Traditional Chinese medicine granules for treating liver cancer and preparation method thereof

Abstract

The invention discloses traditional Chinese medicine granules for treating liver cancer and a preparation method. The traditional Chinese medicine granules are prepared from the following raw materials: codonopsis pilosula, roasted rhizoma atractylodis macrocephalae, poria cocos, fiveleaf akebia fruit, campsis grandiflora, radix paeoniae alba, oldenlandia diffusa, fructus polygoni orientalis, oriental wormwood and radix saposhnikoviae. The traditional Chinese medicine composition has the effects of invigorating the spleen, replenishing qi and supporting the healthy energy by combining the codonopsis pilosula, the poria cocos and the atractylodes macrocephala koidz and is used for treating adverse reactions such as fatigue, diarrhea, appetite loss and weight loss caused by targeted medicines; the rhizoma atractylodis macrocephalae, the radix paeoniae alba, the radix saposhnikoviae and the herba artemisiae scopariae are combined for tonifying the spleen, nourishing the liver, excreting dampness and stopping diarrhea, the rhizoma atractylodis macrocephalae, the radix paeoniae alba, the radix saposhnikoviae and the herba artemisiae scopariae are combined with a product for tonifying the spleen to strengthen diarrhea symptoms caused by targeted treatment of liver cancer, and the herba hedyotidis diffusae, the fructus polygoni orientalis, the herba artemisiae scopariae, the poria cocos, the radix paeoniae alba, the fructus akebiae and the flos campsis are combined to achieve the effects of clearing heat, promoting diuresis and nourishing and activating blood The traditional Chinese medicine granules can treat skin reactions such as hand-foot syndromes caused by targeted drugs, so that the traditional Chinese medicine granules prepared by the invention can well improve diarrhea symptoms caused by liver cancer targeted drugs.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine granule for treating liver cancer and a preparation method thereof. Background Art

[0002] The most common adverse reactions of the liver cancer targeted drugs sorafenib and lenvatinib include diarrhea, but the specific mechanism of diarrhea caused by targeted therapy has not been fully elucidated. It is mainly believed that drug treatment may interfere with the division of intestinal epithelial cells, leading to intestinal mucosal barrier destruction, epithelial cell shedding, disproportionate increase and atypical hyperplasia of goblet cells and crypt cells, disordered reabsorption and secretion function of intestinal microvilli cells, and increased amount of fluid in the intestinal cavity, ultimately leading to diarrhea, which can increase the patient's discomfort. Summary of the invention

[0003] In view of the defects of the prior art, the purpose of the present invention is to provide a Chinese medicine granule for treating liver cancer and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0004] The present invention solves the technical problem by adopting the following technical solution:

[0005] The invention provides a traditional Chinese medicine granule for treating liver cancer. The formula consists of the following raw materials: codonopsis pilosula, stir-fried atractylodes macrocephala, tuckahoe, aconite root, trumpet creeper, white peony root, oldenlandia diffusa, red safflower fruit, capillaris, and siler.

[0006] Preferably, the formula is composed of the following raw materials by weight: Codonopsis pilosula 10-20g, stir-fried Atractylodes macrocephala 11-19g, Poria 12-18g, Atractylodes macrocephala 12-18g, Campsis creeper 5-15g, White Peony 10-20g, Oldenlandia diffusa 13-16g, Fructus Polygoni Orientalis 8-12g, Capillaris 13-17g, Saposhnikovia diffusa 9-11g.

[0007] Preferably, the formula is composed of the following raw materials by weight: 10g of Codonopsis pilosula, 19g of stir-fried Atractylodes macrocephala, 12g of Poria cocos, 18g of Atractylodes macrocephala, 5g of Campsis creeper, 20g of White Peony Root, 13g of Hedyotis diffusa, 12g of Polygonum multiflorum, 13g of Artemisia capillaris, and 11g of Saposhnikovia diffusa.

[0008] Preferably, the formula is composed of the following raw materials by weight: 15g of Codonopsis pilosula, 15g of stir-fried Atractylodes macrocephala, 15g of Poria cocos, 15g of Atractylodes macrocephala, 10g of Campsis creeper, 15g of White Peony Root, 15g of Hedyotis diffusa, 10g of Polygonum multiflorum, 15g of Artemisia capillaris, and 10g of Saposhnikovia diffusa.

[0009] Preferably, the formula is composed of the following raw materials by weight: 20g of Codonopsis pilosula, 11g of stir-fried Atractylodes macrocephala, 18g of Poria cocos, 12g of Atractylodes macrocephala, 15g of Campsis creeper, 10g of White Peony Root, 16g of Hedyotis diffusa, 8g of Polygonum multiflorum, 17g of Artemisia capillaris, and 9g of Saposhnikovia diffusa.

[0010] The present invention also provides a method for preparing Chinese medicine granules for treating liver cancer, comprising the following steps:

[0011] Step 1, weigh the above raw materials, clean them and remove impurities to obtain clean raw materials;

[0012] Step 2: Take the clean raw materials in step 1 and pour them into the Chinese medicine pot, add water and boil twice. For the first boiling, add 10 times the amount of water to soak, and then boil for 50-70 minutes. For the second boiling, add 8 times the amount of water, and then boil for 30-50 minutes, and combine the two decoctions;

[0013] Step 3: Combine the decoctions from the two Chinese medicine pots and pour them into a container, filter, combine the filtrates, concentrate into an extract with a relative density of 1.05-1.10 (70° C.), spray dry, mix well, and obtain a drug extract powder.

[0014] Preferably, the spray drying in step three is carried out under the conditions of an inlet air temperature of 185-195°C and an outlet air temperature of 90-100°C.

[0015] Preferably, during the first decoction in step 2, 10 times the amount of water is added and the mixture is soaked for 20-40 minutes.

[0016] Preferably, in step 1:

[0017] Codonopsis pilosula: remove impurities, wash, soak, cut into thick slices, and dry;

[0018] Atractylodes macrocephala: remove impurities, wash, soak, cut into thick slices, and dry;

[0019] Poria cocos: soak, wash, steam slightly after moistening, peel off the skin in time, cut into blocks or thick slices, and dry;

[0020] Premonition seeds: wash, dry and break into pieces;

[0021] Trumpet creeper: remove impurities, moisten slightly, cut into strips, and dry;

[0022] White peony root: wash, soak, cut into thin slices, and dry;

[0023] Oldenlandia diffusa: remove impurities and cut into sections;

[0024] Water safflower seeds: remove impurities;

[0025] Artemisia capillaris: remove the remaining roots and impurities, and crush or chop them;

[0026] Saposhnikovia divaricata: remove impurities, wash, soak, cut into thick slices, and dry.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] The invention uses codonopsis pilosula, tuckahoe and atractylodes macrocephala together to invigorate the spleen and replenish qi, strengthen the body and strengthen the root, and treat the adverse reactions such as fatigue, diarrhea, decreased appetite and weight loss caused by targeted drugs; the four drugs of atractylodes macrocephala, white peony root, saposhnikovia diffusa and capillaris are used together to invigorate the spleen and soften the liver, eliminate dampness and stop diarrhea, and are used together with the spleen-invigorating products to strengthen the treatment of diarrhea symptoms caused by targeted treatment of liver cancer; the drugs of oldenlandia diffusa, safflower seeds, capillaris, tuckahoe, white peony root, scutellaria baicalensis and campsis flos are used together to have the functions of clearing away heat and removing dampness, nourishing blood and activating blood circulation, and treat skin reactions such as hand-foot syndrome caused by targeted drugs; the drugs of diuresis and eliminating dampness in the prescription also have auxiliary effects on controlling hypertension caused by targeted drugs; the drugs of oldenlandia diffusa, scutellaria baicalensis, capillaris, campsis flos, saposhnikovia diffusa and the like are used together to target the pathological factors of liver cancer such as dampness, poison, blood stasis and wind, so as to achieve the purpose of "eliminating tumors and controlling tumors", so that the Chinese medicine granules prepared by the invention can well improve the diarrhea symptoms caused by targeted drugs for liver cancer. DETAILED DESCRIPTION

[0029] The following is a clear and complete description of the technical solutions in the embodiments of the present invention in conjunction with specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] Example 1.

[0031] The Chinese medicine granules for treating liver cancer of the present embodiment are formulated with the following raw materials: Codonopsis pilosula, stir-fried Atractylodes macrocephala, Poria cocos, Fructus aconiti lobatae, Flos Campsis, Paeonia lactiflora, Hedyotis diffusa, Fructus Polygoni Orientalis, Capillaris ternatae, and Saposhnikovia diffusa.

[0032] The formula of this embodiment is composed of the following raw materials by weight: the formula is composed of the following raw materials by weight: 10g of Codonopsis pilosula, 19g of stir-fried Atractylodes macrocephala, 12g of Poria cocos, 18g of Atractylodes macrocephala, 5g of Campsis creeper, 20g of White Peony Root, 13g of Hedyotis diffusa, 12g of Polygonum multiflorum, 13g of Artemisia capillaris, and 11g of Saposhnikovia diffusa.

[0033] The method for preparing a Chinese medicine granule for treating liver cancer in this embodiment comprises the following steps:

[0034] Step 1, weigh the above raw materials, clean them and remove impurities to obtain clean raw materials;

[0035] Step 2: Take the clean raw materials in step 1 and pour them into the Chinese medicine pot, add water and boil twice. For the first boiling, add 10 times the amount of water to soak, and then boil for 50 minutes. For the second boiling, add 8 times the amount of water, and then boil for 30 minutes, and combine the two decoctions;

[0036] Step 3: Combine the decoctions from the two Chinese medicine pots and pour them into a container, filter, combine the filtrates, concentrate into an extract with a relative density of 1.05 (70° C.), spray dry, mix well, and obtain a drug extract powder.

[0037] In step 3 of this embodiment, spray drying is performed under the conditions of an inlet air temperature of 185°C and an outlet air temperature of 90°C.

[0038] In step 2 of this embodiment, when boiling for the first time, add 10 times the amount of water and soak for 20 minutes.

[0039] In step 1 of this embodiment:

[0040] Codonopsis pilosula: remove impurities, wash, soak, cut into thick slices, and dry;

[0041] Atractylodes macrocephala: remove impurities, wash, soak, cut into thick slices, and dry;

[0042] Poria cocos: soak, wash, steam slightly after moistening, peel off the skin in time, cut into blocks or thick slices, and dry;

[0043] Premonition seeds: wash, dry and break into pieces;

[0044] Trumpet creeper: remove impurities, moisten slightly, cut into strips, and dry;

[0045] White peony root: wash, soak, cut into thin slices, and dry;

[0046] Oldenlandia diffusa: remove impurities and cut into sections;

[0047] Water safflower seeds: remove impurities;

[0048] Artemisia capillaris: remove the remaining roots and impurities, and crush or chop them;

[0049] Saposhnikovia divaricata: remove impurities, wash, soak, cut into thick slices, and dry.

[0050] Example 2.

[0051] The Chinese medicine granules for treating liver cancer of the present embodiment are formulated with the following raw materials: Codonopsis pilosula, stir-fried Atractylodes macrocephala, Poria cocos, Fructus aconiti lobatae, Flos Campsis, Paeonia lactiflora, Hedyotis diffusa, Fructus Polygoni Orientalis, Capillaris ternatae, and Saposhnikovia diffusa.

[0052] The formula of this embodiment is composed of the following raw materials by weight: the formula is composed of the following raw materials by weight: 15g of Codonopsis pilosula, 15g of stir-fried Atractylodes macrocephala, 15g of Poria cocos, 15g of Atractylodes macrocephala, 10g of Campsis creeper, 15g of White Peony Root, 15g of Hedyotis diffusa, 10g of Polygonum multiflorum, 15g of Artemisia capillaris, and 10g of Saposhnikovia diffusa.

[0053] The method for preparing a Chinese medicine granule for treating liver cancer in this embodiment comprises the following steps:

[0054] Step 1, weigh the above raw materials, clean them and remove impurities to obtain clean raw materials;

[0055] Step 2: Take the clean raw materials in step 1 and pour them into the Chinese medicine pot, add water and boil twice. For the first boiling, add 10 times the amount of water to soak, and then boil for 60 minutes. For the second boiling, add 8 times the amount of water, and then boil for 40 minutes, and combine the two decoctions;

[0056] Step 3: Combine the decoctions from the two Chinese medicine pots and pour them into a container, filter, combine the filtrates, concentrate into an extract with a relative density of 1.07 (70° C.), spray dry, mix well, and obtain a drug extract powder.

[0057] In step 3 of this embodiment, spray drying is performed under the conditions of an inlet air temperature of 190°C and an outlet air temperature of 95°C.

[0058] In step 2 of this embodiment, when boiling for the first time, add 10 times the amount of water and soak for 30 minutes.

[0059] In step 1 of this embodiment:

[0060] Codonopsis pilosula: remove impurities, wash, soak, cut into thick slices, and dry;

[0061] Atractylodes macrocephala: remove impurities, wash, soak, cut into thick slices, and dry;

[0062] Poria cocos: soak, wash, steam slightly after moistening, peel off the skin in time, cut into blocks or thick slices, and dry;

[0063] Premonition seeds: wash, dry and break into pieces;

[0064] Trumpet creeper: remove impurities, moisten slightly, cut into strips, and dry;

[0065] White peony root: wash, soak, cut into thin slices, and dry;

[0066] Oldenlandia diffusa: remove impurities and cut into sections;

[0067] Water safflower seeds: remove impurities;

[0068] Artemisia capillaris: remove the remaining roots and impurities, and crush or chop them;

[0069] Saposhnikovia divaricata: remove impurities, wash, soak, cut into thick slices, and dry.

[0070] Example 3.

[0071] The Chinese medicine granules for treating liver cancer of the present embodiment are formulated with the following raw materials: Codonopsis pilosula, stir-fried Atractylodes macrocephala, Poria cocos, Fructus aconiti lobatae, Flos Campsis, Paeonia lactiflora, Hedyotis diffusa, Fructus Polygoni Orientalis, Capillaris ternatae, and Saposhnikovia diffusa.

[0072] The formula of this embodiment is composed of the following raw materials by weight: the formula is composed of the following raw materials by weight: 20g of Codonopsis pilosula, 11g of stir-fried Atractylodes macrocephala, 18g of Poria cocos, 12g of Atractylodes macrocephala, 15g of Campsis creeper, 10g of White Peony Root, 16g of Hedyotis diffusa, 8g of Polygonum multiflorum, 17g of Artemisia capillaris, and 9g of Saposhnikovia diffusa.

[0073] The method for preparing a Chinese medicine granule for treating liver cancer in this embodiment comprises the following steps:

[0074] Step 1, weigh the above raw materials, clean them and remove impurities to obtain clean raw materials;

[0075] Step 2: Take the clean raw materials in step 1 and pour them into the Chinese medicine pot, add water and boil twice. For the first boiling, add 10 times the amount of water to soak, and then boil for 70 minutes. For the second boiling, add 8 times the amount of water, and then boil for 50 minutes, and combine the two decoctions;

[0076] Step 3: Combine the decoctions from the two Chinese medicine pots and pour them into a container, filter, combine the filtrates, concentrate into an extract with a relative density of 1.10 (70° C.), spray dry, mix well, and obtain a drug extract powder.

[0077] In step 3 of this embodiment, spray drying is performed under the conditions of an inlet air temperature of 195°C and an outlet air temperature of 100°C.

[0078] In step 2 of this embodiment, 10 times the amount of water is added during the first decoction and soaked for 40 minutes.

[0079] In step 1 of this embodiment:

[0080] Codonopsis pilosula: remove impurities, wash, soak, cut into thick slices, and dry;

[0081] Atractylodes macrocephala: remove impurities, wash, soak, cut into thick slices, and dry;

[0082] Poria cocos: soak, wash, steam slightly after moistening, peel off the skin in time, cut into blocks or thick slices, and dry;

[0083] Premonition seeds: wash, dry and break into pieces;

[0084] Trumpet creeper: remove impurities, moisten slightly, cut into strips, and dry;

[0085] White peony root: wash, soak, cut into thin slices, and dry;

[0086] Oldenlandia diffusa: remove impurities and cut into sections;

[0087] Water safflower seeds: remove impurities;

[0088] Artemisia capillaris: remove the remaining roots and impurities, and crush or chop them;

[0089] Saposhnikovia divaricata: remove impurities, wash, soak, cut into thick slices, and dry.

[0090] Specific application examples

[0091] The patient, Mr. Liu, male, 50 years old, complained of hepatocellular carcinoma that had been discovered for more than 4 months.

[0092] Current medical history: The patient was found to have elevated AFP during a physical examination at the company in February 2023, but the specific value was unknown. On February 27, he underwent abdominal enhanced MRI in the hospital: nodular and mass-like, slightly longer T1 and slightly longer T2 signal lesions were found in liver S8, approximately 6.5*7.8cm and 2.0cm in size. Liver cancer was considered, and the right anterior branch of the portal vein and the right hepatic vein might be involved. A liver puncture biopsy was performed on March 6, and pathology showed: hepatocellular carcinoma, moderately differentiated, with background viral hepatitis cirrhosis of the liver tissue, type B, active stage, immunohistochemistry results: HBsAg(+), Hepa(+), Ki67(+5%), radiotherapy for liver tumors began on March 11, and ended on March 18, with a total dose of 7.5Gy*7F. Percutaneous hepatic artery embolization was performed on March 20. He is now seeking traditional Chinese medicine treatment in the hospital's oncology outpatient clinic.

[0093] Current symptoms: fatigue, pain in both feet, poor appetite and sleep, regular urination, unformed stool, one bowel movement every two days, dark red tongue, white tongue coating, deep and fine pulse.

[0094] Past medical history: Hepatitis B surface antigen positive for 15 years, history of hypertension for more than 10 years, history of diabetes for 8 years, blood pressure and blood sugar control is acceptable.

[0095] Personal history and allergy history: Born in the native place, lived in the local area for a long time, no history of contact with epidemic water sources, 20 years of drinking history, 20 years of smoking history. Deny the history of drug and food allergies.

[0096] Family history: Father died of bone tumor at the age of 46. There is no history of other infectious diseases or genetic diseases in the family.

[0097] Medication: Use the formula: Chinese medicine granules made of 15g of Codonopsis pilosula, 15g of stir-fried Atractylodes macrocephala, 15g of Poria cocos, 15g of Atractylodes macrocephala, 10g of Campsis creeper, 15g of White Peony Root, 15g of Hedyotis diffusa, 10g of Polygonum multiflorum, 15g of Artemisia capillaris, and 10g of Saposhnikovia diffusa, 24g / time, twice a day, orally.

[0098] Second visit (August 28, 2023): Symptoms: After taking the medicine, fatigue improved, pain in both feet, poor sleep and other symptoms were relieved, stool was not formed, both lower limbs felt slightly weak, dark red tongue, thin white fur, deep and fine pulse

[0099] Third visit (January 6, 2024): Symptoms: fatigue improved, poor sleep, formed stool, no other obvious discomfort. Dark red tongue, yellow fur, deep and fine pulse.

[0100] At the same time, the Chinese medicine granules prepared in the present application were tested: patients with liver depression and spleen deficiency syndrome of middle and late stage primary liver cancer who met the admission and exclusion criteria were divided into a treatment group and a control group. The treatment group was given the Chinese medicine granules prepared in Example 2 combined with Western medicine anti-tumor treatment, and the control group was given Western medicine anti-tumor treatment alone, and clinical observation was carried out for 16 weeks;

[0101] Tumor size, TCM syndrome score, EORTC QLQ-HCC-18, ECOG performance status score, Child-Pugh liver function grade, AFP value, blood routine, liver function, kidney function and diarrhea were recorded at the time of enrollment, after the 8th week of treatment, and after the 16th week of treatment.

[0102] Research findings:

[0103] 1.1 Reduction of tumor size

[0104] After the 8th week of treatment, the ORR of both groups was 0%, the DCR of the treatment group was 100%, and the DCR of the control group was 93.75%. The difference was not statistically significant after the test of p>0.05;

[0105] After the 16th week of treatment, the ORR in the treatment group was 6.9%, and the ORR in the control group was 0%. The test showed that p>0.05, and the difference was not statistically significant; the DCR in the treatment group was 93.10%, and the DCR in the control group was 59.38%, P<0.05, and the difference was statistically significant.

[0106] 1.2 TCM Syndrome Score

[0107] The overall effective rate of symptom improvement in the treatment group was 68.96%, and the overall effective rate of symptom improvement in the control group was 37.50%, p < 0.05, and the difference was statistically significant.

[0108] 1.3 Liver cancer quality of life specific scale

[0109] The patients in the treatment group showed significant improvement in the four dimensions of physical changes, nutritional changes, pain, and fatigue, p < 0.05, which was statistically significant; the patients in the control group showed significant improvement in the two dimensions of pain and fatigue, p < 0.05, which was statistically significant; the treatment group had a significant advantage over the control group in improving the three dimensions of physical changes, nutritional changes, and fatigue, p < 0.05.

[0110] 1.4 ECOG physical condition score

[0111] The improvement rate of ECOG score in the treatment group was 34.48%, and the improvement rate in the treatment group was 12.50%, p < 0.05, the difference was statistically significant.

[0112] 1.5 Child-Pugh liver function classification

[0113] The stable improvement rate of Child-pugh liver function in the treatment group was 93.10%, and the stable improvement rate in the treatment group was 90.63%, p>0.05, and the difference was not statistically significant.

[0114] 1.6AFP value

[0115] The data of the two groups at the 8th and 16th weeks were compared within the group. The AFP values ​​before and after treatment did not change much, p>0.05, and the difference was not statistically significant. The AFP difference between the two groups before and after treatment was compared between the two groups, p>0.05, and the difference was not statistically significant.

[0116] 1.7 Security Analysis

[0117] The incidence of adverse reactions in blood routine, liver function and renal function in the treatment group were 3.45%, 6.90% and 3.45 respectively, while those in the control group were 3.13%, 3.13% and 9.37% respectively. The chi-square test showed that p was greater than 0.05, and the differences were not statistically significant.

[0118] 1.8 Diarrhea

[0119] Diarrhea occurred occasionally in the treatment group after the eighth week, while diarrhea occurred frequently in the control group.

[0120] Through the above research, it is known that the Chinese medicine granules prepared in Example 2 combined with Western medicine anti-tumor treatment have a significant improvement in alleviating tumor size after 16 weeks, and the overall effective rate of symptom improvement has been significantly changed. The patients have obvious improvements in four dimensions: physical changes, nutritional changes, pain, and fatigue. At the same time, the patients' physical strength has also been significantly improved, and the diarrhea has also been significantly improved.

[0121] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-restrictive in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention.

[0122] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A Chinese medicine granule for treating liver cancer, characterized in that: The formula is composed of the following raw materials: codonopsis pilosula, stir-fried atractylodes macrocephala, tuckahoe, aconite, trumpet creeper, white peony root, oldenlandia diffusa, red safflower fruit, capillaris, and siler.

2. A Chinese medicine granule for treating liver cancer according to claim 1, characterized in that: The formula is composed of the following raw materials by weight: 10-20g of Codonopsis pilosula, 11-19g of stir-fried Atractylodes macrocephala, 12-18g of Poria cocos, 12-18g of Atractylodes macrocephala, 5-15g of Campsis creeper, 10-20g of White Peony Root, 13-16g of Hedyotis diffusa, 8-12g of Polygonum multiflorum, 13-17g of Artemisia capillaris, and 9-11g of Saposhnikovia diffusa.

3. A Chinese medicine granule for treating liver cancer according to claim 2, characterized in that: The formula is composed of the following raw materials by weight: 10g of Codonopsis pilosula, 19g of stir-fried Atractylodes macrocephala, 12g of Poria cocos, 18g of Atractylodes macrocephala, 5g of Campsis creeper, 20g of White Peony Root, 13g of Hedyotis diffusa, 12g of Polygonum multiflorum, 13g of Artemisia capillaris, and 11g of Saposhnikovia diffusa.

4. The Chinese medicine granules for treating liver cancer according to claim 1, characterized in that: The formula is composed of the following raw materials by weight: 15g of Codonopsis pilosula, 15g of stir-fried Atractylodes macrocephala, 15g of Poria cocos, 15g of Atractylodes macrocephala, 10g of Campsis creeper, 15g of White Peony Root, 15g of Hedyotis diffusa, 10g of Polygonum multiflorum, 15g of Artemisia capillaris, and 10g of Saposhnikovia diffusa.

5. The Chinese medicine granules for treating liver cancer according to claim 2, characterized in that: The formula is composed of the following raw materials by weight: 20g of Codonopsis pilosula, 11g of stir-fried Atractylodes macrocephala, 18g of Poria cocos, 12g of Atractylodes macrocephala, 15g of Campsis creeper, 10g of White Peony Root, 16g of Hedyotis diffusa, 8g of Polygonum multiflorum, 17g of Artemisia capillaris, and 9g of Saposhnikovia diffusa.

6. A method for preparing a Chinese medicine granule for treating liver cancer according to any one of claims 1 to 5, characterized in that: The following steps are involved: Step 1, weigh the above raw materials, clean them and remove impurities to obtain clean raw materials; Step 2: Take the clean raw materials in step 1 and pour them into the Chinese medicine pot, add water and boil twice. For the first boiling, add 10 times the amount of water to soak, and then boil for 50-70 minutes. For the second boiling, add 8 times the amount of water, and then boil for 30-50 minutes, and combine the two decoctions; Step 3: Combine the decoctions from the two Chinese medicine pots and pour them into a container, filter, combine the filtrates, concentrate into an extract with a relative density of 1.05-1.10 (70° C.), spray dry, mix well, and obtain a drug extract powder.

7. The method for preparing a Chinese medicine granule for treating liver cancer according to claim 6, characterized in that: In the step 3, the spray drying is carried out under the conditions of an inlet air temperature of 185-195°C and an outlet air temperature of 90-100°C.

8. The method for preparing a Chinese medicine granule for treating liver cancer according to claim 6, characterized in that: When boiling for the first time in step 2, add 10 times the amount of water and soak for 20-40 minutes.

9. The method for preparing a Chinese medicine granule for treating liver cancer according to claim 6, characterized in that: In the step 1: Codonopsis pilosula: remove impurities, wash, soak, cut into thick slices, and dry; Atractylodes macrocephala: remove impurities, wash, soak, cut into thick slices, and dry; Poria cocos: soak, wash, steam slightly after moistening, peel off the skin in time, cut into blocks or thick slices, and dry; Premonition seeds: wash, dry and break into pieces; Trumpet creeper: remove impurities, moisten slightly, cut into strips, and dry; White peony root: wash, soak, cut into thin slices, and dry; Oldenlandia diffusa: remove impurities and cut into sections; Water safflower seeds: remove impurities; Artemisia capillaris: remove the remaining roots and impurities, and crush or chop them; Saposhnikovia divaricata: remove impurities, wash, soak, cut into thick slices, and dry.