Traditional Chinese medicine composition for treating blood-deficiency wind-movement type Mejie syndrome

Abstract

The invention provides a traditional Chinese medicine composition for treating blood-deficiency and wind-movement type meliger syndrome, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from twelve traditional Chinese medicines including bear gall powder, lucid ganoderma, Chinese dates, cicada slough, ligusticum, cornu cervi pantotrichum, morinda officinalis, herba epimedii, human placenta, lily, fructus lycii and caulis spatholobi. The traditional Chinese medicine composition takes blood nourishing, nerve calming, wind dispelling and convulsion relieving as main treatment principles, has the effects of clearing away heat and toxic materials, clearing liver and improving eyesight, tonifying middle-Jiao and Qi, relieving pain and relieving convulsion, can obviously relieve clinical symptoms such as double-eyelid spasm, eyelid skin vibration and jumping, eye soreness, eyelid weakness and lusterless complexion of blood-deficiency wind-movement type meiger syndrome patients, and is high in cure rate, good in safety and free of toxic and side effects. The recurrence cannot easily occur.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating Meige syndrome of blood deficiency and wind-induced movement. Background Art

[0002] Meige syndrome, also known as blepharospasm-oromandibular dystonia syndrome, is a rare extrapyramidal disease. The disease is prone to occur in middle-aged and elderly people, with an insidious onset. The typical clinical manifestations are bilateral blepharospasm, or involuntary twitching of the mouth and face. Its characteristic is that the symptoms are alleviated in a quiet state, when the attention is distracted, when coughing, whistling, yawning, singing, and most of the time there is no attack during sleep, which is called the Tricks phenomenon. The disease lacks specific examination methods and is often diagnosed by the patient's clinical manifestations and the Tricks phenomenon. At the same time, it needs to be differentiated from diseases such as hemifacial spasm, myasthenia gravis, and tardive dyskinesia caused by certain antipsychotic drugs. Modern medicine mainly adopts oral nutritional nerve drugs, sedatives, local injection of botulinum toxin and surgical symptomatic treatment. There is no cure, and there are many complications and it is easy to relapse.

[0003] Traditional Chinese medicine classifies Meige syndrome as "eyelid twitching", "eye wind", "spasm", and "muscle twitching and muscle spasm", including the two major syndrome types of "heart and spleen deficiency type" and "blood deficiency and wind type". Blood deficiency and wind type Meige syndrome often manifests as eyelid twitching, eyelid spasm, and some cases start from one eye and gradually affect both eyes. Patients experience constant blinking, twitching of the corners of the mouth, or involuntary twitching of the neck forward or to one side, accompanied by a throbbing feeling and difficulty swallowing. The symptoms of eyelid spasm disappear when patients are quiet or sleeping. The eyelid skin twitches and may extend to the cheeks between the eyebrows. It twitches frequently, the eyes are sore and swollen, the eyelashes are weak, the complexion is dull, and there is dizziness. The "Seven Keys to Diagnosis and Treatment" states: "The eyes and spleen are pulled and vibrated without waiting for people to open and close them. This is a disease of the qi, which belongs to the problem of the liver and spleen meridians being pulled and vibrated. People call it wind, but they don't know that blood deficiency and qi stagnation are not pure wind." Therefore, this disease is mostly caused by liver and kidney qi and blood deficiency, blood deficiency and internal wind, virtual wind disturbs the clear space, invades the head and facial meridians, and qi and blood flow is abnormal, causing the eyebrows, eyelids, cheeks, and corners of the mouth to twitch. Traditional Chinese medicine seeks holistic treatment and syndrome differentiation and treatment. The human body is an organic whole, and the balance of yin and yang is reconciled through mutual coordination and restriction. Therefore, the treatment of Meige syndrome with traditional Chinese medicine is based on the analysis of etiology and pathogenesis. The treatment principle for Meige syndrome of blood deficiency and wind movement type is mainly to nourish blood and calm the mind, dispel wind and stop spasm. Although many traditional Chinese medicine prescriptions for the treatment of Meige syndrome have been published before, most of them are mainly based on acupuncture and medicine combination or traditional Chinese and Western medicine combination, with a long treatment cycle, unsatisfactory efficacy, and large side effects. Therefore, the present invention aims to provide a Chinese medicine composition for treating Meige syndrome of blood deficiency and wind type, which has high cure rate, good safety and is not prone to recurrence. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] In view of the deficiencies in the prior art, the present invention provides a traditional Chinese medicine composition for treating Meige syndrome of blood deficiency and wind type.

[0006] (II) Technical solution

[0007] To achieve the above objectives, the present invention is implemented through the following technical solutions:

[0008] On the one hand, the present invention provides a traditional Chinese medicine composition for treating Meige syndrome of blood deficiency and wind type, wherein the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 1-10 parts of bear bile powder, 1-15 parts of ganoderma lucidum, 10-50 parts of jujube, 1-30 parts of cicada shells, 1-30 parts of Ligusticum chuanxiong, 1-15 parts of deer antler, 10-40 parts of Morinda officinalis, 10-40 parts of epimedium, 1-30 parts of placenta, 10-50 parts of lily, 10-50 parts of wolfberry, and 10-50 parts of Millettia reticulata.

[0009] Specifically, the Chinese medicine composition is composed of the following raw materials in parts by weight: 1-8 parts of bear bile powder, 1-10 parts of Ganoderma lucidum, 20-40 parts of jujube, 5-20 parts of cicada shells, 5-20 parts of Ligusticum chuanxiong, 1-10 parts of deer antler, 15-35 parts of Morinda officinalis, 15-35 parts of Epimedium, 5-20 parts of placenta, 20-40 parts of lily, 20-40 parts of wolfberry, and 20-40 parts of Millettia reticulata.

[0010] Specifically, the Chinese medicine composition is composed of the following raw materials in parts by weight: 3 parts of bear bile powder, 5 parts of Ganoderma lucidum, 30 parts of jujube, 10 parts of cicada shells, 10 parts of Ligusticum chuanxiong, 5 parts of pilose antler, 20 parts of Morinda officinalis, 20 parts of Epimedium, 10 parts of placenta, 30 parts of lily, 30 parts of wolfberry, and 30 parts of Millettia reticulata.

[0011] The Chinese medicine composition provided by the present invention is used to prepare a medicine for treating Meige syndrome of blood deficiency and wind movement type. The Chinese medicine composition is prepared into granules, powders, oral liquids, pills, decoctions or other pharmaceutically acceptable oral dosage forms according to conventional pharmaceutical preparation methods in pharmacy and with medically acceptable adjuvants.

[0012] A Chinese medicine decoction for treating blood deficiency and wind-induced Meige syndrome is prepared according to the following steps:

[0013] (1) Weigh all the raw materials except placenta according to the above weight proportions, add water until the water level is 2-3 cm above the medicinal materials, and soak for 20-30 minutes.

[0014] (2) Transfer the soaked medicinal materials and soaking solution to a clay pot, boil them, and then simmer for 20-30 minutes. Filter the decoction while it is hot; add water to the clay pot again, boil it, simmer for 15-20 minutes, filter the decoction while it is hot, and combine the two decoctions to obtain a water decoction.

[0015] (3) Weigh the placenta according to the above weight proportions, grind it into a very fine powder, and take it with the decoction.

[0016] The pharmacological effects of each Chinese medicine component in the Chinese medicine composition of the present invention are as follows:

[0017] Bear bile powder: bitter in taste, cold in nature, enters the liver, gallbladder, spleen and stomach meridians; has the effects of clearing away heat, calming spasms, improving eyesight and killing insects; used for heat jaundice, summer diarrhea, infantile convulsions, malnutrition, ascariasis, eye opacity, throat paralysis, nasal erosion, carbuncle, hemorrhoids and malignant ulcers.

[0018] Lingzhi: sweet in taste, neutral in nature, enters the heart, lung, liver, and kidney meridians; has the effects of replenishing qi and calming the mind, relieving cough and relieving asthma; used for restlessness, insomnia, palpitations, lung deficiency, cough and asthma, shortness of breath due to consumptive disease, and loss of appetite. Modern pharmacological studies have shown that Lingzhi contains chemical components such as triterpenes, polysaccharides, proteins, and sterols, and has pharmacological activities such as improving immunity, anti-tumor, antibacterial, anti-inflammatory, and antioxidant.

[0019] Jujube: sweet in taste, warm in nature, enters the spleen, stomach, and heart meridians; has the effects of tonifying the middle qi, nourishing blood, and calming the mind; used for spleen deficiency, poor appetite, fatigue, loose stools, and irritability in women. Modern pharmacological research shows that jujube contains chemical components such as sugars, terpenes, alkaloids, flavonoids, amino acids, and vitamins, which have pharmacological activities such as enhancing immunity, inhibiting cancer cell proliferation, protecting the liver, and resisting type I allergic reactions.

[0020] Cicada slough: sweet in taste, cold in nature, enters the lung and liver meridians; has the effects of dispersing wind-heat, relieving sore throat, clearing rashes, improving eyesight and removing cataracts, and relieving spasms; used for wind-heat colds, sore throat and hoarseness, measles that does not break out, itchy rubella, red eyes and cataracts, convulsions, and tetanus; modern pharmacological research shows that cicada slough mainly contains chitin, protein, amino acids, and a variety of trace elements needed by the human body, and has anti-inflammatory, antitussive, expectorant and antiasthmatic, sedative, analgesic, antispasmodic, anticonvulsant, and anticoagulant pharmacological activities.

[0021] Ligusticum chuanxiong: It tastes spicy and warm in nature, and belongs to the bladder meridian; it has the effects of dispelling wind, dispersing cold, removing dampness and relieving pain; it is used for colds, vertex pain, and rheumatic pain; modern pharmacological studies have shown that Ligusticum chuanxiong mainly contains chemical components such as volatile oils, terpenes, coumarins, allyl benzenes, etc., which have anti-inflammatory, antipyretic and analgesic, central nervous system inhibitory, and anti-thrombotic pharmacological activities.

[0022] Deer antler: sweet and salty in taste, warm in nature, enters the kidney and liver meridians; has the effects of strengthening kidney yang, replenishing essence and blood, strengthening tendons and bones, regulating Chong and Ren meridians, and supporting sores and toxins; used for kidney yang deficiency, essence and blood deficiency, impotence and spermatorrhea, uterine cold and infertility, emaciation, fatigue, fear of cold, dizziness, tinnitus, deafness, cold pain in the waist and spine, weakness of tendons and bones, metrorrhagia and leukorrhea, and unhealed genital sores; modern pharmacological studies have shown that deer antler contains a variety of chemical components such as deer antler polypeptides, deer antler polysaccharides, deer antler polyamines, steroids, growth factors, lipids, microorganisms, etc., which have the pharmacological effects of protecting bones, protecting the nervous system, resisting myocardial damage, anti-tumor, lowering blood sugar and lipids, anti-inflammatory, enhancing immunity, anti-oxidation, anti-fatigue, and improving sexual function.

[0023] Morinda officinalis: sweet and spicy in taste, slightly warm in nature, enters the kidney and liver meridians; has the effects of tonifying kidney yang, strengthening tendons and bones, and removing rheumatism; used for impotence and spermatorrhea, uterine cold and infertility, irregular menstruation, cold pain in the lower abdomen, rheumatic pain, and tendon and bone weakness; modern pharmacological research shows that Morinda officinalis contains sugars, cyclopentane ether terpenes, amino acids, anthraquinones, volatile components, etc.; has pharmacological effects such as anti-depression, anti-dementia, anti-aging, promoting angiogenesis, and anti-inflammatory.

[0024] Epimedium: It tastes spicy and sweet, is warm in nature, and enters the liver and kidney meridians; it has the effects of tonifying kidney yang, strengthening tendons and bones, and removing rheumatism; it is used for kidney yang deficiency, impotence and spermatorrhea, tendon and bone atrophy, rheumatic pain, numbness and cramps; modern pharmacological research shows that epimedium mainly contains flavonoids, polysaccharides, lignans, alkaloids and other trace elements, and has significant therapeutic effects on common diseases in the bone, cardiovascular, reproductive and other systems such as osteoporosis, cardiovascular and cerebrovascular diseases, reproductive dysfunction, etc.

[0025] Placenta: sweet and salty, warm in nature, enters the heart, lung and kidney meridians; has the effects of warming the kidney and replenishing essence, replenishing qi and nourishing blood; used for asthenia, bone steaming and night sweats, cough and asthma, poor appetite and shortness of breath, impotence and spermatorrhea, infertility and low milk. Modern pharmacological research shows that placenta contains various amino acids, proteins, lipids, multifunctional active factors and other ingredients, with pharmacological activities such as regulating immunity, hormone-like effects, anti-tumor, anti-inflammatory, anti-allergic, and anti-infection. It can be used clinically to treat diseases of the human motor system, nervous system, circulatory system, respiratory system, digestive system and reproductive system.

[0026] Lily: sweet in taste, cold in nature, enters the heart and lung meridians; has the effects of nourishing yin and moistening the lungs, clearing the heart and calming the mind; used for yin deficiency and dry cough, cough with blood due to fatigue, restlessness and palpitations, insomnia and dreaminess, and mental confusion; modern pharmacological research shows that lily mainly contains polysaccharides, alkaloids, steroidal saponins, flavonoids and phenolic compounds, which have pharmacological activities such as moistening the lungs and relieving cough, sedation and hypnosis, regulating immunity, anti-oxidation, anti-depression, anti-inflammatory, anti-tumor and hypoglycemic.

[0027] Lycium barbarum: sweet in taste, neutral in nature, enters the liver and kidney meridians; has the effects of nourishing the liver and kidney, improving intelligence and improving eyesight; used for deficiency of essence, soreness of waist and knees, dizziness and tinnitus, impotence and spermatorrhea, internal heat and thirst, blood deficiency and sallow complexion, blurred vision; modern pharmacological studies have shown that wolfberry is rich in carbohydrates, alkaloids, flavonoids, and phenolic acids, and has pharmacological activities such as regulating immunity, anti-oxidation, anti-aging, lowering blood sugar and lipids, and anti-tumor.

[0028] Millettia reticulata: bitter and sweet in taste, warm in nature, enters the liver and kidney meridians; has the effects of promoting blood circulation and replenishing blood, regulating menstruation and relieving pain, relaxing muscles and activating collaterals; used for irregular menstruation, dysmenorrhea, amenorrhea, rheumatic pain, numbness and paralysis, and blood deficiency and chlorosis; modern pharmacological studies have shown that Millettia reticulata mainly contains flavonoids, phenolic acids, phenylpropanoids, anthraquinones, terpenes and sterols, which have pharmacological activities such as hematopoiesis and blood replenishing, anti-platelet aggregation, regulation of lipid metabolism, protection of cardiovascular and cerebrovascular vessels, anti-inflammatory and analgesic, anti-tumor, antioxidant, anti-viral, regulation of tyrosinase activity and anti-depression.

[0029] (III) Beneficial effects

[0030] The invention takes nourishing blood and calming the mind, dispelling wind and stopping spasm as main treatment principles, follows the principle of TCM treatment based on syndrome differentiation, and obtains a Chinese medicine composition for treating blood deficiency wind-moving type Meige syndrome composed of twelve Chinese medicines, namely, bear bile powder, ganoderma lucidum, jujube, cicada slough, Ligusticum chuanxiong, deer antler, Morinda officinalis, epimedium, placenta, lily, wolfberry fruit and Millettia spatholobi, through reasonable compatibility and optimized combination; in the prescription, bear bile powder is used as the monarch medicine to calm wind and stop spasm, clear away heat and detoxify, and clear the liver and improve eyesight; ganoderma lucidum, jujube, cicada slough and Ligusticum chuanxiong are used as the assistant medicines to calm and calm the mind, strengthen tendons and bones, invigorate the middle and replenish qi, nourish blood and calm the mind, improve eyesight and stop spasm, dispel wind-heat, relieve pain and relieve spasm; deer antler, Morinda officinalis, epimedium, placenta and lily are used as adjuvants to strengthen kidney yang, benefit essence and blood, and dispel rheumatism; and wolfberry fruit and Millettia spatholobi are used as guiding medicines to nourish the liver and kidney, improve eyesight, relieve pain, and relax tendons and activate collaterals. The Chinese medicine composition of the present invention can significantly alleviate clinical symptoms such as eyelid spasm, eyelid skin twitching, eye soreness and swelling, eyelash weakness, dull complexion, etc. in patients with blood deficiency and wind-induced Meige syndrome, has a high cure rate, good safety, and is not prone to recurrence. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] Example 1

[0033] A traditional Chinese medicine composition for treating Meige syndrome of blood deficiency and wind type, the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 3 parts of bear bile powder, 5 parts of ganoderma lucidum, 30 parts of jujube, 10 parts of cicada slough, 10 parts of Ligusticum chuanxiong, 5 parts of pilose antler, 20 parts of Morinda officinalis, 20 parts of epimedium, 10 parts of placenta, 30 parts of lily, 30 parts of wolfberry and 30 parts of Millettia reticulata.

[0034] Example 2

[0035] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 8 parts of bear bile powder, 10 parts of Ganoderma lucidum, 40 parts of jujube, 18 parts of cicada shells, 18 parts of Ligusticum chuanxiong, 11 parts of pilose antler, 33 parts of Morinda officinalis, 33 parts of Epimedium, 18 parts of placenta, 40 parts of lily, 40 parts of wolfberry, and 40 parts of Millettia reticulata.

[0036] Example 3

[0037] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 2 parts of bear bile powder, 3 parts of Ganoderma lucidum, 12 parts of jujube, 5 parts of cicada molt, 5 parts of Ligusticum chuanxiong, 3 parts of pilose antler, 8 parts of Morinda officinalis, 8 parts of Epimedium, 3 parts of placenta, 12 parts of lily, 12 parts of wolfberry, and 12 parts of Millettia reticulata.

[0038] Example 4

[0039] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 6 parts of bear bile powder, 14 parts of Ganoderma lucidum, 45 parts of jujube, 25 parts of cicada molt, 25 parts of Ligusticum chuanxiong, 14 parts of deer antler, 38 parts of Morinda officinalis, 38 parts of Epimedium, 25 parts of Placenta, 46 parts of Lilium, 46 parts of Lycium barbarum, and 46 parts of Millettia reticulata.

[0040] Example 5

[0041] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 9 parts of bear bile powder, 12 parts of Ganoderma lucidum, 42 parts of jujube, 20 parts of cicada molt, 20 parts of Ligusticum chuanxiong, 12 parts of pilose antler, 35 parts of Morinda officinalis, 35 parts of Epimedium, 20 parts of placenta, 43 parts of lily, 43 parts of wolfberry, and 43 parts of Millettia reticulata.

[0042] Example 6

[0043] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 5 parts of bear bile powder, 8 parts of Ganoderma lucidum, 35 parts of jujube, 12 parts of cicada molt, 12 parts of Ligusticum chuanxiong, 8 parts of pilose antler, 25 parts of Morinda officinalis, 25 parts of Epimedium, 12 parts of placenta, 35 parts of lily, 35 parts of wolfberry, and 35 parts of Millettia reticulata.

[0044] Example 7

[0045] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 10 parts of bear bile powder, 15 parts of Ganoderma lucidum, 50 parts of jujube, 30 parts of cicada molt, 30 parts of Ligusticum chuanxiong, 15 parts of pilose antler, 40 parts of Morinda officinalis, 40 parts of Epimedium, 30 parts of placenta, 50 parts of lily, 50 parts of wolfberry, and 50 parts of Millettia reticulata.

[0046] Example 8

[0047] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 1 part of bear bile powder, 1 part of Ganoderma lucidum, 10 parts of jujube, 1 part of cicada shell, 1 part of Ligusticum chuanxiong, 1 part of deer antler, 10 parts of Morinda officinalis, 10 parts of Epimedium, 1 part of placenta, 10 parts of lily, 10 parts of wolfberry, and 10 parts of Millettia reticulata.

[0048] Example 9

[0049] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 7 parts of bear bile powder, 9 parts of Ganoderma lucidum, 38 parts of jujube, 15 parts of cicada molt, 15 parts of Ligusticum chuanxiong, 10 parts of pilose antler, 30 parts of Morinda officinalis, 30 parts of Epimedium, 15 parts of placenta, 38 parts of lily, 38 parts of wolfberry, and 38 parts of Millettia reticulata.

[0050] Test example

[0051] Typical clinical cases

[0052] The specific method of taking the Chinese medicine composition prepared according to the above embodiment 1 is: decoction, 1 dose / day, twice taken warm after meals, 5 portions of placenta powder each time, 14 doses as a course of treatment.

[0053] Case 1: Zhou, female, 56 years old. First visit on June 28, 2022. Main complaint: left eyelid spasm, accompanied by involuntary twitching of the left oral face, and the symptoms worsen in strong light, fatigue, and tension. The condition has worsened recently, with difficulty opening the eyes, tight and numb facial muscles, and spasms of the muscles around the mouth. Meige syndrome was diagnosed in a hospital, and there was no obvious effect after oral treatment with sulpiride. Current symptoms: left eyelid weakness, involuntary blinking, difficulty opening the eyes, accompanied by eyelid spasm, photophobia, dry eyes, numbness of facial muscles, sallow face, irritability, dry mouth, dark tongue with white fur, and stringy and weak pulse. TCM diagnosis: muscle twitching. Syndrome differentiation: blood deficiency and wind type. Comprehensive diagnosis of Meige syndrome of blood deficiency and wind type. The patient began to take the above-mentioned Chinese medicine composition orally on July 2, 2022, one dose per day, twice a day after meals in the morning and evening, and took two courses of treatment.

[0054] Second visit on July 31, 2022: After taking the medicine, the patient's subjective symptoms were alleviated, the twitching of the corners of the mouth was alleviated, the numbness of the face was improved, and the symptoms of dry eyes and astringent eyes were improved, but he was still upset and irritable, with weakness in both lower limbs, dry mouth, dark tongue with white fur, and weak pulse. The patient was asked to continue taking the above-mentioned Chinese medicine composition, add 15 parts of wine Polygonatum, 10 parts of Anemarrhena, and 10 parts of Phellodendron, and the decoction method was the same as before, and a follow-up visit was conducted after one course of treatment.

[0055] Third visit on August 15, 2022: After taking the medicine, the patient's subjective symptoms were significantly alleviated, the twitching of the corners of the mouth was significantly reduced, the number of blinks was reduced, the symptoms of dry eyes and astringent eyes were significantly improved, the numbness of facial muscles was improved, the photophobia was significantly reduced, the complexion was restored, the weakness of the lower limbs was significantly relieved, the dry mouth symptoms disappeared, the tongue was light red, the fur was thin and white, and the pulse was stringy. The patient was asked to continue taking the first prescription for a follow-up visit after 7 days.

[0056] Fourth visit on August 23, 2022: The patient's symptoms improved after taking the medicine, the twitching of the corners of the mouth basically disappeared, the eyes could open and close normally, there was no involuntary movement, slight photophobia, soft facial muscles, dry eyes and astringent symptoms disappeared, mental state and complexion returned to normal, the tongue was pale with white fur, and the pulse was stringy. The patient was asked to take 7 doses of the first visit prescription intermittently to consolidate the effect of the medicine, and at the same time pay attention to avoid fatigue, emotional excitement, and avoid strong light stimulation. Follow-up after half a year, the patient reported that the eyelids opened and closed normally, there was no discomfort around the eyes and face, and the above symptoms did not recur.

[0057] Case 2: Li, male, 49 years old. First visit on April 6, 2023. Chief complaint: Involuntary blinking with spasms of the corners of the mouth and neck muscles without obvious causes, symptoms gradually worsen, and can be relieved during sleep, yawning, and talking. The patient has been treated in a hospital and clinically diagnosed with Meige syndrome. He has been treated with local botulinum toxin type A injections many times. After treatment, the symptoms have been relieved, but the symptoms recur. Current symptoms: spasm of both eyelids, frequent blinking, photophobia, dry eyes, astringent eyes, symptoms worsen when tired and emotional, and may involve the eyebrows and cheeks, irritability, weak eyelashes, sallow complexion, dizziness, pale red tongue, slightly thick white fur, and thin pulse. TCM diagnosis: tendon twitching. Syndrome differentiation: blood deficiency and wind type. The comprehensive diagnosis is Meige syndrome of blood deficiency and wind type. The patient started taking the above-mentioned Chinese medicine combination on April 8, 2023, one dose per day, taken orally twice a day after meals, in the morning and evening, for two courses of treatment.

[0058] Second visit on May 7, 2023: After taking the medicine, the patient felt that the symptoms of blepharospasm were alleviated, the number of blinks decreased, the photophobia, dry eyes and astringent eyes were improved, the symptoms of facial muscle tension were relieved, the tongue was pale red, the tongue coating was white, and the pulse was stringy. The patient was advised to continue taking the above-mentioned Chinese medicine composition for one course of treatment.

[0059] Third visit on May 22, 2023: After taking the medicine, the patient felt that the symptoms of blepharospasm were significantly alleviated, the number of blinks was significantly reduced, the photophobia was slightly reduced, the dry eyes and astringent eyes disappeared, the symptoms of facial muscle tension were significantly relieved, the complexion returned to normal, the tongue was pale red, the fur was thin and white, and the pulse was stringy. The patient was asked to continue taking the above-mentioned Chinese medicine composition for 7 days.

[0060] Fourth visit on May 30, 2023: After taking the medicine, the patient felt that the symptoms of blepharospasm basically disappeared, and only occasionally occurred when nervous or emotional. The symptoms of photophobia and facial muscle tension disappeared, the mental state was good, the symptoms of dizziness and blurred vision disappeared, the tongue was pale with white fur, and the pulse was stringy. The patient was advised to take 7 doses of the above-mentioned Chinese medicine combination intermittently to consolidate the efficacy of the medicine, and pay attention to rest and regulate emotions. Follow-up by phone six months later, the patient reported that the above symptoms completely disappeared and did not recur.

[0061] Case 3: Wu, female, 66 years old. First visit on October 12, 2023. Chief complaint: Involuntary eyelid spasms in both eyes without obvious cause, frequent blinking, difficulty opening eyes, visited a hospital, normal vision in both eyes, negative eye fatigue test, basically ruled out myasthenia gravis, hemifacial spasm and other diseases, and was later diagnosed with Meige syndrome. After acupuncture treatment, the symptoms did not significantly improve. In the past six months, the patient's symptoms have gradually worsened, and the current symptoms are: eyelid spasms in both eyes, difficulty opening eyes, involuntary twitching of facial and lip muscles, and frequent upward pulling of the left corner of the mouth. Accompanied by involuntary movements such as pursing the mouth, chewing, and clenching teeth, sore eyes, sallow complexion, dull tongue, less moss, and thin pulse. TCM diagnosis: muscle twitching. Syndrome differentiation: blood deficiency and wind type. The comprehensive diagnosis is Meige syndrome of blood deficiency and wind type. The patient started taking the above-mentioned Chinese medicine combination on October 15, 2023, one dose per day, taken orally twice a day after meals, in the morning and evening, for two courses of treatment.

[0062] Second visit on November 13, 2023: After taking the medicine, the patient felt that the eyelid spasm was relieved, the symptoms of muscle tension in the lips were relieved, and the involuntary movements such as pursing the lips, chewing, and clenching teeth were relieved. The tongue was red, the coating was slightly thick, and the pulse was stringy. The patient was asked to continue taking the above-mentioned Chinese medicine combination for one course of treatment and then return for a follow-up visit.

[0063] Third visit on November 28, 2023: After taking the medicine, the patient felt that the eyelid spasm in both eyes was significantly relieved, the tension of the lips and facial muscles was relieved, the chewing ability was basically restored, the complexion was restored, the tongue was light red, the tongue coating was white, and the pulse was stringy. The patient was asked to continue taking the above-mentioned Chinese medicine composition for a follow-up visit after 7 days.

[0064] Fourth visit on December 6, 2023: After taking the medicine, the patient felt that the eyelid spasm in both eyes basically disappeared, the lips and facial muscles were soft, the eyes opened normally, the soreness and swelling in the eyes disappeared, the complexion returned to normal, the tongue was pale with white fur, and the pulse was stringy. The patient was advised to take 7 doses of the above-mentioned Chinese medicine combination intermittently to consolidate the efficacy of the medicine, and at the same time pay attention to rest and regulate emotions. Follow-up by phone six months later, the patient reported that the above symptoms completely disappeared and did not recur.

[0065] In summary, the Chinese medicine composition of the present invention takes nourishing blood and calming the mind, dispelling wind and relieving spasm as the main therapeutic principles, has the effects of clearing away heat and detoxifying, clearing the liver and improving eyesight, tonifying the middle and replenishing qi, relieving pain and relieving spasm, can significantly alleviate the symptoms of double eyelid spasm, eyelid skin twitching, eye soreness and swelling, eyelash weakness, dull complexion and the like in patients with blood deficiency and wind-induced Meige syndrome, has a high cure rate, good safety, and is not prone to recurrence, providing a new idea for the treatment of blood deficiency and wind-induced Meige syndrome.

[0066] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine composition for treating Meige syndrome of blood deficiency and wind movement type, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 1-10 parts of bear bile powder, 1-15 parts of ganoderma lucidum, 10-50 parts of jujube, 1-30 parts of cicada slough, 1-30 parts of Ligusticum chuanxiong, 1-15 parts of pilose antler, 10-40 parts of Morinda officinalis, 10-40 parts of epimedium, 1-30 parts of placenta, 10-50 parts of lily, 10-50 parts of wolfberry, and 10-50 parts of Millettia reticulata.

2. A Chinese medicine composition for treating Meige syndrome of blood deficiency and wind type according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 1-8 parts of bear bile powder, 1-10 parts of ganoderma lucidum, 20-40 parts of jujube, 5-20 parts of cicada slough, 5-20 parts of Ligusticum chuanxiong, 1-10 parts of pilose antler, 15-35 parts of Morinda officinalis, 15-35 parts of epimedium, 5-20 parts of placenta, 20-40 parts of lily, 20-40 parts of wolfberry and 20-40 parts of Millettia reticulata.

3. A Chinese medicine composition for treating Meige syndrome of blood deficiency and wind type according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 3 parts of bear bile powder, 5 parts of ganoderma lucidum, 30 parts of jujube, 10 parts of cicada slough, 10 parts of Ligusticum chuanxiong, 5 parts of pilose antler, 20 parts of Morinda officinalis, 20 parts of epimedium, 10 parts of placenta, 30 parts of lily, 30 parts of wolfberry and 30 parts of Millettia reticulata.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating Meige syndrome of blood deficiency and wind type, characterized in that: The Chinese medicine composition is prepared into granules, powders, oral liquids, pills, decoctions or other pharmaceutically acceptable oral dosage forms by conventional pharmaceutical preparation methods and with medically acceptable adjuvants.