An antibacterial composition, application and drug

By combining trans-cinnamaldehyde with antibiotics, the treatment challenge of multidrug-resistant bacteria has been solved, achieving effective inhibition and killing of *Streptococcus pleuropneumoniae*, *Streptococcus suis*, and *Staphylococcus suis*, reducing the amount of antibiotics used and ensuring food safety.

CN118949047BActive Publication Date: 2025-10-28INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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Patent Information

Application Number
CN202411080202.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-08-07
Publication Date
2025-10-28
Estimated Expiration
2044-08-07

AI Technical Summary

Technical Problem

Multidrug-resistant strains of *Streptococcus pleuropneumoniae*, *Streptococcus suis*, and *Staphylococcus suis* have developed resistance to commonly used antibiotics, leading to treatment difficulties, increased antibiotic usage, and food safety risks.

Method used

Trans-cinnamaldehyde is used in combination with antibiotics such as amoxicillin, penicillin G, ciprofloxacin, erythromycin, and lincomycin in a ratio of 1–1.56 μM: 1.56–400 μg/ml to prepare drugs to inhibit or kill these bacteria. Dosage forms include oral solutions, injections, tablets, and microcapsules.

Benefits of technology

It significantly improves the inhibition and killing effect on multidrug-resistant bacteria, reduces the amount of antibiotics used, lowers antibiotic residues in food, and ensures food safety.

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Abstract

This invention belongs to the field of antibiotics and discloses the use of a combination of trans-cinnamaldehyde and antibiotics in the preparation of medicaments for the prevention and treatment of drug-resistant bacterial infections. This antibacterial composition exhibits good inhibitory or bactericidal effects against multidrug-resistant *Streptococcus pleuropneumoniae*, *Streptococcus suis*, and *Staphylococcus suis*, can reverse drug-resistant antibiotics into sensitive ones, significantly reduce the use of commonly used antibiotics, improve efficacy, and simultaneously avoid antibiotic residues in pork products, ensuring food safety. Furthermore, this invention also provides applications of this antibacterial composition and related pharmaceutical formulations.
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