Muscle and bone pain ointment and preparation method thereof

Abstract

The invention discloses muscle and bone pain ointment and a preparation method thereof, and belongs to the field of traditional Chinese medicine, and the muscle and bone pain ointment is prepared from the following components in parts by mass: 80-120 parts of circium japonicum, 80-120 parts of serrate rabdosia herb, 80-120 parts of Chinese starjasmine stem, 80-120 parts of elsholtzia, 80-120 parts of radix curcumae, 80-120 parts of herba aristolochiae, 80-120 parts of piper wallichii, 80-120 parts of caulis sinomenii, 80-120 parts of honeysuckle stem, 80-120 parts of ferula asafetida, 80-120 parts of acalypha australis, 80-120 parts of euphorbia helioscopia, 400-600 parts of sesame oil and 1000-2000 parts of rosin. The traditional Chinese medicine is safe, effective and high in cure rate. The traditional Chinese medicine can be widely applied to various bone fracture and bone diseases, cervical and lumbar disc herniation, and muscle and bone pain caused by wind, cold and dampness.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine ointments, and particularly relates to an ointment for treating muscle and bone diseases and a preparation method thereof. Background Art

[0002] Musculoskeletal disease in traditional Chinese medicine is a type of acute or chronic muscle and bone injury disease. Various external trauma, exogenous evil obstruction, strain or degenerative diseases can cause local pain, swelling and poor mobility, or accompanied by muscle atrophy, which causes imbalance in the dynamic and static forces of the muscles and bones in the joints and spine. The pain of chronic muscle and bone disease usually lasts or recurs for more than 3 months, which is called chronic musculoskeletal pain in modern medicine. There are many types of bone and muscle pain, such as lumbar disc herniation, frozen shoulder, cervical spondylosis, femoral head necrosis, ankylosing spondylitis, rheumatoid arthritis, and traumatic injuries.

[0003] The existing drugs for treating myositis are mainly oral preparations (capsules, pills, oral liquids, etc.), which all have the same disadvantages: first, there is a first-pass effect, and second, the patient's compliance is poor.

[0004] The bone and muscle pain ointment is developed on the basis of traditional topical medicines, representing the traditional form of external application in China. In the book "Surgery Collection" compiled by Qing and Hu Tingguang, there are 24 kinds of three-character ointments, including bone-setting ointment, swelling-reducing ointment, etc. These ointments are named according to the main functions of the medicines and play a unique role in the treatment of surgical diseases. According to domestic and foreign scholars, topical drugs work through skin absorption. However, because the traditional ointment is made by using red lead to make ointments, and the red lead ointment cannot be re-examined by X-ray after the external application and fixation of the bone injury by manual reduction, and the lead component contained in the red lead is trilead tetroxide, commonly known as red lead, red lead, which is an inorganic compound with the chemical formula of Pb3O4. The traditional ointment used for making plasters is easily absorbed by the skin in excess, causing liver and kidney dysfunction; therefore, it is necessary to use modern scientific methods to study the excipients of external ointments.

[0005] In view of this, the present invention is proposed. Summary of the invention

[0006] The purpose of the present invention is to provide a muscle and bone pain ointment and a preparation method thereof. The muscle and bone pain ointment is developed and prepared on the basis of traditional external compress medicine.

[0007] Based on the above purpose, the present invention adopts the following technical solutions: A bone and muscle pain ointment has the following formula, measured by mass: 80-120 parts of cirsium japonicum, 80-120 parts of cyperus rotundus, 80-120 parts of trachelospermum jasminoides, 80-120 parts of elsholtzia, 80-120 parts of curcuma, 80-120 parts of celery stalks, 80-120 parts of spatholobi, 80-120 parts of spatholobi, 80-120 parts of caulis ophiopogonis, 80-120 parts of spatholobi, 80-120 parts of asafoetida, 80-120 parts of oleander, 80-120 parts of lacquer, 400-600 parts of sesame oil, and 1000-2000 parts of rosin.

[0008] Preferably, the formula is as follows, by mass: 100 parts of cirsium japonicum, 100 parts of chrysanthemum wilfordii, 100 parts of trachelospermum jasminoides, 100 parts of elsholtzia, 100 parts of curcuma, 100 parts of celery stalks, 100 parts of spatholobi, 100 parts of spatholobi, 100 parts of caulis ophiopogonis, 100 parts of spatholobi, 100 parts of asafoetida, 100 parts of amaranthus chinensis, 100 parts of lacquer, 500 parts of sesame oil, and 1500 parts of rosin.

[0009] The preparation method of the above-mentioned ointment for tendon and bone pain is as follows: (1) Weigh cirsium japonicum, cyperus rotundus, trachelospermum officinale, elsholtzia ciliata, curcuma aromatica, scutellaria baicalensis ... (2) Heat sesame oil to 180-220°C, add rosin, and cook while stirring. When the rosin is completely dissolved, add the powder of step (1), and cook at 100-150°C while stirring. When the powder in the pot turns black and shiny, stop heating, spread it on the backing material, and prepare the plaster.

[0010] Furthermore, the coating amount of the ointment on the backing material is 0.1 g~0.5 g / cm 2 .

[0011] The present invention contains more than 10 Chinese herbal medicines, each with unique medicinal properties. Among them, Cirsium japonicum, Herba Trachelospermi, can remove heat from bones, cool blood, disperse blood stasis, and promote blood circulation to relieve pain. If blood stasis is not removed, new blood will not be generated, so they are monarch drugs; Curcuma zedoaria, Herba Asplenii, Herba Elsholtziae can promote blood circulation and qi, regulate qi and reduce swelling. Qi is the power of blood generation and movement, so they serve as minister drugs; Herba Hederae, Herba Caulis, Herba Lonicerae can relieve depression, nourish liver and kidney, and benefit blood in shallow yang. Liver governs tendons and kidney governs bones, which are the effects of regulating and nourishing liver and kidney, and they bear the heavy responsibility of the messenger drug; Ferula, Herba Zeqi, Herba Amaranthus can disperse wind and rash, remove dampness and relieve itching, inhibit melanin production, reduce the skin allergy rate of external plasters, and cover blemishes and peculiar smells. The whole set of prescriptions has an orderly monarch and minister, and they complement each other. Regardless of whether the disease occurs in the bone shaft, epiphysis of the bone end, epiphyseal plate of the metaphysis, bone protrusion, or osteochondrium of the epiphysis, this group of ointments can be applied regularly according to the severity of the disease. It is safe, effective, and has a high cure rate. It can be widely used in various bone injuries and diseases, cervical and lumbar disc herniation, and tendon and bone pain caused by wind, cold, and dampness. DETAILED DESCRIPTION

[0012] The technical solution of the present invention is further described in detail below in conjunction with embodiments.

[0013] Example 1 A bone and muscle pain ointment has the following formula, measured by mass: 100 g of cirsium japonicum, 100 g of scutellaria baicalensis, 100 g of clematis scabra, 100 g of elsholtzia ciliata, 100 g of curcuma aromatica, 100 g of scutellaria baicalensis, 100 g of scutellaria baicalensis, 100 g of scutellaria baicalensis, 100 g of scutellaria baicalensis, 100 g of scutellaria baicalensis, 100 g of scutellaria baicalensis, 100 g of scutellaria baicalensis, 500 g of sesame oil, and 1500 g of rosin.

[0014] The preparation method of the above-mentioned ointment for tendon and bone pain is as follows: (1) Weigh out Cirsium japonicum, Herba Lysimachiae, Caulis Trachelospermi, Elsholtzia ciliata, Curcuma aromatica, Caulis dasyphylla, Caulis spatholobi, Caulis cyrtonema ...ferulae, Caulis spatholobi, Caulis ferulae, Amaranthus chinensis and Rhizoma zedoariae, grin (2) Heat sesame oil to 200°C, add rosin, and cook while stirring. When the pine gum is completely dissolved, add the powder of step (1), and cook at 100°C while stirring. When the powder in the pot turns black and shiny, stop heating and spread it on the backing material to obtain the external plaster.

[0015] Specifically, 25 g of the prepared ointment was applied on a 12 cm×14 cm backing material.

[0016] Example 2 A bone and muscle pain ointment has the following formula, measured by mass: 80 g of cirsium japonicum, 120 g of chrysanthemum officinale, 80 g of trachelospermum officinale, 120 g of elsholtzia, 80 g of curcuma, 120 g of celery stalk, 80 g of scutellaria baicalensis, 120 g of scutellaria baicalensis, 120 g of scutellaria baicalensis, 80 g of scutellaria baicalensis, 120 g of scutellaria baicalensis, 120 g of rosin, 400 g of sesame oil, and 2000 g of rosin.

[0017] The preparation method of the above-mentioned ointment for tendon and bone pain is as follows: (1) Weigh out Cirsium japonicum, Herba Lysimachiae, Caulis Trachelospermi, Elsholtzia ciliata, Curcuma aromatica, Caulis dasyphylla, Caulis spatholobi, Caulis cyrtonema ...ferulae, Caulis spatholobi, Caulis ferulae, Amaranthus chinensis and Rhizoma zedoariae, grin (2) Heat sesame oil to 200°C, add rosin, and cook while stirring. When the rosin is completely dissolved, add the powder of step (1), and cook at 100°C while stirring. When the powder in the pot turns black and shiny, stop heating, spread it on the backing material, and prepare the external plaster.

[0018] Specifically, 30 g of the prepared ointment was spread on a 12 cm×14 cm backing material.

[0019] Example 3 A bone and muscle pain ointment has the following formula, measured by mass: 120 g of cirsium japonicum, 80 g of radix scutellariae, 120 g of clitoria scabra, 80 g of elsholtzia, 120 g of curcuma, 80 g of scutellaria baicalensis, 120 g of scutellaria baicalensis, 80 g of scutellaria baicalensis, 120 g of scutellaria baicalensis, 80 g of scutellaria baicalensis, 120 g of scutellaria baicalensis, 80 g of scutellaria baicalensis, 80 g of scutellaria baicalensis, 600 g of sesame oil, and 1000 g of rosin.

[0020] The preparation method of the above-mentioned ointment for tendon and bone pain is as follows: (1) Weigh out Cirsium japonicum, Herba Lysimachiae, Caulis Trachelospermi, Elsholtzia ciliata, Curcuma aromatica, Caulis dasyphylla, Caulis spatholobi, Caulis cyrtonema ...ferulae, Caulis spatholobi, Caulis ferulae, Amaranthus chinensis and Rhizoma zedoariae, grin (2) Heat sesame oil to 200°C, add rosin, and cook while stirring. When the rosin is completely dissolved, add the powder of step (1), and cook at 100°C while stirring. When the powder in the pot turns black and shiny, stop heating, spread it on the backing material, and prepare the external plaster.

[0021] Specifically, 20 g of the prepared ointment was applied on a 12 cm×14 cm backing material.

[0022] 1. Experimental Example 1. Materials and Methods 1.1 Medicinal ointment for muscle and bone pain.

[0023] 1.2 Experimental animals Six healthy rabbits were selected, weighing about 2500 g, regardless of gender. Experimental groups: blank group (no medication) and medication group (Example 1 bone and muscle pain ointment), 3 rabbits in each group.

[0024] 1.3 Animal models All animals had their left forelimbs hair removed, and were anesthetized with amobarbital sodium at a dosage of 50 mg / kg by slow intravenous injection. Osteotomy was performed under X-ray to create a greenstick fracture of the radius of the left forelimb.

[0025] 1.4 Drug treatment group: All animals in the drug treatment group were externally treated with the muscle and bone pain ointment of Example 1. The blank group did not receive any drug and recovered naturally.

[0026] After the fracture reduction was performed according to the conventional method, the medication group was treated with medication according to the above method and the blank group was fixed according to the conventional method. The bone injury was changed once every 7 days, and 3 times and 21 days were considered as a healing course.

[0027] 1.5 Observation of treatment effect The callus growth was observed by X-ray and the callus shadow area was calculated.

[0028] 2 Results The callus shadow area of ​​the two groups was calculated using the grid calculation method, and the percentage of the occupied area was used for comparison. Through X-ray observation of each animal in each week, the callus growth of the medication group was better than that of the blank group, which was manifested in the early appearance of the callus shadow, the rapid growth of the callus, and the high density of the callus shadow in the medication group. Some of them had basically healed in the third week, and some of them had basically recovered their functions in the fourth week, while the callus in the blank group grew slowly, and none of them could achieve healing in the third week. See Table 1.

[0029] Table 1 Comparison of callus shadow area between the two groups of animals during treatment (x±s, %) The results showed that the percentage of callus shadow area in the medication group was higher than that in the blank group at 2, 3, and 4 weeks, with an average increase of 35.77%, proving that the drug has the effect of promoting callus growth.

[0030] In the present application, X-ray films of rabbits in the medication group and the blank group were taken, and the callus shadow areas were traced on grid calculation paper with carbon paper for calculation, so as to find out the percentage of each callus shadow area. Due to the limitation of conditions and other factors in the basic clinical work of the inventor, the number of animals used in this experimental study was small, and no significant difference was found in the results of the two groups of experiments after statistics. However, we have observed that the callus shadow area of ​​the medication group increased by an average of 35.77% compared with the blank group. From the observation of the functional recovery cycle, there was a significant difference between the medication group and the blank group, which proved that the drug has the effect of promoting the growth of callus, can be recommended for clinical application, and should be further observed, studied and protected.

[0031] 2. Clinical Application After the successful development of the bone and muscle pain ointment, the inventor has first applied it to the clinical treatment of femoral shaft fractures in children. The clinical application is reported as follows: 1. Reset and fix Depending on the dislocation of the fracture, use the corresponding technique to reduce the fracture, then apply bone and muscle pain ointment and a small splint for fixation.

[0032] 2. Clinical Data This group of clinical applications included 104 cases, including 70 males and 34 females; 60 cases on the right side and 44 cases on the left side; the oldest was 12 years old and the youngest was 1 year old. The treatment time after injury ranged from 2 hours to 6 days. Fracture site: 7 cases of upper femoral segment, 83 cases of middle segment, and 14 cases of lower segment; among them, 17 cases were transverse fractures, and 87 cases were oblique and spiral fractures, all of which had varying degrees of displacement and angular deformity. 3. Treatment results (1) Manual reduction, external application of pain relief ointment, and fixation with a small splint.

[0033] (2) Clinical healing time of fractures: According to the 1975 National Draft Standard for Fracture Therapeutic Effect, the shortest clinical healing time was 21 days, the longest was 52 days, and the average was 34 days. All 104 fractures healed.

[0034] (3) Functional assessment: 72 cases were excellent, accounting for 69.2%; 27 cases were good, accounting for 26%; 3 cases were satisfactory, accounting for 2.9%. Among the 104 patients, 2 cases were not followed up and their function could not be assessed. In this group of 104 cases, 102 cases were followed up. The longest follow-up time was 14 years, the shortest was 1 year, and the average was 3 years. All cases recovered hip and knee joint function and had normal gait. There was no pain or discomfort. Except for 3 cases with fracture ends tilted outward at 12°, 13°, and 14° respectively, the remaining 99 cases were completely normal. There were no complications.

[0035] 3. Characteristics and application of the present invention using sesame oil to dissolve natural plant rosin as a medical plaster auxiliary material The synthesis of sesame oil and natural plant rosin is non-toxic, odorless and an authentic environmentally friendly adhesive product.

[0036] The adhesive product is innovative, practical and healthier. The plaster made of this excipient is applied to the surface of human skin, and the active ingredients contained in it can penetrate into the skin and deliver the drug to the uncomfortable part through the systemic circulation, thereby playing the role of relieving pain, unblocking meridians, etc. It can also dilate blood vessels and promote local blood circulation by stimulating nerve endings, thereby achieving the purpose of improving discomfort.

[0037] As an auxiliary material for medical plasters, it must meet the requirements of hypoallergenicity, adhesion to the skin, air permeability after coating, sweat resistance, etc. The cloth-based zinc oxide rubber tape, cloth-based plaster, wound patch and other techniques that were originally widely used in the medical and sanitary fields all cause skin allergies and produce glue transfer to varying degrees.

[0038] The present application can solve these problems smoothly by processing sesame oil and natural plant rosin glue into medical plaster auxiliary glue. With the widespread application of non-woven fabrics and other composite products in the medical and health field, in order to keep the medical non-woven fabric adhesive products breathable and soft, natural plant rosin, with the help of the progress of sizing equipment, makes non-woven fabrics and other materials into various medical composite products, which is more handy.

[0039] Since its application, it has received unanimous praise from users. It can help users compare with the original process. The advantages of sesame oil and natural plant rosin synthesis are non-toxic, environmentally friendly, and do not contain any additives that are harmful to the human body. The plaster made of sesame oil and natural plant rosin as plaster auxiliary materials is more convenient to use. It does not need to be heated. It can be directly pasted on the skin after being torn apart, and no other processes are required. The natural plant pine gum hot auxiliary material plaster is more convenient to transport and store, and has a longer shelf life. The natural plant pine gum auxiliary material plaster is pasted on the body without residue and pain, which is more friendly and hygienic to the body.

[0040] 4. Application Notes: 1. This is a product for external use. Do not take it internally. Keep it out of reach of children.

[0041] 2. It is forbidden to use on red, swollen, ulcerated, damaged skin, pregnant women and lactating women.

[0042] 3. Use with caution if you have sensitive skin or allergies.

[0043] 4. If any adverse reactions occur after application, such as rash or itching, stop applying immediately.

Claims

1. A paste for treating muscle and bone pain, characterized in that: The formula is as follows, in parts by mass: 80-120 parts of Cirsium japonicum, 80-120 parts of Herba Trachelospermi, 80-120 parts of Herba Elsholtziae, 80-120 parts of Herba Curcumae, 80-120 parts of Herba Cinerariae, 80-120 parts of Herba Hederae, 80-120 parts of Herba Cinerariae, 80-120 parts of Herba Lonicerae, 80-120 parts of Herba Asafoetidae, 80-120 parts of Herba Amaranthus, 80-120 parts of Herba Zedoariae, 400-600 parts of sesame oil, and 1000-2000 parts of rosin.

2. The ointment for treating muscle and bone pain according to claim 1, characterized in that: The formula is as follows, by mass: 100 parts of cirsium, 100 parts of chrysanthemum, 100 parts of trachelospermum, 100 parts of elsholtzia, 100 parts of curcuma, 100 parts of celery, 100 parts of spatholobi, 100 parts of heather, 100 parts of clematis, 100 parts of green wind vine, 100 parts of honeysuckle, 100 parts of asafoetida, 100 parts of amaranthus, 100 parts of lacquer, 500 parts of sesame oil, and 1500 parts of rosin.

3. The preparation method of the ointment for treating muscle and bone pain according to claim 1 or 2, characterized in that: The process is as follows: (1) Weigh cirsium japonicum, cyperus rotundus, trachelospermum officinale, elsholtzia ciliata, curcuma aromatica, scutellaria baicalensis ... and scutellaria baicalensis according to the proportion, grind and mix evenly; (2) Heat sesame oil to 180-220°C, add rosin, and cook while stirring. When the rosin is completely dissolved, add the powder of step (1), and cook at 100-150°C while stirring. When the powder in the pot turns black and shiny, stop heating, spread it on the backing material, and prepare the plaster.

4. The preparation method of the ointment for muscle and bone pain according to claim 3, characterized in that: The coating amount of ointment on the backing material is 0.1g~0.5 g / cm 2 .

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