Furanopyrrole alkaloid compound, preparation method and application thereof

By extracting and isolating the furanylpyrrolidone B compound from the marine fungus Trichoderma harziano, the problem of the lack of effective regulation of angiogenesis in the existing technology has been solved, and the inhibitory effect on angiogenesis has been achieved, which has good potential for drug development.

CN120058716BActive Publication Date: 2026-04-17SECOND AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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Patent Information

Application Number
CN202510197014.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-02-21
Publication Date
2026-04-17
Estimated Expiration
2045-02-21

AI Technical Summary

Technical Problem

Existing technologies lack effective compounds for regulating angiogenesis, making it difficult to achieve precise treatment of diseases such as tumor growth and diabetic retinopathy.

Method used

A new compound, harzianopyrrolidone B, was extracted and isolated from the marine fungus *Trichoderma harzianum* ZN-4. The furanylpyrrolidone alkaloid compound, which inhibits angiogenesis, was obtained through fermentation, extraction, and chromatography.

Benefits of technology

harzianopyrrolidone B exhibits good anti-angiogenic activity and low cytotoxicity, showing promising potential for development into drugs related to angiogenesis.

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Abstract

The application discloses a furanopyrrole alkaloid compound and a preparation method and application thereof, and belongs to the technical field of marine fungus active ingredient analysis. Trichoderma harzianum A furanopyrrole alkaloid compound with a novel structure is obtained by extraction and separation from a fermentation culture of ZN-4; through a zebra fish angiogenesis inhibition test in vitro, it is shown that the furanopyrrole alkaloid compound provided by the application has good angiogenesis inhibition activity, and has development prospects in the preparation of new blood vessel related drugs.
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