Bionic myocardial device based on photo-thermal conversion and thermoelectric conversion

By designing a bionic myocardial device based on photothermal conversion and thermoelectric conversion, the combination of photothermal layer and thermoelectric layer is used to solve the problem that it is difficult to install an electrical production system in the heart, and effective electrical stimulation in the heart and improvement of myocardial function is achieved.

CN119680016APending Publication Date: 2025-03-25CHINA PHARM UNIV
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Patent Information

Application Number
CN202411920523.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-25
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

The prior art is difficult to effectively install power production systems in the heart. The low biocompatibility of traditional power production systems and the special cardiac physiological environment limit their clinical applications.

Method used

A bionic myocardial device based on photothermal conversion and thermoelectric conversion is designed, and the near-infrared light is converted into heat using the photothermal layer, and the thermoelectric conversion is realized through the thermoelectric layer using the Fe(CN)64–/Fe(CN)63– system to generate electrical stimulation.

Benefits of technology

Deep penetration and controllable temperature difference in the heart are achieved, continuous production of current, improved cardiomyocyte function, and overcome the operability and biocompatibility problems of traditional power generation systems.

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Abstract

The invention relates to the technical field of high polymer materials, in particular to a preparation method of a bionic myocardial device based on photo-thermal conversion and thermoelectric conversion, and the bionic myocardial device comprises a thermoelectric gel (EpH) and photo-thermal patch (PHP) double-layer structure. Firstly, a conjugated polymer (HPAE-Py) is synthesized, the conjugated polymer (HPAE-Py), gelatin and Fe < 3 + > are uniformly stirred to prepare PHP, and the PHP has strong wet adhesion and conductive characteristics and can respond to NIR-II (1064nm) in vivo to generate heat. Meanwhile, spiral peptide is designed, conductive polypeptide hydrogel is prepared to serve as a basic framework, a redox conjugate Fe (CN) 64- / Fe (CN) 63-is dispersed in the hydrogel to prepare PHP, and the thermocurrent effect is generated through the temperature difference of different layers of hydrogel. In conclusion, the bionic myocardial device prepared by combining the EpH and the PHP has the advantages of strong heart viscosity, high NIR-II responsiveness and in-vivo power generation, overcomes the operability problem of a power generation device at the heart part, and can be used for treating myocardial infarction.
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