Synthesis process of halvorixafor
Through the synthesis process of four-step chemical reactions, the problem of low efficiency of the synthesis process of Mavolishafu in the existing technology is solved, and an efficient and simple synthesis process is achieved, which is suitable for industrial production.
CN119684266APending Publication Date: 2025-03-25WUHAN JIUZHOU YUMIN PHARM TECH CO LTD
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Patent Information
- Application Number
- CN202411871707.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-18
- Publication Date
- 2025-03-25
AI Technical Summary
Technical Problem
There is room for improvement in the synthesis process of Mavolishafu in the prior art, especially in improving efficiency and simplifying the process.
Method used
A four-step chemical reaction synthesis process was adopted: firstly, the (S)-type substrate was separated from the initial raw material using the commercially available lipase Novozyme 435; then the amide condensation reaction was carried out; then the alkylation reaction was carried out; finally, the Mavolishafos was obtained by removing the BOC group.
Benefits of technology
It realizes efficient synthesis of Mavolishafu, simplifies process steps, improves reaction efficiency and yield, and is suitable for mass industrial production.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to a synthesis process of mavorixafor. The preparation method comprises the following steps: separating an (S)-type substrate (a compound shown in a formula 2) from an initial raw material (a compound shown in a formula 1) by using commercially available lipase Novozyme 435, carrying out an amide condensation reaction on the compound shown in the formula 2 and a compound shown in a formula 3 to obtain a compound shown in a formula 4, carrying out an alkylation reaction on the compound shown in the formula 4 and a compound shown in a formula 5 to obtain a compound shown in a formula 6, and removing a BOC group to obtain the compound shown in the formula 6. And filtering to obtain the product, namely the vervorixafor. According to the synthesis process, the synthesis route has the advantages of high yield and the like, the selected raw materials are easy to obtain, the operation method is simple and convenient, the reaction rate of each step is relatively high, and the synthesis process is very suitable for batch industrial production.
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