Lisinopril and hydrochlorothiazide pharmaceutical composition as well as preparation method and application thereof

By preparing lisinopril hydrochlorothiazide drug composition, the problem of difficulty in meeting the standard of hypertension in a single drug is solved, the stability and controllable quality of the drug combination are achieved, the risk of clinical medication is reduced, and patient compliance is improved.

CN119746022APending Publication Date: 2025-04-04JIANGSU TASLY DIYI PHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202411953135.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-27
Publication Date
2025-04-04

AI Technical Summary

Technical Problem

In the prior art, it is difficult to meet the standards for treating hypertension with a single drug, and most patients need to take more than two antihypertensive drugs, which are prone to drug resistance and toxic side effects, and the patient has poor compliance.

Method used

A pharmaceutical composition of lisinopril hydrochlorothiazide and a preparation method thereof is provided, including lisinopril, hydrochlorothiazide, binder, disintegrant, diluent, lubricant and other commonly used pharmaceutically used auxiliary materials. It is prepared by wet granulation and tableting process to ensure the stability and controllability of the product.

Benefits of technology

The preparation process of this pharmaceutical composition is simple, with good product stability and uniform dissolution behavior, which reduces the risk of medication caused by poor dissolution in clinical practice and improves patient compliance.

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Abstract

The invention relates to the technical field of medicinal chemistry, and discloses a lisinopril and hydrochlorothiazide pharmaceutical composition as well as a preparation method and application thereof, and the pharmaceutical composition comprises lisinopril, hydrochlorothiazide, an adhesive, a disintegrating agent, a diluent, a lubricant and other pharmaceutically common auxiliary materials. The mass percent of the lisinopril in the pharmaceutical composition is 8.10%-9.45%; the mass percent of the hydrochlorothiazide in the pharmaceutical composition is 10.13 percent to 11.81 percent. The preparation method has the advantages of reliable process, controllable quality, simple preparation process, convenience, feasibility and easiness in large-scale production, and the prepared lisinopril and hydrochlorothiazide tablets have better stability.
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