Polypeptide targeting ASAP1 / ASAP2 and application thereof

By discovering strong specific interactions between the SH3 domain of ASAP1 or ASAP2 and the design of polypeptides containing a common motif, the problem of SH3 domain-targeted drug development in the prior art was solved, and the signaling of ASAP1/ASAP2 was effectively blocked and the metastasis and invasion of cancer cells was inhibited.

CN119708135APending Publication Date: 2025-03-28SHENZHEN BAY LAB
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Patent Information

Application Number
CN202411764147.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-29
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The prior art is difficult to develop ligands with high affinity and high specificity binding to the SH3 domain, limiting the development and application of drugs targeting the SH3 domain.

Method used

It was found that the SH3 domain of ASAP1 or ASAP2 had a strong and specific interaction with the giant ankyrin B (gAnkB), and through analyzing the complex structure and biochemical analysis, a universal motif (K-P-X-R) that binds high affinity to ASAP1-SH3 was revealed, and a polypeptide containing this universal motif was designed to block the signaling of ASAP1/ASAP2.

Benefits of technology

High affinity and specific blockade of ASAP1/ASAP2 binding to its ligands is achieved, thereby inhibiting the metastasis and invasion of cancer cells, providing a new targeted therapeutic strategy.

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Abstract

The invention relates to a polypeptide targeting ASAP1 / ASAP2 and an application of the polypeptide. Specifically, the present disclosure relates to a polypeptide comprising an amino acid sequence represented by K-X3-X4-R (formula I) or a pharmaceutically acceptable salt, solvate or derivative thereof: wherein X3 is selected from P, V, A, I, G or S, and X4 is selected from any natural amino acid. The invention also relates to a composition containing the polypeptide or the pharmaceutically acceptable salt, solvate or derivative thereof, or application thereof.
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