Aesculin-manganese complex as well as preparation method and application thereof
By developing the quinpietin-manganese complex and using its antibacterial mechanism with bacteria, the bacterial resistance problem caused by existing antibiotics is solved, and the efficient antibacterial effect on bacteria such as Staphylococcus aureus is achieved, and bacterial resistance is not easily induced.
Patent Information
- Application Number
- CN202411794150.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-06
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2044-12-06
AI Technical Summary
The excessive use of existing antibiotics has led to a significant increase in bacterial resistance, the development speed of new antibacterial drugs is lagging, and there is a lack of antibacterial drugs with novel structures, strong antibacterial activity and difficult to induce bacterial resistance.
A quinpi-manganese complex was developed, and by combining quinpi-methylene glycol with Mn2+ to form Mn-O bonds, the complex was synthesized by hydrothermal method, and structural characterization and antibacterial activity were studied.
The Chinpi-ethiin-manganese complex significantly improved the antibacterial activity against a variety of bacteria, especially the antibacterial activity of Staphylococcus aureus by 4 times. After continuous culture for 20 generations, its minimum inhibitory concentration did not change, suggesting that this complex is not easy to induce bacterial resistance.