Extraction and purification method of glycyrrhetinic acid

Through ball mill pretreatment and supercritical CO2 extraction technology, the problems of low extraction efficiency and high impurity content of glycyrrhizic acid are solved, and high purity and high efficiency extraction is achieved, which has good industrial application value.

CN119751539AActive Publication Date: 2025-04-04SHAANXI FUJIE PHARMA
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Patent Information

Application Number
CN202411870851.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-18
Publication Date
2025-04-04
Estimated Expiration
2044-12-18

AI Technical Summary

Technical Problem

The existing methods of extracting and purification of glycyrrhizic acid have problems such as low extraction efficiency, high impurity content and complex process, which are difficult to meet the needs of industrial applications.

Method used

Ball mill pretreatment increases the specific surface area and dissolution efficiency of licorice powder, combined with supercritical CO2 extraction technology, improves the dissolution efficiency and extraction rate of target components, avoids the introduction of impurities, and significantly improves the extraction purity and efficiency.

Benefits of technology

It significantly improves the extraction rate and purity of glycyrrhizic acid, simplifies the process flow, reduces energy consumption and production costs, and has good industrial application value.

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Abstract

The invention provides an extraction and purification method of glycyrrhetinic acid, and relates to the technical field of glycyrrhetinic acid. The extraction and purification method of glycyrrhetinic acid comprises the following steps: drying licorice, crushing to obtain licorice powder, mixing the licorice powder with ethanol, carrying out ball milling, removing ethanol after ball milling, carrying out supercritical CO2 extraction on the product, and recrystallizing the extract to obtain high-purity glycyrrhetinic acid. According to the method, the extraction conditions of glycyrrhetinic acid are optimized through ball milling pretreatment, the extraction rate and product purity of glycyrrhetinic acid are greatly improved by combining a supercritical CO2 extraction technology, the problems of low glycyrrhetinic acid extraction efficiency, high impurity content, high process complexity and the like in the prior art are solved, and the method has good application value.
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