Optical detection device

By designing a device that integrates optical imaging and Raman spectroscopy detection, the problem of time-consuming and possible damage to biological active substances in biological preparation solutions in the prior art is solved, and a fast, high-throughput, and damage-free detection effect is achieved.

CN119757309APending Publication Date: 2025-04-04BIOACES (SHANGHAI) LIFE SCI CO LTD
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Patent Information

Application Number
CN202311277637.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2023-09-28
Publication Date
2025-04-04

AI Technical Summary

Technical Problem

The prior art requires a lot of manual operation when detecting subvisible particles in biological preparation solutions, which is time-consuming and tedious, and cannot meet the needs of fast and high-throughput industrial analysis, and high-power laser detection may damage bioactive substances.

Method used

An optical detection device is designed, including a first light source assembly, an imaging assembly, an image sensor and a Raman spectroscopy assembly. The sample illumination and Raman signal excitation are performed through the first incident light beam. The imaging assembly and the Raman spectroscopy assembly collect and analyze the optical signals along different optical paths respectively to achieve fast and high-throughput particle detection.

Benefits of technology

The rapid and accurate detection of particulate matter in the biological preparation solution is achieved, which reduces manual operation time, improves detection efficiency, and avoids damage to biologically active substances.

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Abstract

The present disclosure relates to an optical detection device, comprising: a first light source component, configured to generate a first incident light beam, the first incident light beam being used to irradiate a sample; an imaging component, configured to collect an outgoing light beam from the sample, and generate a first outgoing light beam traveling along a first optical path and a second outgoing light beam traveling along a second optical path based on the outgoing light beam, wherein at least a portion of the first optical path and at least a portion of the second optical path extend in different directions, respectively; an image sensor, disposed on the first optical path, and configured to generate an optical imaging image of the sample based on the first outgoing light beam; and a Raman spectroscopy component, disposed on the second optical path, and configured to generate a Raman spectrum of the sample based on the second outgoing light beam.
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