Traditional Chinese medicine composition for treating novel coronavirus infection

Abstract

The invention relates to a traditional Chinese medicine composition for treating novel coronavirus infection, which is characterized by being prepared from the following traditional Chinese medicinal materials in parts by weight: 8-12 parts of radix asteris, 8-12 parts of honey-fried flos farfarae, 8-12 parts of herba epimedii, 8-12 parts of salted radix morindae officinalis, 4-8 parts of rhizoma curculiginis, 4-8 parts of herba ephedrae, 8-12 parts of cassia twig, 8-12 parts of radix paeoniae alba, 4-8 parts of rhizoma zingiberis, 1-3 parts of herba asari, 8-12 parts of rhizoma pinellinae praeparata and 4-8 parts of liquorice root. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 4-8 parts of vinegar schisandra chinensis, 8-12 parts of schizonepeta, 4-8 parts of radix angelicae, 4-8 parts of magnolia flower, 4-8 parts of fried cocklebur fruit, 8-12 parts of earthworm, 8-12 parts of radix peucedani, 4-8 parts of platycodon grandiflorum, 8-12 parts of rhizoma phragmitis, 8-12 parts of Chinese waxgourd seed, 8-12 parts of coix seed, 4-8 parts of peach kernel, 12-18 parts of fried malt and 8-12 parts of medicated leaven. The traditional Chinese medicine composition can be used for treating white lung caused by infection of novel coronavirus, and has the characteristics of sufficient medicinal material sources, low cost and relatively high safety.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and specifically is a traditional Chinese medicine composition for treating novel coronavirus infection, especially white lung infection. Background Art

[0002] Common signs of coronavirus infection include respiratory symptoms, fever, cough, shortness of breath and breathing difficulties. Some severely infected patients may also develop pulmonary fibrosis, also known as white lungs, which means that the disease has developed to a more serious stage. White lungs in patients mean that hypoxia has worsened and there is a risk of poor prognosis.

[0003] At present, relevant researchers have proposed some Chinese medicine compositions for treating pneumonia caused by novel coronavirus infection. Although they have a certain effect on novel pneumonia, most compositions can only be used for the prevention, mild symptoms and recovery stages of novel coronavirus infection, and have not shown the efficacy of treating white lungs infected with novel coronavirus, and some of the medicinal materials used in these schemes are toxic or rare and difficult to obtain. For example, patent publication number CN111569022A relates to a Chinese medicine composition, in which the medicinal materials such as Cordyceps sinensis, Ganoderma lucidum, and Rhodiola rosea contained are rare, expensive, difficult to obtain, and difficult to promote and apply. Chinese medicine compositions such as patent publication numbers CN111202802A and CN111388582A are mostly used to treat mild novel coronavirus infection or to prevent novel coronavirus infection, and are not suitable for the treatment of white lungs infected with novel coronavirus. The ingredients such as Aconite, Corydalis cyrtomium, and Smilax glabra contained in the Chinese medicine compositions involved in patent publication numbers CN111110819A and CN112999323A have certain toxicity, and their safety needs to be discussed. Summary of the invention

[0004] 1. Technical issues to be resolved In order to solve the problems existing in the prior art, the inventor hopes to propose a traditional Chinese medicine composition for treating novel coronavirus infection, which can be used to treat white lung caused by novel coronavirus infection and has the characteristics of sufficient source of medicinal materials, low cost and high safety, to make up for the technical problems that the traditional Chinese medicine composition in the prior art can only be used for the prevention, mild symptoms and recovery stages of novel coronavirus infection, is ineffective or has poor effect on white lung, medicinal materials are not easy to obtain, and some medicinal materials are toxic.

[0005] (II) Technical solution A traditional Chinese medicine composition for treating novel coronavirus infection, which is made of the following traditional Chinese medicinal materials in parts by weight: 8-12 parts of aster, 8-12 parts of honey coltsfoot flower, 8-12 parts of epimedium, 8-12 parts of salt Morinda officinalis, 4-8 parts of curculigo, 4-8 parts of ephedra, 8-12 parts of cassia twig, 8-12 parts of white peony root, 4-8 parts of dried ginger, 1-3 parts of asarum, 8-12 parts of French pinellia, 4-8 parts of licorice, 4-8 parts of vinegar schisandra, 8-12 parts of schizonepeta, 4-8 parts of angelica, 4-8 parts of magnolia flower, 4-8 parts of stir-fried Xanthium sibiricum, 8-12 parts of earthworm, 8-12 parts of peucedanum, 4-8 parts of platycodon, 8-12 parts of reed root, 8-12 parts of wax gourd seeds, 8-12 parts of coix seeds, 4-8 parts of peach kernel, 12-18 parts of stir-fried malt, and 8-12 parts of Shenqu.

[0006] Preferably, the Chinese medicine composition is made of the following Chinese medicinal materials in parts by weight: 12 parts of Aster, 12 parts of honey coltsfoot flower, 12 parts of epimedium, 12 parts of salt Morinda officinalis, 4 parts of Curculigo, 4 parts of Ephedra, 8 parts of cinnamon twig, 8 parts of white peony root, 4 parts of dried ginger, 1 part of asarum, 8 parts of French pinellia, 4 parts of liquorice, 4 parts of vinegar Schisandra, 8 parts of Schizonepeta, 4 parts of Angelica dahurica, 4 parts of magnolia flower, 8 parts of stir-fried Xanthium sibiricum, 12 parts of earthworm, 12 parts of Peucedanum, 8 parts of Platycodon, 12 parts of Phragmites australis, 12 parts of wax gourd seeds, 12 parts of Coix seeds, 8 parts of peach kernels, 18 parts of stir-fried malt, 12 parts of Shenqu; or, 9 parts of Aster, 9 parts of honey coltsfoot flower, 9 parts of epimedium, 9 parts of salt Morinda officinalis, 5 parts of Curculigo, 5 parts of Ephedra, 9 parts of cinnamon twig, 9 parts of white peony root, 5 parts of dried ginger, 2 parts of asarum, 9 parts of French pinellia, 5 parts of liquorice, 5 parts of vinegar Schisandra, 9 parts of Schizonepeta, 5 parts of Angelica dahurica, 5 parts of magnolia flower, 5 parts of stir-fried Xanthium sibiricum, 9 parts of earthworm, 9 parts of Peucedanum, 5 parts of Platycodon, 9 parts of Phragmites australis, 9 parts of wax gourd seeds, 9 parts of Coix seeds, 5 parts of peach kernels, 14 parts of stir-fried malt, 9 parts of Shenqu; or, 8 parts of Aster, 8 parts of honey coltsfoot flower, 8 parts of epimedium, 8 parts of salt Morinda officinalis, 4 parts of Curculigo, 6 parts of Ephedra, 10 parts of cinnamon twig, 10 parts of white peony root, 6 parts of dried ginger, 3 parts of asarum, 10 parts of French pinellia, 6 parts of liquorice, 6 parts of vinegar Schisandra, 8 parts of Schizonepeta, 4 parts of Angelica dahurica, 4 parts of magnolia flower, 4 parts of stir-fried Xanthium sibiricum, 8 parts of earthworm, 8 parts of Peucedanum, 4 parts of Platycodon, 8 parts of Phragmites australis, 8 parts of wax gourd seeds, 8 parts of Coix seeds, 4 parts of peach kernels, 15 parts of stir-fried malt, 10 parts of Shenqu; or, 12 parts of Aster, 12 parts of honey coltsfoot flower, 12 parts of Epimedium, 12 parts of salt Morinda officinalis, 8 parts of Curculigo, 4 parts of Ephedra, 8 parts of Cinnamomum, 8 parts of White Peony Root, 4 parts of Dry Ginger, 3 parts of Asarum, 8 parts of French Pinellia, 4 parts of Licorice, 4 parts of Vinegar Schisandra, 8 parts of Schizonepeta, 4 parts of Angelica dahurica, 8 parts of Flos Magnoliae, 8 parts of stir-fried Fructus Xanthii, 12 parts of Pheretima, 12 parts of Peucedanum, 8 parts of Platycodon, 12 parts of Phragmites australis, 12 parts of Wax Melon Seeds, 12 parts of Coix Seeds, 8 parts of Semen Prunuse, 17 parts of stir-fried Malt, 12 parts of Shenqu.

[0007] Preferably, the Chinese medicine composition is a capsule, Chinese medicine granules, Chinese medicine ointment, Chinese medicine pills or decoction.

[0008] Preferably, the preparation method of the capsule is as follows: after cleaning and drying each medicinal material, chopping it into pieces, putting it into a casserole for decoction, filtering, harvesting the filtrate, concentrating the filtrate into a paste, drying, sterilizing, grinding, passing through a 100-200 mesh sieve, and then putting it into capsules; Preferably, the preparation method of the Chinese medicine granules is: after cleaning and drying each medicinal material, chopping it into pieces, putting it into a casserole for decoction, filtering, harvesting the filtrate, concentrating the filtrate into an extract, mixing the extract with a flavoring agent and an excipient, and then granulating; the excipient is dextrin or starch; Preferably, the preparation method of the Chinese medicine pills is: after cleaning and drying the medicinal materials, chopping them into pieces, putting them into a casserole for decoction, filtering, harvesting the filtrate, concentrating the filtrate to a fluid extract with a relative density of 1.1-1.2, mixing the auxiliary materials, stirring evenly and making the pills; the auxiliary materials are water, honey, wine or vinegar; Preferably, the preparation method of the Chinese medicine ointment is: after cleaning and drying the medicinal materials, pounding them into powder, putting them into a casserole for decoction, filtering, harvesting the filtrate, adding 10% of auxiliary materials to the filtrate, mixing, and then concentrating it into a thick paste with a relative density of 1.5-1.6 to obtain the ointment; the auxiliary materials are donkey-hide gelatin, sucrose or honey; Preferably, the preparation method of the decoction is: after cleaning, drying and chopping each medicinal material, soaking the treated raw materials in water for 30-60 minutes, boiling over high heat, decocting for the first time at 80-100°C for 10-15 minutes, pouring out 1 / 3-1 / 2 of the medicinal liquid; then adding water to the original volume, decocting for the second time for 10-15 minutes, the decoction temperature range is 60-80°C, and then pouring out 1 / 3-1 / 2 of the medicinal liquid, mixing the two medicinal liquids to obtain the decoction.

[0009] Preferably, in the preparation process of the above dosage forms of the Chinese medicine composition, the amount of water added during decoction is enough to cover all the Chinese medicinal materials by 3-5 cm; the medicinal materials are first fully absorbed by water and then put into the casserole, and water is added until all the Chinese medicinal materials are covered by 3-5 cm.

[0010] In the present invention, the pretreatment and processing methods of various medicinal materials are detailed in the "Chinese Pharmacopoeia 2010 Edition".

[0011] The medicinal materials that need to be pre-processed or pre-processed are as follows: Honey coltsfoot: Honey coltsfoot is processed by special techniques, while raw coltsfoot is not processed, tends to resolve phlegm and relieve cough and has poor efficacy; after coltsfoot is processed by honey, the efficacy of moistening lungs and relieving cough is significantly enhanced. Expectorant cough relief focuses on promoting the dilution and discharge of sputum, thereby relieving cough, which is suitable for coughs caused by phlegm or phlegm heat, such as yellow sputum, sticky sputum that is difficult to cough up. Lung moistening and cough relief focuses on nourishing lung yin, which is suitable for dry cough without sputum or less sputum, as well as cough caused by lung heat and lung dryness. By moisturizing the lungs, relieving dryness and relieving dry cough, it is suitable for dry cough, itchy throat, hoarseness and other symptoms caused by insufficient lung yin or dry evil invading the lungs. In the early stage of new coronavirus infection, dry cough may be the main symptom, and honey coltsfoot can moisturize the lung inflammation caused by the virus; as the disease progresses, symptoms of excessive sputum may appear, and expectorant cough relief can help sputum discharge and relieve breathing difficulties.

[0012] Salted Morinda officinalis: Salted Morinda officinalis is made by steaming thoroughly with salt, removing the pith while hot, cutting and drying. After processing, the toxicity of Morinda officinalis is weakened, and its kidney-tonifying properties are enhanced, which helps to support the positive energy and improve the patient's own immunity. The kidney is the foundation of the body's innate nature. The strength of the kidney qi directly affects the body's resistance. By tonifying the kidney, pneumonia patients can better resist pathogens and promote recovery. The kidney is responsible for receiving qi. Tonifying the kidney can consolidate the lower yuan and assist the lungs in completing respiratory functions. It has a certain auxiliary improvement effect on symptoms such as shortness of breath and wheezing caused by lung diseases. Pneumonia patients are often accompanied by symptoms such as sputum and edema, which is related to the failure of the lungs to descend and the kidneys to control water. Tonifying the kidney can strengthen the kidney's gasification function, promote the normal metabolism of water, and facilitate the discharge of sputum and the disappearance of edema.

[0013] French Pinellia: French Pinellia is processed through licorice and lime using a special process. After processing, the toxicity of the Pinellia is reduced and its dryness is milder. It also has the effect of harmonizing the spleen and stomach, helping to improve drug absorption rate, enhance appetite, nutritional supplements, relieve stomach discomfort caused by pneumonia, and then help the positive energy and improve the patient's own immunity.

[0014] Schisandra chinensis in vinegar: Schisandra chinensis in vinegar is Schisandra chinensis that has been processed with rice vinegar. After being processed with vinegar, its sour and astringent properties are enhanced, which can play the role of astringing the lungs and relieving cough (by enhancing the astringent function of the lungs, reducing cough reflex and promoting respiratory comfort), promoting body fluid and moistening dryness (can promote the production of body fluids in the body, and can relieve dry throat and thirst caused by lung heat and body fluid damage), astringent to the intestines and stop diarrhea (helps stop diarrhea, stabilizes intestinal function, and avoids fluid loss and nutrient consumption caused by diarrhea), strengthen physical fitness (long-term coughing and fever consume physical strength, sour and astringent medicinal materials can often nourish the body, enhance the body's resistance, and indirectly promote recovery from pneumonia) and improve the body's overall disease resistance (nourish the body, enhance the body's resistance, and promote recovery from pneumonia).

[0015] Stir-fried Xanthium sibiricum: Stir-fried Xanthium sibiricum is processed using special techniques, while raw Xanthium sibiricum has not been processed; the toxicity of Xanthium sibiricum is reduced after processing, which enhances its effect of dispelling wind and cold; and dispelling wind and cold can dredge wind and cold (induce sweating and relieve exterior symptoms, so that the wind and cold evil can be expelled with sweat, dredge blocked lung qi, and thus relieve these symptoms), warm the lungs and transform phlegm (warm the lungs and dispel cold, promote the dissipation of cold phlegm, and improve problems such as cough and excessive sputum), enhance the body's defense (can stimulate the body's positive energy and fight against exogenous pathogens) and prevent complications (prevent the disease from further developing to more serious stages such as phlegm-heat blocking the lungs, and reduce the occurrence of complications, such as preventing symptoms such as high fever and wheezing caused by cold evil turning into heat), etc.

[0016] Roasted malt: Roasted malt is malt that has been processed by special techniques, while raw malt has not been processed. After being roasted, the malt has a stronger effect in digesting food and relieving stagnation. Roasted malt helps to strengthen the body constitution (improve the patient's digestive function, increase appetite, promote nutrient absorption, thereby strengthening the body constitution and accelerating recovery), reduce complications (reduce abdominal distension, diarrhea, etc.), promote drug absorption (high absorption efficiency of drugs needed to treat pneumonia, making the treatment effect better) and harmonize the medicinal properties (used as an adjuvant to harmonize the medicinal properties of the whole prescription, avoid the obstruction of the middle-jiao qi due to the excessive nourishment of the drug, and ensure the smooth implementation of the treatment plan).

[0017] (III) Beneficial effects Compared with the prior art, the inventors took into account that the white lung caused by the new coronavirus is already evil and the body is weak, the lungs are disturbed by evil, and the kidney yang is damaged when developing the Chinese medicine composition of the formula of the present invention. Therefore, the Chinese medicine composition of the present invention uses Aster and Honey Coltsfoot as the main medicines, and the main medicines Aster and Honey Coltsfoot warm the lungs and resolve phlegm, moisten the lungs and descend qi; Epimedium, Salt Morinda officinalis, and Curculigo are used as ministerial medicines, and the ministerial medicines Epimedium, Salt Morinda officinalis, and Curculigo warm and nourish the kidney yang, dispel cold and dampness, and the monarch and ministers work together to warm and assist the lungs and kidneys, strengthen the body and eliminate evil; and Ephedra, Cassia twig, White Peony Root, Dry Ginger, Asarum, Pinellia ternata, Licorice, Vinegar Schisandra, Schizonepeta, Angelica dahurica, Magnolia Flower, Stir-fried Xanthium sibiricum, Pheretima, Peucedanum, Phragmites australis, Wax Gourd Seed, Coix Seed, Peach Kernel, Stir-fried Malt, and Shenqu are used as adjuvants. Among the adjuvants, ephedra and cinnamon twig warm the lungs and dispel cold, and are matched with schizonepeta, angelica dahurica, magnolia flower, and fried Xanthium sibiricum to strengthen the effects of dispelling wind and cold, removing dampness and opening the orifices. The pungent and warming dried ginger, the pungent and dispersing asarum, and the bitter and dry French pinellia are used to warm the lungs and transform fluid, resolve phlegm and reduce adverse reactions. Earthworm and peucedanum are used to clear the lungs and relieve coughs, and to promote and descend in ensemble, so as to suit the nature of the lungs. Patients with novel coronavirus infection, especially those with white lung, are prone to phlegm and blood stasis. Phragmites australis, wax gourd seeds, and coix seeds can resolve phlegm and promote diuresis, and are matched with peach kernels to promote blood circulation, and treat phlegm and blood stasis in the lungs. White peony root, vinegar schisandra chinensis, and glycyrrhizic acid and sweet are used as counter-adjuvants. The lungs are delicate organs, so they should be prevented from damaging the lung yin. Finally, Platycodon grandiflorum is used as the guiding drug, which is the boat of the lungs and guides the medicine into the lungs. The above-mentioned formula achieves the effect of treating the lungs and kidneys together, warming the lungs and kidneys together, strengthening the body and eliminating evil, and dispelling cold, removing dampness, and resolving phlegm. Since the novel coronavirus infection, especially the white lung patients, often have phlegm and dampness blockage, which affects the spleen's function, we add roasted malt and Shenqu to eliminate the accumulation and invigorate the spleen, so as to eliminate the source of phlegm. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 These are lung CT images of typical treatment cases 1-3 before and after treatment.

[0019] Figure 2 These are lung CT images of typical cases 4-6 before and after treatment. DETAILED DESCRIPTION

[0020] In order to better explain the present invention and facilitate understanding, the present invention is described in detail below through specific implementation modes in conjunction with the accompanying drawings.

[0021] The present invention provides a traditional Chinese medicine composition for treating novel coronavirus infection. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 8-12 parts of aster, 8-12 parts of honey coltsfoot flower, 8-12 parts of epimedium, 8-12 parts of salt Morinda officinalis, 4-8 parts of curculigo, 4-8 parts of ephedra, 8-12 parts of cassia twig, 8-12 parts of white peony root, 4-8 parts of dried ginger, 1-3 parts of asarum, 8-12 parts of French pinellia, 4-8 parts of licorice, 4-8 parts of vinegar schisandra, 8-12 parts of schizonepeta, 4-8 parts of angelica, 4-8 parts of magnolia flower, 4-8 parts of stir-fried xanthium sibiricum fruit, 8-12 parts of earthworm, 8-12 parts of peucedanum, 4-8 parts of platycodon, 8-12 parts of reed root, 8-12 parts of wax gourd seeds, 8-12 parts of coix seeds, 4-8 parts of peach kernel, 12-18 parts of stir-fried malt, and 8-12 parts of Shenqu.

[0022] The prescription of the traditional Chinese medicine composition of the present invention is as follows: the main drugs are aster and honey coltsfoot flower; the ministerial drugs are epimedium, salt Morinda officinalis and curculigo; the adjuvant drugs are ephedra, cinnamon twig, white peony root, dried ginger, asarum, French pinellia, liquorice, vinegar schisandra, schizonepeta, angelica dahurica, magnolia flower, stir-fried xanthium sibiricum, earthworm, peucedanum peucedanum, reed root, wax gourd seed, coix seed, peach kernel, stir-fried malt and Shenqu; the guiding drug is platycodon.

[0023] The prescription of the present invention is derived from the classic prescriptions Xiaoqinglong Decoction, Xanthium sibiricum Powder, and Weijing Decoction, etc., with reference to the classic Chinese medicine works "Treatise on Febrile and Miscellaneous Diseases", "Secrets of the Imperial Pharmacy" of the Tang Dynasty, and "Jisheng Prescriptions" of the Song Dynasty. Xiaoqinglong Decoction is mainly used to warm the lungs and dispel cold, dissolve phlegm and relieve cough; Xanthium sibiricum Powder is mainly used to dispel wind and cold, clear the channels and dissolve dampness; Weijing Decoction is mainly used to clear the lungs and dissolve phlegm, remove blood stasis and discharge pus.

[0024] The functions of the above components in the Chinese medicine composition of the present invention are as follows: Aster: It is bitter and warm in nature. It is used to treat cough, shortness of breath, cold and heat in the chest, remove poison, paralysis, and soothe the five internal organs. It can warm the lungs and resolve phlegm, and it also has the function of nourishing the lungs. Pharmacologically, it has antitussive, expectorant, antibacterial and antiviral effects.

[0025] Coltsfoot: It is pungent, warm and moistening in nature. It is used to treat cough, shortness of breath, wheezing, throat numbness, epilepsy, cold and heat evil spirits. It can warm the lungs and resolve phlegm while nourishing the lung yin. It has antitussive, expectorant and respiratory effects. Aster and coltsfoot are used together to warm the lungs. After coltsfoot is made into honey, its effect of moistening the lungs and relieving cough is significantly enhanced.

[0026] Epimedium: Also known as Xianlingpi, it is pungent in nature and warm in taste. It nourishes the kidney and strengthens yang, dispels rheumatism and promotes diuresis.

[0027] Curculigo: The combination with Epimedium is called Erxian, which can replenish the life gate and invigorate the yang. In addition, Morinda officinalis can warm the kidney and replenish the essence. The three medicines together help to make up for the deficiency of kidney yang, strengthen the body and eliminate evil.

[0028] Salt Morinda officinalis: Salt Morinda officinalis is sweet and slightly warm, and belongs to the liver and kidney meridians. It can replenish yang and essence, replenish kidney yang, nourish the liver and kidneys, and strengthen the tendons and bones. In addition, it may also have modern pharmacological effects such as improving immunity, anti-fatigue, hypoxia resistance and anti-inflammatory. The strength of kidney qi directly affects the body's resistance. By replenishing the kidney, it can help pneumonia patients better resist pathogens and promote recovery.

[0029] Ephedra: It can relieve the symptoms of wind-cold syndrome, such as aversion to cold and fever, headache and body pain, wheezing without sweating, and can help relieve respiratory diseases such as bronchial asthma and acute bronchitis. It can help relieve fever, cough, chest tightness, shortness of breath and other symptoms after infection with the new coronavirus.

[0030] Cinnamon twig: ① Relieve the exterior and dispel cold: It can induce sweating and dissolve muscles, dispel the cold evil on the surface of the muscles, and is suitable for treating wind-cold exterior symptoms, such as aversion to cold, fever, headache, body pain, etc. ② Harmonize the body's Ying and Wei: Cinnamon twig can harmonize the body's Ying Qi (the Yin Qi that nourishes the whole body) and Wei Qi (the Yang Qi that protects the body's surface). ③ It has a good effect on symptoms such as spontaneous sweating, night sweats, aversion to wind, and fear of cold caused by disharmony between Ying and Wei. ④ For those patients who show symptoms of wind-cold exterior deficiency, such as mild fever, headache, body pain, fear of wind, sweating, etc., Cinnamon twig decoction may help relieve these symptoms, enhance the body's resistance, and promote recovery through its effects of relieving the exterior and dispersing cold, and harmonizing Ying and Wei.

[0031] White peony root: White peony root can astringe yin fluid, reduce abnormal sweating, and relieve cramp pain in the limbs. For patients showing symptoms of liver qi disharmony, blood deficiency, or insufficient yin fluid, white peony root may be used to help harmonize qi and blood, nourish yin fluid, and thus indirectly promote the patient's overall recovery.

[0032] Dried ginger: ①Warming the middle and dispelling cold: Dried ginger can warm the middle jiao and dispel the cold in the body. ②Warming the lungs and dissolving phlegm: For cases of lung cold cough, cough with thin sputum, etc., dried ginger can help dissolve cold phlegm, relieve cough and shortness of breath, and relieve cold and dampness symptoms caused by viruses, such as body chills, gastrointestinal discomfort (such as nausea, vomiting, diarrhea), mild respiratory symptoms (such as cough), etc., especially in patients in the early stages of the disease or with cold and dampness.

[0033] Asarum: ① Dispelling cold and dispersing the exterior: It can help dispel the wind and cold on the body surface, and relieve symptoms such as headaches and body pain caused by colds. ② Promoting lung function and relieving asthma: It is suitable for treating respiratory diseases such as coughs and asthma, and can relieve lung inflammation and excessive mucus. ③ Analgesic effect: It has a certain relieving effect on headaches, toothaches, body pains, etc. ④ Antipyretic effect: It can help lower body temperature and is used to treat fever. Expelling wind and dampness: It is used to treat joint pain caused by wind, cold and dampness, and helps improve the patient's clinical symptoms such as fever, cough, shortness of breath, etc., and may have certain anti-inflammatory and immunomodulatory effects.

[0034] Banxia: It can dry dampness and resolve phlegm, relieve adverse symptoms and stop vomiting, and eliminate lumps and resolve lumps. It can improve the symptoms caused by phlegm and dampness blocking the lungs, such as chest tightness and nausea. Especially when patients have symptoms such as sputum, cough, and chest tightness, Banxia can help alleviate a series of symptoms caused by phlegm and dampness in patients with pneumonia through its effect of drying dampness and resolving phlegm, such as reducing phlegm secretion, relieving cough, and improving gastrointestinal discomfort caused by phlegm and dampness stagnation, such as loss of appetite and nausea. In addition, it may also help relieve other symptoms caused by the condition, such as chest tightness, thereby improving the overall comfort of patients.

[0035] Licorice: used to relieve symptoms, including: ① Antitussive and expectorant, relieve cough and remove sputum caused by viral infection. ② Anti-inflammatory and immune regulation: Glycyrrhizin (liquiritin) in licorice has anti-inflammatory effects, can reduce the inflammatory response caused by viruses, regulate the function of the immune system, and help control the progression of the disease. ③ Relieve respiratory discomfort: Licorice's soothing effect on the respiratory tract may help alleviate tracheal and bronchial inflammation caused by viruses and improve respiratory conditions. ④ Auxiliary treatment: Licorice can also replenish qi and tonify the middle, clear away heat and detoxify, and may be beneficial for the physical recovery and auxiliary treatment of some patients.

[0036] Vinegar Schisandra: It has the effects of astringency, invigorating Qi and promoting body fluid, calming the mind and tonifying the kidney. Its role focuses on regulating body functions and enhancing certain aspects of the body, such as improving respiratory symptoms, regulating the immune system and nervous system functions, assisting in improving coughs, night sweats, insomnia, etc., helping to strengthen the body and promote the recovery process.

[0037] Schizonepeta: Its main effects include dispelling cold and relieving exterior pathogens. It can be used to treat colds and headaches, and to help relieve some symptoms such as fever and cough, or as an auxiliary means to enhance immunity.

[0038] Angelica dahurica: It is pungent and warm in nature, and has the effects of dispelling cold, clearing the orifices and relieving pain, drying dampness and stopping leukorrhea, and reducing swelling and draining pus. In traditional Chinese medicine theory, Angelica dahurica can be used to treat wind-cold symptoms, headaches (especially Yangming headaches), toothaches, nasal congestion and runny nose (such as sinusitis), cold-damp leukorrhea, and sores and swelling.

[0039] Magnolia flower: It is warm in nature and pungent in taste. It belongs to the lung and stomach meridians. It has good wind-dispelling and orifice-opening effects. It is used to treat headaches, sinusitis (similar to rhinitis in modern medicine), nasal congestion and other symptoms. It can promote the smooth flow of the respiratory tract and help relieve some respiratory symptoms of COVID-19 patients, such as nasal congestion.

[0040] Fried Xanthium sibiricum: used to dispel wind and cold, clear the nasal passages, and eliminate rheumatism. It is suitable for symptoms such as nasal congestion, headache, and rheumatic joint pain caused by colds. It has certain anti-inflammatory and analgesic effects.

[0041] Earthworm: It has the effects of clearing away heat and calming wind, promoting blood circulation, clearing the lungs and calming asthma, clearing away heat and promoting urination, etc. It is used to treat symptoms such as high fever convulsions, insanity, hemiplegia, asthma, emphysema and urinary problems. Earthworm is included in the compound in order to improve the patient's symptoms or enhance the body's resistance.

[0042] Peucedanum chinense: It has the effects of clearing away heat and detoxifying, promoting lung function and relieving cough. It is used to treat cough, sore throat and other symptoms caused by exogenous wind-heat. Peucedanum chinense is included in compound Chinese medicine for auxiliary treatment in order to relieve the patient's fever, cough and other symptoms, as an auxiliary means to help regulate the body's state, alleviate symptoms, or enhance immunity.

[0043] Platycodon grandiflorum: In traditional Chinese medicine, it is used to treat cough, phlegm, sore throat and other symptoms because of its effects of clearing the lungs, relieving sore throat, expectoration and pus discharge. Platycodon grandiflorum helps relieve respiratory symptoms caused by viruses, such as cough and phlegm. In addition, studies have shown that Platicotin D contained in Platycodon grandiflorum has shown the ability to inhibit the activity of proteases associated with COVID-19 infection.

[0044] Phragmites australis: It is used to clear away heat, promote the production of body fluid, stop vomiting, promote diuresis, and clear heat from the lungs and stomach. It has a certain effect on treating fever-induced thirst, lung heat cough, stomach heat vomiting, and other symptoms. For COVID-19, Phragmites australis may help relieve certain symptoms caused by the virus, such as relieving the accompanying fever symptoms and cough.

[0045] Winter melon seeds: They have the effects of clearing the lungs and reducing phlegm, promoting diuresis and removing dampness, and eliminating carbuncle and pus. They are often used to treat phlegm-heat cough, lung carbuncle, intestinal carbuncle, edema and other diseases. Winter melon seeds may help relieve cough and discomfort caused by possible lung inflammation.

[0046] Coix seed: Coix seed is included in the regimen for its properties of promoting the removal of dampness and strengthening the spleen, clearing away heat and detoxifying. Coix seed is used to help relieve indigestion, feelings of heaviness, and respiratory symptoms that may be related to dampness in some patients. Coix seed helps to clear the lungs and detoxify, helps regulate the patient's constitution, and promotes the removal of dampness from the body, which may help the patient's overall recovery.

[0047] Peach kernel: Peach kernel is used for its effects of promoting blood circulation and removing blood stasis, moistening the intestines and promoting bowel movements, and relieving cough and asthma. It can be used as an auxiliary treatment for symptoms such as cough and asthma caused by certain respiratory diseases.

[0048] Roasted malt: It can strengthen the spleen and appetite, aid digestion, eliminate food accumulation, relieve bloating, improve digestive system function, and relieve spleen and stomach weakness. Roasted malt helps to strengthen the body, reduce complications, promote drug absorption and harmonize drug properties.

[0049] Shenqu: It aids digestion, strengthens the spleen and stimulates appetite, helps digestion and eliminates food stagnation, and is used to treat symptoms such as indigestion, abdominal distension, and loss of appetite. Shenqu, asarum, and coix seed can achieve an effect similar to that of the classic Chinese medicine recipe "Qingfei Paidu Decoction".

[0050] The Chinese medicine composition of this application, from the analysis of nature and taste, has a warm nature, various medicines match, the lung and kidney are in harmony, the whole prescription is monarch, minister, assistant and messenger, the compatibility is appropriate, and both tonification and purgation are used, with a clear degree, it is intended to strengthen the body and eliminate evil, attack the real without hurting the body, and replenish the deficiency without helping the evil, and play the role of warming the lungs and kidneys, dispersing cold and resolving phlegm, and dispersing blood stasis, and protecting the lung yin, which is very consistent with the mechanism of white lung formation caused by new coronavirus infection. Experiments have shown that the Chinese medicine composition of the present invention can accelerate the absorption rate of lung tissue inflammation and prevent lung tissue fibrosis in the treatment of new coronavirus infection.

[0051] The following is a description of the preferred embodiments and technical effects of the present invention.

[0052] Example 1 This embodiment provides a Chinese medicine decoction for treating novel coronavirus infection, and its preparation method is as follows: (1) Weighing: 120g of Aster, 120g of honey coltsfoot flower, 120g of Epimedium, 120g of salt Morinda officinalis, 40g of Curculigo, 40g of Ephedra, 80g of Cassia twig, 80g of White Peony Root, 40g of Dry Ginger, 10g of Asarum, 80g of French Pinellia, 40g of Licorice, 40g of Vinegar Schisandra, 80g of Schizonepeta, 40g of Angelica dahurica, 40g of Magnolia flower, 80g of stir-fried Xanthium sibiricum, 120g of Pheretima, 120g of Peucedanum, 80g of Platycodon, 120g of Phragmites australis, 120g of Wax Gourd Seed, 120g of Coix Seed, 80g of Peach Kernel, 180g of stir-fried Malt, 120g of Shenqu.

[0053] (2) The preparation method of the decoction is as follows: After cleaning, drying and chopping the medicinal materials, soak the processed raw materials in water for 60 minutes, let the medicinal materials absorb water first and then put them into a casserole, add water to cover all the Chinese medicinal materials by 5 cm. After boiling over high heat, boil at 90℃ for 15 minutes for the first time, pour out 1 / 2 of the liquid; add water to the original volume, boil for the second time for 15 minutes, the boiling temperature range is 70℃, pour out 1 / 2 of the liquid, mix the two liquids, filter the liquid with two layers of gauze, remove the small residues, and obtain a clear and transparent decoction.

[0054] Example 2 This embodiment provides a Chinese medicine pill for treating novel coronavirus infection, and the preparation method thereof is as follows: (1) Weighing: 90g of Aster, 90g of Honey Coltsfoot, 90g of Epimedium, 90g of Salt Morinda, 50g of Curculigo, 50g of Ephedra, 90g of Cinnamon Twig, 90g of White Peony Root, 50g of Dry Ginger, 20g of Asarum, 90g of Pinellia, 50g of Licorice, 50g of Vinegar Schisandra, 90g of Schizonepeta, 50g of Angelica Dahurica, 50g of Magnolia Flower, 50g of Stir-fried Xanthium, 90g of Pheretima, 90g of Peucedanum, 50g of Platycodon, 90g of Phragmites australis, 90g of Wax Gourd Seed, 90g of Coix Seed, 50g of Peach Kernel, 140g of Stir-fried Malt, and 90g of Shenqu.

[0055] (2) The preparation method of the pills is as follows: prepare honey in a ratio of 1:1 to the total weight of the above-mentioned Chinese medicinal materials. After cleaning and chopping the above-mentioned medicinal materials, put them into a casserole for decoction and filtration, collect the filtrate, boil the filtrate into a fluid extract with a relative density of 1.1, mix it with the auxiliary material honey, stir it evenly and make Chinese medicinal pills.

[0056] Example 3 This embodiment provides a Chinese medicine granule for treating novel coronavirus infection, and the preparation method thereof is as follows: (1) Weighing: 80g of Aster, 80g of Honey Coltsfoot, 80g of Epimedium, 80g of Salt Morinda, 40g of Curculigo, 60g of Ephedra, 100g of Cinnamon Twig, 100g of White Peony Root, 60g of Dry Ginger, 30g of Asarum, 100g of Pinellia, 60g of Licorice, 60g of Vinegar Schisandra, 80g of Schizonepeta, 40g of Angelica Dahurica, 40g of Magnolia Flower, 40g of Stir-fried Xanthium, 80g of Pheretima, 80g of Peucedanum, 40g of Platycodon, 80g of Phragmites australis, 80g of Wax Gourd Seed, 80g of Coix Seed, 40g of Peach Kernel, 150g of Stir-fried Malt, 100g of Shenqu.

[0057] (2) The preparation method of granules is as follows: clean and dry the medicinal materials, chop them into pieces, put them into a casserole, boil them, filter them, collect the filtrate, concentrate the filtrate into an extract, mix the extract with white sugar and dextrin, and then granulate them.

[0058] Comparative Example 1 This comparative example provides a Chinese medicine decoction for treating novel coronavirus infection, and its preparation method is as shown in Example 1, but the ministerial medicine does not contain "Salt Morinda officinalis and Curculigo orchioides", and the ministerial medicine only retains Epimedium; the adjuvant does not contain "Stir-fried Xanthium sibiricum". The Chinese medicine decoction is prepared according to the method of Example 1.

[0059] Clinical trials 1. Data and diagnostic criteria (1) Case sources: A total of 180 patients with severe pneumonia caused by the new coronavirus who were admitted to the designated hospital for the treatment of new coronavirus infection with integrated traditional Chinese and Western medicine in Jiangxi Province from February 1, 2022 to May 31, 2020 were collected.

[0060] (2) Diagnostic criteria: The diagnosis of novel coronavirus infection shall refer to the diagnostic criteria in the Diagnosis and Treatment Plan for Pneumonia Caused by Novel Coronavirus Infection (Trial Version 4, 5, and 6) issued by the National Health Commission and the State Administration of Traditional Chinese Medicine.

[0061] 2. Diagnosis criteria (1) Real-time fluorescence RT-PCR test of respiratory specimens or blood specimens for positive novel coronavirus nucleic acid; (2) Clinical classification - severe pneumonia standard: meet any of the following: ① Respiratory distress, respiratory rate (RR) ≥ 30 times / min; ② At rest, blood oxygen saturation (SO 2 ) ≤93%; ③ Arterial oxygen partial pressure (PaO2) / oxygen concentration (FiO2) ≤300mmHg (1mmHg≈0.133kPa) (3) White lung diagnosis criteria: Chest CT shows: The white lung image area of ​​the lungs reaches 50%~80%.

[0062] 3. Inclusion criteria: (1) Meet the above-mentioned diagnosis criteria, and the clinical classification of the disease meets the diagnostic criteria for severe pneumonia and white lung; (2) Age ≥ 20 years old; (3) The patient and his / her family members are informed and agree and sign the informed consent form.

[0063] 4. Exclusion criteria: (1) Confirmed patients with mild / common or critical illness; (2) Patients with bronchial asthma; (3) Patients with severe interstitial lung disease, bronchiectasis and other underlying lung diseases; (4) Patients with severe congenital respiratory tract malformations, congenital heart disease and other underlying diseases; (5) Patients with severe primary diseases of the heart, liver, kidney, digestive and hematopoietic systems; (6) Children, pregnant women, etc.; (7) Patients who are allergic to Chinese medicine compositions; ⑧ Patients who do not meet the above diagnostic criteria and inclusion criteria.

[0064] 5. Test methods (1) Grouping method: According to the random principle, the patients were divided into a control group (60 cases), an experimental group (60 cases), and a comparison group (60 cases).

[0065] (2) Treatment methods: All patients were given general routine treatment in accordance with the Diagnosis and Treatment Plan for Pneumonia Caused by Novel Coronavirus Infection (Trial Version 4, 5, and 6), including: ① bed rest, enhanced supportive treatment, and adequate heat; attention to water and electrolyte balance to maintain a stable internal environment; close monitoring of vital signs and oxygen saturation; ② timely provision of effective oxygen therapy measures, including nasal cannula, facial oxygen delivery, and nasal high-flow oxygen therapy.

[0066] The control group received conventional treatment combined with antiviral treatment: antiviral (5 million U of interferon-α, nebulized inhalation, bid, 250 mL of 0.9% sodium chloride injection + 0.5 g of ribavirin, intravenous drip, bid), anti-infection (selecting quinolone antibiotics and / or third-generation cephalosporins) and other Western medicine treatments.

[0067] The experimental group was given 300 ml of the Chinese medicine decoction of Example 1 on the basis of the control group. Usage: one dose per day, divided into two times, taken warm in the morning and evening.

[0068] The control group was given 300 ml of the Chinese medicine decoction of comparative example 1 on the basis of the control group. Usage: one dose per day, divided into two times, taken warm in the morning and evening.

[0069] Treatment course: 14 days is one treatment cycle. Clinical data are collected at the beginning of treatment and on the 15th day of treatment to observe changes before and after taking the medicine.

[0070] (3) Observation indicators ① Changes in clinical symptoms. Observe the improvement of fever, fatigue, cough, dry throat, poor appetite, chest tightness and other symptoms in the control group and the experimental group before and after treatment.

[0071] ②Nucleic acid negative conversion time. Refers to the date of the second negative test of coronavirus in two consecutive respiratory pathogen nucleic acid tests (at least 24 hours apart) - the date of the first respiratory pathogen nucleic acid test positive for coronavirus.

[0072] ③ Absorption of lung lesions. Computed tomography (CT) imaging changes were performed on patients before and after treatment. The imaging results analysis and efficacy judgment criteria were formulated with reference to the "Guidelines for Imaging-Assisted Diagnosis of Novel Coronavirus Infection" and related literature. Ⅰ Basically cured, the shadow area decreased by ≥70%; Ⅱ Significant improvement, 70%> shadow area decreased by ≥30%; Ⅲ No significant change, shadow area decreased by <30%; Ⅳ Aggravated, shadow area increased by ≥30%. Total effective rate = (basic cure + number of cases with significant improvement) / total number of cases × 100%.

[0073] ④ At the beginning of treatment and on the 15th day of treatment, blood was drawn for laboratory index testing, including white blood cell count (WBC), neutrophil count (NEUT), lymphocyte count (LYM), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and procalcitonin (PCT).

[0074] ⑤Safety indicators: serum creatinine (Cr), blood urea nitrogen (BUN), alanine aminotransferase (ALT), aspartate aminotransferase (AST). Adverse reaction rate = number of patients with adverse reactions after taking Qingfei Paidu Decoction / total number of observed cases × 100%. Adverse reactions include gastrointestinal reactions such as diarrhea and nausea, as well as liver and kidney function damage.

[0075] ⑥Statistical analysis: Enumeration data are expressed as cases (%), using chi-square test or exact probability method; measurement data are expressed as ±S indicates that the data conformed to the normal distribution and had homogeneous variance, and the t-test was used. The t'-test was used for the data with unequal variance, and the non-parametric test was used for the data that did not conform to the normal distribution. P < 0.05 indicated that the difference was statistically significant.

[0076] (4) Test results ① Comparison of general information of patients in the control group, experimental group and comparison group is shown in Table 1.

[0077] Table 1: Comparison of general information between the control group and the experimental group ; A total of 180 patients with severe novel coronavirus infection-white lung were collected, including 60 cases in the experimental group, 60 cases in the control group, and 60 cases in the comparison group. There was no statistically significant difference in gender, age, and onset time among the three groups of patients (P>0.05), and they were comparable.

[0078] ② Comparison of the main clinical symptoms of patients before and after treatment, see Table 2.

[0079] Table 2: Comparison of improvement of main clinical symptoms in the control group, experimental group and comparison group before and after treatment ; Note: a: The main clinical symptoms after treatment were compared with those in the control group, P < 0.05; b: The main clinical symptoms after treatment were compared with those in the control group, P < 0.05; c: The main clinical symptoms of each group were compared before and after treatment, P < 0.05.

[0080] Before treatment (control group, experimental group, comparison group), there was no significant difference in the number of patients with main clinical symptoms (fever, fatigue, cough, dry throat, poor appetite, chest tightness) in the three groups, and they were comparable (P>0.05). After treatment (control group, experimental group, comparison group), the number of patients with main clinical symptoms (fever, fatigue, cough, dry throat, poor appetite, chest tightness) in the three groups decreased compared with before, and the number of patients with reduced symptoms in the experimental group and the comparison group was significantly higher than that in the control group, and the number of patients with reduced symptoms in the experimental group was higher than that in the comparison group, and the difference was statistically significant (P<0.05). In summary, the Chinese medicine composition of the present invention can better improve the main clinical symptoms (fever, fatigue, cough, dry throat, poor appetite, chest tightness) of patients with severe new coronavirus infection-white lung.

[0081] ③ Comparison of the average disappearance time of the main symptoms and the time for nucleic acid to turn negative in the three groups (control group, experimental group and comparison group), see Table 3.

[0082] Table 3: Comparison of the average disappearance time of the main symptoms and the time of nucleic acid turning negative among the three groups of patients ( ±S, n=60) ; Note: a: The time for the main symptoms to disappear and the average time for the nucleic acid to turn negative after treatment were compared with those in the control group, P < 0.05; b: The time for the main symptoms to disappear and the average time for the nucleic acid to turn negative after treatment were compared with those in the control group, P < 0.05.

[0083] The results showed that after 14 days of treatment, compared with the control group, the average disappearance time of the main clinical symptoms (fever, fatigue, cough, dry throat, poor appetite, chest tightness) and the average time for nucleic acid to turn negative in the experimental group and the comparison group were significantly shortened, and the difference was statistically significant (P<0.05); and the average disappearance time of the main clinical symptoms and the average time for nucleic acid to turn negative in the experimental group were shorter than those in the comparison group, and the difference was statistically significant (P<0.05).

[0084] ④Comparison of CT imaging changes among the three groups (control group, experimental group and comparison group), see Table 4-5.

[0085] Table 4: Comparison of the efficacy of CT imaging improvement in three groups (control group, experimental group and comparison group) ; Note: a: The improvement of CT images after treatment was compared with that of the control group, P < 0.05; b: The improvement of CT images after treatment was compared with that of the control group, P < 0.05.

[0086] Table 5: Comparison of changes in CT image shadow area of ​​patients in the three groups (control group, experimental group and comparison group) ±S) ; Note: a: The CT image area after treatment was compared with that in the control group, P < 0.05; b: The CT image area after treatment was compared with that in the control group, P < 0.05; c: The CT image area of ​​each group was compared before and after treatment, P < 0.05.

[0087] As can be seen from the table above, after 14 days of treatment, the total effective rate of CT image improvement in the experimental group was 90.00% (54 / 60), which was higher than 80.00% (48 / 60) in the control group and 70.00% (42 / 60) in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the shadow area of ​​lung CT among the three groups (control group, experimental group and comparison group) before treatment (P>0.05). After 14 days of treatment, the shadow area of ​​lung in the three groups (control group, experimental group and comparison group) was significantly reduced. Compared with the control group, the reduction degree of the experimental group and the comparison group was significantly better than that of the control group; and compared with the comparison group, the reduction degree of the experimental group was better than that of the comparison group, and the difference was statistically significant (P<0.05).

[0088] ⑤ Comparison of laboratory test indicators among the three groups (control group, experimental group and comparison group) of patients, see Table 6.

[0089] Table 6: Comparison of laboratory test indicators among the three groups of patients ( ±S, n=60) ; Note: WBC: white blood cell count, NEUT: neutrophil count, LYM: lymphocyte count, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, PCT: procalcitonin. a: laboratory test after treatment compared with the control group, P < 0.05; b: laboratory test after treatment compared with the control group, P < 0.05; c: laboratory test before and after treatment in each group, P < 0.05.

[0090] Before treatment, there were no significant differences in WBC count, NEUT count, LYM count, ESR, CRP and PCT levels among the three groups (control group, experimental group and comparison group), and they were comparable (P>0.05).

[0091] After 14 days of treatment, the WBC count and NEUT count of the three groups (control group, experimental group and comparison group) were lower than those before treatment, but the difference was not statistically significant (P>0.05); the LYM count of the three groups (control group, experimental group and comparison group) was higher than that before treatment, and the increase in the experimental group and the comparison group was significantly higher than that in the control group, and the increase in the experimental group was significantly higher than that in the comparison group, and the difference was statistically significant (P<0.05); the ESR, CRP and PCT levels of the three groups (control group, experimental group and comparison group) were significantly lower than those before treatment, and the decrease in the experimental group and the comparison group was significantly better than that in the control group, and the decrease in the experimental group was significantly better than that in the comparison group, and the difference was statistically significant (P<0.05).

[0092] ⑥Safety evaluation: During the 14-day treatment period, the biochemical examination indicators, liver function, kidney function, blood routine, urine routine, blood lipids, blood creatinine and other routine examination indicators of the three groups of patients were compared within the group. There was no situation where the indicators were normal before treatment and abnormal after treatment, and the patients did not experience allergic reactions and other adverse reactions.

[0093] Typical treatment cases Case 1: Cheng, male, 58 years old, from Yichun City, Jiangxi Province, came to the hospital for "coughing and expectoration for 1 week". Symptoms: The patient was conscious, weak, coughed, coughed more severely in cold weather, had less expectoration, white and sticky sputum, difficult to cough up, limb fatigue, aversion to wind, fear of cold, chest tightness and shortness of breath, severe shortness of breath when moving, shortness of breath, panic, palpitations, no fever, no nausea and vomiting, no chest pain or abdominal pain, poor appetite, tasteless mouth, restless sleep, difficulty falling asleep, loose stools, undigested food, 2-3 times / day, clear and long urine, pale and fat tongue, greasy white fur, deep and fine pulse. Chest CT showed extensive ground-glass density shadows in both lungs, with thickening of the interstitial tissue and unclear boundaries. The lung lesions were mainly distributed under the pleura, with a lesion area of ​​about 50%. Diagnosed as novel coronavirus infection-white lung, the Chinese medicine decoction of Example 1 was used twice a day, 300 mL each time. Follow-up after 1 month of treatment showed that the patient's symptoms improved, with occasional cough and sputum, no chest tightness and wheezing, no fever, and stable condition. Chest CT scan showed ( Figure 1 ): Multiple fibrous cord shadows and small patchy dense shadows in both lungs, with obvious absorption compared with the previous lesions, considering inflammatory changes.

[0094] Case 2: Mr. Liu, male, 83 years old, from Xihu District, Nanchang City, Jiangxi Province, was diagnosed with "cough and sputum for 2 weeks". Symptoms: The patient was clear-headed, weak in spirit, general fatigue, coughing and sputum, which was not easy to cough up, thick sputum, accompanied by chest tightness and shortness of breath, slight wheezing, occasional headache and dizziness, no nausea and vomiting, no chest pain or abdominal pain, poor appetite, poor sleep at night, dry stool, flat urine, pale tongue, white and greasy tongue coating, and deep pulse. Chest CT showed scattered ground-glass high-density shadows in both lungs, with thickening of the interstitium and unclear boundaries. The lesions were mainly distributed under the pleura. No obvious abnormal changes were found in the mediastinum and chest cavity. Diagnosed as new coronavirus infection-white lung, the Chinese medicine granules of Example 3 were used, twice a day, one small grid (30g) each time with warm water. Follow-up after 15 days of treatment showed that the patient's chest tightness, cough and sputum improved and his condition was stable. Reexamination of chest CT showed ( Figure 1 ): Scattered ground-glass opacities and linear high-density shadows were seen in both lungs, with thickening of the interstitial tissue and unclear boundaries. The lesions were mainly distributed under the pleura. The lesions were absorbed more than before, and the original right pleural effusion was basically absorbed.

[0095] Case 3: Tu, male, 69 years old, from Xinjian District, Nanchang City, Jiangxi Province, was diagnosed with “cough and sputum for 1 week”. Symptoms: The patient was clear-minded, pale-faced, weak, coughed and sputum, which was not easy to cough up, thick sputum, accompanied by chest tightness and shortness of breath, slight wheezing, headache and dizziness, no nausea and vomiting, no chest pain or abdominal pain, poor appetite and sleep, flat stool, rapid and distended urine, pale tongue, greasy tongue coating, and deep pulse. Chest CT showed extensive ground-glass density shadows in both lungs, with thickening of the interstitium and unclear boundaries. The lung lesions were mainly distributed under the pleura, with a lesion area of ​​about 80%. Diagnosed as novel coronavirus infection-white lung, the Chinese medicine pills of Example 2 were used, twice a day, 1 pill each time (15g / pill). Follow-up after 2 months of treatment showed that the patient's cough and sputum improved and his condition was stable. Reexamination of chest CT showed ( Figure 1 ): Multiple fibrous cord shadows and small patchy dense shadows in both lungs, with obvious absorption compared with the previous lesions, considering inflammatory changes.

[0096] Case 4: Xiao, female, 90 years old, from Xihu District, Nanchang City, Jiangxi Province, sought medical treatment for "coughing and expectoration for more than 10 days". Symptoms: intermittent coughing, unsmooth coughing, nausea, a small amount of white sticky phlegm in the throat, not easy to cough out, occasional chest tightness, aversion to cold without fever, spontaneous sweating, slight dizziness and headache, no chest pain or abdominal pain, poor appetite, normal sleep, normal bowel movements, pale and fat tongue, greasy tongue coating, and deep pulse. Chest CT showed extensive ground-glass density shadows in both lungs, with thickening of the interstitium and unclear boundaries. The lung lesions were mainly distributed under the pleura, with a lesion area of ​​about 50%. Diagnosed as novel coronavirus infection-white lung, the Chinese medicine pills of Example 2 were used, twice a day, 1 pill each time (15g / pill). Follow-up after 1 month of treatment showed that the patient's cough and sputum improved, with no chest tightness or pain, good appetite and sleep, and stable condition. Reexamination of chest CT showed ( Figure 2): Multiple fibrous cord shadows and small patchy dense shadows in both lungs, with obvious absorption compared with the previous lesions, considering inflammatory changes.

[0097] Case 5: Ms. Xu, female, 87 years old, from Wanli District, Nanchang City, Jiangxi Province, was treated for "fever and cough for 7 days". Symptoms included: cough and sputum, coughing up white thick and sticky sputum, dizziness and drowsiness, no dry mouth and bitter taste, body aches, poor appetite, poor sleep, difficulty falling asleep, loose stools, and flat urine. Pale and fat tongue, white and greasy tongue coating, and fine and floating pulse. Chest CT showed extensive ground-glass density shadows in both lungs, with thickening of the interstitium and unclear boundaries. The lung lesions were mainly distributed under the pleura, with a lesion area of ​​about 60%. Diagnosed as novel coronavirus infection-white lung, the Chinese medicine decoction of Example 1 was used, twice a day, 300 mL each time. After 15 days of treatment, the patient's cough and sputum improved, with no fever, no dizziness or headache, good appetite and sleep, flat bowel movements, and stable condition. Reexamination of chest CT showed ( Figure 2 ): Multiple fibrous cord shadows and small patchy dense shadows in both lungs, with obvious absorption compared with the previous lesions, considering inflammatory changes.

[0098] Case 6: Long, female, 93 years old, Xihu District, Nanchang City, Jiangxi Province, was diagnosed for "fever for more than 1 week". Symptoms: The patient was conscious, weak, feverish, coughing, coughing aggravated by cold, less sputum, white and sticky sputum, difficult to cough out, limb fatigue, aversion to wind, fear of cold, chest tightness and asthma, panting when moving, shortness of breath, panic, palpitations, no chest pain and abdominal pain, poor appetite, bland mouth, restless sleep, easy to wake up, loose stools, clear and long urine, pale and fat tongue, white and greasy fur, and deep and fine pulse. Chest CT showed extensive ground glass density shadows in both lungs, with thickening of the interstitium and unclear boundaries. The lung lesions were mainly distributed under the pleura, and the lesion area was about 40%. Diagnosed as new coronavirus infection-white lung, the Chinese medicine decoction of Example 1 was adopted, twice a day, 300 mL each time. After 2 months of treatment, the patient's symptoms improved, no fever, occasional cough and sputum, no chest tightness and asthma, and stable condition. Chest CT scan showed Figure 2 ): Multiple fibrous cord shadows and small patchy dense shadows in both lungs, with obvious absorption compared with the previous lesions, considering inflammatory changes.

[0099] It can be seen from the above typical cases that the treatment with the Chinese medicine composition of the present invention has a significant effect on improving white lung caused by new coronavirus infection. CT shows that after treatment, the small flake-like dense shadows in the lungs are significantly absorbed compared with the previous lesions.

[0100] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine composition for treating novel coronavirus infection, characterized in that: The invention is prepared from the following Chinese medicinal materials in parts by weight: 8-12 parts of aster, 8-12 parts of honey coltsfoot flower, 8-12 parts of epimedium, 8-12 parts of salt Morinda officinalis, 4-8 parts of curculigo, 4-8 parts of ephedra, 8-12 parts of cassia twig, 8-12 parts of white peony root, 4-8 parts of dried ginger, 1-3 parts of asarum, 8-12 parts of French pinellia, 4-8 parts of liquorice, 4-8 parts of vinegar schisandra, 8-12 parts of schizonepeta, 4-8 parts of angelica, 4-8 parts of magnolia flower, 4-8 parts of stir-fried xanthium sibiricum fruit, 8-12 parts of earthworm, 8-12 parts of peucedanum, 4-8 parts of platycodon, 8-12 parts of reed root, 8-12 parts of wax gourd seeds, 8-12 parts of coix seeds, 4-8 parts of peach kernel, 12-18 parts of stir-fried malt and 8-12 parts of Shenqu.

2. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition is made of the following Chinese medicinal materials in parts by weight: 12 parts of Aster, 12 parts of honey coltsfoot flower, 12 parts of epimedium, 12 parts of salt Morinda officinalis, 4 parts of Curculigo, 4 parts of Ephedra, 8 parts of cinnamon twig, 8 parts of white peony root, 4 parts of dried ginger, 1 part of asarum, 8 parts of French pinellia, 4 parts of liquorice, 4 parts of vinegar Schisandra, 8 parts of Schizonepeta, 4 parts of Angelica dahurica, 4 parts of magnolia flower, 8 parts of stir-fried Xanthium sibiricum, 12 parts of earthworm, 12 parts of Peucedanum, 8 parts of Platycodon, 12 parts of Phragmites australis, 12 parts of wax gourd seeds, 12 parts of Coix seeds, 8 parts of peach kernels, 18 parts of stir-fried malt, 12 parts of Shenqu; or, 9 parts of Aster, 9 parts of honey coltsfoot flower, 9 parts of epimedium, 9 parts of salt Morinda officinalis, 5 parts of Curculigo, 5 parts of Ephedra, 9 parts of cinnamon twig, 9 parts of white peony root, 5 parts of dried ginger, 2 parts of asarum, 9 parts of French pinellia, 5 parts of liquorice, 5 parts of vinegar Schisandra, 9 parts of Schizonepeta, 5 parts of Angelica dahurica, 5 parts of magnolia flower, 5 parts of stir-fried Xanthium sibiricum, 9 parts of earthworm, 9 parts of Peucedanum, 5 parts of Platycodon, 9 parts of Phragmites australis, 9 parts of wax gourd seeds, 9 parts of Coix seeds, 5 parts of peach kernels, 14 parts of stir-fried malt, 9 parts of Shenqu; or, 8 parts of Aster, 8 parts of honey coltsfoot flower, 8 parts of epimedium, 8 parts of salt Morinda officinalis, 4 parts of Curculigo, 6 parts of Ephedra, 10 parts of cinnamon twig, 10 parts of white peony root, 6 parts of dried ginger, 3 parts of asarum, 10 parts of French pinellia, 6 parts of liquorice, 6 parts of vinegar Schisandra, 8 parts of Schizonepeta, 4 parts of Angelica dahurica, 4 parts of magnolia flower, 4 parts of stir-fried Xanthium sibiricum, 8 parts of earthworm, 8 parts of Peucedanum, 4 parts of Platycodon, 8 parts of Phragmites australis, 8 parts of wax gourd seeds, 8 parts of Coix seeds, 4 parts of peach kernels, 15 parts of stir-fried malt, 10 parts of Shenqu; or, 12 parts of Aster, 12 parts of honey coltsfoot flower, 12 parts of Epimedium, 12 parts of salt Morinda officinalis, 8 parts of Curculigo, 4 parts of Ephedra, 8 parts of Cinnamomum, 8 parts of White Peony Root, 4 parts of Dry Ginger, 3 parts of Asarum, 8 parts of French Pinellia, 4 parts of Licorice, 4 parts of Vinegar Schisandra, 8 parts of Schizonepeta, 4 parts of Angelica dahurica, 8 parts of Flos Magnoliae, 8 parts of stir-fried Fructus Xanthii, 12 parts of Pheretima, 12 parts of Peucedanum, 8 parts of Platycodon, 12 parts of Phragmites australis, 12 parts of Wax Melon Seeds, 12 parts of Coix Seeds, 8 parts of Semen Prunuse, 17 parts of stir-fried Malt, 12 parts of Shenqu.

3. The Chinese medicine composition according to claim 1 or 2, characterized in that: The Chinese medicine composition is a capsule, Chinese medicine granules, Chinese medicine ointment, Chinese medicine pill or decoction.

4. The Chinese medicine composition according to claim 2, characterized in that: The preparation method of the capsule is as follows: after cleaning and drying the medicinal materials, chopping them into pieces, putting them into a casserole for decoction, filtering, collecting the filtrate, concentrating the filtrate into a paste, drying, sterilizing, grinding, passing through a 100-200 mesh sieve, and then putting them into capsules; The preparation method of the Chinese medicine granules is as follows: after cleaning and drying each medicinal material, chopping it into pieces, putting it into a casserole for decoction, filtering, harvesting the filtrate, concentrating the filtrate into an extract, mixing the extract with a flavoring agent and an excipient, and then granulating; The excipient is dextrin or starch; The preparation method of the Chinese medicine pills is as follows: after cleaning and drying the medicinal materials, the medicinal materials are chopped, put into a casserole for decoction, filtered, and the filtrate is harvested, and the filtrate is concentrated to a fluid extract with a relative density of 1.1-1.2, mixed with auxiliary materials, and stirred evenly to form pills; the auxiliary materials are water, honey, wine or vinegar; The preparation method of the Chinese medicine ointment is as follows: after cleaning and drying the medicinal materials, the medicinal materials are pounded into powder, put into a casserole for decoction, filtered, and the filtrate is harvested, and the filtrate is mixed with 10% auxiliary materials and then concentrated into a thick paste with a relative density of 1.5-1.6 to obtain the ointment; the auxiliary materials are donkey-hide gelatin, sucrose or honey; The preparation method of the decoction is as follows: after cleaning, drying and chopping the medicinal materials, soaking the processed raw materials in water for 30-60 minutes, boiling them with high fire, decocting them for the first time at 80-100° C. for 10-15 minutes, pouring out 1 / 3-1 / 2 of the medicinal liquid; adding water to the original volume, decocting them for the second time for 10-15 minutes, the decoction temperature range is 60-80° C., pouring out 1 / 3-1 / 2 of the medicinal liquid, mixing the two medicinal liquids to obtain the decoction.

5. The Chinese medicine composition according to claim 4, characterized in that: In the preparation process of the above-mentioned Chinese medicine compositions, the amount of water added during decoction is enough to cover all the Chinese medicinal materials by 3-5 cm; specifically, the medicinal materials are first fully absorbed with water and then put into the casserole, and water is added until all the Chinese medicinal materials are covered by 3-5 cm.

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