Zeaxanthin nano-liposome with high entrapment rate and preparation method of zeaxanthin nano-liposome
The preparation of nanoliposomes by using soy lecithin, β-sitosterol and zeaxanthin was solved, and the problem of poor stability of zeaxanthin was achieved, which improved the high encapsulation rate and bioavailability, avoided health risks.
CN119745800APending Publication Date: 2025-04-04JILIN AGRICULTURAL UNIV
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Patent Information
- Application Number
- CN202510035178.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-09
- Publication Date
- 2025-04-04
AI Technical Summary
Technical Problem
Zeaxanthin has problems such as poor stability, poor water solubility and low bioavailability, which limits its application in food, medicine and other fields.
Method used
Soy lecithin, β-sitosterol and zeaxanthin were used as raw materials to prepare high-encapsulation rate zeaxanthin nanoliposomes through dissolution, evaporation, hydration and sonication.
Benefits of technology
Zeaxanthin nanoliposomes with uniform particle size and high encapsulation rate were successfully constructed, which improved their bioavailability and avoided the health risks caused by excessive cholesterol addition.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of preparation of nano-liposomes, in particular to a zeaxanthin nano-liposome with high encapsulation efficiency and a preparation method of the zeaxanthin nano-liposome. Comprising the following steps: weighing soybean lecithin, beta-sitosterol and zeaxanthin, and dissolving in a certain volume of organic solvent; evaporating to remove the organic solvent to obtain a uniform lipid film; adding a phosphate buffer solution with the concentration of 0.1 M into the lipid membrane, and carrying out full hydration reaction for 20-40 minutes; carrying out ultrasonic treatment on the hydrated solution to obtain a coarse nano-liposome; and filtering the coarse nano-liposome to obtain the zeaxanthin nano-liposome with high encapsulation efficiency. The beta-sitosterol-containing stable nano-liposome has the advantages that the beta-sitosterol-containing stable nano-liposome is utilized to successfully construct the zeaxanthin nano-liposome with uniform particle size and high encapsulation efficiency, and compared with the common stable liposome composed of cholesterol, the beta-sitosterol-containing stable nano-liposome has obviously improved encapsulation efficiency and loading capacity.
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