heart and liver, calming the mind and soothing the nerves, and astringing sweat and promoting body fluid production. It is used to treat insomnia due to deficiency and restlessness, palpitations and excessive dreaming, insomnia and forgetfulness, etc.

[0006] This invention relates to a medicinal wine containing roasted jujube seeds for improving sleep, its preparation method, and its uses. The wine contains six medicinal ingredients: Poria cocos, longan pulp, mulberry, jujube seeds, Ganoderma lucidum, and raw lily bulbs, which are prepared by soaking in white wine or rice wine.

[0007] The technical solution of the present invention is as follows:

[0008] A traditional Chinese medicine wine for improving sleep containing roasted jujube seeds, characterized in that the wine is prepared from the following raw materials in parts by weight: Poria cocos 9-15, longan pulp 9-12, mulberry 9-12, jujube seed 9-12, Ganoderma lucidum 6-10, raw lily bulb 6-10, and white wine or rice wine 800-1000.

[0009] Furthermore, the medicinal wine is prepared from the following ingredients in parts by weight: Poria cocos 12, longan pulp 9, mulberry 9, jujube seed 9, Ganoderma lucidum 6, raw lily bulb 6, and white wine or rice wine 800.

[0010] Alternatively, the medicinal wine may be prepared from the following ingredients in parts by weight: Poria cocos 15, longan pulp 12, mulberry 12, jujube seed 10, Ganoderma lucidum 8, raw lily bulb 8, and white wine or rice wine 1000.

[0011] Alternatively, the medicinal wine may be prepared from the following ingredients in parts by weight: Poria cocos 15, longan pulp 12, mulberry 12, jujube seed 9, Ganoderma lucidum 6, raw lily bulb 6, and white wine or rice wine 900.

[0012] The preparation method of this invention is as follows:

[0013] The preparation method of the medicinal wine described in this invention is simple and easy to operate, and its preparation method includes the following steps:

[0014] 1) Select the following ingredients in the prescribed amounts: Poria cocos, longan pulp, mulberry, jujube seed, Ganoderma lucidum, and raw lily bulb;

[0015] 2) Wash the raw materials with clean water and let them air dry naturally;

[0016] 3) The dried medicinal materials are crushed, and after crushing, they are put into a percolation device. White wine or rice wine is poured in to adjust the flow rate to obtain the prepared wine.

[0017] 4) After the medicinal materials are percolated with white wine or rice wine, they are filtered, bottled, and ready for use.

[0018] The selected liquor or rice wine should be 55% ABV.

[0019] The medicinal wine of this invention uses various Chinese medicinal herbs in combination to overcome the shortcomings of single herbs having limited effects, enhance efficacy, and regulate multiple aspects to achieve the effects of nourishing the heart and liver, calming the mind and soothing the nerves, and astringing sweat and promoting body fluid production. The formula of this medicinal wine uses Poria cocos as the principal herb, which strengthens the spleen, calms the mind and soothes the nerves, and is an essential medicine for restlessness, palpitations, and insomnia. It is combined with longan pulp and mulberry to nourish the heart and soothe the nerves, nourish blood and benefit the spleen, and relieve symptoms of liver and kidney yin deficiency and qi and blood deficiency; these serve as assistant herbs. Ziziphus jujuba seed is sweet and sour, nourishing yin and blood, and calming the mind and soothing the nerves. Combined with longan pulp and mulberry, it enhances its yin-nourishing effect. Lilium brownii, which clears the heart and calms the nerves, and Ganoderma lucidum, which tonifies qi and calms the mind, serve as adjuvant herbs. The combined effects of these herbs nourish the heart and liver, calm the mind and soothe the nerves, and astringe sweat and promote body fluid production, and are used for restlessness, insomnia, palpitations, excessive dreaming, and forgetfulness.

[0020] Poria cocos:

[0021] Properties and Channels Entered: Sweet, bland, neutral. Enters the Heart, Lung, Spleen, and Kidney channels.

[0022] Functions and indications: It promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. It is used for edema with scanty urine, phlegm retention with dizziness and palpitations, spleen deficiency with poor appetite, loose stools and diarrhea, restlessness, palpitations and insomnia.

[0023] Longan pulp:

[0024] Properties and Channels Entered: Sweet, warm. Enters the Heart and Spleen channels.

[0025] Functions and indications: Tonifies the heart and spleen, nourishes blood and calms the mind. Used for deficiency of qi and blood, palpitations, forgetfulness, insomnia, and chlorosis due to blood deficiency.

[0026] Mulberry:

[0027] Properties and Channels Entered: Sweet, sour, cold. Enters the Heart, Liver, and Kidney channels.

[0028] Functions and indications: Nourishes Yin and blood, generates fluids and moistens dryness. Used for liver and kidney Yin deficiency, dizziness and tinnitus, palpitations and insomnia, premature graying of hair, thirst due to fluid depletion, internal heat and thirst, and constipation due to intestinal dryness.

[0029] Sour jujube seed:

[0030] Properties and Channels Entered: Sweet, sour, neutral. Enters the Liver, Gallbladder, and Heart channels.

[0031] Functions and indications: Nourishes the heart and liver, calms the mind and soothes the nerves, reduces sweating, and promotes the production of body fluids. Used for insomnia due to deficiency and restlessness, palpitations and excessive dreaming, excessive sweating due to physical weakness, and thirst due to fluid depletion.

[0032] Raw lilies:

[0033] Properties and Channels Entered: Sweet, cold. Enters the Heart and Lung channels.

[0034] Functions and indications: Nourishes Yin and moistens the lungs, clears the heart and calms the mind. Used for dry cough due to Yin deficiency, cough with hemoptysis due to overwork, restlessness and palpitations, insomnia and dreaminess, and mental confusion.

[0035] Ganoderma lucidum:

[0036] Properties and Channels Entered: Sweet, neutral. Enters the Heart, Lung, Liver, and Kidney channels.

[0037] Functions and indications: Tonifies Qi and calms the mind, relieves cough and asthma. Used for restlessness, insomnia and palpitations, cough and asthma due to lung deficiency, shortness of breath due to weakness, and loss of appetite.

[0038] Compared with existing technologies, the present invention has the following beneficial effects: the medicinal wine of the present invention is safe and non-toxic, and can effectively improve insomnia symptoms. Clinical experiments have proven that the medicinal wine of the present invention can effectively improve symptoms such as insomnia, excessive dreaming, palpitations, anxiety, and irritability in insomnia sufferers.

[0039] The technical solution of the present invention will be further described below with reference to specific embodiments to help those skilled in the art to more fully understand the present invention.

Detailed Implementation Methods

[0040] Example 1

[0041] A medicinal wine for improving sleep, containing roasted jujube seeds, is prepared from the following ingredients by weight: 12g Poria cocos, 9g longan pulp, 9g mulberry, 9g jujube seeds, 6g Ganoderma lucidum, 6g raw lily bulbs, and 800g rice wine. Its preparation method includes the following steps:

[0042] 1) Select the following ingredients in the prescribed amounts: Poria cocos, longan pulp, mulberry, jujube seed, Ganoderma lucidum, and raw lily bulb;

[0043] 2) Wash the raw materials with clean water and let them air dry naturally;

[0044] 3) The dried medicinal materials are crushed, and after crushing, they are put into a percolation device. White wine or rice wine is poured in to adjust the flow rate to obtain the prepared wine.

[0045] 4) After the medicinal materials are percolated with white wine or rice wine, they are filtered, bottled, and ready for use.

[0046] The selected liquor or rice wine should be 55% ABV.

[0047] Example 2

[0048] A medicinal wine for improving sleep, containing roasted jujube seeds, is prepared from the following ingredients by weight: 15g Poria cocos, 12g longan pulp, 12g mulberry, 10g jujube seeds, 8g Ganoderma lucidum, 8g raw lily bulbs, and 1000g rice wine. Its preparation method includes the following steps:

[0049] 1) Select the following ingredients in the prescribed amounts: Poria cocos, longan pulp, mulberry, jujube seed, Ganoderma lucidum, and raw lily bulb;

[0050] 2) Wash the raw materials with clean water and let them air dry naturally;

[0051] 3) The dried medicinal materials are crushed, and after crushing, they are put into a percolation device. White wine or rice wine is poured in to adjust the flow rate to obtain the prepared wine.

[0052] 4) After the medicinal materials are percolated with white wine or rice wine, they are filtered, bottled, and ready for use.

[0053] The selected liquor or rice wine should be 55% ABV.

[0054] Example 3

[0055] A medicinal wine for improving sleep, containing roasted jujube seeds, is prepared from the following ingredients by weight: 15g Poria cocos, 12g longan pulp, 12g mulberry, 9g jujube seeds, 6g Ganoderma lucidum, 6g raw lily bulbs, and 900g rice wine. Its preparation method includes the following steps:

[0056] 1) Select the following ingredients in the prescribed amounts: Poria cocos, longan pulp, mulberry, jujube seed, Ganoderma lucidum, and raw lily bulb;

[0057] 2) Wash the raw materials with clean water and let them air dry naturally;

[0058] 3) The dried medicinal materials are crushed, and after crushing, they are put into a percolation device. White wine or rice wine is poured in to adjust the flow rate to obtain the prepared wine.

[0059] 4) After the medicinal materials are percolated with white wine or rice wine, they are filtered, bottled, and ready for use.

[0060] The selected liquor or rice wine should be 55% ABV.

[0061] Example 4

[0062] A medicinal wine for improving sleep, containing roasted jujube seeds, is prepared from the following ingredients by weight: 15g Poria cocos, 12g longan pulp, 12g mulberry, 9g jujube seeds, 6g Ganoderma lucidum, 6g raw lily bulbs, and 900g white wine. Its preparation method includes the following steps:

[0063] 1) Select the following ingredients in the prescribed amounts: Poria cocos, longan pulp, mulberry, jujube seed, Ganoderma lucidum, and raw lily bulb;

[0064] 2) Wash the raw materials with clean water and let them air dry naturally;

[0065] 3) The dried medicinal materials are crushed, and after crushing, they are put into a percolation device. White wine or rice wine is poured in to adjust the flow rate to obtain the prepared wine.

[0066] 4) After the medicinal materials are percolated with white wine or rice wine, they are filtered, bottled, and ready for use.

[0067] The selected liquor or rice wine should be 55% ABV.

[0068] Example 5

[0069] Experiment on the anti-insomnia effect of medicinal wine:

[0070] Experimental sample: the medicinal wine described in Example 3.

[0071] Experimental animals: 40 Wistar rats, SPF grade, half male and half female, weighing 250±20g.

[0072] Experimental model preparation:

[0073] Thirty Wistar rats were injected intraperitoneally with 300 mg / kg of p-chlorophenylalanine once a day for three consecutive days. After this, the rats exhibited loss of their diurnal rhythm and almost complete insomnia, thus successfully establishing the model.

[0074] Experimental methods:

[0075] Forty Wistar rats that successfully developed the model were randomly divided into a model group, a drug control group, a treatment group, and a control group. Ten rats that did not develop the model were used as a normal control group. The treatment group was administered the drug described in Example 3 via gavage at a dose of 10 ml / kg. The drug control group was administered diazepam at a dose of 1 mg / kg. The control group was prepared using the method described in Example 3, consisting of 15 g of jujube seed, 12 g of longan pulp, 12 g of mulberry, 9 g of poria cocos, 6 g of ganoderma lucidum, 6 g of raw lily bulb, and 900 g of rice wine, and administered via gavage at a dose of 10 ml / kg. Rats in the normal control group and the model group were administered an equal volume of distilled water via gavage once daily for 14 consecutive days.

[0076] Experimental results:

[0077] Morphological aspects:

[0078] In the normal control group, rats exhibited normal diet, water intake, and defecation, normal diurnal rhythms, and smooth fur. In the treatment and drug control groups, rats gradually recovered their diurnal rhythms, and their fur became smooth, their activity levels moderate, and their lethargy disappeared. In the model group, rats displayed dry fur, lethargy, and severe fatigue, exhibiting signs of drowsiness.

[0079] Measurement of neurotransmitter content in the hypothalamus:

[0080] Experimental rats were euthanized by cervical dislocation. Hypothalamic tissue was collected from each group of rats, rinsed with distilled water, and then added to pre-cooled physiological saline. The tissue was homogenized to prepare a 10% (w / w) extract. The extract was centrifuged at 5000 rpm for 15 min at 4°C. The supernatant was collected, and the levels of serotonin, dopamine, and norepinephrine in the rat hypothalamic tissue were determined using enzyme-linked immunosorbent assay (ELISA). See Table 1.

[0081] Table 1:

[0082] Model group 211.74±10.32** 542.19±9.23* 298.12±13.24** Drug control group 320.56±8.22 500.98±6.89 235.76±12.35 Treatment group <![CDATA[338.42±11.233 # ]]> <![CDATA[513.22±5.33 # ]]> <![CDATA[225.55±6.78 # ]]> Comparative Example 1 305.13±9.22 530.74±8.33 256.45±5.68 normal control group 352.89±6.28 499.35±10.34 229.45±6.32

[0083] *There was a significant difference compared with the normal control group, p<0.05; **There was an extremely significant difference compared with the normal control group, p<0.01. # There was a significant difference compared to Comparative Example 1, p<0.05.

[0084] Table 1 shows that the serotonin level in the model group rats was significantly lower than that in the normal control group. After 14 days of treatment in the treatment group and the drug control group, the diurnal rhythm of the insomnia-inducing rats gradually returned to normal, their fur became smooth again, and the levels of serotonin, dopamine, and norepinephrine in the hypothalamus were all at normal levels, with no significant difference compared to the normal control group. This suggests that the product of this invention has a good effect on improving insomnia. Comparative Example 1 used jujube seed as the principal ingredient in the formulation. Compared with Comparative Example 1, the treatment group showed significant differences in the levels of serotonin, dopamine, and norepinephrine in the hypothalamus. This suggests that Poria cocos, as the principal ingredient in the product of this invention, has an irreplaceable role.

[0085] Example 6

[0086] Clinical trials of medicinal wine for treating insomnia:

[0087] Experimental sample: the medicinal wine described in Example 3.

[0088] Subjects: 30 patients with insomnia who meet the Chinese Classification and Diagnostic Criteria for Mental Disorders.

[0089] Experimental methods:

[0090] The subjects were divided into four groups: a treatment group and comparative examples 1-3, with 10 patients with insomnia in each group. Treatment group: Oral administration of the medicinal wine described in Example 3, 100ml / time, twice daily, for 14 days as one course of treatment; Comparative example 1: The formula with jujube seed as the principal ingredient, 100ml / time, twice daily, for 14 days as one course of treatment; Comparative example 2: In the formula of Example 3, Poria cocos was replaced with an equal amount of Polygonatum sibiricum, otherwise the same as in Example 3, 100ml / time, twice daily, for 14 days as one course of treatment; Comparative example 3: In the formula of Example 3, longan pulp was replaced with an equal amount of Lycium barbarum, otherwise the same as in Example 3, 100ml / time, twice daily, for 14 days as one course of treatment.

[0091] Table 2: Composition of Traditional Chinese Medicine Raw Materials in the Treatment Group, Comparative Example 1, and Comparative Example 2 (Unit: g)

[0092]

[0093] The patient wore a smart bracelet to record sleep duration and deep sleep duration, and the percentage increase in sleep duration and deep sleep duration was calculated.

[0094] Increase in sleep duration = (Sleep duration after treatment - Sleep duration before treatment) / Sleep duration before treatment;

[0095] Increase in deep sleep duration = (Deep sleep duration after treatment - Deep sleep duration before treatment) / Deep sleep duration before treatment. Results are shown in Table 3.

[0096] Treatment group 43.8 14.7 Comparative Example 1 34.1 9.9 Comparative Example 2 36.8 10.3 Comparative Example 3 36.2 10.0

[0097] The comparison of the test results of the treatment group and Comparative Examples 1-3 shows that the medicinal wine of Example 3 has a greater effect on increasing the proportion of sleep duration and deep sleep duration than Comparative Examples 1-3, indicating that the medicinal wine of the present invention has a good effect on improving insomnia and improving sleep quality.

[0098] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A medicinal wine containing roasted jujube seeds to improve sleep, characterized in that, The medicinal wine is prepared from the following ingredients in parts by weight: Poria cocos 12, longan pulp 9, mulberry 9, stir-fried jujube seed 9, Ganoderma lucidum 6, raw lily bulb 6, and white wine or rice wine 800.

2. A medicinal wine containing roasted jujube seeds to improve sleep, characterized in that, The medicinal wine is prepared from the following ingredients in parts by weight: Poria cocos 15, longan pulp 12, mulberry 12, stir-fried jujube seed 9, Ganoderma lucidum 6, raw lily bulb 6, and white wine or rice wine 900.

3. A method for preparing the medicinal wine as described in claims 1-2, characterized in that... The manufacturing method includes the following steps: 1) The following ingredients are used in the prescribed amounts: Poria cocos, longan pulp, mulberry, stir-fried jujube seed, Ganoderma lucidum, and raw lily bulb; 2) Wash the raw materials with clean water and let them air dry naturally; 3) The dried medicinal materials are crushed and then put into a percolation device. White wine or rice wine is poured in to adjust the flow rate to obtain the prepared wine. 4) After the medicinal materials are percolated with white wine or rice wine, they are filtered, bottled, and ready for use.

4. The medicinal wine as described in claim 3, characterized in that: The selected liquor or rice wine should be 55% ABV.

5. The use of the medicinal wine as described in any one of claims 1-2 in the preparation of a medicine for treating insomnia.

Images