Essential oil composition for improving headache, dizziness and fatigue and application thereof

Abstract

The invention provides an essential oil composition for improving headache, dizziness and fatigue. The essential oil composition is prepared from the following raw materials in parts by weight: 1.0-3.0 parts of ligusticum wallichii essential oil, 1.0-3.0 parts of notopterygium root essential oil and 0.5-1.5 parts of divaricate saposhnikovia root essential oil. The invention also provides application of the essential oil composition. The essential oil composition disclosed by the invention is prepared by compatibility under the guidance of basic theories of traditional Chinese medicine, is rapid and obvious in effect of improving headache, dizziness and fatigue and convenient to use, and the essential oil raw materials are all in a cosmetic raw material catalog, so that the essential oil composition is safer in clinical use and is not easy to generate drug resistance and dependence.

Description

Technical Field

[0001] The invention relates to an essential oil composition for improving headache, dizziness and fatigue. Background Art

[0002] Headache refers to pain that occurs in the upper part of the head, including the brow arch, the upper edge of the ear helix, and the area above the external occipital protuberance. It is a common clinical symptom that can occur alone or in the course of a variety of acute and chronic diseases. According to the cause of headache, it is divided into primary headaches such as migraine, tension headache, cluster headache; secondary headaches caused by head and neck trauma, cranial and neck vascular factors, intracranial non-vascular diseases, infection, drug withdrawal and other reasons; headaches caused by facial structural lesions such as cranial neuralgia, central, primary facial pain, and other types of headaches. The incidence rate has been on the rise in recent years, especially migraine. Migraine has now become the third most common disease and the sixth most disabling disease in humans. The causes of most primary headaches are unknown or complex, and the pathogenesis has not been clearly studied. Modern medical treatment focuses on relieving symptoms, adopting graded diagnosis and treatment, and often using non-steroidal anti-inflammatory drugs, acetanilide antipyretic analgesics, triptans, caffeine-containing compound preparations, receptor blockers and anti-epileptic drugs for symptomatic analgesia. Although it can achieve certain therapeutic effects, as the course of the disease progresses, the drug efficacy is poorly controlled, and it is easy to develop drug dependence, drug resistance, side effects and other reactions, which limits its clinical application. At the same time, its repeated attacks bring serious economic and medical burdens to the patient's family and society.

[0003] Causes of primary headaches, such as cerebral vasospasm, long-term tension and contraction of head and neck muscles, abnormal release of neurotransmitters (such as 5-hydroxytryptamine), and hypothalamic dysfunction, can also reduce local blood flow in the brain, affect blood supply to the brain, and interfere with brain nerve regulation, which can lead to dizziness. Headache attacks, abnormal discharge of brain neurons, and continuous tension and contraction of head and neck muscles all require a lot of energy consumption, which can lead to fatigue. Dizziness and fatigue can also affect the blood vessels and nerve regulation of the brain through the nervous system, affect the secretion of hormones (such as cortisol), and compress the blood vessels and nerves in the neck, thereby inducing and aggravating headaches.

[0004] Headache belongs to the category of "head wind", "head wind" and "brain wind" in traditional Chinese medicine. It was first recorded in the "Inner Canon of Medicine", pointing out that exogenous and internal injuries are its main causes. "Suwen. Wind Theory" says that "a stroke after a bath is head wind," and "wind qi follows the wind palace, it is brain wind." It is believed that all six meridian lesions can cause headaches. TCM treatment of headaches focuses on syndrome differentiation and treatment, overall policy, full-process management, and comprehensive intervention. Clinical studies have confirmed that it has the characteristics of outstanding efficacy, high safety, and multi-target treatment. As an important part of traditional Chinese medicine, Chinese aromatherapy shows unique advantages in the treatment of headaches. It has the characteristics of rapid action, effectiveness, safety, mildness, not easy to produce drug resistance and dependence, and is suitable for long-term use. Chinese herbal essential oils usually have strong pharmacological activity, are mostly aromatic, pungent, dispersing, warming, and their molecules are fine, highly volatile, and highly lipid-soluble. They can easily pass through the biological membrane in the body and have high bioavailability. They can be quickly absorbed and effective through the gastrointestinal tract, nasal, oral mucosa, skin and other pathways. Chinese herbal essential oils can directly and quickly improve symptoms of headache, dizziness, and fatigue by regulating blood vessel status, improving blood supply to the brain, and regulating the nervous system. They can also act on the internal organs and meridians, promote the circulation of qi and blood, balance the body's yin and yang, and regulate the body's functions as a whole, which can not only improve symptoms but also prevent recurrence.

[0005] Application number: 202310216228, invention name: A Chinese herbal aromatherapy essential oil for treating headache and dizziness and its preparation method, relates to a Chinese herbal aromatherapy essential oil for treating headache and dizziness and its preparation method, the Chinese herbal aromatherapy essential oil comprises base oil, aromatherapy Chinese herbal oil, composite flexible liposome and penetration enhancer; the aromatherapy Chinese herbal oil comprises St. John's wort soaked oil, peppermint essential oil, rosemary oil, clary sage essential oil, helichrysum essential oil, spike lavender oil, frankincense oil, eucalyptus oil, ginger oil, selfheal oil, cassia seed oil, chuanxiong oil, angelica oil, asarum oil, angelica dahurica essential oil, saposhnikovia oil, notopterygium wilfordii oil, and gamma-aminobutyric acid. This application is a combination of Chinese herbal oil and aromatherapy essential oil.

[0006] Application No. 202010667016.3, Invention Name: A kind of rehabilitation essential oil for neck and shoulder strain for phlegm and blood stasis constitution and its preparation method, the invention discloses a kind of rehabilitation essential oil for neck and shoulder strain for phlegm and blood stasis constitution and its preparation method. The massage essential oil of the invention is prepared from grape seed oil, sunflower seed oil, arnica oil, sesame oil, vitamin E, angelica, chuanxiong, cyperus, notopterygium, eucommia, panax notoginseng, zedoaria and saposhnikovia, and its preparation method comprises the following steps: 1) preparing angelica powder, chuanxiong powder, cyperus powder, notopterygium powder, eucommia powder, panax notoginseng powder, zedoaria powder and saposhnikovia powder; 2) preparing angelica essential oil, chuanxiong essential oil, cyperus essential oil, notopterygium essential oil, eucommia essential oil, panax notoginseng essential oil, zedoaria essential oil and saposhnikovia essential oil; 3) batch mixing of various ingredients. The massage essential oil of the invention has a good effect of relieving muscle strain in combination with appropriate massage techniques.

[0007] Currently, there are many raw materials for the formulation of aromatic essential oils. Among them, the use of asarum essential oil and angelica dahurica essential oil poses safety risks, and the ingredients that exert their effects are unclear. Summary of the invention

[0008] The invention provides an essential oil composition for improving headache, dizziness and fatigue and application thereof, which is suitable for the prevention and treatment of diseases and daily health care.

[0009] The present invention provides an essential oil composition for improving headache, dizziness and fatigue, which is prepared from the following raw materials in weight ratio:

[0010] 1.0-3.0 parts of Chuanxiong essential oil, 1.0-3.0 parts of Notopterygium essential oil, and 0.5-1.5 parts of Saposhnikovia essential oil.

[0011] Preferably, it is prepared from the following raw materials in weight ratio:

[0012] 2.0 parts of Chuanxiong essential oil, 2.0 parts of Notopterygium essential oil, and 1.0 part of Saposhnikovia essential oil.

[0013] The raw materials also contain schizonepeta essential oil, and the weight ratio of the raw materials is: 1.0-3.0 parts of chuanxiong essential oil, 1.0-3.0 parts of angelica dahurica essential oil, 0.5-1.5 parts of siler essential oil, and 0.5-1.5 parts of schizonepeta essential oil.

[0014] Preferably, it is prepared from the following raw materials in weight ratio:

[0015] 2.0 parts of Chuanxiong essential oil, 2.0 parts of Notopterygium essential oil, 1.0 part of Saposhnikovia essential oil, and 1.0 part of Schizonepeta essential oil.

[0016] Wherein, the raw materials also contain dried ginger essential oil and peppermint essential oil, and the weight ratio of the raw materials is:

[0017] 1.0-3.0 parts of Chuanxiong essential oil, 1.0-3.0 parts of Qianghuo essential oil, 0.5-1.5 parts of Saposhnikovia essential oil, 0.5-1.5 parts of Schizonepeta essential oil, 0.5-1.5 parts of dried ginger essential oil, and 0.25-0.75 parts of peppermint essential oil.

[0018] Preferably, it is prepared from the following raw materials in weight ratio:

[0019] 2.0 parts of Chuanxiong essential oil, 2.0 parts of Qianghuo essential oil, 1.0 part of Saposhnikovia essential oil, 1.0 part of Nepeta essential oil, 1.0 part of dried ginger, and 0.5 part of mint.

[0020] Wherein, the raw material further contains camphor leaf essential oil or wintergreen essential oil or turmeric essential oil or cyperus rotundus essential oil or frankincense essential oil or myrrh essential oil; the weight ratio of the raw materials is:

[0021] 1.0-3.0 parts of Chuanxiong essential oil, 1.0-3.0 parts of Qianghuo essential oil, 0.5-1.5 parts of Saposhnikovia essential oil, 0.5-1.5 parts of Schizonepeta, 0.5-1.5 parts of dried ginger, 0.25-0.75 parts of mint, 0.5-3.0 parts of camphor leaf essential oil, or wintergreen essential oil, or turmeric essential oil, or cyperus essential oil, or frankincense essential oil, or myrrh essential oil.

[0022] Preferably, it is prepared from the following raw materials in weight ratio:

[0023] 2.0 parts of Chuanxiong essential oil, 2.0 parts of Qianghuo essential oil, 1.0 part of Fangfeng essential oil, 1.0 part of Schizonepeta, 1.0 part of dried ginger, 0.5 part of mint, 1.0 part of camphor leaf essential oil, and 1.0 part of wintergreen essential oil.

[0024] The essential oil composition of the invention is prepared from the raw materials as active ingredients and added with acceptable auxiliary materials or auxiliary ingredients to form common inhalation preparations and external preparations.

[0025] Among them, the inhalation preparations are: inhalation preparations, external preparations; the inhalation preparations include aerosols, inhalation powder aerosols, nebulized inhalations, inhalation liquid preparations, nasal sprays, and aromatherapy agents; the external preparations include aqueous solutions, emulsions, creams, ointments, oils, liniments, coatings, gels, sprays, aerosols, tinctures, and patches.

[0026] The present invention also provides the use of the composition in preparing a medicine having the efficacy of improving headache, dizziness and fatigue.

[0027] The medicine is a medicine for reducing the frequency of migraine attacks or the duration of a single headache; or, the medicine is a medicine for improving the symptoms of common cold headache and dizziness.

[0028] The present invention also provides use of the composition in preparing a health product that helps to relieve physical fatigue.

[0029] Chuanxiong can invigorate blood circulation and promote qi, and is a blood qi medicine, and can dispel wind and relieve pain. "New Compilation of Materia Medica" says that it "can clear blood stasis, disperse exogenous infection, and treat headaches". "Compendium of Materia Medica" says that it "goes up to the head, regulates menstrual fluid, relieves depression, and is a blood qi medicine... It is pungent in taste and yang in nature, and the qi is dispersed and roaming without the state of yin coagulation and stickiness. Although it enters the blood, it can remove all wind and regulate all qi". Chuanxiong can not only promote qi in the blood, but also dispel wind in the blood, and is good at dispelling external wind. "Wind is the leader of all diseases, and it is good at promoting yang flavor". Chuanxiong is good at dispelling wind, and then exerts the effects of ascending the head, dispelling wind and relieving pain. It is especially good at treating pain in Shaoyang, Jueyin, and the top of the head; Qianghuo is pungent, warm and dispersing, dispelling wind, overcoming dampness and relieving pain, and runs in the Taiyang meridian. It is mainly used to treat Taiyang headaches and is good at treating pain in the neck, back, shoulders and back. The two medicines are both monarch medicines. Saposhnikovia divaricata can dispel wind and relieve exterior symptoms, overcome dampness and relieve pain, and stop spasms. It is an essential medicine for dispelling wind. It can dispel external wind and calm internal wind, and is good at dispersing wind evil in the head and eyes. Schizonepeta tenuifolia is pungent and warm, can relieve exterior symptoms and dispel wind, and can ascend to the head and eyes. It has a mild effect and has a good effect on both wind-cold and wind-heat, and is especially good at dispersing wind in the head and face. The two medicines are ministers, helping the monarch medicine to dispel wind and relieve pain, and clear the head and eyes. Ganjiang warms the middle and dispels cold. Its warm and hot nature can warm and dispel cold evil and warm the meridians, promoting the circulation of qi and blood; mint dispels wind-heat, clears the head and eyes, and soothes the liver and promotes qi. It can dispel wind-heat evil and improve wind evil disturbance; the two medicines are adjuvants. Camphor tree leaves, turmeric, cyperus rotundus, etc. can dispel wind, dispel cold and relieve pain, promote blood circulation and qi and relieve pain, and enhance the analgesic effect of the whole prescription. The combination of these medicines has a good therapeutic effect on symptoms such as headache and body pain caused by exogenous wind evil (including wind-cold and wind-heat), wind-evil combined with dampness, and poor blood circulation.

[0030] The essential oil composition of the invention is prepared under the guidance of the basic theory of traditional Chinese medicine, has rapid and obvious effects on improving headache, dizziness and fatigue, and is easy to use. The essential oil raw materials of the invention are all in the catalog of cosmetic raw materials, and are safer to use clinically, and are not prone to drug resistance and dependence. DETAILED DESCRIPTION

[0031] Preparation of essential oils

[0032] Example 1 Essential oil composition of the present invention

[0033] Chuanxiong essential oil 1.0g, Qianghuo essential oil 1.0g, Fangfeng essential oil 1.0g;

[0034] Example 2 Essential oil composition of the present invention

[0035] Chuanxiong essential oil 2.0g, Qianghuo essential oil 1.0g, Fangfeng essential oil 1.0g;

[0036] Example 3 Essential oil composition of the present invention

[0037] Chuanxiong essential oil 2.0g, Qianghuo essential oil 2.0g, Fangfeng essential oil 1.0g;

[0038] Example 4 Essential oil composition of the present invention

[0039] Chuanxiong essential oil 2.0g, Qianghuo essential oil 2.0g, Fangfeng essential oil 1.0g, Nepeta essential oil 0.5g;

[0040] Example 5 Essential oil composition of the present invention

[0041] Chuanxiong essential oil 2.0g, Qianghuo essential oil 2.0g, Fangfeng essential oil 1.0g, Nepeta essential oil 1.0g;

[0042] Example 6 Essential oil composition of the present invention

[0043] Chuanxiong essential oil 2.0g, Qianghuo essential oil 2.0g, Fangfeng essential oil 1.0g, Nepeta essential oil 1.0g, dried ginger 0.5g, mint 0.5g;

[0044] Example 7 Essential oil composition of the present invention

[0045] Chuanxiong essential oil 2.0g, Qianghuo essential oil 2.0g, Fangfeng essential oil 1.0g, Nepeta essential oil 1.0g, dried ginger 1.0g, mint 0.5g;

[0046] Example 8 Essential oil composition of the present invention

[0047] Chuanxiong essential oil 2.0g, Qianghuo essential oil 2.0g, Fangfeng essential oil 1.0g, Nepeta essential oil 1.0g, dried ginger 1.0g, mint 0.5g, camphor leaf essential oil 2.0g, wintergreen essential oil 2.0g;

[0048] Example 9 Essential oil composition of the present invention

[0049] Chuanxiong essential oil 2.0g, Qianghuo essential oil 2.0g, Fangfeng essential oil 1.0g, Nepeta essential oil 1.0g, dried ginger 1.0g, mint 0.5g, camphor leaf essential oil 1.0g, wintergreen essential oil 1.0g;

[0050] The compositions in the above examples are prepared by directly mixing the essential oils.

[0051] When the components in the essential oil composition are combined, the selection of their dosage needs to comprehensively consider the therapeutic effect after combination as well as the smell, properties, safety, irritation and other factors of the essential oil after combination.

[0052] The efficacy pre-test was used to screen the ratio of essential oil compatibility. The compound essential oils could significantly prolong the time of ear red appearance and shorten the time of ear red disappearance in rats with migraine induced by nitroglycerin, and Example 9 had the best effect. The compound essential oils could significantly reduce the dizziness reaction index of dizzy mice and improve the dizziness reaction symptoms of mice after dizziness stimulation, and Example 7 had the best effect. The compound essential oils could significantly prolong the time of mice climbing poles and the time of weight-bearing swimming exhaustion, and Example 5 had the best effect. The smell acceptability of Examples 7 and 9 was the best.

[0053] The beneficial effects of the present invention are demonstrated by specific pharmacodynamic tests and clinical trials as follows.

[0054] Experimental Example 1 Effect of the essential oil composition of the present invention on nitroglycerin-induced migraine in rats

[0055] 1. Experimental grouping, drug administration and modeling

[0056] A total of 140 SPF SD rats, weighing 200±20g, with half ♀ and ♂, were housed in the laboratory for 3 days and randomly divided into a blank group, a model group, a Chuanxiong essential oil group, a Notopterygium essential oil group, a Saposhnikovia essential oil group, a Nepeta essential oil group, a dried ginger essential oil group, a peppermint essential oil group, a Chuanxiong-Notopterygium drug pair group (Chuanxiong-Notopterygium 1:1), a Chuanxiong-Saposhnikovia drug pair group (Chuanxiong-Saposhnikovia 2:1), and a compound essential oil group 1 (Chuanxiong- Group 1 (qianghuo-fangfeng 2:2:1), compound essential oil group 2 (chuanxiong-qianghuo-fangfeng-jingjie 2:2:1:1), compound essential oil group 3 (chuanxiong-qianghuo-fangfeng-jingjie-ganjiang-mentha 2:2:1:1:1:0.5), compound essential oil group 4 (chuanxiong-qianghuo-fangfeng-jingjie-ganjiang-mentha-camphor leaf-holly 2:2:1:1:1:0.5:1:1), 10 rats in each group.

[0057] Rats in the blank group, model group, and essential oil group were subjected to nebulized aromatherapy for 15 minutes. The blank group and model group were given 50 ml of water, and the essential oil group was given 50 ml of water with about 0.5 g of essential oil dropped into it. The volume of the animal aromatherapy room was about 50 L (52 cm × 38 cm × 25 cm). The dosage was 0.25 g / kg (calculated as essential oil dosage), and the drug was administered continuously for 14 days.

[0058] 30 minutes after the last administration of each group, the model group and essential oil group were subcutaneously injected with nitroglycerin (GTN) at a dose of 10 mg / kg at the back of the neck once to establish a migraine rat model. 5 minutes after the injection of nitroglycerin injection (GTN), the rats showed red ears, frequent scratching of the head with the forelimbs, increased number of cage climbing, and irritability, indicating that the model was successfully prepared. And these phenomena lasted for about 3 hours, and then the rats turned to a state of curling up and reduced activity. The blank group was subcutaneously injected with an equal dose of normal saline at the back of the neck once.

[0059] 2. Effects on the duration of ear redness and behavioral head scratching frequency in rats

[0060] The onset and disappearance time of ear redness in rats after injection of nitroglycerin were recorded; 5 minutes after injection of nitroglycerin, the number of times the rats scratched their heads with their forelimbs every 30 minutes within 2 hours.

[0061] 3. Elisa method to determine the content of NO, CGRP, ET-1 and 5-HT in serum

[0062] Four hours after modeling, the rats were anesthetized and blood was collected from the abdominal aorta. Serum was collected by centrifugation and the levels of nitric oxide (NO), calcitonin gene-related peptide (CGRP), endothelin-1 (ET-1) and 5-hydroxytryptamine (5-HT) in the rat serum were determined according to the instructions of the Elisa kit.

[0063] 4. Experimental results

[0064] 4.1 Time of ear redness in rats

[0065] The ears of the rats in the normal group did not show redness. Compared with the model group, compound essential oil 4 could significantly prolong the time of ear redness (P < 0.05), and there was no significant difference in the other groups (P > 0.05); Chuanxiong essential oil, Chuanxiong-Qianghuo herbal pair essential oil, Chuanxiong-Saposhnikovia herbal pair essential oil and compound essential oil could significantly shorten the time of ear redness disappearance (P < 0.05), and there was no significant difference in the single essential oil groups (P > 0.05). The results are shown in Table 1.

[0066] Table 1 Results of rat ear redness time

[0067]

[0068] Compared with the model group, * P<0.05, ** P < 0.01;

[0069] 4.2 Effects on the number of head scratching in rats at different time periods

[0070] Compared with the normal group, the model group rats scratched their heads significantly more frequently at each time period. Compared with the model group, the essential oils of Chuanxiong-Qianghuo herbal pair, Chuanxiong-Saposhnikovia divaricata herbal pair and compound essential oils could significantly reduce the number of head scratching in rats at each time period. Chuanxiong essential oil and Qianghuo essential oil could significantly reduce the number of head scratching in rats 60 minutes and 90 minutes after modeling, respectively (P < 0.05). There were no significant differences in the other groups (P > 0.05). The results are shown in Table 2.

[0071] Table 2 Effects on the number of head scratching in migraine rats at different time periods

[0072]

[0073]

[0074] Compared with the model group, * P<0.05, ** P<0.01; compared with the blank group, # P<0.05, ## P < 0.01;

[0075] 4.3 Effects on the levels of NO, CGRP, ET-1, and 5-HT in the serum of migraine rats

[0076] Compared with the normal group, the NO, CGRP, and ET-1 levels in the serum of the model group rats were increased, and the 5-HT level was decreased. Compared with the model group, Chuanxiong essential oil, Chuanxiong-Qianghuo herbal pair, Chuanxiong-Saposhnikovia herbal pair, and compound essential oil could significantly reduce the CGRP and ET-1 levels in the serum of migraine rats; except for dried ginger essential oil, the essential oil groups could reduce the NO level in the serum of migraine rats and increase the 5-HT level (P < 0.05), and there were no significant differences in the other groups (P > 0.05). The results are shown in Table 3.

[0077] Table 3 Effects on the levels of NO, CGRP, ET-1 and 5-HT in serum

[0078]

[0079] Compared with the model group, * P<0.05, ** P<0.01; compared with the blank group, # P<0.05, ## P < 0.01;

[0080] Experimental Example 2 Effect of the essential oil composition of the present invention on vertigo model mice

[0081] 1. Replicate the animal model of vertigo

[0082] The Crampton rotating device was used to replicate the animal model of vertigo. The rotation dizziness stimulation method was: variable speed rotation stimulation, alternating clockwise and counterclockwise rotation of the horizontal axis, during which the clockwise and counterclockwise rotation was performed 20 times in total for a total of 40 minutes.

[0083] 2. Experimental Grouping and Drug Administration

[0084] 140 SPF KM mice, weighing 20±2g, half ♀ and half ♂, housed in the laboratory for 3 days. The mice were randomly divided into blank group, model group, chuanxiong essential oil group, notopterygium essential oil group, saposhnikovia essential oil group, schizonepeta essential oil group, dried ginger essential oil group, mint essential oil group, chuanxiong-notopterygium drug pair group (chuanxiong-notopterygium 1:1), chuanxiong-schizonepeta drug pair group (chuanxiong-schizonepeta 2:1), compound essential oil group 1 (chuanxiong-notopterygium-schizonepeta 2:2:1), compound essential oil group 2 (chuanxiong-notopterygium-schizonepeta-schizonepeta 2:2:1:1), compound essential oil group 3 (chuanxiong-notopterygium-schizonepeta-schizonepeta-dried ginger-mint 2:2:1:1:1:0.5), and compound essential oil group 4 (chuanxiong-notopterygium-schizonepeta-schizonepeta-dried ginger-mint-camphor tree leaf-holly 2:2:1:1:1:0.5:1:1), with 10 mice in each group.

[0085] The mice in the blank group, model group, and essential oil group were subjected to nebulized aromatherapy for 15 minutes. The blank group and model group were given 25 ml of water, and the essential oil group was given 25 ml of water with about 0.10 g of essential oil dropped into it. The volume of the animal aromatherapy room was about 50 L (52 cm × 38 cm × 25 cm). The dosage was 0.50 g / kg. The drug was administered continuously for 7 days.

[0086] 30 minutes after the last administration, the model group and essential oil were given rotation dizziness stimulation, while the normal group was not given stimulation. The dizziness reaction index was recorded during the dizziness stimulation and 10 minutes after the end of the stimulation.

[0087] Dizziness reaction index: score according to the following four indicators, and the dizziness reaction index is the sum of the four indicators.

[0088] 1) The number of fecal particles is the base number: no particles is 0 points, 1 particle is 1 point;

[0089] 2) Urinating: 0 points for no urination and 1.2 points for urination;

[0090] 3) Piloerection: 0 points for no piloerection, 0.6 points for mild piloerection, and 1.2 points for severe piloerection;

[0091] 4) Shiver: 0 points for absence, 0.6 points for mild, 1.2 points for moderate, and 2.4 points for severe.

[0092] 3. Experimental results: Effect on the dizziness index of mice

[0093] Compared with the normal group, the dizziness reaction index of the mice in the model group was significantly higher than that in the normal group (P<0.05). Compared with the model group, dried ginger essential oil, peppermint essential oil, chuanxiong essential oil, saposhnikovia essential oil, chuanxiong-qianghuo herbal pair, chuanxiong-saposhnikovia herbal pair, and compound essential oil can significantly reduce the dizziness reaction index of dizzy mice (P<0.05), and can effectively improve the dizziness reaction symptoms of mice after dizziness stimulation, and compound essential oil 3 has the best effect. The results are shown in Table 4.

[0094] Table 4 Effects on the dizziness reaction index of dizzy mice ( n=10)

[0095]

[0096]

[0097] Compared with the model group, * P<0.05, ** P<0.01; compared with the normal group, #P<0.05, ##P<0.01.

[0098] Test Example 3 Anti-fatigue effect of the essential oil composition of the present invention

[0099] 1. Experimental groups and drug administration methods

[0100] A total of 140 SPF KM mice, weighing 20±2g, with half ♀ and ♂, were housed in the laboratory for 5 days and randomly divided into a blank group, a Chuanxiong essential oil group, a Notopterygium essential oil group, a Saposhnikovia essential oil group, a Nepeta essential oil group, a Dry Ginger essential oil group, a Peppermint essential oil group, a Chuanxiong-Notopterygium drug pair group (Chuanxiong-Notopterygium 1:1), a Chuanxiong-Saposhnikovia drug pair group (Chuanxiong-Saposhnikovia 2:1), and a compound essential oil group 1 (Chuanxiong-Notopterygium-Saposhnikovia 2:2). 1), compound essential oil group 2 (Chuanxiong-Qianghuo-Saposhnikovia-Schizonepeta 2:2:1:1), compound essential oil group 3 (Chuanxiong-Qianghuo-Saposhnikovia-Schizonepeta-dried ginger-mint 2:2:1:1:1:0.5), compound essential oil group 4 (Chuanxiong-Qianghuo-Saposhnikovia-Schizonepeta-dried ginger-mint-camphor leaves-Ilex 2:2:1:1:1:0.5:1:1), and positive control Rhodiola rosea capsule group, 10 rats in each group.

[0101] The mice in the blank group and essential oil group were subjected to nebulized aromatherapy for 15 minutes. The blank group was given 25 ml of water, and the essential oil group was given 0.1 g of essential oil dropped into 25 ml of water. The volume of the animal aromatherapy room was about 50 L (52 cm × 38 cm × 25 cm). The dosage was 0.50 g / kg. The Rhodiola rosea capsule group was given 0.50 g / kg by oral gavage for 14 consecutive days.

[0102] 2. Mouse climbing pole experiment

[0103] The pole climbing test was performed 30 minutes after the last administration. The mice were placed on the top of the glass rod to put their muscles in a static tension state. The time it took for the mice to fall from the glass rod due to muscle fatigue was recorded. The average of the three measurements was taken as the pole climbing time.

[0104] 3. Mouse weighted swimming experiment

[0105] After the pole climbing test, the mice were allowed to recover after 3 days of adaptation. During the adaptation period, each group continued to receive atomized aromatherapy. The swimming test was performed 30 minutes after the last administration. The tail of the mouse was loaded with a lead wire that was 6% of the mouse's body weight. The mouse was placed in a bucket with a water depth of 40 cm and a water temperature of 25±2°C. The water surface was stirred to make the mouse swim continuously. The time from entering the water to the head completely sinking into the water for 6S and not being able to float to the surface was recorded, which was the exhaustive swimming time of the mouse. After recording the time, the mouse was fished out.

[0106] 4. Results of the pole climbing test and weighted swimming test on mice

[0107] Compared with the blank group, the groups treated with Chuanxiong essential oil, peppermint essential oil, Chuanxiong-Notopterygium essential oil, Chuanxiong-Saposhnikovia essential oil and compound essential oil could significantly prolong the pole climbing time of mice; the groups treated with Chuanxiong essential oil, Chuanxiong-Notopterygium essential oil, Chuanxiong-Saposhnikovia essential oil and compound essential oil could significantly prolong the weighted swimming exhaustion time of mice (P<0.05); compared with the positive drug group, compound essential oil 1 and compound essential oil 2 were significantly better than the positive group (P<0.05), compound essential oil 3 and compound essential oil 4 had no significant difference with the positive group, and compound essential oil 2 had the best effect. The results are shown in Table 5.

[0108] Table 5 Effects on the climbing time and weight-bearing swimming exhaustion of mice

[0109]

[0110] Compared with the blank group, * P<0.05, ** P<0.01; compared with the positive group, # P<0.05, ## P < 0.01;

[0111] The compound essential oil can significantly prolong the time for mice to climb the pole and the time for mice to swim to exhaustion with weight.

[0112] Test Example 4 Clinical efficacy of the essential oil composition of the present invention on migraine

[0113] 1. Therapeutic effect on migraine

[0114] General information: 80 patients with migraine admitted to a hospital in Yibin from November 2023 to November 2024 were selected. There were 32 males and 48 females, aged 36.53±6.74 years, and a course of disease of 4.12±0.97 years. They were randomly divided into two groups for a prospective controlled study. There was no statistically significant difference in gender, age, course of disease, and past medical history between the two groups (P>0.05), and they were comparable.

[0115] 2. Inclusion criteria

[0116] (1) Refer to the "Guidelines for the Prevention and Treatment of Migraine in China" and the "International Classification of Headaches" (3rd edition) published by the International Headache Society in 2018, combined with medical history, symptom assessment, neurological examination, etc., and meet the diagnostic criteria for migraine;

[0117] (2) The duration of the disease was ≥ 6 months, the frequency of migraine attacks was > 2 times per month in the 3 months before the consultation, and the duration of each attack was > 4 hours.

[0118] (3) No treatment with antiepileptic drugs, 5-hydroxytryptamine (5-HT) receptor blockers, antidepressants, or other related drugs within 3 months before the visit.

[0119] (4) Voluntarily sign the informed consent form.

[0120] 3. Exclusion criteria

[0121] (1) History of drug or alcohol abuse;

[0122] (2) Headache caused by brain trauma or organic brain lesions;

[0123] (3) Combined with dysfunction of important organs such as heart, lung, liver, and kidney;

[0124] (4) Psychiatric patients;

[0125] (5) Pregnant women.

[0126] 4. Dosage method

[0127] Compound essential oil 4 was diluted with a base oil containing 0.05% vanillyl butyl ether to form a massage oil with a concentration of 10%.

[0128] The control group was given Flunarizine Hydrochloride Capsules, 5 mg / capsule, 1 capsule per night. The experimental group applied Compound Essential Oil 4 massage oil on Baihui acupoint, Fengchi acupoint, and temples, once in the morning and evening, about 2 ml each time.

[0129] 5. Efficacy evaluation

[0130] The efficacy was evaluated by the frequency of monthly headache attacks, the duration of a single attack, and the Visual Analog Scale (VAS) score of pain during the attack. The VAS score is proportional to the degree of pain. The higher the score, the more severe the pain. The range is 0 to 10 points. 0 means completely painless, 1 to 3 means mild headache, pain but tolerable, does not affect work and daily life, and sleep is not disturbed; 4 to 6 means moderate headache, obvious pain, difficult to bear, affecting normal life, and sleep is disturbed; 7 to 9 means severe headache, severe pain, extremely difficult to bear, seriously affecting normal life, severe sleep disturbance, accompanied by autonomic nervous system disorders or passive posture, and bed rest is required. 10 means severe headache, unbearable, unable to live and sleep normally.

[0131] The efficacy was determined based on the VAS score: markedly effective: efficacy index ≥ 70%; effective: efficacy index 30% ≤ efficacy index < 70%; ineffective: efficacy index < 30%. Total effective rate = (markedly effective + effective) cases / total cases × 100%.

[0132] Therapeutic index = (VAS score before treatment - VAS score after treatment) / VAS score before treatment × 100%.

[0133] 6. Therapeutic effect on migraine

[0134] The compound essential oil can reduce the frequency of migraine attacks and the duration of a single headache, and can improve the effectiveness of flunarizine hydrochloride in treating migraine. The results are shown in Tables 6 and 7.

[0135] Table 6 Comparison of pain symptoms between the two groups of migraine patients before and after treatment

[0136]

[0137] Compared with the control group, * P<0.05, ** P<0.01; compared with before treatment, # P<0.05, ## P < 0.01;

[0138] Table 7 Comparison of clinical efficacy between the two groups of migraine patients

[0139]

[0140] Test Example 5 Clinical efficacy of the essential oil composition of the present invention on headache and dizziness caused by cold

[0141] 1. General data: 90 patients with common cold with obvious headache and dizziness symptoms diagnosed in the outpatient department of a hospital in Yibin from February 2024 to November 2024 were selected (the degree of headache and dizziness was tolerable and did not affect normal work and study), including 42 males and 48 females, aged 15 to 65 years old. They were randomly divided into control group, experimental group 1 and experimental group 2. There was no statistically significant difference in gender, age, course of disease, previous medical history, etc. among the three groups (P>0.05), and they were comparable.

[0142] 2. Diagnostic criteria

[0143] Refer to the Expert Consensus on Standardized Diagnosis and Treatment of Common Cold (2012). Meet the diagnostic criteria for common cold, exclude other diseases such as influenza, acute bacterial sinusitis, streptococcal pharyngitis, etc.; headache and dizziness symptoms are more obvious; compliance is good.

[0144] 3. Dosage method

[0145] Patients in the control group did not use any medication within 3 days.

[0146] Patients in experimental group 1 were given essential oil 3, and patients in experimental group 2 were given essential oil 4, and atomized aromatherapy for 30 minutes, once in the morning and evening, 30 minutes each time, for 2 days. The number of cases in which headache and dizziness symptoms improved or disappeared after 1 day and 2 days of administration was recorded respectively.

[0147] Significant effect: Headache and dizziness symptoms completely disappeared;

[0148] Effective: Headache and dizziness symptoms are significantly improved;

[0149] Ineffective: No obvious changes in headache and dizziness symptoms.

[0150] Total effective rate = (markedly effective + effective) / total number of people × 100%

[0151] 4. Clinical efficacy for headache and dizziness caused by cold

[0152] Compared with the control group, the number of patients with significant effects and the total effective rate in the test group were higher than those in the control group, and there was a significant difference on the first day of administration. The compound essential oil can quickly improve the headache and dizziness symptoms of patients with common cold. The results are shown in Table 8.

[0153] Table 8 Comparison of the improvement effect on dizziness and vertigo symptoms in patients with cold

[0154]

[0155]

[0156] Nebulization administration of compound essential oil 3 and compound essential oil 4 can quickly improve the symptoms of headache and dizziness in patients with common cold, and there is no significant difference between the two.

Claims

1. An essential oil composition for improving headache, dizziness and fatigue, characterized in that: It is prepared from the following raw materials in weight ratio: 1.0-3.0 parts of Chuanxiong essential oil, 1.0-3.0 parts of Notopterygium essential oil, and 0.5-1.5 parts of Saposhnikovia essential oil.

2. The essential oil composition for improving headache, dizziness and fatigue according to claim 1, characterized in that: It is prepared from the following raw materials in weight ratio: 2.0 parts of Chuanxiong essential oil, 2.0 parts of Notopterygium essential oil, and 1.0 part of Saposhnikovia essential oil.

3. The essential oil composition for improving headache, dizziness and fatigue according to claim 1, characterized in that: The raw materials also contain schizonepeta essential oil, and the weight ratio of the raw materials is: 1.0-3.0 parts of chuanxiong essential oil, 1.0-3.0 parts of qianghuo essential oil, 0.5-1.5 parts of siler essential oil, and 0.5-1.5 parts of schizonepeta essential oil. Preferably, it is prepared from the following raw materials in weight ratio: 2.0 parts of Chuanxiong essential oil, 2.0 parts of Notopterygium essential oil, 1.0 part of Saposhnikovia essential oil, and 1.0 part of Schizonepeta essential oil.

4. The essential oil composition for improving headache, dizziness and fatigue according to claim 3, characterized in that: The raw materials also contain dried ginger essential oil and peppermint essential oil, and the weight ratio of the raw materials is: 1.0-3.0 parts of Chuanxiong essential oil, 1.0-3.0 parts of Qianghuo essential oil, 0.5-1.5 parts of Saposhnikovia essential oil, 0.5-1.5 parts of Schizonepeta essential oil, 0.5-1.5 parts of dried ginger essential oil, and 0.25-0.75 parts of peppermint essential oil. Preferably, it is prepared from the following raw materials in weight ratio: 2.0 parts of Chuanxiong essential oil, 2.0 parts of Qianghuo essential oil, 1.0 part of Saposhnikovia essential oil, 1.0 part of Nepeta essential oil, 1.0 part of dried ginger, and 0.5 part of mint.

5. The essential oil composition for improving headache, dizziness and fatigue according to claim 4, characterized in that: The raw materials further contain camphor leaf essential oil, wintergreen essential oil, turmeric essential oil, cyperus rotundus essential oil, frankincense essential oil or myrrh essential oil; the weight ratio of the raw materials is: 1.0-3.0 parts of Chuanxiong essential oil, 1.0-3.0 parts of Qianghuo essential oil, 0.5-1.5 parts of Saposhnikovia essential oil, 0.5-1.5 parts of Schizonepeta, 0.5-1.5 parts of dried ginger, 0.25-0.75 parts of mint, 0.5-3.0 parts of camphor leaf essential oil, or wintergreen essential oil, or turmeric essential oil, or cyperus essential oil, or frankincense essential oil, or myrrh essential oil. Preferably, it is prepared from the following raw materials in weight ratio: 2.0 parts of Chuanxiong essential oil, 2.0 parts of Qianghuo essential oil, 1.0 part of Fangfeng essential oil, 1.0 part of Schizonepeta, 1.0 part of dried ginger, 0.5 part of mint, 1.0 part of camphor leaf essential oil, and 1.0 part of wintergreen essential oil.

6. The essential oil composition for improving headache, dizziness and fatigue according to any one of claims 1 to 5, characterized in that: The raw material is used as an active ingredient, and acceptable auxiliary materials or auxiliary ingredients are added to prepare commonly used inhalation preparations and external preparations.

7. The essential oil composition for improving headache, dizziness and fatigue according to claim 6, characterized in that: The inhalation preparations are: inhalation preparations, external preparations; the inhalation preparations include aerosols, inhalation powder aerosols, nebulized inhalation preparations, inhalation liquid preparations, nasal sprays, and aromatherapy agents; the external preparations include aqueous solutions, emulsions, creams, ointments, oils, liniments, coatings, gels, sprays, aerosols, tinctures, and patches.

8. Use of the composition according to any one of claims 1 to 7 in the preparation of a medicament for improving headache, dizziness and fatigue.

9. The use according to claim 8, characterized in that: The medicine is a medicine for reducing the frequency of migraine attacks or the duration of a single headache; or, the medicine is a medicine for improving the symptoms of common cold headache and dizziness.

10. Use of the composition according to any one of claims 1 to 7 in the preparation of a health product that helps relieve physical fatigue.

Images