Silicate / macromolecular polysaccharide oral protein delivery system as well as preparation method and application thereof

The protein drugs are loaded into the gastrointestinal tract through silicate/polymer polysaccharide complex, which solves the problem that it is difficult to reach the inflammatory site by oral administration of protein drugs, achieves sustained release and retention of proteins, and effectively alleviates the symptoms of allergic rhinitis.

CN119679703APending Publication Date: 2025-03-25CHINA PHARM UNIV
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Patent Information

Application Number
CN202411891765.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-20
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

The prior art is difficult to effectively deliver protein drugs to the inflammatory site by oral administration, while avoiding damage to normal tissues, especially when treating chronic inflammation such as inflammatory bowel disease and allergic rhinitis.

Method used

A silicate/polymer polysaccharide complex is used as an oral protein delivery system. By combining the protein-loaded polymer polysaccharide hydrogel with silicates, a complex is formed, which uses its sustained release and retention ability in the gastrointestinal tract to protect the protein from degradation and promote its release at the inflammatory site.

Benefits of technology

It achieves long-term sustained release and retention of protein in the gastrointestinal tract, protects protein from degradation of the gastrointestinal environment, and effectively alleviates the symptoms of allergic rhinitis.

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Abstract

The invention discloses a silicate / high-molecular polysaccharide oral protein delivery system as a carrier for delivering oral protein. The silicate / high-molecular polysaccharide oral protein delivery system is prepared by adsorbing high-molecular polysaccharide hydrogel loaded with protein by silicate; the protein delivery system has a good drug sustained release characteristic and relatively strong mucous membrane adhesion and mucous membrane infiltration capacity; the prepared silicate / macromolecular polysaccharide oral protein preparation can protect protein drugs from being degraded by the gastrointestinal tract environment, and the retention capacity of protein in the gastrointestinal tract is enhanced; meanwhile, the loaded antibody is used for treating mucous membrane related inflammation, and the anti-TNF-alpha antibody delivered by the carrier can effectively relieve allergic rhinitis.
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