Method, device, equipment and medium for obtaining differences in brain neural activity in patients with depression

By constructing an experimental paradigm that includes physiological pain and social pain stimulation, combining microstate and electroencephalogram analysis, we can obtain the differences in brain neural activity in depressed patients under different emotional stimulation, solving the problems of research paradigm limitations and insufficient samples in the existing technology, and achieving a more comprehensive understanding of the neural mechanisms of depressed patients.

CN119322949BActive Publication Date: 2025-03-25SHENZHEN UNIV
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Patent Information

Application Number
CN202411854445.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-12-17
Publication Date
2025-03-25
Estimated Expiration
2044-12-17

AI Technical Summary

Technical Problem

The prior art has small sample size, insufficient clinical diagnosis, limitations of the study paradigm, and research defects under different emotional stimuli when studying the abnormal neural mechanisms of depressed patients.

Method used

An experimental paradigm including physiological pain stimulation and social pain stimulation was constructed, and EEG signals from depressed patients were collected, and the differences in brain neural activity of depressed patients in the face of different emotional stimulations were obtained through micro-state analysis strategies and electroencephalogram tracing analysis strategies were obtained.

Benefits of technology

A comprehensive understanding of the differences in brain neural activity in depressed patients under different emotional stimuli was achieved, revealing the underlying mechanisms of brain function and activity patterns, and providing new ways for early diagnosis and treatment of depressed patients.

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Abstract

The present invention is applicable to the field of neuroscience technology, and provides a method for obtaining differences in brain neural activity of depressed patients, the method comprising: constructing an experimental paradigm including two emotional stimuli, namely physiological and social pain stimuli, collecting first EEG signals of several depressed patients in first and second test groups in the experiment of the experimental paradigm, preprocessing each first EEG signal to obtain a second EEG signal of each depressed patient in the emotional stimulation stage of the experiment, processing the second EEG signal in combination with a microstate analysis strategy and an electroencephalogram tracing analysis strategy to obtain differences in brain neural activity of depressed patients in the first and second test groups when facing physiological and social pain stimuli, thereby achieving a comprehensive understanding of the brain functional network of depressed patients and revealing the underlying mechanisms of brain functions and activity patterns, having obvious advantages in the study of abnormal neural mechanisms of depressed patients, and providing a new approach for early diagnosis and treatment of NSSI behaviors of depressed patients.
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