A gas chromatography detection method for 2,5-dimethoxytetrahydrofuran related substances
Through the application of gas chromatography, the problem of difficulty in removing 2,5-dimethoxytetrahydrofuran and its related impurities in the esprazole synthesis process was solved, and effective quality control of esprazole starting materials was achieved, ensuring the quality of the final product.
Patent Information
- Application Number
- CN202411754707.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-03
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2044-12-03
AI Technical Summary
The prior art is difficult to effectively remove 2,5-dimethoxytetrahydrofuran and its related impurities in the esprazole synthesis process, affecting the quality of the final product esprazole.
By using gas chromatography, effective separation and detection of 2,5-dimethoxytetrahydrofuran and its related impurities are achieved by selecting appropriate chromatographic columns and temperature programs. The specific steps include taking the resolution solution and the test sample solution for injection, detecting according to specific gas chromatographic conditions, recording the chromatogram, and calculating the detection amount of impurities by peak area normalization.
The effective separation of compound (Va), i.e. 2,5-dimethoxytetrahydrofuran (cis-trans isomer mixture) and each impurity is achieved. The detection method is simple to operate, specialized, linear, precision, and high sensitivity. It is suitable for the quality control of esprazole starting materials.