Highly enhanced targeted ultrasonic nano contrast agent capable of combining photo-thermal and immunotherapy as well as preparation method and application of highly enhanced targeted ultrasonic nano contrast agent

By using modified mesoporous silica and photothermal agent polydopamine in ultrasonic nanocontrast agents and encapsulated in IR780 lipid membranes, the problems of weak imaging intensity and insufficient drug carrying capacity are solved, and the imaging and therapeutic effects of highly enhanced targeted ultrasonic nanocontrast agents are improved.

CN119746099APending Publication Date: 2025-04-04FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Application Number
CN202411969607.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-30
Publication Date
2025-04-04

AI Technical Summary

Technical Problem

The weak imaging intensity of existing ultrasonography nanocontrast agents reduces the accuracy of clinical diagnosis, and the single structure of the lipid shell encapsulates the gas core limits the drug carrying capacity, resulting in a single treatment method.

Method used

By phenyl-modified loaded immunoadjuvant R848 on mesoporous silica, and the outer layer is modified with the photothermal agent polydopamine, encapsulated in the IR780 lipid membrane modified with near-infrared fluorescent dye, a "fig"-type ultrasonozoic nanocontrast agent is formed to enhance ultrasound imaging contrast and achieve photothermal and immunotherapy.

Benefits of technology

The ultrasound imaging contrast of ultrasound nanocontrast agents is significantly enhanced, the accuracy of diagnosis is improved, and combined photothermal and immunotherapy is achieved by carrying a variety of drugs, which enhances the therapeutic effect on tumors.

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Abstract

The invention discloses a highly enhanced targeted ultrasonic nano contrast agent capable of combining photo-thermal and immunotherapy as well as a preparation method and application of the highly enhanced targeted ultrasonic nano contrast agent. The preparation method comprises the following steps: carrying out phenyl modification on mesoporous silica, loading an immunologic adjuvant, namely Rescimod, then modifying an outer layer with a photothermal agent, namely polydopamine, wrapping the obtained nano-particles into IR780 modified with near-infrared fluorescent dye, and filling inert gas, namely perfluoropropane, so as to form the ultrasonic nano-contrast agent with a structure similar to a fig shape. According to the invention, a cascade enhancement system based on ultrasonic nano contrast agent photo-thermal therapy can be formed, and an effective way is provided for realizing complete removal of tumor tissues.
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