Liquid inhalation formulation for surface wave nebulizer, cartridge and aerosol-generating device comprising same

Abstract

The present invention provides: a liquid inhalation preparation for a surface wave nebulizer, the liquid inhalation preparation having a viscosity of 1.0 to 120 mPa.s at 20 DEG C, the liquid inhalation preparation comprising at least one selected from the group consisting of propylene glycol, glycerol, and physiological saline, the viscosity of the liquid inhalation preparation being 1.0 to 120 mPa.s at 20 DEG C, the viscosity of the liquid inhalation preparation being 1.0 to 120 mPa.s, and the viscosity of the liquid inhalation preparation being 1.0 to 120 mPa.s at 20 DEG C; relative to the total weight of the propylene glycol, the glycerol and the normal saline, the content of the glycerol is more than 50 wt%.

Description

Technical Field

[0001] The invention relates to a liquid inhalation preparation for a surface wave atomizer, a cigarette cartridge containing the liquid inhalation preparation and an aerosol generating device. Background Art

[0002] In order to overcome the shortcomings of combustion-type cigarettes, the method of heating aerosol-generating substances in cigarettes or cigarette cartridges to generate aerosols is widely used instead of burning cigarettes to generate aerosols, and such demand is also increasing. Therefore, research on heated (non-combustion) cigarettes or heated (non-combustion) aerosol generating systems is being actively carried out.

[0003] Specifically, the aerosol generating system has a form similar to that of a traditional combustion cigarette, and generates mainstream smoke containing aerosol by heating the aerosol generating material in a heated (non-combustion) cigarette or in a cigarette cartridge through a heater or ultrasonic vibration.

[0004] Among liquid aerosol generating devices, electrically heated aerosol generating devices that achieve vaporization by boiling liquid have the characteristics of fast heat conduction and high atomization efficiency. However, the functional inhalation materials in the liquid may be denatured. For example, harmful components such as aldehydes may be released at high temperatures, posing great health risks.

[0005] On the other hand, the existing ultrasonic atomization method does not require boiling during atomization. However, the problem with this method is that the temperature rises during the vibration process, and even if a cooling method is used to reduce the temperature, it is impossible to continuously and stably atomize high-viscosity liquids without trouble, and the atomization consumes a lot of power and has low efficiency.

[0006] Therefore, there is an urgent need for a liquid inhalation preparation using a surface wave (SAW) atomizer, a cigarette cartridge including the same, and a liquid aerosol generating device, which can achieve atomization through vibration, will not malfunction due to temperature rise and high viscosity liquid, and can continuously and stably generate aerosol. Summary of the invention

[0007] Problem that the invention aims to solve

[0008] Therefore, in order to overcome the above-mentioned problems and / or limitations of the prior art, an object of the present invention is to provide a liquid inhalation preparation for a surface wave nebulizer, a cartridge containing the same, and an aerosol generating device.

[0009] However, the technical problems to be solved by this embodiment are not limited to the above-mentioned topics, and other topics not mentioned will be clearly understood by ordinary technicians in this field through the following description.

[0010] Means used to solve problems

[0011] According to one embodiment of the present invention, a liquid inhalation preparation is provided, which is a liquid inhalation preparation for a surface wave nebulizer. At 20°C, the viscosity of the liquid inhalation preparation is 1.0 to 120 mPa·s, and the liquid inhalation preparation includes at least one selected from the group consisting of propylene glycol, glycerol and physiological saline, and the content of the glycerol is 50 weight% or more relative to the total weight of the propylene glycol, the glycerol and the physiological saline.

[0012] According to one aspect of the present invention, a cigarette cartridge comprising the liquid inhalation preparation is provided.

[0013] According to another aspect of the present invention, there is provided an aerosol generating device, comprising: a cartridge comprising the liquid inhalation formulation; and a control unit.

[0014] Effects of the Invention

[0015] By using the liquid inhalation preparation for surface wave nebulizer according to one aspect of the present invention, atomization can be realized continuously and stably in a larger viscosity range, and the liquid in a larger viscosity range can be used in an aerosol generating device. In addition, liquid inhalation preparation of the present invention provides abundant atomization and is easier to be delivered to lungs. In addition, spices can be mixed in the liquid inhalation preparation, and functional substances (solid or liquid) can be mixed in physiological saline to suck.

[0016] According to one aspect of the present invention, a cartridge and an aerosol generating device including a liquid inhalation preparation for a surface wave atomizer use surface waves, so that the temperature of the liquid does not increase when vibration is generated, and even when a high-viscosity liquid is used, atomization can be continuously and stably achieved without malfunction.

[0017] The effects of the present invention are not limited to the above effects, and other effects not mentioned will be clearly understood by those skilled in the art through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 4 is a graph showing changes in viscosity (20° C.) based on the composition of a liquid inhalation preparation for a surface wave nebulizer and the content of a functional material (VIT B3) according to an embodiment of the present invention.

[0019] Figure 2 3 is a graph showing the surface tension (25° C.) variation of the composition of a liquid inhalation preparation based on a surface wave nebulizer according to an embodiment of the present invention and the content of a functional material (VIT B3).

[0020] Figure 3 4 is a graph showing changes in liquid density (25° C.) based on the composition of a liquid inhalation preparation for a surface wave nebulizer and the content of a functional material (VIT B3) according to an embodiment of the present invention. DETAILED DESCRIPTION

[0021] Below, the embodiments will be described in detail with reference to the accompanying drawings. However, various changes can be made to the embodiments, and the scope of the rights of this application is not limited to these embodiments. It should be understood that all changes, equivalents and even substitutes of the embodiments are included in the scope of rights.

[0022] The terms used in the embodiments are for illustrative purposes only and should not be interpreted as limiting the intent. In the absence of special instructions in the content, singular expressions include plural expressions. In this specification, terms such as "including" or "having" are used to express the presence of stated features, numbers, steps, actions, constituent elements, parts or combinations thereof, but do not exclude the possibility of the presence or additional presence of one or more other features, numbers, steps, actions, constituent elements, parts, or combinations thereof.

[0023] In the absence of other definitions, all terms, including technical or scientific terms used herein, have the common meanings understood by ordinary technicians in the field to which the examples belong. Commonly used terms as defined in dictionaries should be understood as the meanings in the relevant technical content, and should not be interpreted as idealized or overly formalized meanings if they are not clearly defined in this specification.

[0024] In the process of describing the examples with reference to the drawings, the same components are marked with the same reference numerals and repeated descriptions are omitted. In the process of describing the example embodiments, when it is determined that the detailed description of the relevant well-known structure or function will cause unnecessary confusion to the present disclosure, its detailed description is omitted.

[0025] Also, when describing components of the exemplary embodiments, terms such as first, second, A, B, (a), (b), etc. may be used. These terms are only used to distinguish one component from other components and are not used to limit the nature, order or sequence of the corresponding components.

[0026] When a component has a common function with a component of an exemplary embodiment, the same name is used for description in other embodiments. Without mentioning a counterexample, the configuration disclosed in an exemplary embodiment can be applied to other embodiments, and the specific description of the repeated configuration can be omitted.

[0027] According to one embodiment of the present invention, a liquid inhalation preparation for a surface wave nebulizer is provided, which has a viscosity of 1.0 to 120 millipascals·seconds (mPa·s) at 20°C and contains at least one selected from the group consisting of propylene glycol, glycerol and saline, and the content of the glycerol is 50 weight % or more relative to the total weight of the propylene glycol, glycerol and saline.

[0028] Atomizer refers to the operation of vaporizing a liquid into droplets in a gas. For example, the atomizer can be implemented as a coil for resistive (Joule) heating, a resistive wire formed into different shapes, or an electric heater including a susceptor for inductive heating, and a capillary or a porous element with working performance adjacent to the heater and absorbing liquid from a liquid reservoir and delivering it to the electric heater.

[0029] Surface waves can propagate along the surface of liquids, and their energy is mainly concentrated on the surface of the medium. Therefore, the amplitude inside the medium decays exponentially with the distance from the surface. The characteristics of surface waves can be used to generate aerosols on the surface of liquids. Its directional energy concentration characteristics can improve the atomization efficiency and continuously and stably generate aerosols with uniform particle size distribution. Compared with ultrasound, it is more suitable for atomizing high-viscosity tobacco solutions. The frequency of surface waves is usually 10MHz to 500MHz, which is higher than the frequency of ultrasound. Therefore, compared with ultrasound, the aerosol particles generated by surface waves are smaller, less likely to remain on the oral mucosa or tongue surface, have stronger inhalation power, and have a richer, mellower and softer aroma.

[0030] The liquid inhalation preparation as an aerosol-forming preparation can be a mixture of glycol and glycerol, and in the present invention, the glycol can be propylene glycol. In the present invention, propylene glycol can be understood as 1,2-propylene glycol (propane-1,2-diol), and glycerol can be understood as 1,2,3-propylene triol (propane-1,2,3-triol).

[0031] The viscosity of the liquid inhalation preparation is very important for the atomization stability of the aerosol generating device. Generally, when the viscosity of the liquid composition is 10 mPa·s or more, it is considered to have high viscosity. When such a high-viscosity liquid composition is applied to an aerosol generating device using an electric heating method or an ultrasonic method, the device may easily malfunction and it may be difficult to achieve stable atomization.

[0032] The surface tension of the liquid inhalation preparation according to one embodiment of the present invention may be 50 to 70 dynes at 25° C. When the surface tension is higher than the above range (50 to 70 dynes), the droplet size will be smaller. However, a large amount of ethanol must be added to increase the surface tension, which may be harmful to the human body and increase the process risk.

[0033] The density of the liquid inhalation preparation according to an embodiment of the present invention measured after storage at 25° C. for one day may be 0.995 to 1.164 g / cc.

[0034] The mass ratio of propylene glycol to glycerol in the liquid inhalation preparation according to an embodiment of the present invention may be 1:3 to 1:5.

[0035] The ratio of propylene glycol to glycerol affects the viscosity of the liquid inhalation preparation. When the mass ratio of propylene glycol to glycerol is 1:3 to 1:5, the viscosity of the liquid inhalation preparation can be 1.0 to 120 mPa·s (20° C.).

[0036] The mass ratio of physiological saline to glycerol in the liquid inhalation preparation is 4:5 to 1:7, preferably, the mass ratio of physiological saline to glycerol is 4:5 to 2:6, and the density at 25° C. may be 1.125 to 1.164 g / cc.

[0037] The physiological saline of the liquid inhalation preparation according to an embodiment of the present invention can include functional inhalation materials. The functional inhalation material can be liquid or solid. Relative to the weight of physiological saline, the content of the functional inhalation material can be 0 to 20 weight %. The functional inhalation material can be nicotine, caffeine, vitamins or natural extract materials etc. The natural extract materials can be rosemary, pine needles, peppermint, spearmint, coffee, pineapple, chamomile, orange, eucalyptus, thyme, geranium, jasmine, lavender, lemongrass, pine needles, alfalfa, sage, taxol, bergamot, basil, thyme, valerian, hyssop, tea tree, myrrh tree or juniper etc. However, the scope of the present disclosure is not limited to the examples listed above.

[0038] When propylene glycol is added to the liquid inhalation preparation according to an embodiment of the present invention, spices can be mixed. Spices can be selected from at least one of the group consisting of mint, chocolate, cocoa, coffee, licorice, coriander, vanillin, ethyl vanillin, maltol, ethyl maltol, eucalyptol, acetic acid, breath freshener, bergamot oil, rosemary, geranium oil, lemon oil, orange oil, lime oil, grapefruit oil, peppermint oil, ginger oil, ISO sweetener (isosweet) and fruit fragrance components, but not limited to the above types. Under the condition of no fragrance, propylene glycol may not be included.

[0039] An aerosol generating device according to an embodiment of the present invention may include a cartridge having the liquid inhalation formulation and a control unit.

[0040] An aerosol generating device may refer to a device that uses an aerosol-forming substrate to generate an aerosol for the user to inhale directly into the lungs through the mouth. The aerosol generating device of the present invention uses a surface wave nebulizer to aerosolize a liquid inhalation formulation.

[0041] The cartridge may generally include a reservoir containing a liquid inhalation formulation.

[0042] The liquid storage part may be a cylindrical shape with a hollow part, and the hollow part may be a suction port. The suction port may provide steam to a user.

[0043] The control unit may generally include a battery that provides power required for the operation of the aerosol generating device, a control unit that controls system driving, etc. The battery transmits power to activate the heater in the atomizer, which vaporizes the liquid delivered from the liquid reservoir, and the user can inhale the vaporized liquid.

[0044] The present invention will be described in detail below by way of examples, but the present invention is not limited to the following examples.

[0045] Experimental Example 1: Measuring the viscosity of liquid inhalation preparations and observing atomization

[0046] The inventors used a Brookfield viscometer to measure the viscosity of the liquid inhalation preparation at 20°C. A No. 0 spindle was used with a rotation speed of 4 to 100 rpm and a water bath was used to maintain the temperature. The analysis was commissioned to the Polymer Detection Research Institute and the analysis was also performed by the inventors themselves (cross-checking), and repeated three times. The results are shown in Tables 1 and Figure 1 shown.

[0047] [Table 1]

[0048]

[0049] Example 1 - A liquid inhalation preparation having a mass ratio of normal saline: propylene glycol (PG): glycerol (VG) of 4:1:5.

[0050] Example 2 - A liquid inhalation preparation having a mass ratio of normal saline: propylene glycol (PG): glycerol (VG) of 2:2:6.

[0051] Example 3 - A liquid inhalation preparation having a mass ratio of normal saline: propylene glycol (PG): glycerol (VG) of 1:2:7.

[0052] Comparative Example - Liquid inhalation formulation containing only saline.

[0053] When the viscosity exceeds 120mPa·s, many large droplets with a diameter of 200μm or more are generated. More vibration energy is required to vibrate the surface of a high-viscosity liquid, and it can be inferred that the irregularity of the surface vibration increases, resulting in many large droplets. Large droplets may adhere to the inner wall of the ventilation pipe and block the airflow channel, or they may be discharged outside the ventilation pipe and cause discomfort to the smoker, and the spray itself may not be smooth. In addition, it will be difficult to store due to changes in temperature and humidity.

[0054] In addition, in order to observe whether stable atomization is performed within the above-mentioned viscosity range, a surface wave conventional element for smartphone frequency filtering and a solution soaked in a cigarette paper filter were used. As a result of confirming that the solution was atomized, aerosol was continuously, stably and uniformly generated within the above-mentioned viscosity range. Thus, the liquid inhalation preparation according to the present invention can stably and continuously achieve atomization in the high viscosity region up to 120 mPa·s.

[0055] Experimental Example 2: Observation of the surface tension of liquid inhalation preparations

[0056] In order to obtain the results shown in Table 2 below, a plate type surface tension meter was used to measure at 25°C. The results are shown in Table 2 and Figure 2 shown.

[0057] [Table 2]

[0058]

[0059] Experimental Example 3: Observation of the density of liquid inhalation preparations

[0060] In order to measure the density of the liquid inhalation preparation at 25°C, a certain volume of liquid was measured with a measuring cylinder, weighed and calculated to 4 significant figures. The results are shown in Table 3 and Figure 3 shown.

[0061] [Table 3]

[0062]

[0063] As described above, although the embodiments are described by limiting the drawings, a person skilled in the art can implement various technical modifications and variations based on the above contents. For example, even if the described techniques and / or multiple structural elements of the described systems, structures, devices, circuits, etc. are performed in a different order from the described methods, or multiple structural elements of the described systems, structures, devices, circuits, etc. are combined or combined in a different form from the described methods, or replaced or substituted by other structural elements or equivalent technical solutions, appropriate results can be achieved.

[0064] Therefore, other implementations, other embodiments, and equivalents thereof are within the scope of the appended claims.

Claims

1. A liquid inhalation preparation, the liquid inhalation preparation is a liquid inhalation preparation for a surface wave nebulizer, wherein: The viscosity of the liquid inhalation preparation is 1.0 to 120 mPa·s at 20°C, The liquid inhalation preparation comprises at least one selected from the group consisting of propylene glycol, glycerol and physiological saline, The content of the glycerol is 50% by weight or more relative to the total weight of the propylene glycol, the glycerol and the physiological saline.

2. The liquid inhalation preparation according to claim 1, wherein The surface tension of the liquid inhalation formulation is 50 to 70 dynes at 25°C.

3. The liquid inhalation preparation according to claim 1, wherein The liquid inhalation formulation has a density of 0.995 to 1.164 g / cc at 25°C.

4. The liquid inhalation preparation according to claim 1, wherein The mass ratio of the propylene glycol to the glycerol is 1:3 to 1:

5.

5. The liquid inhalation preparation according to claim 4, wherein The mass ratio of the physiological saline to glycerol is 4:5 to 1:

7.

6. The liquid inhalation preparation according to claim 4, wherein The mass ratio of the physiological saline to glycerol is 4:5 to 2:6, The liquid inhalation formulation has a density of 1.125 to 1.164 g / cc at 25°C.

7. The liquid inhalation preparation according to claim 1, wherein The saline solution includes a functional inhalation material.

8. The liquid inhalation preparation according to claim 7, wherein The content of the functional inhalation material is 0 to 20 wt % relative to the weight of the physiological saline.

9. The liquid inhalation preparation according to claim 7, wherein The functional inhalation material includes at least one selected from the group consisting of nicotine, caffeine, vitamins and natural product extraction materials.

10. The liquid inhalation preparation according to claim 9, wherein The natural extract material includes at least one selected from the group consisting of rosemary, pine leaves, peppermint, spearmint, coffee, pineapple, chamomile, orange, eucalyptus, thyme, geranium, jasmine, lavender, lemongrass, pine needles, alfalfa, sage, paclitaxel, bergamot, basil, thyme, valerian, hyssop, tea tree, myrrh tree, and juniper.

11. The liquid inhalation preparation according to claim 1, wherein The propylene glycol contains fragrance.

12. The liquid inhalation preparation according to claim 11, wherein The flavor is at least one selected from the group consisting of mint, chocolate, cocoa, coffee, licorice, coriander, vanillin, ethyl vanillin, maltol, ethyl maltol, eucalyptol, acetic acid, breath freshener fragrance, bergamot oil, rosemary, geranium oil, lemon oil, orange oil, lime oil, grapefruit oil, peppermint oil, ginger oil, ISO sweetener and fruit fragrance ingredients.

13. A cigarette cartridge, wherein: Comprising a liquid inhalation formulation according to any one of claims 1 to 12.

14. An aerosol generating device, in, include: A cartridge comprising a liquid inhalation formulation according to any one of claims 1 to 12; as well as Control unit.

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