Water-soluble chitin-glucan compound polysaccharide as well as preparation method and application thereof
The water-soluble chitin-glucan complex polysaccharides were isolated from higher fungi by gentle preparation methods, which solved the problem of difficult dissolution of CGC in the prior art, achieved high purity and high solubility products, and expanded their application in the field of biological activity.
CN119745914APending Publication Date: 2025-04-04SOUTH CHINA UNIV OF TECH
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Patent Information
- Application Number
- CN202411808240.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-10
- Publication Date
- 2025-04-04
AI Technical Summary
Technical Problem
The prior art is difficult to prepare water-soluble chitin-glucan complex polysaccharides, which limits its development and application in the field of biological activity.
Method used
Water-soluble CGCs were isolated from the fruiting bodies or mycelium of higher fungi, and a gentle preparation method was adopted, including cleaning, lyophilization, crushing, heating reaction, NaOH-NaBH4 treatment, alkali-urea solution treatment, running water dialysis and ultrasonic dissolution, and water-soluble CGCs of high purity and high solubility were obtained.
Benefits of technology
The water solubility of CGC has been achieved, which has improved its application potential in the field of biological activity, especially in anti-tumor and immunomodulation.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention belongs to the technical field of biological medicines, and discloses a water-soluble chitin-glucan compound polysaccharide as well as a preparation method and application thereof. In order to give full play to the unique advantage that two active polysaccharides including chitin and dextran coexist in the same compound and expand the application of the chitin and dextran in biological activity, the water-soluble CGC is prepared by using an alkali-urea solvent system through a freeze-dissolving regeneration method, the interaction of the chitin and dextran with in-vivo and cell receptors in a solution environment is given full play, and the bioactivity of the chitin and dextran is improved. Therefore, the obvious biological activity effect is generated in the aspects of anti-tumor and immunoregulation.
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