Sanitary insecticidal composition containing methoxy acrylate compound and application thereof

Abstract

The invention relates to a sanitary pest insecticide composition, which is characterized in that the effective components of the compound insecticide comprise A and B. The A is a compound with the following structure, and the component B is one or more of tetramethrin, dimefluthrin, tetrafluthrin, trifluthrin, dextro-trans-propargyl chloride, dextro-phenothrin, teflumethrin, dextro-teflumethrin, bioallethrin, dextro-allethrin, rich dextro-trans-allethrin, chloenthrin, dextro-tetramethrin and tetramethrin. The compound weight ratio of A to B is (20: 1)-(1: 20), preferably (20: 1)-(1: 1), the compound insecticide has the characteristics of high efficiency, low toxicity and the like, and when the compound insecticide is used as a sanitary insecticide, the compound insecticide takes effect quickly and is thorough in killing, the pesticide application amount is reduced, the pesticide application irritation is reduced, and the generation of pesticide resistance of pests is delayed. As a lethal agent, the component A has no cross resistance and a good lethal effect, is widely applied to hotels, schools, factories, families and public places, and has a special effect on prevention and treatment of sanitary pests. # imgabs0 #

Description

Technical Field

[0001] The invention relates to a sanitary insecticide composition, in particular to a sanitary insecticide composition containing a methoxyacrylate compound and application thereof. Background Art

[0002] Pyrethroids for sanitary use have stomach poison, contact killing and fumigation effects. They are a good knockdown agent and lethal agent and are widely used in the field of household sanitary medicines, such as mosquito coils, aerosols, liquid mosquito coils, etc. They are also suitable for space spraying in sanitary outdoor environments.

[0003] With the widespread use of pyrethroids, sanitary pests have developed resistance to pyrethroids, resulting in unsatisfactory efficacy and pests recovering after being knocked down. In response to this situation, it is considered to select compound active ingredients to have no cross-resistance and delay the development of resistance, which can improve the control effect of sanitary pests and have a synergistic effect. Compared with a single agent, the amount of medicine used can be reduced, and a compound drug combination with good market prospects can be obtained. Summary of the invention

[0004] One of the purposes of the present invention is to provide a compound insecticidal composition containing a methoxyacrylate compound and a pyrethroid, which has good insecticidal effect, low drug cost, synergistic effect and is not easy to produce drug resistance.

[0005] In order to achieve the above object, the present invention adopts the following technical solution:

[0006] A sanitary insecticide composition containing a methoxyacrylate compound, the composition is composed of component A and component B, component A is a methoxyacrylate compound shown in the following structural formula, and component B is any one of cypermethrin, cypermethrin, cypermethrin, cypermethrin, d-trans chlorpromazine, d-phenothrin, sepfluthrin, d-sepfluthrin, bio-allethrin, d-allethrin, d-trans-allethrin, chlorpyrifos, d-tetramethrin, and tetramethrin; component A is a compound A shown in the following structural formula

[0007]

[0008] The mass ratio of component A to component B is 20:1 to 1:1.

[0009] The weight ratio of compound A to tetrafluthrin is 15:1 to 2:1;

[0010] The weight ratio of compound A to tetrafluthrin is 15:1 to 1:1;

[0011] The weight ratio of compound A to transfluthrin is 9:1 to 1:1;

[0012] The weight ratio of compound A to metofluthrin is 10:1 to 2:1;

[0013] The weight ratio of compound A to D-trans-chlorpromazine is 20:1 to 1:1;

[0014] The weight ratio of compound A to d-phenothrin is 9:1 to 1:1;

[0015] The weight ratio of compound A to tefluthrin is 10:1 to 1:1;

[0016] The weight ratio of compound A to dexamethasone is 10:1 to 5:1;

[0017] The weight ratio of compound A to bio-allethrin is 8:1 to 2:1;

[0018] The weight ratio of compound A to d-allethrin is 8:1 to 2:1;

[0019] The weight ratio of compound A to dextrorotatory trans-allethrin is 8:1 to 2:1.

[0020] The weight ratio of compound A to chlorpyrifos is 10:1 to 4:1;

[0021] The weight ratio of compound A to d-methrin is 12:1 to 3:1;

[0022] The weight ratio of compound A to tetramethrin is 5:1 to 1:1;

[0023] A sanitary insecticide preparation, the preparation uses the composition as an effective active ingredient, which accounts for 0.1% to 30% of the preparation mass.

[0024] The preparation further contains auxiliary materials, which are any one or more of solvents, emulsifiers, dispersants, wetting agents, defoamers, antifreeze agents, preservatives, thickeners, and water.

[0025] The solvent is selected from: one or more of trimethylbenzene, tetramethylbenzene, pentamethylbenzene, ethanol, cyclohexanone, C8-C19 low-grade alkane solvents, white oil, diesel, N,N-dimethylacetamide, N,N-dimethylpropionamide, N,N-dimethylhexylamide, N-methylpyrrolidone, diisopropyl adipate, tributyl citrate, acetyl tributyl citrate, isopropyl myristate, isopropyl hexadecanoate, ethylene glycol methyl ether, piperonyl butoxide, and dodecylbenzene.

[0026] The emulsifier is selected from: styrylphenol polyoxyethylene ether (such as Nongru 600# series), calcium dodecylbenzene sulfonate (such as Nongru 500# of Nanjing Taihua Co., Ltd.), OP series phosphate (alkylphenol polyoxyethylene ether phosphate), phenylphenol polyoxyethyl ether phosphate (such as Jiangsu Kaiyuan 600# phosphate), benzyl dimethylphenol polyoxyethyl ether (such as Nongru 400#), Ningru 36# (phenylethylphenol formaldehyde resin polyoxyethyl ether), phenylethylphenol polyoxyethyl polypropylene ether (such as Nongru 16 00#), ethylene oxide-propylene oxide block copolymer, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether (such as Jiangsu Kaiyuan's EL series), alkylaryl polyoxypropylene polyoxyethylene ether (such as Nanjing Taihua's Nongru 33#), alkylaryl polyoxyethylene polyoxypropylene ether (such as Nanjing Taihua's Nongru 34#), Span series (sorbitan monostearate), Tween series (dehydrated sorbitan fatty acid ester polyoxyethylene ether), fatty alcohol polyoxyethylene ether (such as Hai'an Petrochemical MOA series) or one or more thereof.

[0027] The dispersant is selected from: one or more of polycarboxylates (e.g., TERSPERSE 2500, produced by Huntsman Corporation, USA), lignin sulfonates, alkylphenol polyoxyethylene ether formaldehyde condensate sulfates, alkylbenzene sulfonate calcium salts, naphthalenesulfonic acid formaldehyde condensate sodium salts, alkylphenol polyoxyethylene ethers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene esters, and glycerol fatty acid ester polyoxyethylene ethers.

[0028] The wetting agent is selected from: alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate (such as TERSPERSE 2425, Huntsman), naphthalene sulfonate (such as NNO), sodium dodecyl sulfate, opening powder BX, wetting penetrant F, sodium dodecylbenzene sulfonate or one or more thereof.

[0029] The defoaming agent is selected from one or more of silicone compounds, polydimethylsiloxane, C8-10 fatty alcohol compounds, and C10-20 saturated fatty acid compounds.

[0030] The antifreeze agent is selected from: one or more of ethylene glycol, propylene glycol, glycerol and urea.

[0031] The preservative is selected from one or more of potassium sorbate and sodium benzoate.

[0032] The thickener is selected from one or more of xanthan gum, hydroxyethyl cellulose, methyl cellulose and magnesium aluminum silicate.

[0033] The preparation dosage form is aerosol, emulsifiable concentrate, aqueous emulsion, microemulsion, soluble liquid, thermal mist or suspoemulsion.

[0034] An application of the composition or the preparation, and an application of the composition or the preparation in preventing and controlling sanitary pests.

[0035] The sanitary pests are one or more of Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Argus harassingus, Chironomids, Housefly, Cityfly, Chrysopa longituba, Lucilia sericata, Lucilia cuprina, Lucilia brighten, Summer toilet fly, Meta toilet fly, Bed bug, Human flea, Ixodes persulcatus, Ixodes sinensis, Ixodes steppe, Boophilus microplus, Gamas and Scabies.

[0036] The composition or the preparation can be widely used in hotels, schools, factories, homes, public places and the like.

[0037] When the insecticide composition is used to control sanitary pests, the insecticide composition can be used directly, prepared into an aerosol and used directly indoors, or a thermal fog machine can be used to spray the liquid medicine into the space. The insecticide composition can be diluted 20-40 times and sprayed into the space using ultra-low volume equipment. The insecticide composition can be diluted 20-100 times and sprayed into the space using a constant volume spray device. DETAILED DESCRIPTION

[0038] The specific implementation methods of the technical solution of the present invention are described in detail below, but the present invention is not limited to the following descriptions.

[0039] Example 1

[0040] The composition is a mixture of compound A and metofluthrin, tefluthrin, tetrafluthrin or other pyrethrins to determine the co-toxicity coefficient:

[0041] Component A is compound A, and component B is pyrethroid;

[0042]

[0043] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0044] Test method: Refer to GB / T26350-2010 "Methods for detecting insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of combined effects of mixtures" for test insects;

[0045] Table 1 Determination of the co-toxicity coefficient of compound A and metofluthrin (for houseflies)

[0046]

[0047] As shown in Table 1, when the compound A and metofluthrin were mixed in a ratio of 20:1 to 1:20, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the compound ratio was 10:1, the synergistic effect was most obvious.

[0048] Table 2 Determination of the co-toxicity coefficient of compound A and tefluthrin (for houseflies)

[0049]

[0050]

[0051] As shown in Table 2, when the compound A and tefluthrin were mixed in a ratio of 20:1 to 1:20, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the compound ratio was 6:1, the synergistic effect was most obvious.

[0052] Table 3 Determination of the co-toxicity coefficient of compound A and tetrafluthrin (for houseflies)

[0053]

[0054] As shown in Table 3, when the compound A and tetrafluthrin were mixed in a ratio of 20:1 to 1:20, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the compound ratio was 2:1, the synergistic effect was most obvious.

[0055] Table 4 Optimal co-toxicity coefficient of compound A with other pyrethroids (for houseflies)

[0056]

[0057]

[0058] As can be seen from Table 4, the optimal ratios of compound A and other pyrethroids after compounding are all in the range of 10:1 to 2:1, especially for tetrafluthrin, d-trans-chlorprophagen, d-heptafluthrin and chlorpyrifos, the co-toxicity coefficients all reach more than 200, and the synergistic effect is obvious.

[0059] The preparation method of the dosage form of Example 2 is as follows:

[0060] The laboratory preparation method of aerosol is as follows: weigh the original drug and solvent in proportion, heat and mix them in a beaker, cool them, put them into an aerosol can, seal them, and fill them with propane and butane gas to produce the aerosol.

[0061] The laboratory preparation method of emulsifiable concentrate is as follows: weigh the original drug, emulsifier and solvent in proportion, heat and mix them evenly in a beaker, and then the concentrate can be prepared.

[0062] The laboratory preparation method of water-in-water emulsion is as follows: weigh the original drug, emulsifier, and solvent in proportion, heat and dissolve them to form an oil phase, weigh the antifreeze, defoaming agent and water in proportion and mix them to form an aqueous phase, and slowly add the aqueous phase to the oil phase under high-speed shear conditions to prepare the water-in-water emulsion.

[0063] The laboratory preparation method of microemulsion is: weigh the original drug, emulsifier, and solvent in proportion, heat and dissolve them completely, add water under stirring, and stir evenly to obtain the microemulsion.

[0064] Soluble liquid: Weigh the original drug, emulsifier and solvent in proportion, heat and fully dissolve them to obtain a soluble liquid.

[0065] Thermal fog agent: Weigh the original drug and solvent in proportion, heat and dissolve them completely to produce the thermal fog agent.

[0066] Suspoemulsion: Weigh the liquid technical drug, solvent and emulsifier in proportion, add water after they are completely dissolved, stir evenly, add dispersant, wetting agent, solid technical drug, antifreeze, thickener, preservative and defoamer, mix evenly, shear with a high-speed shearing machine for 5 minutes, transfer to a sand mill and sand grind for 2-3 hours to control the particle size D90 below 5μm, and then the spoemulsion can be obtained.

[0067] Formulation Example 1: 16% Compound A·Permethrin emulsifiable concentrate

[0068]

[0069]

[0070] Preparation Example 2: 6.5% Compound A·Tetrafluoroether aqueous emulsion

[0071] Compound A 6g Perfluthrin 0.5g N,N-dimethylacetamide 8g Alkylbenzene polyoxyethylene ether phosphate 4g Castor Oil Polyoxyethylene Ether 5g Naphthalenesulfonic acid formaldehyde condensate sodium salt 1g Propylene glycol 5g Dimethicone 0.2g water Up to 100g

[0072] Formulation Example 3: 5% Compound A·Permethrin Microemulsion

[0073] Compound A 4g Perfluthrin 1g Calcium dodecylbenzenesulfonate 6g Castor Oil Polyoxyethylene Ether 15g N-Methylpyrrolidone 20g water Up to 100g

[0074] Formulation Example 4: 12% Compound A·Permethrin soluble liquid

[0075] Compound A 8g Perfluthrin 4g Ethylene oxide-propylene oxide block copolymer 5g Alkylphenol polyoxyethylene ether 12g Agricultural milk 33# 6g N,N-Dimethylpropionamide Up to 100g

[0076] Formulation Example 5: 0.2% Compound A·Permethrin Aerosol

[0077] Compound A 0.1g Perfluthrin 0.1g Diisopropyl adipate 5g Odorless kerosene Up to 50g Propylene butane gas 50g

[0078] Formulation Example 6: 8% Compound A·Permethrin emulsifiable concentrate

[0079]

[0080] Preparation Example 7: 5% Compound A·Tetrafluoromethyl ether aqueous emulsion

[0081] Compound A 4.5g Perfluthrin 0.5g N,N-dimethylpropionamide 12g Alkylphenol polyoxyethylene ether phosphate 3g Ningru 36# 2g Calcium dodecylbenzenesulfonate 5g Propylene glycol 5g Dimethicone 0.2g water Up to 100g

[0082] Formulation Example 8: 7.5% Compound A·Permethrin Microemulsion

[0083] Compound A 7g Perfluthrin 0.5g Calcium dodecylbenzenesulfonate 15g Phenylethylphenol polyoxyethyl polypropylene ether 6.5g Ethanol 5g water Up to 100g

[0084] Formulation Example 9: 14% Compound A·Permethrin soluble liquid

[0085] Compound A 12g Perfluthrin 2g Calcium dodecylbenzenesulfonate 10g Castor Oil Polyoxyethylene Ether 6g Twain 80 2g Piperonyl butoxide 3g N,N-Dimethylacetamide Up to 100g

[0086] Formulation Example 10: 10% Compound A·Transfluthrin emulsifiable concentrate

[0087] Compound A 9g Transfluthrin 1g Calcium dodecylbenzenesulfonate 6g Phenol polyoxyethylene ether 2g Castor Oil Polyoxyethylene Ether 4g Cyclohexanone 6g N,N-dimethylacetamide Up to 100g

[0088] Formulation Example 11: 5% Compound A·Transfluthrin Emulsion in Water

[0089] Compound A 4g Transfluthrin 1g Diisopropyl adipate 2g Calcium dodecylbenzenesulfonate 6g Ethylene oxide-propylene oxide block copolymer 4g Castor Oil Polyoxyethylene Ether 2g Glycerol 3g Silicone compounds 0.3g water Up to 100g

[0090] Formulation Example 12: 5% Compound A·Transfluthrin Microemulsion

[0091] Compound A 2.5g Transfluthrin 2.5g Calcium dodecylbenzenesulfonate 4g Castor Oil Polyoxyethylene Ether 15g Fatty alcohol polyoxyethylene ether 4g N,N-dimethylacetamide 13g water Up to 100g

[0092] Formulation Example 13: 10% Compound A·Transfluthrin soluble liquid

[0093] Compound A 8g Transfluthrin 2g Calcium dodecylbenzenesulfonate 4g Castor Oil Polyoxyethylene Ether 9g Ethylene oxide-propylene oxide block copolymer 5g Acetyl tributyl citrate 10g N,N-dimethylacetamide Up to 100g

[0094] Formulation Example 14: 1.5% Compound A·Transfluthrin Hot Mist

[0095] Compound A 1g Transfluthrin 0.5g Ethylene glycol methyl ether 8g White oil Up to 100g

[0096] Formulation Example 15: 12% Compound A·Transfluthrin Suspension Emulsion

[0097]

[0098] Formulation Example 16: 11% Compound A·Metofluthrin emulsifiable concentrate

[0099] Compound A 10g Metofluthrin 1g Calcium dodecylbenzenesulfonate 8g Benzyl dimethylphenol polyoxyethyl ether 5g N,N-dimethylacetamide Up to 100g

[0100] Formulation Example 17: 0.6% Compound A·Metofluthrin Aerosol

[0101] Compound A 0.4g Metofluthrin 0.2g Isopropyl hexadecanoate 5g D80 Up to 50g Propylene butane gas 50g

[0102] Formulation Example 18: 5% Compound A·Metofluthrin Emulsion in Water

[0103] Compound A 4g Metofluthrin 1g N,N-dimethylpropionamide 15g Calcium dodecylbenzenesulfonate 3g Alkylphenol polyoxyethylene ether phosphate 7g Castor Oil Polyoxyethylene Ether 3g Ethylene glycol 5g Dimethicone 0.1g water Up to 100g

[0104] Formulation Example 19: 7% Compound A·Metofluthrin Microemulsion

[0105] Compound A 6g Metofluthrin 1g Calcium dodecylbenzenesulfonate 8g Castor Oil Polyoxyethylene Ether 20g N,N-dimethylacetamide 20g water Up to 100g

[0106] Formulation Example 20: 15% Compound A·Metofluthrin Soluble Liquid

[0107] Compound A 10g Metofluthrin 4g Calcium dodecylbenzenesulfonate 5g Castor Oil Polyoxyethylene Ether 13g Ningru 36# 7g Piperonyl butoxide 1g N,N-Dimethylacetamide Up to 100g

[0108] Formulation Example 21: 0.9% Compound A·Metofluthrin Thermal Mist

[0109] Compound A 0.8g Metofluthrin 0.1g N,N-Dimethylacetamide 12g diesel fuel Up to 100g

[0110] Formulation Example 22: 22% Compound A·Metofluthrin Suspension Emulsion

[0111] Compound A 20g Metofluthrin 2g Isopropyl hexadecanoate 18g Calcium dodecylbenzenesulfonate 2g Castor Oil Polyoxyethylene Ether 0.5g Ethylene oxide-propylene oxide block copolymer 1g Glyceryl fatty acid ester polyoxyethylene ether 3g Alkyl sulfate 5g Isopropyl myristate 8g Xanthan gum 0.25g White Carbon Black 1.5g Potassium Sorbate 0.4g Sodium Benzoate 0.2g Glycerol 5g water Up to 100g

[0112] Formulation Example 23: 10.5% Compound A·D-trans-chlorpromazine emulsifiable concentrate

[0113]

[0114] Formulation Example 24: 5% Compound A·D-trans-chlorpromazine aqueous emulsion

[0115] Compound A 4.5g D-trans-chlorpromazine 0.5g N, N-dimethyl decanoic acid amide 10g Diisopropyl adipate 8g Alkylphenol polyoxyethylene ether phosphate 3g Ethylene oxide-propylene oxide block copolymer 2g Calcium dodecylbenzenesulfonate 5g Castor Oil Polyoxyethylene Ether 5g Ethylene glycol 3g Silicone compounds 0.3g water Up to 100g

[0116] Formulation Example 25: 7% Compound A·D-trans-chlorpromazine microemulsion

[0117] Compound A 6g D-trans-chlorpromazine 1g Calcium dodecylbenzenesulfonate 6g Castor Oil Polyoxyethylene Ether 20g Ethylene oxide-propylene oxide block copolymer 2g N,N-dimethylacetamide 20g water Up to 100g

[0118] Formulation Example 26: 8% Compound A·D-trans-chlorpromazine soluble liquid

[0119] Compound A 6g D-trans-chlorpromazine 2g Calcium dodecylbenzenesulfonate 5g Castor Oil Polyoxyethylene Ether 4g Phenylphenol polyoxyethyl ether phosphate 10g Piperonyl butoxide 5g N,N-dimethylpropionamide Up to 100g

[0120] Formulation Example 27: 2% Compound A·D-trans-chlorpromazine thermal spray

[0121] Compound A 1g D-trans-chlorpromazine 1g Diisopropyl adipate 11g White oil Up to 100g

[0122] Formulation Example 28: 0.6% Compound A·D-trans-chlorpromazine aerosol

[0123]

[0124] Formulation Example 29: 27% Compound A·D-trans-chlorpromazine pyrethrin suspension emulsion

[0125] Compound A 25.5g D-trans-chlorpromazine 1.5g Diisopropyl adipate 12g Calcium dodecylbenzenesulfonate 5g Castor Oil Polyoxyethylene Ether 2.5g Ethylene oxide-propylene oxide block copolymer 1.5g Lignin sulfonate 5g Sodium Lauryl Sulfate 2.5g Diisopropyl adipate 10g Xanthan gum 0.25g White Carbon Black 1g Potassium Sorbate 0.5g Propylene glycol 6g Dimethicone 0.2g water Up to 100g

[0126] Formulation Example 30: 10% Compound A·D-phenothrin emulsifiable concentrate

[0127] Compound A 9g D-phenothrin 1g Ningru 36# 3g Fatty alcohol polyoxyethylene ether 5g Castor Oil Polyoxyethylene Ether 2g Trimethylbenzene 8g Tetramethylbenzene 5g Dodecylbenzene Up to 100g

[0128] Formulation Example 31: 6% Compound A·D-phenothrin Emulsion in Water

[0129]

[0130] Formulation Example 32: 7% Compound A·D-phenothrin Microemulsion

[0131] Compound A 5g D-phenothrin 2g Ethylene oxide-propylene oxide block copolymer 2g Calcium dodecylbenzenesulfonate 6g Castor Oil Polyoxyethylene Ether 12g Fatty alcohol polyoxyethylene ether 3g N,N-dimethylacetamide 15g water Up to 100g

[0132] Formulation Example 33: 10% Compound A·D-phenothrin soluble liquid

[0133] Compound A 5g D-phenothrin 5g Sorbitan monostearate 2g Alkylphenol polyoxyethylene ether 5g Phenylphenol polyoxyethyl ether phosphate 11g Cyclohexanone 10g N,N-dimethylacetamide Up to 100g

[0134] Formulation Example 34: 6% Compound A·Sepfluthrin emulsifiable concentrate

[0135] Compound A 5g Tefluthrin 1g Calcium dodecylbenzenesulfonate 54.5g Fatty alcohol polyoxyethylene ether 2g Castor Oil Polyoxyethylene Ether 2.5g N-Methylpyrrolidone 12g N,N-dimethylpropionamide Up to 100g

[0136] Formulation Example 35: 5% Compound A·Sesfluthrin Emulsion in Water

[0137] Compound A 4g Tefluthrin 1g N, N-dimethyl decanoic acid amide 15g Alkylphenol polyoxyethylene ether phosphate 2g Ethylene oxide-propylene oxide block copolymer 3g Calcium dodecylbenzenesulfonate 6g Ethylene glycol 5g Dimethicone 0.3g water Up to 100g

[0138] Formulation Example 36: 4.5% Compound A·Sesfluthrin Microemulsion

[0139] Compound A 4g Tefluthrin 0.5g Ethylene oxide-propylene oxide block copolymer 1g Castor Oil Polyoxyethylene Ether 13g Fatty alcohol polyoxyethylene ether 6g N,N-dimethylpropionamide 15g water Up to 100g

[0140] Formulation Example 37: 6% Compound A·Sesfluthrin Soluble Liquid

[0141] Compound A 3g Tefluthrin 3g Sorbitan monostearate 3g Alkylphenol polyoxyethylene ether 6g Benzyl dimethylphenol polyoxyethyl ether 12g Cyclohexanone 7g N,N-dimethylacetamide Up to 100g

[0142] Formulation Example 38: 0.3% Compound A·Sesfluthrin Aerosol

[0143] Compound A 0.2g Metofluthrin 0.1g Isopropyl myristate 5g D100 Up to 50g Propylene butane gas 50g

[0144] Formulation Example 39: 11% Compound A·D-tefomethrin emulsifiable concentrate

[0145] Compound A 10g Dexamethasone 1g Calcium dodecylbenzenesulfonate 6g Fatty alcohol polyoxyethylene ether 1g Castor Oil Polyoxyethylene Ether 5g Cyclohexanone 15g Trimethylbenzene Up to 100g

[0146] Formulation Example 40: 6% Compound A·D-tefothrin Emulsion in Water

[0147]

[0148]

[0149] Formulation Example 41: 9% Compound A·D-tefothrin Microemulsion

[0150] Compound A 8g Dexamethasone 1g Ethylene oxide-propylene oxide block copolymer 3g Castor Oil Polyoxyethylene Ether 7g Fatty alcohol polyoxyethylene ether 9g N,N-dimethylpropionamide 17g Isopropyl myristate 3g water Up to 100g

[0151] Formulation Example 42: 13% Compound A·D-tefothrin soluble liquid

[0152] Compound A 11g Dexamethasone 2g Sorbitan monostearate 2g Calcium dodecylbenzenesulfonate 10g Fatty alcohol polyoxyethylene ether 5g Cyclohexanone 10g N,N-dimethylacetamide Up to 100g

[0153] Formulation Example 43: 6% Compound A·Biological Propylene / D-allyl / D-Trans-Allethrin Emulsifiable Concentrate

[0154]

[0155] Formulation Example 44: 7% Compound A·Biological Propylene / D-allyl / D-Trans-Allethrin Emulsion in Water

[0156]

[0157]

[0158] Formulation Example 45: 4.5% Compound A·Biological Propylene / D-allylene / D-Trans-Allethrin-Rich Microemulsion

[0159]

[0160] Formulation Example 46: 8% Compound A·Biological Propylene / D-allylene / Rich D-Trans-Allethrin Soluble Liquid

[0161]

[0162] Formulation Example 47: 0.5% Compound A·Biological Propylene / D-allylene / D-Trans-Allethrin-Rich Aerosol

[0163]

[0164] Formulation Example 48: 11% Compound A·Clonazepam EC

[0165]

[0166]

[0167] Formulation Example 49: 5% Compound A·Clonazepam Emulsion in Water

[0168] Compound A 4g Chloroenyne 1g N-Methylpyrrolidone 12g Castor Oil Polyoxyethylene Ether 6g Ethylene oxide-propylene oxide block copolymer 2g Calcium dodecylbenzenesulfonate 6g Isopropyl myristate 5g Glycerol 4g Dimethicone 0.2g water Up to 100g

[0169] Formulation Example 50: 3.5% Compound A·Clonazepam Microemulsion

[0170] Compound A 3g Chlorpheniramine 0.5g Ethylene oxide-propylene oxide block copolymer 2g Castor Oil Polyoxyethylene Ether 3g Fatty alcohol polyoxyethylene ether 3g Phenylphenol polyoxyethyl ether phosphate 12g N,N-dimethylpropionamide 20g water Up to 100g

[0171] Formulation Example 51: 10% Compound A·Clonazepam Soluble Liquid

[0172] Compound A 8g Chlorpheniramine 2g Styrylphenol polyoxyethylene ether 4g Alkylphenol polyoxyethylene ether 4g Castor Oil Polyoxyethylene Ether 12g Tributyl citrate 15g N,N-dimethylacetamide Up to 100g

[0173] Formulation Example 52: 1% Compound A·Clonazepam Aerosol

[0174] Compound A 0.8g Chlorpheniramine 0.2g Diisopropyl adipate 12g Odorless kerosene Up to 50g Propylene butane gas 50g

[0175] Formulation Example 53: 13% Compound A·D-methrin emulsifiable concentrate

[0176]

[0177] Formulation Example 54: 6% Compound A·D-methrin Emulsion in Water

[0178] Compound A 5g Dexamethrin 1g Diisopropyl adipate 10g Calcium dodecylbenzenesulfonate 8g Ethylene oxide-propylene oxide block copolymer 3g Fatty alcohol polyoxyethylene ether 3g Glycerol 4g Silicone compounds 0.3g water Up to 100g

[0179] Formulation Example 55: 0.8% Compound A·D-methrin Aerosol

[0180] Compound A 0.6g Dexamethrin 0.2g Diisopropyl adipate 5g Odorless kerosene Up to 50g Propylene butane gas 50g

[0181] Formulation Example 56: 9% Compound A·D-methrin Microemulsion

[0182] Compound A 8g Dexamethrin 1g Calcium dodecylbenzenesulfonate 6g Castor Oil Polyoxyethylene Ether 12g Fatty alcohol polyoxyethylene ether 3g N,N-dimethylacetamide 15g water Up to 100g

[0183] Formulation Example 57: 10% Compound A·D-methanthrin soluble liquid

[0184] Compound A 8g Dexamethrin 2g Calcium dodecylbenzenesulfonate 7g Alkylphenol polyoxyethylene ether 5g Ethylene oxide-propylene oxide block copolymer 3g Acetyl tributyl citrate 12g N,N-dimethylacetamide Up to 100g

[0185] Formulation Example 58: 1.5% Compound A·D-methanthrin thermal mist

[0186] Compound A 1g Dexamethrin 0.5g Ethylene glycol methyl ether 8g White oil 20g diesel fuel Up to 100g

[0187] Formulation Example 59: 11% Compound A·D-methrin Suspension Emulsion

[0188] Compound A 9.5g Dexamethrin 1.5g Isopropyl myristate 10g Calcium dodecylbenzenesulfonate 5g Castor Oil Polyoxyethylene Ether 7g Ethylene oxide-propylene oxide block copolymer 0.5g Alkylphenol polyoxyethylene ether formaldehyde condensate sulfate 6g Alkyl sulfonate 4g Alkylphenol polyoxyethylene ether formaldehyde condensate sulfate 0.5g Xanthan gum 0.3g Magnesium Aluminum Silicate 1.0g Potassium Sorbate 0.5g Ethylene glycol 5g water Up to 100g

[0189] Formulation Example 60: 6% Compound A·Permethrin emulsifiable concentrate

[0190] Compound A 5g Tetramethrin 1g Calcium dodecylbenzenesulfonate 5g Benzyl dimethylphenol polyoxyethyl ether 1g Castor Oil Polyoxyethylene Ether 6g Cyclohexanone 20g Trimethylbenzene Up to 100g

[0191] Formulation Example 61: 5% Compound A·tetramethrin aqueous emulsion

[0192]

[0193] Formulation Example 62: 0.6% Compound A·tetramethrin aerosol

[0194] Compound A 0.3g Tetramethrin 0.3g Diisopropyl adipate 4g D110 Up to 50g Propylene butane gas 50g

[0195] Formulation Example 63: 5.5% Compound A·tetramethrin Microemulsion

[0196] Compound A 5g Tetramethrin 0.5g Calcium dodecylbenzenesulfonate 10g Castor Oil Polyoxyethylene Ether 6g Fatty alcohol polyoxyethylene ether 5g N,N-dimethylpropionamide 20g water Up to 100g

[0197] Formulation Example 64: 8% Compound A·tetramethrin soluble liquid

[0198] Compound A 7g Tetramethrin 1g Calcium dodecylbenzenesulfonate 6g Alkylphenol polyoxyethylene ether 6g Sorbitan fatty acid ester polyoxyethylene ether 2g Isopropyl hexadecanoate 10g N,N-dimethylacetamide Up to 100g

[0199] Formulation Example 65: 1.5% Compound A·Permethrin Thermal Mist

[0200] Compound A 2g Tetramethrin 0.5g Diisopropyl adipate 10g White oil Up to 100g

[0201] Formulation Example 66: 11% Compound A·tetramethrin Suspension Emulsion

[0202]

[0203] Preparations prepared using the above-mentioned formulation examples were used for indoor efficacy tests against mosquitoes and flies

[0204] Test targets: Culex pipiens pallens (a local resistant mosquito species in Yangzhou), female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0205] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0206] Test method: refer to GB / T 13917.10-2009, simulate the site, and use the simulated room hanging cage method to conduct the test;

[0207] Application method: Ultra-low volume spray

[0208] Dosage setting: The spray concentration of the active ingredient in the preparation examples is 1.5 mg / m 3 ;

[0209] Control sample: Control sample 1: 5% compound A emulsifiable concentrate, spraying dose 1.5 mg / m 3 ;

[0210] Control sample 2: 5% tetrafluthrin emulsifiable concentrate, spraying dose 1.5 mg / m 3 ;

[0211] Control 3: 5% metofluthrin EC, spraying dose 1.5 mg / m 3 ;

[0212] Control sample 4: 5% D-trans-chlorpromazine emulsifiable concentrate, spraying dose 1.5 mg / m 3 ;

[0213] The control sample also selected a mainstream commercial hygienic insecticide, control sample 5: 10.4% chlorpyrifos·allethrin emulsion (Jiangsu Gongcheng Biotechnology Co., Ltd.), spraying dose 1.5 mg / m 3 ; Control sample 6: 5% chlorpyrifos·permethrin emulsion (Jiangsu Youjia Plant Protection Co., Ltd.), spraying dose 1.5 mg / m 3 ;

[0214] Test results:

[0215] The efficacy of the single-dose emulsifiable concentrate of control sample 1 on mosquitoes and flies is significantly worse than that of the formulation examples of the present invention in terms of knockdown effect; the 5% tetrafluthrin emulsifiable concentrate of control sample 2, the 5% metofluthrin emulsifiable concentrate of control sample 3 and the 5% dextro-trans-chlorprothrin emulsifiable concentrate of control sample 4 have good knockdown effects on mosquitoes and flies, but their lethal effects are poor and the lethality rates are low; the formulation examples 3, 18 and 24 of the present invention not only have good knockdown effects, but also have relatively high lethality rates (see Tables 5, 6 and 7).

[0216] Table 5 Efficacy test of formulation example 3 against Culex pipiens pallens and housefly

[0217]

[0218] Table 6: Efficacy test of preparation examples 18 against Culex pipiens pallens and housefly

[0219]

[0220] Table 7: Efficacy test of preparation example 24 against Culex pipiens pallens and housefly

[0221]

[0222] Table 8 Efficacy test of the preparation examples against Culex pipiens pallens and housefly

[0223]

[0224]

[0225] The test results show (see Table 8) that the knockdown effects of the formulation examples described in Table 8 on Culex pipiens pallens and housefly are better than those of the commercially available control sample 5 (10.4% chlorpyrifos·permethrin emulsion), and the knockdown effects of some formulation examples are better than those of the commercially available control sample 6 (5% chlorpyrifos·permethrin emulsion), and the 24h lethality of the formulation examples of the present invention are all above 90%, among which the lethality of formulation examples 7-10, 23, 26, 34, 39-40, 43, and 48 all reach 100% (see Table 8). It can be seen that the formulation examples can achieve the efficacy of the mainstream sanitary insecticides on the current market, and the efficacy of some examples is significantly better than the control.

[0226] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A sanitary insecticide composition containing a methoxyacrylate compound, characterized in that: The composition is composed of component A and component B, wherein component A is a methoxyacrylate compound shown in the following structural formula, and component B is any one of cypermethrin, cypermethrin, cypermethrin, cypermethrin, d-trans-chlorpropthrin, d-phenothrin, sepfluthrin, d-sepfluthrin, bio-allethrin, d-allethrin, d-trans-allethrin, chlormethrin, d-tetramethrin, and tetramethrin; 2. The sanitary insecticide composition containing methoxyacrylate compounds according to claim 1, characterized in that: The mass ratio of component A to component B is 20:1 to 1:

1.

3. A sanitary insecticide preparation, characterized in that: The preparation uses the composition of claim 1 as an effective active ingredient, which accounts for 0.1% to 30% of the preparation mass.

4. The sanitary insecticide preparation according to claim 3, characterized in that: The preparation further contains auxiliary materials, which are any one or more of solvents, emulsifiers, dispersants, wetting agents, defoamers, antifreeze agents, preservatives, thickeners, and water.

5. The sanitary insecticide preparation according to claim 3, characterized in that: The preparation dosage form is aerosol, emulsifiable concentrate, aqueous emulsion, microemulsion, soluble liquid, thermal mist or suspoemulsion.

6. Use of the composition according to claim 1 or the preparation according to claim 3, characterized in that: Use of the composition according to claim 1 or the preparation according to claim 3 in controlling sanitary pests.

7. The use according to claim 6, characterized in that: The sanitary pests are one or more of Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Argus harassingus, Chironomids, Housefly, Cityfly, Chrysopa longituba, Lucilia sericata, Lucilia cuprina, Lucilia brighten, Summer toilet fly, Meta toilet fly, Bed bug, Human flea, Ixodes persulcatus, Ixodes sinensis, Ixodes steppe, Boophilus microplus, Gamas and Scabies.

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