Application of Myrtle Polysaccharide P5 in the Preparation of Antibacterial and Antioxidant Drugs

Through the extraction and isolation and purification of myrtle polysaccharide P5, the potential application of myrtle polysaccharide in the prior art was solved, and effective inhibition of specific bacteria and efficient removal of free radicals were achieved.

CN119367390BActive Publication Date: 2025-04-04SOUTH CHINA NORMAL UNIV
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Patent Information

Application Number
CN202411918354.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-12-25
Publication Date
2025-04-04
Estimated Expiration
2044-12-25

AI Technical Summary

Technical Problem

The prior art has not yet fully utilized the potential application of myrtle polysaccharide in the preparation of antibacterial and antioxidant drugs, especially in the inhibition of E. coli, Salmonella and Staphylococcus aureus and free radical scavenging.

Method used

The crude polysaccharide was extracted by water extraction and enzyme-assisted method, and protein was removed by combining Sevag method, and chromatography was used for separation and purification by DEAE-Sepharose Fast Flow ion exchange column and dextran gel column to obtain myrtle polysaccharide P5. The polysaccharide contains a specific monosaccharide composition and molecular weight, and has antibacterial and antioxidant activities.

Benefits of technology

Myrtle polysaccharide P5 significantly inhibited the proliferation of E. coli, Salmonella and Staphylococcus aureus and showed the ability to scavenge free radicals in vitro, especially in DPPH, hydroxyl and ABTS free radical scavenging.

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Abstract

The present invention discloses the use of myrtle polysaccharide P5 in the preparation of antibacterial and antioxidant drugs. The myrtle polysaccharide P5 contains the following molar percentages of monosaccharides: 7.49% rhamnose, 26.05% arabinose, 13.22% galactose, 3.97% glucose, and 49.28% galacturonic acid; the number average molecular weight (Mn) is 15.02 kDa, and the weight average molecular weight (Mw) is 40.56 kDa. The present invention is the first to discover that myrtle polysaccharide has antibacterial and antioxidant effects, which expands the potential application range of myrtle polysaccharide.
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