Preparation method and application of high-entropy nano-enzyme with multi-path synergistic antibacterial effect

By synthesizing oxygen-rich vacancies, the problems of single catalytic pathways and poor component tunability of existing nanoenzyme materials are solved, and the multi-path coordinated antibacterial effect is achieved, which significantly improves the killing ability of bacteria and the prevention and control of marine biological pollution.

CN119733526AActive Publication Date: 2025-04-01HARBIN INST OF TECH
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Patent Information

Application Number
CN202411920938.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-25
Publication Date
2025-04-01
Estimated Expiration
2044-12-25

AI Technical Summary

Technical Problem

The existing anti-fouling nanoenzyme materials have single catalytic pathways and poor component tunability, making it difficult to effectively exert antibacterial effects in complex environments.

Method used

The oxygen-rich vacancies with halogen-like peroxidase, peroxidase-like and glutathione-like oxidase-rich high-entropy oxide nanoenzymes with halogen-like peroxidase-like and glutathione-like oxidase-like activities can catalyze the generation of hypobromic acid and hydroxyl radicals, and consume glutathione to achieve multi-path collaborative antibacterial.

Benefits of technology

Multi-path coordinated and efficient bacterial damage and inactivation have been achieved, which significantly improves antibacterial efficiency, especially in low concentrations to effectively kill high-concentration bacteria, and the bactericidal rate of E. coli and Staphylococcus aureus has reached 100%, and has demonstrated excellent marine biological pollution prevention and control performance.

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Abstract

The invention discloses a preparation method and application of a high-entropy nano-enzyme with a multi-path synergistic antibacterial effect, and belongs to the field of nano-enzyme catalytic materials. According to the invention, the oxygen vacancy-rich high-entropy oxide with similar halogen peroxidase activity, similar peroxidase activity and similar glutathione oxide enzyme activity is synthesized by using a hydrothermal method and a high-temperature calcination method for the first time; bromide ions and hydrogen peroxide can be catalyzed to generate hypobromous acid with a bacterial quorum sensing interference effect and hydroxyl free radicals with a structural function destroying effect, glutathione with a bacterial internal redox balance maintaining effect is consumed, and multi-way synergistic efficient bacterial damage and inactivation are achieved. The problems that an existing antifouling nano-enzyme material is single in catalysis way and poor in component adjustability are solved, actual extension and application of the high-entropy nano-enzyme coating are achieved, and the high-entropy nano-enzyme coating has potential application prospects in the marine organism antifouling field.
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