New method for rapidly screening anti-tumor drugs by using field effect transistor

By using AlGaN/GaN field effect transistors to detect the electrical changes of drugs to cells, the problem of limited operation difficulty and long time during drug screening in the prior art is solved, and rapid and accurate screening of anti-tumor drugs is achieved, with high sensitivity and non-invasiveness.

CN119715742APending Publication Date: 2025-03-28NANJING UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Application Number
CN202411895073.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-21
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The prior art has problems such as difficulty in operation, possible damage to cell membranes, limited recording range and long time limitations in the drug screening process, making it difficult to achieve rapid and precise screening of anti-tumor drugs.

Method used

AlGaN/GaN field-effect transistors (HFETs) were used as biosensors to quickly screen the charge generation induced by B lymphoma cells by detecting drugs, use highly conductive regions to detect the electrical changes of the drug to cells, and use flow cytometry to verify the intrinsic concentration distribution of the drug.

Benefits of technology

It has achieved rapid screening of anti-tumor drugs, significantly shortened detection time, has high sensitivity and low sample requirements, and has non-invasive detection. It can deeply analyze the mechanism of drug action and is suitable for high-throughput drug screening scenarios.

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Abstract

The invention relates to a novel method for rapidly screening antitumor drugs by using a field effect transistor, and provides a practical physical method for rapidly screening drugs from cancer cells and normal cells by using an AlGaN / GaN field effect transistor (HFETs). According to the method, charge generation induced by B lymphoma cells by a high-conductivity region detection drug of the AlGaN / GaN HFET is detected. The use of GaN field effect transistors assesses the influence of two anti-cancer drugs, camptothecin (CPT) and doxorubicin (DOX), on normal cell lines and tumor cell lines. Experimental results show that the action effect of the drug and the action rate of the drug on cells can be analyzed through the method, and the evaluation of the action effect of the anti-cancer drug can be facilitated.
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