Preparation and application of new compounds for the treatment of methamphetamine addiction and cognitive impairment

By developing the new compound NBU513-1 and its synthetic route, the difficult problems in treating methamphetamine addiction and cognitive impairment have been solved, and the efficient and safe synthesis of the compound and significant therapeutic effects have been achieved. It is suitable for the preparation of drugs for methamphetamine addiction and cognitive impairment.

CN118994115BActive Publication Date: 2025-09-09NINGBO UNIV
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Patent Information

Application Number
CN202411018874.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-07-29
Publication Date
2025-09-09
Estimated Expiration
2044-07-29

AI Technical Summary

Technical Problem

At present, the exact mechanism of cognitive impairment in methamphetamine-addicted patients is still unclear, and existing treatments are insufficient to effectively improve methamphetamine addiction and its induced cognitive impairment.

Method used

A novel compound, NBU513-1, was developed, and its total synthesis route was provided. By optimizing the reaction conditions, avoiding the use of sodium azide reaction, and adopting safer solvents and catalysts, the compound was efficiently and safely synthesized for the treatment of methamphetamine addiction and cognitive impairment.

Benefits of technology

The compound NBU513-1 significantly improved methamphetamine addiction behavior and significantly enhanced cognitive function, is suitable for industrial production, and has significant effects in treating methamphetamine addiction and cognitive impairment.

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Abstract

The present invention discloses a compound for treating methamphetamine addiction and cognitive impairment, its preparation method and application. The new compound NBU513-1 for treating methamphetamine addiction and cognitive impairment induced by the present invention can significantly improve the addictive behavior of mice for methamphetamine, has a therapeutic effect on the cognitive dysfunction caused by methamphetamine, and can be used to prepare a medicine for treating methamphetamine addiction and cognitive impairment induced by methamphetamine. The present invention provides a total synthesis route of compound NBU513-1. Compared with the preparation method of similar compounds in the prior art, the method of the present invention does not need to react with sodium azide, does not produce powerful explosives and highly toxic substances, has high stability and low reaction risk; the method has mild reaction conditions, simple scheme, safe and reliable production and can prepare target products with higher yields, and is suitable for industrial production.
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