Traditional Chinese medicine composition for treating child snoring syndrome and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating child snoring and application thereof, and belongs to the technical field of traditional Chinese medicine, and the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 40-60 parts of bighead atractylodes rhizome, 80-100 parts of Chinese yam, 20-50 parts of endothelium corneum gigeriae galli, 80-100 parts of radix pseudostellariae, 20-40 parts of rhizoma acori graminei, 20-50 parts of massa medicata fermentata fujianensis, 40-60 parts of radix angelicae, 30-50 parts of platycodon grandiflorum, 20-40 parts of radix scrophulariae, 20-55 parts of selfheal, 80-100 parts of radix fici simplicissimae, 15-35 parts of pericarpium citri reticulatae, 20-30 parts of rhizoma pinellinae praeparata, 15- The lotus seed and malt beverage is prepared from 70-100 parts of lotus seeds, 45-65 parts of malt, 25-35 parts of clean hawthorn fruits and 80-110 parts of maltose. Clinical tests prove that the traditional Chinese medicine composition can effectively improve the clinical symptoms of snore, mouth breathing, enuresis, attention decline, hyperactivity, sleepiness, abnormal behavior and emotion and the like during sleeping of child patients, reduce adenoid hypertrophy and tonsil hypertrophy, and effectively prevent the child patients from being repeatedly troubled by diseases.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating pediatric snoring and application thereof. Background Art

[0002] Pediatric snoring refers to a common otolaryngology disease in which children frequently experience partial or complete upper airway obstruction during sleep, which affects the ventilation status, sleep quality and even normal growth and development of children. It is often manifested by snoring, mouth breathing, respiratory apnea or waking up due to suffocation, enuresis, restless sleep, decreased daytime attention, hyperactivity, drowsiness, abnormal emotions and behaviors, etc. In addition to causing maxillofacial malformations and abnormal growth and development, it may even increase the probability of cardiovascular and cerebrovascular events. Therefore, it has gradually received attention from parents and society. The main cause of pediatric snoring is hypertrophy of adenoids and tonsils. In addition, it may also be related to obesity, abnormal anatomical structure, and incomplete development of neuromuscular function.

[0003] The treatment options for pediatric snoring in the prior art are divided into conservative treatment and surgical treatment. Western medicine treatment is mainly based on actively treating rhinitis, sinusitis and other related diseases that are prone to lymphatic tissue hyperplasia, improving the body's immunity, avoiding respiratory tract infections, and supplemented by improving the child's sleep habits, standardizing the diet structure, and strengthening exercise and other lifestyle adjustments. The treatment effect varies from person to person. Surgical treatment is to remove the adenoids and tonsils to open the airway and restore the airway width, but it cannot guarantee that there will be no recurrence. Traditional Chinese medicine is also divided into internal treatment and external treatment methods. Chinese medicine decoctions and ointments are used according to syndrome differentiation. The method focuses on tonifying the lungs and strengthening the middle, removing dampness and resolving phlegm, and is combined with layman's branding, picking and other techniques to achieve the purpose of relieving symptoms.

[0004] Snoring seriously endangers children's health. Currently, surgical resection is mostly used clinically to treat such children. Although the effect is certain, some families of children have low acceptance, and the children's immunity will also be affected after surgery. As a more reliable alternative therapy, Chinese medicine has played a good role in treating this disease and is relatively safe. For children who refuse to accept surgical treatment or whose obstruction is mild and whose clinical symptoms are still in the initial stage, oral Chinese medicine decoction treatment can be considered first. Chinese medicine decoction is guided by the concept of TCM syndrome differentiation and treatment. It is made by decocting the processed pieces in water. Children with snoring of different syndromes and different constitutions can basically achieve partial symptom relief. However, due to differences in physicians' syndrome differentiation, the selected Chinese medicinal materials and their dosages are often not completely consistent, and the quality and type of medicinal materials affect the actual efficacy.

[0005] In view of this, the inventor conducted in-depth research on the above-mentioned technical problems, which led to the present case. Summary of the invention

[0006] In order to solve the problem that due to differences in physicians' differentiation of syndromes, the selected Chinese medicinal materials and their dosages are often not completely consistent, and the actual therapeutic effects cannot be unified, the inventors have verified through clinical research that a Chinese medicine composition for treating pediatric snoring and its application is widely applicable to the prevention and treatment of pediatric snoring and the improvement of children's poor physical constitution.

[0007] The first aspect of the present invention provides a traditional Chinese medicine composition for treating snoring in children, which comprises the following raw materials in parts by weight: 40-60 parts of Atractylodes macrocephala, 80-100 parts of yam, 20-50 parts of chicken gizzard lining, 80-100 parts of Pseudostellaria heterophylla, 20-40 parts of Acorus calamus, 20-50 parts of Jianqu, 40-60 parts of Angelica dahurica, 30-50 parts of Platycodon grandiflorum, 20-40 parts of Scrophularia ningpoensis, 20-55 parts of Prunella vulgaris, 80-100 parts of Prunella vulgaris, 15-35 parts of dried tangerine peel, 20-30 parts of Pinellia ternata, 15-30 parts of Strigosa tricholoma, 30-50 parts of Poria cocos, 70-100 parts of lotus seeds, 45-65 parts of malt, 25-35 parts of pure hawthorn, and 80-110 parts of maltose.

[0008] As a preferred embodiment, the invention comprises the following raw materials in parts by weight: 45-55 parts of Atractylodes macrocephala, 90-100 parts of yam, 30-45 parts of chicken gizzard lining, 95-100 parts of Pseudostellaria pseudoginseng, 35-40 parts of Acorus calamus, 40-50 parts of Jianqu, 45-55 parts of Angelica dahurica, 35-45 parts of Platycodon grandiflorum, 25-35 parts of Scrophularia ningpoensis, 45-55 parts of Prunella vulgaris, 90-100 parts of Prunella vulgaris, 15-20 parts of dried tangerine peel, 25-30 parts of Pinellia ternata, 20-30 parts of Strigosa tricholoma, 45-50 parts of Poria cocos, 80-95 parts of lotus seeds, 45-50 parts of malt, 25-30 parts of pure hawthorn, and 80-100 parts of maltose.

[0009] As a preferred embodiment, the invention comprises the following raw materials by weight: 50 parts of Atractylodes macrocephala, 100 parts of yam, 40 parts of chicken gizzard lining, 100 parts of Pseudostellaria heterophylla, 40 parts of Acorus calamus, 50 parts of Jianqu, 50 parts of Angelica dahurica, 40 parts of Platycodon grandiflorum, 30 parts of Scrophularia ningpoensis, 50 parts of Prunella vulgaris, 100 parts of Prunella vulgaris, 20 parts of dried tangerine peel, 30 parts of Pinellia ternata, 25 parts of Strigosa tricholoma, 50 parts of Poria, 90 parts of lotus seeds, 50 parts of malt, 30 parts of pure hawthorn, and 90 parts of maltose.

[0010] The second aspect of the present invention provides the use of the above-mentioned Chinese medicine composition in the preparation and / or treatment of drugs for pediatric snoring.

[0011] As a preferred implementation manner, the pediatric snoring includes pediatric adenoids and tonsils hypertrophy.

[0012] The third aspect of the present invention provides a Chinese medicine composition for treating pediatric snoring and pharmaceutically acceptable excipients, wherein the excipients include at least one or more of the following: a disintegrant, an emulsifier, a filler, a flavoring agent, a wetting agent, a binder, an absorption promoter, a colorant and a solubilizing agent.

[0013] In some more preferred embodiments, the dosage form of the drug includes one or more of the following: ointment, decoction, granules, pills, capsules, tablets, mixtures, suspensions, powders or oral solutions.

[0014] In some of the more preferred embodiments, the drug is a drug for improving snoring during sleep, mouth breathing, sleep breathing disorders, enuresis, decreased attention, hyperactivity, drowsiness, abnormal behavior and mood, and hypertrophy of adenoids and tonsils.

[0015] The fourth aspect of the present invention provides a method for preparing the drug as a traditional Chinese medicine ointment as follows:

[0016] Step 1, weigh all the remaining raw materials except maltose according to weight ratio, add purified water and soak;

[0017] Step 2, extracting the raw material drug three times, collecting the extract and filtering;

[0018] Step three, add maltose after filtering and concentrate to obtain.

[0019] In some more preferred embodiments, in step 1, 6 times the amount of water as the API is added and soaked for at least 12 hours;

[0020] The extraction process in step 2 includes: collecting the medicinal liquid after 1.5 hours of first decoction, adding 6 times the amount of water of the total raw materials for decoction for 1 hour and collecting the medicinal liquid, adding 3 times the amount of water of the total raw materials for decoction for the third time and decoct for 1 hour and collecting the medicinal liquid, and combining the three extraction filtrates and filtering.

[0021] This prescription is based on regulating the Qi and helping the spleen and stomach to function, and aims to resolve phlegm and tonify the Qi of the lungs and spleen. Among them, Radix Pseudostellariae, Poria, Atractylodes macrocephala, and Chinese yam can strengthen the spleen and replenish Qi, lotus seeds can eliminate dampness, Platycodon grandiflorum and Licorice can clear the lungs and relieve throat pain, mainly to move the Qi of the lungs and spleen, and clear the phlegm of the lungs and spleen. Pinellia tuber can lower Qi, and combined with Atractylodes macrocephala can play the role of strengthening the spleen and resolving phlegm, regulating Qi and tonifying the lungs. Some Lingnan specialty medicinal materials are added to the prescription, such as Jianqu, Crataegus pinnatifida, Gallus gallus lining, and malt to eliminate accumulation and digestion; Angelica dahurica and Acorus calamus can eliminate dampness and help to clear the nasal passages; Five-fingered ginseng can invigorate Qi, strengthen the spleen and eliminate dampness, resolve phlegm and eliminate snoring. The addition of Herba striatae is the dried whole herb of Herba striatae, a plant of the Scrophulariaceae family. It is mainly produced in Guangdong and Guangxi. It is a traditional folk medicinal plant in Lingnan. It has the effect of clearing heat and eliminating accumulation, and is a good medicine for treating malnutrition in children. The herb Prunella Vulgaris in the formula is mainly used to relieve sore throat and swelling, and disperse enlarged adenoids and tonsils, to assist in clearing the orifices and eliminating snoring. The various components work synergistically, so that the combination can give full play to the advantages of various drugs and improve the overall efficacy.

[0022] The beneficial effects produced by the technical solution of the present invention are as follows:

[0023] The present invention provides a Chinese medicine composition for treating pediatric snoring and its associated symptoms, wherein Jianqu, hawthorn, chicken gizzard lining, and malt can eliminate stagnation and digestion, while angelica dahurica and calamus can eliminate dampness and help clear the nasal passages, and five-fingered ginseng can invigorate qi, so as to strengthen the spleen and eliminate dampness, thereby achieving the effect of eliminating phlegm and eliminating snoring, helping the children to improve other body dysfunctions caused by bad living habits, and fundamentally treating pediatric snoring. Clinical trials have shown that the medicine composition of the present invention can effectively improve clinical symptoms such as snoring during sleep, mouth breathing, enuresis, decreased attention, hyperactivity, drowsiness, abnormal behavior and emotions in children, reduce enlarged adenoids and tonsils, and effectively prevent children from suffering from repeated troubles caused by the disease. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention is clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all the embodiments. Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely represents the selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] The inventor has obtained a composition for treating pediatric snoring and its preparation method and application through clinical research verification, which is widely applicable to treating pediatric snoring and improving children's weak constitution, especially having a certain effect in the early stage of pediatric snoring. The specific implementation method is as follows:

[0026] The invention provides a traditional Chinese medicine composition for treating pediatric snoring. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 40-60 parts of atractylodes macrocephala, 80-100 parts of yam, 20-50 parts of chicken gizzard lining, 80-100 parts of pseudoginseng, 20-40 parts of calamus, 20-50 parts of jianqu, 40-60 parts of angelica dahurica, 30-50 parts of platycodon, 20-40 parts of scrophularia, 20-55 parts of selfheal, 80-100 parts of quinquefolius, 15-35 parts of tangerine peel, 20-30 parts of pinellia tuber, 15-30 parts of striga, 30-50 parts of tuckahoe, 70-100 parts of lotus seeds, 45-65 parts of malt, 25-35 parts of pure hawthorn and 80-110 parts of maltose.

[0027] A traditional Chinese medicine composition for treating pediatric snoring, wherein a better formula ratio is selected as follows: 45-55 parts of Atractylodes macrocephala, 90-100 parts of Chinese yam, 30-45 parts of chicken gizzard lining, 95-100 parts of Pseudostellaria pseudoginseng, 35-40 parts of Acorus calamus, 40-50 parts of Jianqu, 45-55 parts of Angelica dahurica, 35-45 parts of Platycodon grandiflorum, 25-35 parts of Scrophularia ningpoensis, 45-55 parts of Prunella vulgaris, 90-100 parts of Trichosanthes kirilowii, 15-20 parts of dried tangerine peel, 25-30 parts of Pinellia ternata, 20-30 parts of Strigosa tricholoma, 45-50 parts of Poria cocos, 80-95 parts of lotus seeds, 45-50 parts of malt, 25-30 parts of pure hawthorn, and 80-100 parts of maltose.

[0028] A traditional Chinese medicine composition for treating pediatric snoring, wherein the optimal formula ratio is 50 parts of atractylodes macrocephala, 100 parts of yam, 40 parts of chicken gizzard lining, 100 parts of pseudoginseng, 40 parts of calamus, 50 parts of jianqu, 50 parts of angelica dahurica, 40 parts of platycodon, 30 parts of scrophulariae, 50 parts of selfheal, 100 parts of quinquefolius, 20 parts of tangerine peel, 30 parts of pinellia tuber, 25 parts of strigastrifolia, 50 parts of tuckahoe, 90 parts of lotus seeds, 50 parts of malt, 30 parts of pure hawthorn and 90 parts of maltose.

[0029] Under the above formula ratio, the snoring treatment drugs provided by the present invention can effectively treat snoring symptoms and significantly improve sleep quality. At the same time, in the present invention, the snoring treatment drugs can be made into pills, decoctions, etc., and can also be made into injections, powders and other dosage forms.

[0030] The second aspect of the present invention provides the use of the above-mentioned Chinese medicine composition in the preparation and / or treatment of drugs for pediatric snoring.

[0031] As a preferred implementation manner, the pediatric snoring includes pediatric adenoids and tonsils hypertrophy.

[0032] The third aspect of the present invention provides a Chinese medicine composition for treating pediatric snoring and pharmaceutically acceptable excipients, wherein the excipients include at least one or more of the following: a disintegrant, an emulsifier, a filler, a flavoring agent, a wetting agent, a binder, an absorption promoter, a colorant and a solubilizing agent.

[0033] In some more preferred embodiments, the dosage form of the drug includes one or more of the following: ointment, decoction, granules, pills, capsules, tablets, mixtures, suspensions, powders or oral solutions.

[0034] Taking into account some characteristics of children when taking medicine, paste is preferred as a more preferred dosage form. Pastes are made by repeatedly decocting, filtering and concentrating Chinese medicinal materials, which reduces the multiple doses of decoction into one portion. When taking, scoop it out and rinse it with warm water. It is simple and easy to operate, and has the same therapeutic effect as decoction. It does not add high-animal high-protein ingredients such as honey and donkey-hide gelatin, which reduces the risk of allergic reactions in children. The auxiliary material is maltose, which will not affect the gastrointestinal burden of children. The use of paste prescriptions is not limited to autumn and winter, but can be used all year round.

[0035] In some of the more preferred embodiments, the drug is a drug for improving snoring during sleep, mouth breathing, sleep breathing disorders, enuresis, decreased attention, hyperactivity, drowsiness, abnormal behavior and mood, and hypertrophy of adenoids and tonsils.

[0036] The fourth aspect of the present invention provides a method for preparing the drug as a traditional Chinese medicine ointment as follows:

[0037] Step 1, weigh all the remaining raw materials except maltose according to weight ratio, add purified water and soak;

[0038] Step 2, extracting the raw material drug three times, collecting the extract and filtering;

[0039] Step three, add maltose after filtering and concentrate to obtain.

[0040] In some of the more preferred embodiments,

[0041] In the step 1, add 6 times the amount of water as the raw material and soak for at least 12 hours;

[0042] In the step 2, the decoction temperature is set to 100°C, the medicine is kept for 1 hour and operated at a micro-pressure, the medicine liquid is collected after 1.5 hours of the first decoction, 6 times the amount of water of the total raw materials is added for the second decoction and the medicine liquid is collected after 1 hour of decoction, 3 times the amount of water of the total raw materials is added for the third decoction and the medicine liquid is collected after 1 hour of decoction, and the filtrates of the three extractions are combined and filtered.

[0043] When producing the ointment in step 3, maltose is added to the clear ointment. When the medicinal liquid boils without bubbles, it is ready to be made into an ointment. Stir it until it is drawn into flags, hanging threads or dripping into beads. Drop the ointment into clear water to condense into beads without dispersing. Finally, put it into a cooling ointment cabinet and let it stand overnight.

[0044] In the present invention, the Radix Pseudostellariae in the Chinese medicine composition has the effects of invigorating qi and strengthening spleen, promoting body fluid and moistening lung. It is mainly used to treat poor appetite, fatigue, palpitations, insomnia, and excessive sweating due to deficiency heat. Modern pharmacological studies have shown that the Radix Pseudostellariae protein hydrolyzate Pseudostellariae peptide can activate Ca 2+ / CaN / NFATc1 / IFN-γ pathway, thereby promoting splenic T lymphocytes to release TNF-α, INF-γ and IL-10, which plays an immune-enhancing role. Five-fingered hair peach has the effects of strengthening the spleen and lungs, promoting qi and removing dampness, and relaxing muscles and activating collaterals. Its spleen deficiency edema, less appetite and weakness; cough due to tuberculosis, night sweats; leucorrhea, postpartum agalactia; rheumatic pain, edema, ascites due to cirrhosis, hepatitis; traumatic injuries. Scrophularia has the effects of clearing heat and cooling blood, nourishing yin and reducing fire, detoxifying and dispersing nodules. Its heat enters the blood, warm poison causes spots; fever damages yin, body fluid damage causes constipation, bone steaming and cough; red eyes and sore throat, scrofula, diphtheria, carbuncle and sore. Modern pharmacological studies have shown that Scrophularia contains cyclopentadiene ether terpenoid compounds such as harpagine and aucubin, which have the effect of enhancing immunity. The above three are collectively monarch drugs.

[0045] Among them, Chinese yam has the effects of nourishing qi and yin, tonifying spleen, lung and kidney, consolidating essence and stopping nocturnal emission, and is mainly used to treat spleen and stomach deficiency, lung and kidney deficiency, and thirst syndrome caused by yin deficiency and internal heat. Modern pharmacological studies have shown that nano-yam polysaccharide bifidobacterium synbiotic colon-targeted microecological regulator can reduce intestinal inflammation, increase the level of hemolysin, sIgA and GM-CSF content, reduce IL-1β, IL-6 and TNF-α content, and improve the body's immune ability. Atractylodes macrocephala has the effects of invigorating qi and strengthening the spleen, drying dampness and promoting diuresis, consolidating the surface and stopping sweating. It is mainly used to treat spleen and stomach qi deficiency, poor digestion, loose stools, abdominal distension, limb weakness and fatigue caused by poor digestion and poor digestion; phlegm and fluid retention, edema, and urinary difficulties caused by spleen deficiency and poor digestion, and spontaneous sweating caused by weak spleen qi and weak skin surface. Modern pharmacological studies have shown that the atractylodes ketone, atractylodes lactone A, B and sugars (mainly mannose and fructose) contained in Atractylodes macrocephala have the function of regulating immunity and can significantly enhance the expression of interleukin-2 (IL-2) receptors on the surface of human peripheral blood lymphocytes. Poria has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and calming the mind. It is mainly used to treat edema, urinary difficulties, spleen deficiency diarrhea, palpitations and insomnia, and phlegm and fluid. Modern pharmacological studies have shown that Poria cocos ethanol extract inhibits the levels of iNOS, COX-2, IL-1β and the inactivation of TNF-α / NF-κB signaling pathways, and targets the inflammatory response of macrophages to play a therapeutic role in inflammation. Lotus seeds have the effects of tonifying the spleen and stopping diarrhea, stopping leukorrhea, benefiting the kidney and astringing essence, nourishing the heart and calming the mind. They are mainly used to treat spleen deficiency diarrhea, leukorrhea, spermatorrhea, palpitations and insomnia. Modern pharmacological studies have shown that lotus seeds contain raffinose, which has the effects of enhancing immunity, increasing bifidobacteria, bidirectionally regulating gastrointestinal function, calming, improving sleep, and promoting fat decomposition. Tangerine peel has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm, and is mainly used to treat abdominal distension and pain, poor appetite, vomiting and diarrhea, vomiting, hiccups, phlegm and chest tightness, cough and asthma. Modern pharmacological studies have shown that tangerine peel contains volatile oils, and the fat-soluble component of tangerine peel, dextrorotatory limonene, is considered to be an expectorant component. Tangerine peel essential oil can block NF-κB, JNK, and ERK signaling pathways to exert anti-inflammatory effects. Its mechanism is related to the expression of inflammatory cytokines and pro-inflammatory mediators tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in macrophages. It can also improve cell migration and protein extravasation, showing significant anti-inflammatory effects. French Pinellia has the effects of drying dampness and resolving phlegm, dispelling wind and relieving spasm, and external swelling and pain relief. It is mainly used to treat dizziness caused by damp phlegm, cold phlegm, and wind phlegm, stroke, epilepsy, tetanus, carbuncle swelling and pain, scrofula phlegm, and snake bites. Modern pharmacological studies have shown that the water extract of French Pinellia can reduce the secretion of cellular inflammatory factors interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), improve respiratory inflammation, inhibit p38 and IκB phosphorylation, and downregulate the content of IL-6 and IL-8 in the bronchoalveolar lavage fluid of mice with respiratory symptoms. Acorus calamus has the effects of opening the orifices and resolving phlegm, refreshing the mind and improving intelligence, removing dampness and stimulating appetite. It is mainly used to treat phlegm blocking the mind, coma, epilepsy, forgetfulness, insomnia, tinnitus and deafness, dampness blocking the middle burner, abdominal distension and lack of hunger, and dysentery with lockjaw.Modern pharmacological research shows that the volatile oil of Acorus tatarinowii contains asarone, acorus ether and other ingredients, which have the functions of sedation, improving learning and memory, resisting heart and brain ischemia, regulating gastrointestinal motility, etc. The above seven components are collectively the ministerial drugs.

[0046] Among them, Jianqu has the effects of digesting food and eliminating accumulation, regulating qi and eliminating dampness, and dispersing wind and cold. It is mainly used to treat food accumulation or wind-cold exterior syndrome. Angelica dahurica has the effects of dispelling cold, dispelling wind and relieving pain, drying dampness and stopping leukorrhea, reducing swelling and draining pus, and clearing the nasal passages. It is mainly used to treat wind-cold exterior syndrome. Angelica dahurica can treat various pains, and is good at treating Yangming meridian forehead pain and gingival swelling and pain; it can treat nasal sinusitis, nasal congestion; sores, swelling and poison, skin itching, and leukorrhea. It is a commonly used drug for surgery. Modern pharmacological studies have shown that Angelica dahurica contains a variety of coumarin compounds such as imperatorin and white angelica, which have an excitatory effect on the respiratory center in small doses and have anti-inflammatory effects. Pure hawthorn has the effects of digesting food and strengthening the stomach, promoting qi and dispersing blood stasis, removing turbidity and reducing fat. It is mainly used to treat food accumulation syndrome, diarrhea, dysentery, blood stasis syndrome, and hyperlipidemia. Hawthorn mainly contains flavonoids, triterpenoid saponins, saponin tannins, free acids, fatty acids, vitamin C, inorganic salts, red pigments, etc. Modern pharmacological studies have shown that the fatty acids contained in clean hawthorn can promote fat digestion, increase the secretion of gastric digestive enzymes to promote digestion, and have a certain regulating effect on gastrointestinal function. Single-footed gold has the effects of strengthening the spleen and eliminating accumulation, calming the liver, clearing away heat and promoting diuresis, and is mainly used to treat children's food injury, malnutrition, and urinary incontinence. Malt flavor has the effects of digestion and stomach, milk recovery and swelling, and is mainly used to treat food accumulation. Modern pharmacological studies have shown that malt contains α- and β-amylase, catalytic enzyme, maltose and hordenine, and the amylase contained can aid digestion; decoction promotes the secretion of gastric acid and pepsin; and there is a pancreatic amylase activator in the water decoction. Chicken gizzard has the effects of digestion and stomach, solidifying essence and stopping nocturnal emission, and clearing stranguria and removing stones. It is mainly used to treat food accumulation syndrome, nocturnal emission and nocturnal enuresis, and sandstone stranguria syndrome. Modern pharmacological studies have shown that chicken gizzard contains gastric hormones, keratin, trace pepsin, amylase and other ingredients, which can increase the secretion and acidity of gastric juice, enhance gastric motility and digestive enzyme activity. Prunella vulgaris has the effects of clearing away heat and purging fire, improving eyesight, reducing swelling and dispersing nodules. It is mainly used to treat red and swollen eyes, headache and dizziness, scrofula, goiter, mastitis, and mastitis. Modern pharmacological studies have shown that Prunella vulgaris contains organic acid components such as rosmarinic acid, which have anti-pathogenic microbial effects. Platycodon grandiflorum has the effects of opening and dispersing lung qi, removing phlegm and pus, and relieving sore throat. It is mainly used to treat cough with phlegm, chest tightness, lung abscess caused by heat and toxicity, sore throat, and aphonia. Modern pharmacological studies have shown that Platycodon grandiflorum contains a variety of saponins and polysaccharides, mainly triterpenoid saponins, which have anti-inflammatory, sedative, immunomodulatory, expectorant, antitussive and antiasthmatic effects. The above eight components are adjuvants.

[0047] Among them, maltose is sweet in taste and warm in nature. It enters the spleen, stomach, and lung meridians. It has the effects of nourishing the spleen and replenishing qi, relieving pain, moistening the lungs and relieving cough. It is mainly used to treat fatigue and spleen damage, abdominal pain, dry cough, vomiting blood, thirst, sore throat, and constipation. It is a guiding medicine.

[0048] The above components work together to exert anti-inflammatory effects, reduce the secretion level of anti-inflammatory factors and reduce the expression of cellular inflammation-related genes; clinical trial results show that the Chinese medicine combination can effectively improve clinical symptoms such as snoring during sleep, mouth breathing, sleep breathing disorders, enuresis, decreased attention, hyperactivity, drowsiness, behavioral and emotional abnormalities, reduce the size of adenoids and tonsils, and can effectively treat pediatric snoring.

[0049] The present invention is further described in detail below in conjunction with specific embodiments:

[0050] Example 1

[0051] Preparation of the paste of the Chinese medicine composition of the present invention (I)

[0052] Weigh the following medicinal materials by weight: 50 parts of Atractylodes macrocephala, 100 parts of yam, 40 parts of chicken gizzard lining, 100 parts of Pseudostellaria pseudoginseng, 40 parts of Acorus calamus, 50 parts of Jianqu, 50 parts of Angelica dahurica, 40 parts of Platycodon grandiflorum, 30 parts of Scrophularia ningpoensis, 50 parts of Prunella vulgaris, 100 parts of Prunella vulgaris, 20 parts of dried tangerine peel, 30 parts of Pinellia ternata, 25 parts of Strigosa tricholoma, 50 parts of Poria, 90 parts of lotus seeds, 50 parts of malt, 30 parts of pure hawthorn, and 90 parts of maltose.

[0053] Weigh the first 18 medicinal materials except maltose, add 6 times the amount of water and soak for 12 hours, set the decoction temperature to 100℃, store for 1 hour, operate at micro pressure, decoct for the first time, collect the liquid after 1.5 hours of decoction and extraction, add 6 times the amount of water of the total raw materials to the filter residue for the second decoction, decoct and extract for 1 hour and collect the liquid; add 3 times the amount of water of the total raw materials to the filter residue for the third decoction, decoct and extract for 1 hour and collect the liquid; combine the liquid extracted three times and filter. Heat and concentrate, add 90 parts of maltose, stir continuously when it becomes concentrated liquid, stir until it is drawn into flags, hanging silk or dripping into beads, drop the paste juice into clear water to condense into beads without dispersing, obtain the extract and drop it on mulberry paper, transfer it into a sterile bottle and seal it for storage without water seepage.

[0054] Example 2

[0055] Preparation of the paste of the Chinese medicine composition of the present invention (II)

[0056] The following medicinal materials were weighed by weight: 45 parts of Atractylodes macrocephala, 100 parts of Chinese yam, 30 parts of chicken gizzard lining, 100 parts of Pseudostellaria heterophylla, 20 parts of Acorus calamus, 40 parts of Jianqu, 45 parts of Angelica dahurica, 35 parts of Platycodon grandiflorum, 30 parts of Scrophularia ningpoensis, 45 parts of Prunella vulgaris, 100 parts of Prunella vulgaris, 20 parts of dried tangerine peel, 25 parts of Pinellia ternata, 30 parts of Strigosa tricholoma, 45 parts of Poria, 95 parts of lotus seeds, 65 parts of malt, 25 parts of clean hawthorn, and 80 parts of maltose. The preparation method of the ointment is the same as that of Example 1.

[0057] Example 3

[0058] Preparation of the paste of the Chinese medicine composition of the present invention (III)

[0059] The following medicinal materials were weighed by weight: 60 parts of Atractylodes macrocephala, 100 parts of Chinese yam, 45 parts of chicken gizzard lining, 100 parts of Pseudostellaria heterophylla, 40 parts of Acorus calamus, 50 parts of Jianqu, 40 parts of Angelica dahurica, 50 parts of Platycodon grandiflorum, 30 parts of Scrophularia ningpoensis, 50 parts of Prunella vulgaris, 100 parts of Prunella vulgaris, 25 parts of dried tangerine peel, 30 parts of Pinellia ternata, 30 parts of Strigosa tricholoma, 50 parts of Poria cocos, 100 parts of lotus seeds, 60 parts of malt, 35 parts of clean hawthorn, and 100 parts of maltose. The preparation method of the ointment is the same as that of Example 1.

[0060] Example 4

[0061] Preparation of the paste of the Chinese medicine composition of the present invention (IV)

[0062] The following medicinal materials were weighed by weight: 40 parts of Atractylodes macrocephala, 80 parts of Chinese yam, 20 parts of chicken gizzard lining, 100 parts of Pseudostellariae Radix, 20 parts of Acorus calamus, 20 parts of Jianqu, 40 parts of Angelica dahurica, 30 parts of Platycodon grandiflorum, 20 parts of Scrophulariae Radix, 45 parts of Prunella vulgaris, 100 parts of Prunella vulgaris, 19 parts of dried tangerine peel, 25 parts of Pinellia ternata, 15 parts of Strigosa Striga, 45 parts of Poria, 80 parts of lotus seeds, 55 parts of malt, 25 parts of clean hawthorn, and 80 parts of maltose. The preparation method of the ointment is the same as that of Example 1.

[0063] Example 5

[0064] Preparation of the paste of the Chinese medicine composition of the present invention (V)

[0065] The following medicinal materials were weighed by weight: 60 parts of Atractylodes macrocephala, 100 parts of Chinese yam, 50 parts of chicken gizzard lining, 100 parts of Pseudostellaria heterophylla, 40 parts of Acorus calamus, 50 parts of Jianqu, 60 parts of Angelica dahurica, 50 parts of Platycodon grandiflorum, 30 parts of Scrophularia ningpoensis, 55 parts of Prunella vulgaris, 100 parts of Prunella vulgaris, 35 parts of Citrus reticulata, 30 parts of Pinellia ternata, 30 parts of Streptococcus glutinosa, 50 parts of Poria cocos, 100 parts of Lotus seeds, 65 parts of Malt, 35 parts of Clean Hawthorn, and 110 parts of Maltose. The preparation method of the ointment is the same as that of Example 1.

[0066] Example 6

[0067] Preparation of the paste of the Chinese medicine composition of the present invention (VI)

[0068] The following medicinal materials were weighed by weight: 50 parts of Atractylodes macrocephala, 100 parts of Chinese yam, 40 parts of chicken gizzard lining, 100 parts of Pseudostellaria heterophylla, 40 parts of Acorus calamus, 50 parts of Jianqu, 40 parts of Angelica dahurica, 45 parts of Platycodon grandiflorum, 35 parts of Rhizoma Citri Reticulatae, 45 parts of Herba Prunellae, 100 parts of Prunella vulgaris, 25 parts of dried tangerine peel, 25 parts of Pinellia ternata, 25 parts of Radix Trichosanthis, 50 parts of Poria, 95 parts of lotus seeds, 55 parts of malt, 30 parts of clean hawthorn, and 90 parts of maltose. The preparation method of the ointment is the same as that of Example 1.

[0069] Example 7

[0070] Clinical trial of the Chinese medicine composition of the present invention

[0071] 1 Materials and methods

[0072] 1.1 Research subjects and groups

[0073] Fifty patients aged 3 to 10 years old who visited the ENT clinic of the First Affiliated Hospital of Guangzhou University of Chinese Medicine from November 2023 to May 2024 were randomly selected. They were diagnosed with pediatric snoring and had taken at least 250 grams of the ointment prepared in Example 1. The clinical symptoms and signs before and after taking the ointment were recorded in the form of outpatient and electronic medical record system collection combined with telephone follow-up, and the efficacy of the ointment in treating pediatric snoring was evaluated by comparing the improvement of clinical symptoms and signs.

[0074] 1.2 Diagnostic criteria

[0075] Western medicine diagnostic criteria: Refer to the diagnostic criteria formulated in the "Guidelines for the Diagnosis and Treatment of Obstructive Sleep Apnea in Chinese Children (2020)": (1) The child snores during sleep and breathes with his mouth open. In severe cases, there may be apnea or suffocation during sleep, daytime sleepiness, inattention, slow reaction, and abnormal growth and development; (2) Adenoid facies; (3) Endoscopic examination suggests enlarged adenoids and / or tonsils; (4) Polysomnography results indicate the presence of simple snoring or obstructive sleep apnea-hypopnea syndrome.

[0076] TCM diagnostic criteria: With reference to the national undergraduate textbook for higher TCM education, TCM Otolaryngology, edited by Liu Peng, and the Consensus of TCM Diagnosis and Treatment Experts on Snoring (2019 edition) of the Chinese Association of Traditional Chinese Medicine, the following diagnostic criteria were formulated: (1) The main manifestations of snoring are snoring during sleep, accompanied by open-mouth breathing, occasional apnea or waking up from suffocation, restless sleep, daytime sleepiness, inattention, slow reaction, and abnormal growth and development; (2) Syndrome types: ① Phlegm-dampness obstruction syndrome; ② Qi deficiency and phlegm stasis syndrome; ③ Lung and spleen qi deficiency syndrome; ④ Spleen and kidney deficiency syndrome; ⑤ Other syndrome types that cannot be classified into the above four syndrome types.

[0077] 1.3 Inclusion and Exclusion Criteria

[0078] Inclusion criteria:

[0079] (1) The first diagnosis is consistent with the diagnostic criteria for pediatric snoring in traditional Chinese medicine, and the diagnostic criteria for simple snoring in children and obstructive sleep apnea-hypopnea syndrome in children in Western medicine.

[0080] (2) The patient must be between 3 and 10 years old, regardless of gender; must be compliant and able to take medication to complete the course of treatment; and the guardian must have given informed consent.

[0081] (3) Under nasal endoscopy, adenoids block less than 70% of the posterior nares; tonsils are 1-3 degrees enlarged.

[0082] (4) Refusing surgical treatment; no obvious nasal septum deviation or abnormal nasal anatomical structure.

[0083] (5) It is consistent with the TCM syndrome of lung and spleen qi deficiency, spleen and stomach weakness, and phlegm and dampness obstruction.

[0084] Exclusion criteria:

[0085] (1) Patients with cardiovascular, cerebrovascular, mental and other serious diseases.

[0086] (2) A history of acute respiratory infection in the past two weeks or the patient is currently experiencing an acute respiratory disease attack.

[0087] (3) The child has a severe allergic constitution and is allergic to the ingredients in traditional Chinese medicine.

[0088] 1.4 Treatment options

[0089] The Chinese medicine composition of the present invention is used for treatment. The medicinal materials of the prescription are 50 parts of Atractylodes macrocephala, 100 parts of yam, 40 parts of chicken gizzard lining, 100 parts of Pseudostellaria heterophylla, 40 parts of Acorus calamus, 50 parts of Jianqu, 50 parts of Angelica dahurica, 40 parts of Platycodon grandiflorum, 30 parts of Scrophularia ningpoensis, 50 parts of Prunella vulgaris, 100 parts of Prunella vulgaris, 20 parts of dried tangerine peel, 30 parts of Pinellia ternata, 25 parts of Strigosa tricholoma, 50 parts of Poria, 90 parts of lotus seeds, 50 parts of malt, 30 parts of pure hawthorn and 90 parts of maltose to prepare an ointment.

[0090] Dosage: Take 20g each time and mix with 100-150ml warm water.

[0091] Take once a day for the first week, then increase to twice a day. Take at least one full dose, which means at least 12 days.

[0092] 1.5 Scoring Criteria

[0093] The TCM syndrome scoring table was drawn up in accordance with the Guiding Principles for Clinical Research of New Chinese Medicines, which includes the main symptoms: snoring and / or mouth breathing during sleep, which are recorded as 0, 1, 2, and 3 points according to the four levels of never or no symptoms in the past month, occasional occurrence, frequent occurrence, and always occurrence. Secondary symptoms: apnea or waking up due to suffocation, which are recorded as 0, 1, 2, and 3 points according to the four levels of never or no symptoms in the past month, occasional occurrence, frequent occurrence, and always occurrence; mood and behavioral changes such as restlessness at night, daytime sleepiness, slow reaction, and memory loss, which are recorded as 0, 1, 2, and 3 points according to the four levels of never or no symptoms in the past month, occasional occurrence, frequent occurrence, and always occurrence; the size of the adenoids, which is recorded as 0, 1, 2, and 3 points according to the four levels of the degree of adenoids blocking the posterior nasal cavity less than 50%, 50-65%, 65-80%, and more than 80% according to the fiber (electronic) nasopharyngeal endoscopy. The sum of the scores of each symptom is the total symptom score, and the higher the score, the more severe the symptom, as shown in Table 1.

[0094] Table 1

[0095]

[0096] Occasionally, it occurs 1 to 2 times a week; frequently, it occurs 3 to 4 times a week; and always, it occurs every day.

[0097] 1.6 Treatment outcomes

[0098] The improvement rate was calculated based on the symptom and sign scores before and after treatment to evaluate the degree of improvement, which was divided into four levels: significantly improved, slightly improved, not significantly improved, and ineffective.

[0099] Improvement rate = (pre-treatment score - post-treatment score) / pre-treatment score × 100%

[0100] Improvement degree: >70% is significant improvement, 50%-70% is slight improvement, 30%-50% is not obvious improvement, and <30% is ineffective.

[0101] Results Statistics Time: The follow-up time of 50 research subjects was to conduct efficacy evaluation after taking 250-750 grams of the ointment prepared in Example 1. The results are shown in Table 2.

[0102] Table 2 Treatment results (n=50)

[0103] Degree of improvement Significant improvement Slightly improved No significant improvement No effect Quantity (example) 30 10 6 4 Improved efficiency 60％ 20％ 12％ 8％

[0104] After the patient took 250 grams of the ointment prepared in Example 1, the overall effective rate of the treatment reached 80%, and the significant effective rate reached 60%. The ointment is prepared by decocting and concentrating the compound prescription and adding maltose to refine the ointment. It treats pediatric snoring from the lungs and spleen, achieves the effects of tonifying the lungs and strengthening the middle, removing dampness and resolving phlegm, helps the children improve other body dysfunctions caused by bad living habits, and fundamentally treats pediatric snoring.

[0105] 1.7 Specific clinical examples;

[0106] Clinical case 1: Huang XX, male, 8 years old, was diagnosed on March 19, 2024. He snored and breathed with his mouth open during sleep for 2 years. At first, he had snoring 2-3 times a week, and then developed into daily nighttime sleep. He did not have apnea or wake up due to suffocation. He was sleepy and unable to concentrate during the day. His height, weight and intelligence were consistent with the normal level of his peers. He also had nasal itching and sneezing, normal appetite, good sleep, and normal bowel movements.

[0107] Physical examination: The nasal septum is basically centered, the two inferior turbinates are swollen and light in color, and there is no obvious secretion in each nasal passage. There is no congestion in the pharyngeal mucosa, and the two tonsils are enlarged to the first degree, light red in color, without pus spots and secretions.

[0108] Nasal endoscopy showed: adenoids blocked 75% of the posterior nostril. The tongue was pale red, the coating was thin and white, and the pulse was thin.

[0109] Traditional Chinese medicine diagnosis: snoring, lung and spleen qi deficiency syndrome; Western medicine diagnosis: mouth breathing, adenoids hypertrophy.

[0110] Take 250 grams of the ointment prepared in Example 1, mixed with warm water, 20 grams once a day for the first week, and 20 grams once a day after the second week.

[0111] On the second visit on April 2, 2024, the child's snoring and mouth breathing during sleep had improved, with about 4 to 5 attacks a week, less than before. There was no apnea or waking up due to suffocation, but there was still occasional nasal itching and sneezing. His appetite and sleep were good, and his bowel movements were normal.

[0112] Physical examination: The nasal septum is basically intact, the lower nails are swollen and light in color, and no obvious secretions are found in the nasal passages. There is no congestion in the pharyngeal mucosa, and the tonsils are enlarged to the first degree, light red in color, without pus spots and secretions. The patient was asked to continue taking 250 grams of the paste prescription, once a day, 15g at a time, until it is finished. After two weeks, the third visit showed that the symptoms were greatly relieved compared with the previous symptoms, the nasal itching and sneezing frequency were reduced, and snoring and mouth breathing occurred 1 to 2 times a week.

[0113] Clinical case 2: Tan XX, female, 4 years old, visited the hospital on March 14, 2024. She had been snoring with open mouth breathing for 1 month, about 3 to 4 times a week, without apnea or waking up due to suffocation, and no daytime sleepiness, inattention, memory loss, etc. Her height, weight and intelligence were consistent with the normal level of her peers. She had a good appetite and sleep, normal urination, and loose stools.

[0114] Physical examination: The nasal septum was basically centered, the two inferior turbinates were swollen and light in color, and no obvious secretions were found in the nasal passages. The pharyngeal mucosa was not congested, and the two tonsils were not large, light red in color, and had no pus spots or secretions.

[0115] Nasal endoscopy showed: adenoids blocked 40% of the posterior nostril. The tongue was pale red, the coating was thin and white, and the pulse was thin.

[0116] TCM diagnosis: snoring, lung and spleen deficiency syndrome. Western medicine diagnosis: mouth breathing.

[0117] Take 250 grams of the ointment obtained in Example 1, mixed with warm water, 20 grams once a day for the first week, and 20 grams once a day after the second week, until it is finished.

[0118] On April 12, 2024, the patient was followed up with a follow-up visit. Snoring and mouth breathing during sleep occurred 1 to 2 times a week, but did not occur most of the time.

[0119] Clinical case 3: Wen XX, female, 3 years old, snored with open mouth breathing during sleep for 3 weeks. She was admitted to the hospital on January 30, 2024. She had 2-3 episodes a week, no apnea or waking up due to suffocation, no daytime sleepiness, inattention, memory loss, etc., and her height, weight and intelligence were consistent with the normal level of her peers. She had a normal appetite, good sleep, normal urination, and loose stools.

[0120] Physical examination: The nasal septum was basically centered, the inferior turbinates were swollen and light in color, and no obvious secretions were found in the nasal passages. The pharyngeal mucosa was not congested, and the tonsils were enlarged to the first degree and light red in color.

[0121] Nasal endoscopy showed: adenoids blocked 60% of the posterior nostril. Pale red tongue, thin white fur, weak pulse

[0122] TCM diagnosis: snoring, spleen deficiency and dampness syndrome. Western medicine diagnosis: mouth breathing.

[0123] Take 250 grams of the ointment obtained in Example 1, add warm water and take 15 grams once in the first week, twice a day; after the second week, take 15 grams once a day, until it is finished.

[0124] On February 22, 2024, the patient was re-examined. The physical examination was basically the same as before, and the symptoms of snoring and mouth breathing during sleep basically disappeared. The patient was advised to continue taking 250 grams of the paste prescription, 10 grams at a time with warm water, once a day. There was no recurrence of symptoms at the third visit.

[0125] Clinical case 4: Gao XX, male, 5 years old, snored repeatedly with open mouth breathing during sleep for half a year, and was diagnosed on February 6, 2024. The episodes occurred 3 to 4 times a week, without apnea or waking up due to suffocation, and occasional inattention. He had undergone adenoidectomy, and the symptoms recurred after the operation. His appetite was normal, his sleep was good, and his bowel movements were regular.

[0126] Physical examination: Nasal septum is basically centered, bilateral inferior turbinate is swollen and light in color, yellow discharge is seen in the common nasal passage. Bilateral tonsils are III degree enlarged and light red in color. Tongue is light red, with thin white fur, and pulse is thready and rapid.

[0127] TCM diagnosis: snoring, spleen deficiency and dampness syndrome. Western medicine diagnosis: mouth breathing.

[0128] Take 250g of the ointment obtained in Example 1, add warm water and take 15g once in the first week, twice a day; 15g once after the second week, once a day, until it is finished. After three weeks, the second visit showed that snoring with open mouth breathing during sleep improved, and the attack occurred 1 to 2 times a week.

[0129] Clinical case 5: Yan XX, female, 5 years old, had repeated snoring and mouth breathing during sleep for more than 2 years, dry mouth, and was diagnosed on January 31, 2024. Initially, it occurred 2 to 3 times a week, and then developed into daily attacks. There was no apnea or suffocation, and no daytime sleepiness, inattention, memory loss, etc. were found. The height, weight and intelligence were consistent with the normal level of peers. Appetite was normal, sleep was good, urination was normal, and the stool was rotten.

[0130] Physical examination: The nasal septum was basically centered, the inferior turbinates were swollen and light in color, and no obvious secretions were found in the nasal passages. The pharyngeal mucosa was not congested, and the tonsils were enlarged to the first degree and light red in color.

[0131] Nasal endoscopy showed: adenoids blocked 70% of the posterior nostril. The tongue was pale red, the coating was thin and white, and the pulse was thin and rapid.

[0132] TCM diagnosis: snoring, spleen deficiency and dampness syndrome. Western medicine diagnosis: mouth breathing.

[0133] Take 250g of the ointment obtained in Example 1, add warm water and take 15g once in the first week, twice a day; 15g once after the second week, once a day, until it is finished. After two weeks, the second visit showed that the symptoms of snoring with open mouth breathing during sleep were completely relieved, and no recurrence was observed.

[0134] Clinical case 6: Xie XX, female, 6 years old, 3 weeks after adenoidectomy, 1 week of mouth breathing, occasional snoring during sleep, came to the hospital on February 20, 2024. The episodes occurred about 2 to 3 times a week, with no other accompanying symptoms.

[0135] Physical examination: The nasal septum is in the middle, the two inferior turbinates are enlarged and pale, and white secretions are seen in each nasal passage. The pharynx is slightly congested, the two tonsils are not large, and the lymph follicles on the posterior pharyngeal wall are hyperplastic. The tongue is light red, the coating is white, and the pulse is thin and rapid.

[0136] TCM diagnosis: snoring, lung and spleen deficiency syndrome. Western medicine diagnosis: mouth breathing.

[0137] Take 250g of the ointment obtained in Example 1, add warm water and take 20g once in the first week, twice a day; after the second week, take 15g once a day, once a day, until it is finished. After two weeks, the second visit showed that the symptoms of snoring and mouth breathing during sleep were completely relieved, and no recurrence was observed.

[0138] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating pediatric snoring, characterized in that: The invention comprises the following raw materials by weight: 40-60 parts of Atractylodes macrocephala, 80-100 parts of Dioscorea opposita, 20-50 parts of Gallus gallus domesticus, 80-100 parts of Pseudostellaria pseudoginseng, 20-40 parts of Acorus calamus, 20-50 parts of Jianqu, 40-60 parts of Angelica dahurica, 30-50 parts of Platycodon grandiflorum, 20-40 parts of Scrophularia ningpoensis, 20-55 parts of Prunella vulgaris, 80-100 parts of Prunella vulgaris, 15-35 parts of Citrus reticulata, 20-30 parts of Pinellia ternata, 15-30 parts of Radix Achyranthis Bidentatae, 30-50 parts of Poria cocos, 70-100 parts of Lotus seeds, 45-65 parts of malt, 25-35 parts of Hawthorn fruit and 80-110 parts of Maltose.

2. The Chinese medicine composition for treating pediatric snoring according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 45-55 parts of Atractylodes macrocephala, 90-100 parts of Dioscorea opposita, 30-45 parts of Gallus gallus domesticus, 95-100 parts of Pseudostellaria pseudoginseng, 35-40 parts of Acorus calamus, 40-50 parts of Jianqu, 45-55 parts of Angelica dahurica, 35-45 parts of Platycodon grandiflorum, 25-35 parts of Scrophularia ningpoensis, 45-55 parts of Prunella vulgaris, 90-100 parts of Trichosanthes kirilowii, 15-20 parts of Citrus reticulatae, 25-30 parts of Pinellia ternata, 20-30 parts of Radix Achyranthis Bidentatae, 45-50 parts of Poria cocos, 80-95 parts of Lotus seeds, 45-50 parts of malt, 25-30 parts of Hawthorn fructus and 80-100 parts of maltose.

3. The Chinese medicine composition for treating pediatric snoring according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 50 parts of Atractylodes macrocephala, 100 parts of yam, 40 parts of chicken gizzard lining, 100 parts of Pseudostellaria heterophylla, 40 parts of Acorus calamus, 50 parts of Jianqu, 50 parts of Angelica dahurica, 40 parts of Platycodon grandiflorum, 30 parts of Scrophularia ningpoensis, 50 parts of Prunella vulgaris, 100 parts of Prunella vulgaris, 20 parts of dried tangerine peel, 30 parts of Pinellia ternata, 25 parts of Radix Achyranthis Bidentatae, 50 parts of Poria cocos, 90 parts of lotus seeds, 50 parts of malt, 30 parts of pure hawthorn, and 90 parts of maltose.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating pediatric snoring.

5. The application according to claim 4, characterized in that: The pediatric snoring includes pediatric adenoids and tonsil hypertrophy.

6. A drug for treating pediatric snoring, characterized in that: A Chinese medicine composition for treating pediatric snoring according to any one of claims 1 to 3 and pharmaceutically acceptable excipients; The auxiliary materials include at least one or more of the following: disintegrants, emulsifiers, fillers, flavoring agents, wetting agents, adhesives, absorption promoters, colorants and solubilizers.

7. The drug for treating pediatric snoring according to claim 6, characterized in that: The dosage form of the drug includes one or more of the following: ointment, decoction, granules, pills, capsules, tablets, mixtures, suspensions, powders or oral solutions.

8. The drug for treating pediatric snoring according to claim 6, characterized in that: The medicine is a medicine for improving snoring during sleep, mouth breathing, abnormal sleep breathing, enuresis, decreased attention, hyperactivity, drowsiness, abnormal behavior and mood, and hypertrophy of adenoids and tonsils.

9. A method for preparing a drug for treating pediatric snoring according to any one of claims 6 to 8, characterized in that: When the medicine is a traditional Chinese medicine ointment, its preparation method is as follows: Step 1, weigh all the remaining raw materials except maltose according to weight ratio, add purified water and soak; Step 2, extracting the raw material drug three times, collecting the extract and filtering; Step three, add maltose after filtering and concentrate to obtain.

10. The method for preparing a drug for treating pediatric snoring according to claim 9, characterized in that: In the step 1, add 6 times the amount of water as the raw material and soak for at least 12 hours; The extraction process in step 2 includes: collecting the medicinal liquid after 1.5 hours of first decoction, adding 6 times the amount of water of the total raw materials for decoction for 1 hour and collecting the medicinal liquid, adding 3 times the amount of water of the total raw materials for decoction for the third time and decoct for 1 hour and collecting the medicinal liquid, and combining the three extraction filtrates and filtering.

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