Real-time three-dimensional photoacoustic multimodal imaging system and imaging method thereof

Through the two-dimensional array ultrasound array receiving system and multi-mode imaging technology, the problems of low imaging rate and limited depth range in the existing technology are solved, and real-time three-dimensional photoacoustic and ultrasound imaging is achieved, which is suitable for fast, high-precision imaging and multi-mode research of living small animals.

CN118986278BActive Publication Date: 2025-10-24PEKING UNIV
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Patent Information

Application Number
CN202411083170.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-08-08
Publication Date
2025-10-24
Estimated Expiration
2044-08-08

AI Technical Summary

Technical Problem

The existing non-real-time three-dimensional imaging systems have the disadvantages of low imaging rate, complex mechanical structure, susceptibility to motion artifacts, limited imaging depth and range, and cannot meet the needs of fast and high-precision imaging of living small animals.

Method used

A two-dimensional ultrasonic array receiving system is used, combined with a pulsed laser and a circulating constant temperature water system to achieve photoacoustic and ultrasonic imaging. The Fibonacci-like arrangement of the detector array and the multi-mode imaging mode avoids mechanical rotation, ensuring real-time imaging and deep, large-scale imaging.

Benefits of technology

It realizes real-time three-dimensional photoacoustic and ultrasonic imaging, improves imaging rate, reduces motion artifacts, supports multimodal imaging, expands imaging depth and range, and provides comprehensive diagnostic capabilities of function and structure, which is suitable for a wide range of biomedical research and clinical applications.

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Abstract

The application discloses a real-time three-dimensional photoacoustic multimodal imaging system and an imaging method thereof. The application introduces a two-dimensional surface array ultrasonic detector array system based on a partial spherical shell, realizes real-time three-dimensional photoacoustic and ultrasonic imaging, significantly improves the imaging rate, effectively reduces the interference of motion artifacts, supports two imaging modes of normal and upside-down, enhances the ability to adapt to different research needs, greatly expands the application scenarios, can image in deeper tissues, has a larger imaging range, and provides stronger applicability and flexibility for complex biomedical research, combines photoacoustic imaging and ultrasonic imaging organically, utilizes the molecular contrast advantage of photoacoustic imaging and the structural contrast advantage of ultrasonic imaging, and realizes complementation, so that the dual-mode imaging method can simultaneously acquire functional and structural information in one system, and greatly improves the comprehensive diagnostic capability of imaging.
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