Nanoassembly capable of self-releasing CO, preparation method and application thereof
The amphiphilic block polymer nanoassembly formed by hydrophilic self-assembly combines the CO donor with a singlet oxygen donor to achieve spontaneous release of CO in the internal environment of the human body, solving the problem of poor therapeutic effect of existing CORMs in deep tissues, and avoiding the risk of biotoxicity of metal-based CORMs, significantly improving the anti-inflammatory effect.
CN119385952BActive Publication Date: 2025-04-04HEFEI FIRST PEOPLES HOSPITAL
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Patent Information
- Application Number
- CN202510002670.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-02
- Publication Date
- 2025-04-04
- Estimated Expiration
- 2045-01-02
AI Technical Summary
Technical Problem
The clinical effect of existing organic small molecule CORMs triggered by external stimuli is not ideal in deep tissue treatment, and traditional metal-based CORMs have biotoxicity problems.
Method used
Nanoassembly is constructed using amphiphilic block polymers A and B formed by hydrophilic self-assembly, combining CO donors and singlet oxygen donors to achieve the ability to spontaneously release CO in the internal environment of the human body.
Benefits of technology
Spontaneous release of CO is achieved in normal oxygen, hypoxia and dark internal environments of human body, avoiding the triggering dependence on external stimuli such as light/ultrasound, and significantly improving the anti-inflammatory effect in deep tissues in the body.
✦ Generated by Eureka AI based on patent content.
Abstract
The present application discloses a nanoassembly capable of self-releasing CO, a preparation method and application thereof, and belongs to the technical field of biomedical materials. The nanoassembly of the present application comprises a co-assembly product prepared by a hydrophilic-hydrophobic self-assembly forming method comprising the following component systems; (1) an amphiphilic block polymer A for a CO donor, which has a chemical structure of formula (I) or (II) of the present application; and (2) an amphiphilic block polymer B for a singlet oxygen donor, which has a chemical structure of formula (III) of the present application. The present application combines a CO donor with a singlet oxygen donor that can release singlet oxygen at a temperature close to that of the human body, so that singlet oxygen can be released in the human body through the singlet oxygen donor to oxidize the CO donor to release CO, thereby avoiding dependence on triggering of external stimuli such as light / ultrasound, and effectively achieving the spontaneous release of CO in the human body environment in normoxic, hypoxic, and dark environments.
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